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Protein

Transcriptional activator protein LysR

Gene

lysR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 40H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • lysine biosynthetic process via diaminopimelate Source: EcoCyc
  • positive regulation of gene expression Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00360

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein LysR
Gene namesi
Name:lysR
Ordered Locus Names:b2839, JW2807
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10551 lysR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056691 – 311Transcriptional activator protein LysRAdd BLAST311

Proteomic databases

PaxDbiP03030
PRIDEiP03030

Interactioni

Protein-protein interaction databases

BioGridi4262309, 10 interactors
DIPiDIP-10135N
IntActiP03030, 6 interactors
STRINGi316385.ECDH10B_3011

Structurei

3D structure databases

ProteinModelPortaliP03030
SMRiP03030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61HTH lysR-typePROSITE-ProRule annotationAdd BLAST61

Phylogenomic databases

eggNOGiENOG4105RQF Bacteria
ENOG410XT7K LUCA
HOGENOMiHOG000233527
InParanoidiP03030
OMAiFHAVMTT
PhylomeDBiP03030

Family and domain databases

CDDicd08456 PBP2_LysR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037414 LysR_PBP2
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P03030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVNLRHIE IFHAVMTAGS LTEAAHLLHT SQPTVSRELA RFEKVIGLKL
60 70 80 90 100
FERVRGRLHP TVQGLRLFEE VQRSWYGLDR IVSAAESLRE FRQGELSIAC
110 120 130 140 150
LPVFSQSFLP QLLQPFLARY PDVSLNIVPQ ESPLLEEWLS AQRHDLGLTE
160 170 180 190 200
TLHTPAGTER TELLSLDEVC VLPPGHPLAV KKVLTPDDFQ GENYISLSRT
210 220 230 240 250
DSYRQLLDQL FTEHQVKRRM IVETHSAASV CAMVRAGVGI SVVNPLTALD
260 270 280 290 300
YAASGLVVRR FSIAVPFTVS LIRPLHRPSS ALVQAFSGHL QAGLPKLVTS
310
LDAILSSATT A
Length:311
Mass (Da):34,365
Last modified:July 21, 1986 - v1
Checksum:i3E1913BB6A2CF8F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01614 Genomic DNA Translation: AAA83862.1
U29581 Genomic DNA Translation: AAB40486.1
U00096 Genomic DNA Translation: AAC75878.1
AP009048 Genomic DNA Translation: BAE76908.1
J03732 Genomic DNA Translation: AAA23471.1
PIRiA03565 RGECK
RefSeqiNP_417316.1, NC_000913.3
WP_000741825.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75878; AAC75878; b2839
BAE76908; BAE76908; BAE76908
GeneIDi947311
KEGGiecj:JW2807
eco:b2839
PATRICifig|1411691.4.peg.3895

Similar proteinsi

Entry informationi

Entry nameiLYSR_ECOLI
AccessioniPrimary (citable) accession number: P03030
Secondary accession number(s): Q2M9Z8, Q46936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health