##gff-version 3 P03070 UniProtKB Chain 1 708 . . . ID=PRO_0000115046;Note=Large T antigen P03070 UniProtKB Domain 12 75 . . . Note=J;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00286 P03070 UniProtKB Domain 400 560 . . . Note=SF3 helicase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00551 P03070 UniProtKB DNA binding 139 254 . . . Note=T-ag OBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00620 P03070 UniProtKB Zinc finger 265 357 . . . Note=T-ag D1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00671 P03070 UniProtKB Region 63 89 . . . Note=Binding of LT to the CUL7 complex P03070 UniProtKB Region 109 134 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03070 UniProtKB Region 337 672 . . . Note=Binding to host TP53 protein P03070 UniProtKB Region 418 616 . . . Note=ATPase activity P03070 UniProtKB Region 627 708 . . . Note=C-terminal region P03070 UniProtKB Region 630 685 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03070 UniProtKB Region 699 708 . . . Note=CPD P03070 UniProtKB Motif 103 107 . . . Note=LXCXE motif;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11226179;Dbxref=PMID:11226179 P03070 UniProtKB Motif 125 132 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6096007;Dbxref=PMID:6096007 P03070 UniProtKB Compositional bias 120 134 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03070 UniProtKB Compositional bias 645 659 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03070 UniProtKB Compositional bias 660 684 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P03070 UniProtKB Binding site 302 302 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00671 P03070 UniProtKB Binding site 305 305 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00671 P03070 UniProtKB Binding site 313 313 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00671 P03070 UniProtKB Binding site 317 317 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00671 P03070 UniProtKB Binding site 426 433 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00551 P03070 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine%3B by host;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:205802;Dbxref=PMID:205802 P03070 UniProtKB Modified residue 106 106 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2838952;Dbxref=PMID:2160857,PMID:2838952 P03070 UniProtKB Modified residue 112 112 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2838952;Dbxref=PMID:2160857,PMID:2838952 P03070 UniProtKB Modified residue 120 120 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2160857;Dbxref=PMID:2160857 P03070 UniProtKB Modified residue 123 123 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2838952;Dbxref=PMID:2160857,PMID:2838952 P03070 UniProtKB Modified residue 124 124 . . . Note=Phosphothreonine%3B by host;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2552322,ECO:0000269|PubMed:2838952,ECO:0000269|PubMed:8648725;Dbxref=PMID:2160857,PMID:2552322,PMID:2838952,PMID:8648725 P03070 UniProtKB Modified residue 639 639 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2160857;Dbxref=PMID:2160857 P03070 UniProtKB Modified residue 676 676 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:2838952;Dbxref=PMID:2838952 P03070 UniProtKB Modified residue 677 677 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2838952;Dbxref=PMID:2160857,PMID:2838952 P03070 UniProtKB Modified residue 679 679 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2838952;Dbxref=PMID:2160857,PMID:2838952 P03070 UniProtKB Modified residue 697 697 . . . Note=N6-acetyllysine%3B by host;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15254196;Dbxref=PMID:15254196 P03070 UniProtKB Modified residue 701 701 . . . Note=Phosphothreonine%3B by host;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2160857,ECO:0000269|PubMed:2838952;Dbxref=PMID:2160857,PMID:2838952 P03070 UniProtKB Alternative sequence 132 135 . . . ID=VSP_035893;Note=In isoform 17kT antigen. VEDP->ALLT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8223482;Dbxref=PMID:8223482 P03070 UniProtKB Alternative sequence 136 708 . . . ID=VSP_035894;Note=In isoform 17kT antigen. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8223482;Dbxref=PMID:8223482 P03070 UniProtKB Natural variant 531 531 . . . Note=Y->F P03070 UniProtKB Natural variant 549 549 . . . Note=P->A P03070 UniProtKB Mutagenesis 98 98 . . . Note=Complete loss of interaction with host CUL7. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16140746;Dbxref=PMID:16140746 P03070 UniProtKB Mutagenesis 124 124 . . . Note=200-fold reduction in phosphorylation by CDC2. No DNA replication activation. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8648725;Dbxref=PMID:8648725 P03070 UniProtKB Mutagenesis 679 679 . . . Note=Enhanced DNA replication. S->A P03070 UniProtKB Mutagenesis 701 701 . . . Note=Complete loss of interaction with host FBW7gamma isoform. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15611062;Dbxref=PMID:15611062 P03070 UniProtKB Helix 7 16 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Helix 27 36 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Turn 37 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Turn 43 45 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Turn 48 52 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Helix 53 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Beta strand 87 89 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Helix 91 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1GH6 P03070 UniProtKB Beta strand 136 138 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Helix 140 145 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Beta strand 156 163 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Helix 165 178 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Beta strand 182 189 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Beta strand 192 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Helix 205 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Beta strand 217 219 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4GDF P03070 UniProtKB Beta strand 221 227 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Helix 229 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Beta strand 242 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Helix 251 254 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FUF P03070 UniProtKB Helix 270 279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 285 293 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 294 296 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Turn 299 301 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVO P03070 UniProtKB Helix 303 306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 311 314 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 317 327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 333 354 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 357 375 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 377 379 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVL P03070 UniProtKB Helix 384 394 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Turn 395 397 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 401 414 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 421 425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 428 431 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1N25 P03070 UniProtKB Helix 432 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 446 448 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 450 452 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2H1L P03070 UniProtKB Turn 454 456 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 457 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 462 464 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 470 472 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Turn 479 484 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 490 495 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 498 502 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 507 509 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 512 514 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 517 519 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 524 528 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 535 538 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Beta strand 541 546 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 551 558 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 562 565 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 572 582 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 585 587 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 590 592 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 593 606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM P03070 UniProtKB Helix 609 621 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SVM