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Protein

Transcriptional activator II

Gene

cII

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator that allows virus to initiate a latent state. Following infection, participates together with cIII in activation of the Pe and Pi promoters, which are responsible for the transcription of the cI (repressor) and int (integrase) genes, respectively. Both of these gene products are required for the establishment of latency.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi26 – 45H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator II
Gene namesi
Name:cII
Ordered Locus Names:lambdap59
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000775921 – 97Transcriptional activator IIAdd BLAST97

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homotetramer. Interacts with cIII; this interaction is essential to stabilize cII that would otherwise be quickly degraded by host protease FtsH.

Protein-protein interaction databases

IntActiP03042. 2 interactors.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 24Combined sources19
Helixi26 – 33Combined sources8
Helixi37 – 46Combined sources10
Helixi48 – 58Combined sources11
Helixi64 – 77Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XWRX-ray2.56A/B/C/D1-97[»]
1ZPQX-ray2.80A/B/C/D1-97[»]
1ZS4X-ray1.70A/B/C/D4-82[»]
ProteinModelPortaliP03042.
SMRiP03042.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03042.

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda phage cII protein family.Curated

Family and domain databases

InterProiIPR010982. Lambda_DNA-bd_dom.
IPR007933. Transcrpt_activ_CII.
[Graphical view]
PfamiPF05269. Phage_CII. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.

Sequencei

Sequence statusi: Complete.

P03042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRANKRNEA LRIESALLNK IAMLGTEKTA EAVGVDKSQI SRWKRDWIPK
60 70 80 90
FSMLLAVLEW GVVDDDMARL ARQVAAILTN KKRPAATERS EQIQMEF
Length:97
Mass (Da):11,056
Last modified:July 21, 1986 - v1
Checksum:iAF4E0428E68DB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02460 Genomic DNA. Translation: AAA32246.1.
J02459 Genomic DNA. Translation: AAA96583.1.
PIRiA03579. QCBP2L.
RefSeqiNP_040630.1. NC_001416.1.

Genome annotation databases

GeneIDi2703494.
KEGGivg:2703494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02460 Genomic DNA. Translation: AAA32246.1.
J02459 Genomic DNA. Translation: AAA96583.1.
PIRiA03579. QCBP2L.
RefSeqiNP_040630.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XWRX-ray2.56A/B/C/D1-97[»]
1ZPQX-ray2.80A/B/C/D1-97[»]
1ZS4X-ray1.70A/B/C/D4-82[»]
ProteinModelPortaliP03042.
SMRiP03042.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03042. 2 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703494.
KEGGivg:2703494.

Miscellaneous databases

EvolutionaryTraceiP03042.

Family and domain databases

InterProiIPR010982. Lambda_DNA-bd_dom.
IPR007933. Transcrpt_activ_CII.
[Graphical view]
PfamiPF05269. Phage_CII. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPC2_LAMBD
AccessioniPrimary (citable) accession number: P03042
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Lambda-imm434 is a hybrid of bacteriophages 434 and lambda. The cII protein coding region is in the lambda portion of the imm434 genome.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.