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P03132 (VNCA_AAV2S) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA replication protein
Alternative name(s):
Non-capsid protein
Gene names
Name:REP
OrganismAdeno-associated virus 2 (isolate Srivastava/1982) (AAV-2)
Taxonomic identifier648242 [NCBI]
Taxonomic lineageViruses › ssDNA viruses › Parvoviridae › Parvovirinae › Dependovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for DNA replication.

Subunit structure

Interacts with host KCTD5. Ref.2

Sequence similarities

Belongs to the parvoviruses non-capsid protein family.

Contains 1 SF3 helicase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536DNA replication protein
PRO_0000222474

Regions

Domain308 – 463156SF3 helicase
Nucleotide binding334 – 3418ATP Potential

Secondary structure

1 ........................................ 536
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P03132 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 7C1ECDD4E07703C8

FASTA53660,754
        10         20         30         40         50         60 
MPGFYEIVIK VPSDLDGHLP GISDSFVNWV AEKEWELPPD SDMDLNLIEQ APLTVAEKLQ 

        70         80         90        100        110        120 
RDFLTEWRRV SKAPEALFFV QFEKGESYFH MHVLVETTGV KSMVLGRFLS QIREKLIQRI 

       130        140        150        160        170        180 
YRGIEPTLPN WFAVTKTRNG AGGGNKVVDE CYIPNYLLPK TQPELQWAWT NMEQYLSACL 

       190        200        210        220        230        240 
NLTERKRLVA QHLTHVSQTQ EQNKENQNPN SDAPVIRSKT SARYMELVGW LVDKGITSEK 

       250        260        270        280        290        300 
QWIQEDQASY ISFNAASNSR SQIKAALDNA GKIMSLTKTA PDYLVGQQPV EDISSNRIYK 

       310        320        330        340        350        360 
ILELNGYDPQ YAASVFLGWA TKKFGKRNTI WLFGPATTGK TNIAEAIAHT VPFYGCVNWT 

       370        380        390        400        410        420 
NENFPFNDCV DKMVIWWEEG KMTAKVVESA KAILGGSKVR VDQKCKSSAQ IDPTPVIVTS 

       430        440        450        460        470        480 
NTNMCAVIDG NSTTFEHQQP LQDRMFKFEL TRRLDHDFGK VTKQEVKDFF RWAKDHVVEV 

       490        500        510        520        530 
EHEFYVKKGG AKKRPAPSDA DISEPKRVRE SVAQPSTSDA EASINYADRL ARGHSL

« Hide

References

[1]"Nucleotide sequence and organization of the adeno-associated virus 2 genome."
Srivastava A., Lusby E.W., Berns K.I.
J. Virol. 45:555-564(1983) [PubMed: 6300419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of a cytoplasmic interaction partner of the large regulatory proteins Rep78/Rep68 of adeno-associated virus type 2 (AAV-2)."
Weger S., Hammer E., Goetz A., Heilbronn R.
Virology 362:192-206(2007) [PubMed: 17239418] [Abstract]
Cited for: INTERACTION WITH KCTD5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J01901 Genomic DNA. Translation: AAA42372.1.
PIRUYAD1A. A03694.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1S9HX-ray2.40A/B/C225-490[»]
1U0JX-ray2.10A225-490[»]
ProteinModelPortalP03132.
SMRP03132. Positions 1-198, 225-490.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-6732280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR014015. Helicase_SF3_DNA-vir.
IPR001257. Parvovirus_NS1_helicase.
IPR014835. Rep_N.
[Graphical view]
PfamPF01057. Parvo_NS1. 1 hit.
PF08724. Rep_N. 1 hit.
[Graphical view]
PROSITEPS51206. SF3_HELICASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVNCA_AAV2S
AccessionPrimary (citable) accession number: P03132
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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