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Protein

Regulatory protein cro

Gene

cro

Organism
Enterobacteria phage lambda (Bacteriophage lambda)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in fine-tuning the lytic phase activation and the transition from latent to lytic development. Turns down the expression of the transcriptional activator cII, a factor that initiates the expression of repressor cI, the major component promoting latency. Additionally, cro is able to directly bind to the promoter region of cI thereby preventing the transcription of cI repressor. These two mechanisms ultimately lead to a strong decrease in the amount of cI that will become unable to maintain the latent phase, allowing the transition to lytic growth. A second function assigned to cro is the fine-tuning of the lytic phase activation. Indeed, cro initially diminishes the strength of activation by turning down the expression of lytic genes as well as its own expression.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi16 – 3520H-T-H motifAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Latency-replication switch, Transcription, Transcription regulation, Viral latency

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein cro
Gene namesi
Name:cro
Ordered Locus Names:lambdap57
OrganismiEnterobacteria phage lambda (Bacteriophage lambda)
Taxonomic identifieri10710 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeLambdalikevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000001711 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Regulatory protein croPRO_0000077579Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

IntActiP03040. 1 interaction.
MINTiMINT-121263.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Helixi7 – 148Combined sources
Helixi16 – 238Combined sources
Helixi27 – 3610Combined sources
Beta strandi39 – 446Combined sources
Turni46 – 483Combined sources
Beta strandi50 – 556Combined sources
Beta strandi56 – 594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1COPNMR-D/E1-66[»]
1D1LX-ray2.10A1-61[»]
1D1MX-ray2.05A/B1-60[»]
1ORCX-ray1.54A1-66[»]
2A63NMR-A1-66[»]
2ECSX-ray1.40A/B1-66[»]
2ORCNMR-A1-66[»]
2OVGX-ray1.35A1-66[»]
3ORCX-ray3.00A2-61[»]
4CROX-ray3.90A/B/C/D/E/F1-66[»]
5CROX-ray2.30A/B/C/O1-66[»]
6CROX-ray3.00A2-61[»]
DisProtiDP00741.
ProteinModelPortaliP03040.
SMRiP03040. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03040.

Family & Domainsi

Family and domain databases

Gene3Di3.30.240.10. 1 hit.
InterProiIPR000655. Cro.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF09048. Cro. 1 hit.
[Graphical view]
PIRSFiPIRSF003217. Cro_protein. 1 hit.
PRINTSiPR00030. HTHCRO.
ProDomiPD054632. HTH_lambda_Cro. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47413. SSF47413. 1 hit.

Sequencei

Sequence statusi: Complete.

P03040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRITLKDY AMRFGQTKTA KDLGVYQSAI NKAIHAGRKI FLTINADGSV
60
YAEEVKPFPS NKKTTA
Length:66
Mass (Da):7,363
Last modified:July 21, 1986 - v1
Checksum:i233A02DA0873E4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96582.1.
PIRiB94614. RCBPL.
RefSeqiNP_040629.1. NC_001416.1.

Genome annotation databases

GeneIDi2703491.
KEGGivg:2703467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02459 Genomic DNA. Translation: AAA96582.1.
PIRiB94614. RCBPL.
RefSeqiNP_040629.1. NC_001416.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1COPNMR-D/E1-66[»]
1D1LX-ray2.10A1-61[»]
1D1MX-ray2.05A/B1-60[»]
1ORCX-ray1.54A1-66[»]
2A63NMR-A1-66[»]
2ECSX-ray1.40A/B1-66[»]
2ORCNMR-A1-66[»]
2OVGX-ray1.35A1-66[»]
3ORCX-ray3.00A2-61[»]
4CROX-ray3.90A/B/C/D/E/F1-66[»]
5CROX-ray2.30A/B/C/O1-66[»]
6CROX-ray3.00A2-61[»]
DisProtiDP00741.
ProteinModelPortaliP03040.
SMRiP03040. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP03040. 1 interaction.
MINTiMINT-121263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703491.
KEGGivg:2703467.

Miscellaneous databases

EvolutionaryTraceiP03040.

Family and domain databases

Gene3Di3.30.240.10. 1 hit.
InterProiIPR000655. Cro.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF09048. Cro. 1 hit.
[Graphical view]
PIRSFiPIRSF003217. Cro_protein. 1 hit.
PRINTSiPR00030. HTHCRO.
ProDomiPD054632. HTH_lambda_Cro. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47413. SSF47413. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRCRO_LAMBD
AccessioniPrimary (citable) accession number: P03040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 14, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.