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Protein

Transcriptional activator protein LysR

Gene

lysR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 4020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • lysine biosynthetic process via diaminopimelate Source: EcoCyc
  • positive regulation of gene expression Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00360.
ECOL316407:JW2807-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein LysR
Gene namesi
Name:lysR
Ordered Locus Names:b2839, JW2807
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10551. lysR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Transcriptional activator protein LysRPRO_0000105669Add
BLAST

Proteomic databases

PaxDbiP03030.

Interactioni

Protein-protein interaction databases

BioGridi4262309. 10 interactions.
DIPiDIP-10135N.
IntActiP03030. 6 interactions.
MINTiMINT-1320169.
STRINGi511145.b2839.

Structurei

3D structure databases

ProteinModelPortaliP03030.
SMRiP03030. Positions 2-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6161HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105RQF. Bacteria.
ENOG410XT7K. LUCA.
HOGENOMiHOG000233527.
InParanoidiP03030.
OMAiQMLHTSQ.
PhylomeDBiP03030.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVNLRHIE IFHAVMTAGS LTEAAHLLHT SQPTVSRELA RFEKVIGLKL
60 70 80 90 100
FERVRGRLHP TVQGLRLFEE VQRSWYGLDR IVSAAESLRE FRQGELSIAC
110 120 130 140 150
LPVFSQSFLP QLLQPFLARY PDVSLNIVPQ ESPLLEEWLS AQRHDLGLTE
160 170 180 190 200
TLHTPAGTER TELLSLDEVC VLPPGHPLAV KKVLTPDDFQ GENYISLSRT
210 220 230 240 250
DSYRQLLDQL FTEHQVKRRM IVETHSAASV CAMVRAGVGI SVVNPLTALD
260 270 280 290 300
YAASGLVVRR FSIAVPFTVS LIRPLHRPSS ALVQAFSGHL QAGLPKLVTS
310
LDAILSSATT A
Length:311
Mass (Da):34,365
Last modified:July 21, 1986 - v1
Checksum:i3E1913BB6A2CF8F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01614 Genomic DNA. Translation: AAA83862.1.
U29581 Genomic DNA. Translation: AAB40486.1.
U00096 Genomic DNA. Translation: AAC75878.1.
AP009048 Genomic DNA. Translation: BAE76908.1.
J03732 Genomic DNA. Translation: AAA23471.1.
PIRiA03565. RGECK.
RefSeqiNP_417316.1. NC_000913.3.
WP_000741825.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75878; AAC75878; b2839.
BAE76908; BAE76908; BAE76908.
GeneIDi947311.
KEGGiecj:JW2807.
eco:b2839.
PATRICi32121096. VBIEscCol129921_2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01614 Genomic DNA. Translation: AAA83862.1.
U29581 Genomic DNA. Translation: AAB40486.1.
U00096 Genomic DNA. Translation: AAC75878.1.
AP009048 Genomic DNA. Translation: BAE76908.1.
J03732 Genomic DNA. Translation: AAA23471.1.
PIRiA03565. RGECK.
RefSeqiNP_417316.1. NC_000913.3.
WP_000741825.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP03030.
SMRiP03030. Positions 2-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262309. 10 interactions.
DIPiDIP-10135N.
IntActiP03030. 6 interactions.
MINTiMINT-1320169.
STRINGi511145.b2839.

Proteomic databases

PaxDbiP03030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75878; AAC75878; b2839.
BAE76908; BAE76908; BAE76908.
GeneIDi947311.
KEGGiecj:JW2807.
eco:b2839.
PATRICi32121096. VBIEscCol129921_2937.

Organism-specific databases

EchoBASEiEB0546.
EcoGeneiEG10551. lysR.

Phylogenomic databases

eggNOGiENOG4105RQF. Bacteria.
ENOG410XT7K. LUCA.
HOGENOMiHOG000233527.
InParanoidiP03030.
OMAiQMLHTSQ.
PhylomeDBiP03030.

Enzyme and pathway databases

BioCyciEcoCyc:PD00360.
ECOL316407:JW2807-MONOMER.

Miscellaneous databases

PROiP03030.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYSR_ECOLI
AccessioniPrimary (citable) accession number: P03030
Secondary accession number(s): Q2M9Z8, Q46936
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.