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Protein

HTH-type transcriptional regulator GalR

Gene

galR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Repressor of the galactose operon. Binds galactose as an inducer.

Pathwayi: galactose metabolism

This protein regulates the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • identical protein binding Source: IntAct

GO - Biological processi

  • galactose metabolic process Source: UniProtKB-UniPathway
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processCarbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD03028
UniPathwayiUPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GalR
Alternative name(s):
Galactose operon repressor
Gene namesi
Name:galR
Ordered Locus Names:b2837, JW2805
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG10364 galR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079511 – 343HTH-type transcriptional regulator GalRAdd BLAST343

Proteomic databases

PaxDbiP03024
PRIDEiP03024

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4262964, 20 interactors
DIPiDIP-9733N
IntActiP03024, 3 interactors
STRINGi316385.ECDH10B_3009

Structurei

3D structure databases

ProteinModelPortaliP03024
SMRiP03024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 56HTH lacI-typePROSITE-ProRule annotationAdd BLAST56

Phylogenomic databases

eggNOGiENOG41060NJ Bacteria
COG1609 LUCA
HOGENOMiHOG000220179
InParanoidiP03024
KOiK02529
OMAiGYKAIIC
PhylomeDBiP03024

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PRINTSiPR00036 HTHLACI
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

P03024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIKDVARL AGVSVATVSR VINNSPKASE ASRLAVHSAM ESLSYHPNAN
60 70 80 90 100
ARALAQQTTE TVGLVVGDVS DPFFGAMVKA VEQVAYHTGN FLLIGNGYHN
110 120 130 140 150
EQKERQAIEQ LIRHRCAALV VHAKMIPDAD LASLMKQMPG MVLINRILPG
160 170 180 190 200
FENRCIALDD RYGAWLATRH LIQQGHTRIG YLCSNHSISD AEDRLQGYYD
210 220 230 240 250
ALAESGIAAN DRLVTFGEPD ESGGEQAMTE LLGRGRNFTA VACYNDSMAA
260 270 280 290 300
GAMGVLNDNG IDVPGEISLI GFDDVLVSRY VRPRLTTVRY PIVTMATQAA
310 320 330 340
ELALALADNR PLPEITNVFS PTLVRRHSVS TPSLEASHHA TSD
Length:343
Mass (Da):37,094
Last modified:July 21, 1986 - v1
Checksum:iA4855FC8A2527A30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00280 Genomic DNA Translation: CAA23543.1
U29581 Genomic DNA Translation: AAB40484.1
U00096 Genomic DNA Translation: AAC75876.1
AP009048 Genomic DNA Translation: BAE76906.1
J01614 Genomic DNA Translation: AAA83860.1
PIRiA93910 RPECG
RefSeqiNP_417314.1, NC_000913.3
WP_000201063.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75876; AAC75876; b2837
BAE76906; BAE76906; BAE76906
GeneIDi947314
KEGGiecj:JW2805
eco:b2837
PATRICifig|1411691.4.peg.3897

Entry informationi

Entry nameiGALR_ECOLI
AccessioniPrimary (citable) accession number: P03024
Secondary accession number(s): Q2MA00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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