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Protein

TrfB transcriptional repressor protein

Gene

trfB

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

In conjunction with KorB, inhibits the transcription of kilA, trfA and korAB operons. In conjunction with KorC is responsible for the negative control of kilC and kilE operons.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 56H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TrfB transcriptional repressor protein
Alternative name(s):
Regulatory protein KorA
Gene namesi
Name:trfB
Synonyms:korA
Encoded oniPlasmid IncP-alpha RK20 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000683801 – 101TrfB transcriptional repressor proteinAdd BLAST101

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
korBP076742EBI-6405477,EBI-6405482

Protein-protein interaction databases

DIPiDIP-27644N.
IntActiP03052. 1 interactor.

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 14Combined sources8
Helixi21 – 31Combined sources11
Helixi37 – 44Combined sources8
Helixi48 – 64Combined sources17
Beta strandi65 – 67Combined sources3
Beta strandi71 – 78Combined sources8
Helixi80 – 94Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N5GNMR-A/B1-101[»]
2W7NX-ray1.85A/B1-101[»]
5CKTX-ray2.00A/B/C1-99[»]
D1-101[»]
5CLVX-ray2.50A/B2-97[»]
E/F/I/J/M/N2-66[»]
5CM3X-ray2.30A/B1-97[»]
SMRiP03052.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03052.

Family & Domainsi

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR032428. TrfB.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF16509. KORA. 1 hit.

Sequencei

Sequence statusi: Complete.

P03052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRLTESQF QEAIQGLEVG QQTIEIARGV LVDGKPQATF ATSLGLTRGA
60 70 80 90 100
VSQAVHRVWA AFEDKNLPEG YARVTAVLPE HQAYIVRKWE ADAKKKQETK

R
Length:101
Mass (Da):11,306
Last modified:July 21, 1986 - v1
Checksum:i25622FB8F98F21A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03962 Genomic DNA. Translation: CAA27596.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKORA2_ECOLX
AccessioniPrimary (citable) accession number: P03052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 12, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references