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Protein

HTH-type transcriptional regulator GalR

Gene

galR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the galactose operon. Binds galactose as an inducer.

Pathwayi: galactose metabolism

This protein regulates the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

  • galactose metabolic process Source: UniProtKB-UniPathway
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD03028.
ECOL316407:JW2805-MONOMER.
UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GalR
Alternative name(s):
Galactose operon repressor
Gene namesi
Name:galR
Ordered Locus Names:b2837, JW2805
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10364. galR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079511 – 343HTH-type transcriptional regulator GalRAdd BLAST343

Proteomic databases

PaxDbiP03024.
PRIDEiP03024.

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-556902,EBI-556902
galSP257485EBI-556902,EBI-1117006

Protein-protein interaction databases

BioGridi4262964. 15 interactors.
DIPiDIP-9733N.
IntActiP03024. 3 interactors.
MINTiMINT-1295860.
STRINGi511145.b2837.

Structurei

3D structure databases

ProteinModelPortaliP03024.
SMRiP03024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 56HTH lacI-typePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41060NJ. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220179.
InParanoidiP03024.
KOiK02529.
OMAiLLINNRC.
PhylomeDBiP03024.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIKDVARL AGVSVATVSR VINNSPKASE ASRLAVHSAM ESLSYHPNAN
60 70 80 90 100
ARALAQQTTE TVGLVVGDVS DPFFGAMVKA VEQVAYHTGN FLLIGNGYHN
110 120 130 140 150
EQKERQAIEQ LIRHRCAALV VHAKMIPDAD LASLMKQMPG MVLINRILPG
160 170 180 190 200
FENRCIALDD RYGAWLATRH LIQQGHTRIG YLCSNHSISD AEDRLQGYYD
210 220 230 240 250
ALAESGIAAN DRLVTFGEPD ESGGEQAMTE LLGRGRNFTA VACYNDSMAA
260 270 280 290 300
GAMGVLNDNG IDVPGEISLI GFDDVLVSRY VRPRLTTVRY PIVTMATQAA
310 320 330 340
ELALALADNR PLPEITNVFS PTLVRRHSVS TPSLEASHHA TSD
Length:343
Mass (Da):37,094
Last modified:July 21, 1986 - v1
Checksum:iA4855FC8A2527A30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00280 Genomic DNA. Translation: CAA23543.1.
U29581 Genomic DNA. Translation: AAB40484.1.
U00096 Genomic DNA. Translation: AAC75876.1.
AP009048 Genomic DNA. Translation: BAE76906.1.
J01614 Genomic DNA. Translation: AAA83860.1.
PIRiA93910. RPECG.
RefSeqiNP_417314.1. NC_000913.3.
WP_000201063.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75876; AAC75876; b2837.
BAE76906; BAE76906; BAE76906.
GeneIDi947314.
KEGGiecj:JW2805.
eco:b2837.
PATRICi32121092. VBIEscCol129921_2935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00280 Genomic DNA. Translation: CAA23543.1.
U29581 Genomic DNA. Translation: AAB40484.1.
U00096 Genomic DNA. Translation: AAC75876.1.
AP009048 Genomic DNA. Translation: BAE76906.1.
J01614 Genomic DNA. Translation: AAA83860.1.
PIRiA93910. RPECG.
RefSeqiNP_417314.1. NC_000913.3.
WP_000201063.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP03024.
SMRiP03024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262964. 15 interactors.
DIPiDIP-9733N.
IntActiP03024. 3 interactors.
MINTiMINT-1295860.
STRINGi511145.b2837.

Proteomic databases

PaxDbiP03024.
PRIDEiP03024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75876; AAC75876; b2837.
BAE76906; BAE76906; BAE76906.
GeneIDi947314.
KEGGiecj:JW2805.
eco:b2837.
PATRICi32121092. VBIEscCol129921_2935.

Organism-specific databases

EchoBASEiEB0359.
EcoGeneiEG10364. galR.

Phylogenomic databases

eggNOGiENOG41060NJ. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220179.
InParanoidiP03024.
KOiK02529.
OMAiLLINNRC.
PhylomeDBiP03024.

Enzyme and pathway databases

UniPathwayiUPA00214.
BioCyciEcoCyc:PD03028.
ECOL316407:JW2805-MONOMER.

Miscellaneous databases

PROiP03024.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALR_ECOLI
AccessioniPrimary (citable) accession number: P03024
Secondary accession number(s): Q2MA00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.