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Protein

DNA-invertase hin

Gene

hin

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10O-(5'-phospho-DNA)-serine intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi162 – 181H-T-H motifAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA invertase, DNA-binding
Biological processDNA integration, DNA recombination

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2799-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-invertase hin
Gene namesi
Name:hin
Ordered Locus Names:STM2772
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001963591 – 190DNA-invertase hinAdd BLAST190

Proteomic databases

PaxDbiP03013

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2772

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi148 – 157Combined sources10
Helixi162 – 167Combined sources6
Helixi173 – 179Combined sources7
Helixi182 – 184Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCRX-ray2.30A139-190[»]
1IJWX-ray2.40C139-190[»]
1JJ6X-ray2.30C139-190[»]
1JJ8X-ray2.75C139-190[»]
1JKOX-ray2.24C139-190[»]
1JKPX-ray2.80C139-190[»]
1JKQX-ray2.86C139-190[»]
1JKRX-ray2.28C139-190[»]
ProteinModelPortaliP03013
SMRiP03013
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03013

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 135Resolvase/invertase-type recombinase catalyticPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108C33 Bacteria
COG1961 LUCA
HOGENOMiHOG000275578
OMAiRAINRHE
PhylomeDBiP03013

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR006118 Recombinase_CS
IPR006119 Resolv_N
IPR036162 Resolvase-like_N_sf
IPR006120 Resolvase_HTH_dom
PfamiView protein in Pfam
PF02796 HTH_7, 1 hit
PF00239 Resolvase, 1 hit
SMARTiView protein in SMART
SM00857 Resolvase, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF53041 SSF53041, 1 hit
PROSITEiView protein in PROSITE
PS00397 RECOMBINASES_1, 1 hit
PS00398 RECOMBINASES_2, 1 hit
PS51736 RECOMBINASES_3, 1 hit

Sequencei

Sequence statusi: Complete.

P03013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIGYIRVS TIDQNIDLQR NALTSANCDR IFEDRISGKI ANRPGLKRAL
60 70 80 90 100
KYVNKGDTLV VWKLDRLGRS VKNLVALISE LHERGAHFHS LTDSIDTSSA
110 120 130 140 150
MGRFFFHVMS ALAEMERELI VERTLAGLAA ARAQGRLGGR PRAINKHEQE
160 170 180 190
QISRLLEKGH PRQQLAIIFG IGVSTLYRYF PASRIKKRMN
Length:190
Mass (Da):21,426
Last modified:January 23, 2002 - v2
Checksum:i3599962ADE1748E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184R → S (PubMed:6933466).Curated1
Sequence conflicti184R → S (PubMed:6271461).Curated1
Sequence conflicti184R → S (PubMed:6251543).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01801 Genomic DNA Translation: AAA27073.1
V01370 Genomic DNA Translation: CAA24654.1
M12292 Genomic DNA Translation: AAA27140.1
AE006468 Genomic DNA Translation: AAL21658.1
PIRiA03544 JWEBT
RefSeqiNP_461699.1, NC_003197.2
WP_000190912.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21658; AAL21658; STM2772
GeneIDi1254295
KEGGistm:STM2772
PATRICifig|99287.12.peg.2924

Similar proteinsi

Entry informationi

Entry nameiHIN_SALTY
AccessioniPrimary (citable) accession number: P03013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2002
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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