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Protein

DNA-invertase hin

Gene

hin

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

A DNA fragment of approximately 900 base pairs, adjacent to the fljB (H2) gene, which specifies the synthesis of phase-2 flagellin, can exist in either orientation with respect to fljB. The orientation of the inversion region controls expression of fljB. The hin gene occupies about two-thirds of the inversion region; it is required for the inversion of the fljB controlling region.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101O-(5'-phospho-DNA)-serine intermediatePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi162 – 18120H-T-H motifAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA invertase

Keywords - Biological processi

DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2789-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-invertase hin
Gene namesi
Name:hin
Ordered Locus Names:STM2772
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190DNA-invertase hinPRO_0000196359Add
BLAST

Proteomic databases

PaxDbiP03013.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2772.

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi148 – 15710Combined sources
Helixi162 – 1676Combined sources
Helixi173 – 1797Combined sources
Helixi182 – 1843Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HCRX-ray2.30A139-190[»]
1IJWX-ray2.40C139-190[»]
1JJ6X-ray2.30C139-190[»]
1JJ8X-ray2.75C139-190[»]
1JKOX-ray2.24C139-190[»]
1JKPX-ray2.80C139-190[»]
1JKQX-ray2.86C139-190[»]
1JKRX-ray2.28C139-190[»]
ProteinModelPortaliP03013.
SMRiP03013. Positions 139-183.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP03013.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 135134Resolvase/invertase-type recombinase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 resolvase/invertase-type recombinase catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108C33. Bacteria.
COG1961. LUCA.
HOGENOMiHOG000275578.
OMAiKGDEQSN.
PhylomeDBiP03013.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.1390. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006118. Recombinase_CS.
IPR006119. Resolv_N.
IPR006120. Resolvase_HTH_dom.
[Graphical view]
PfamiPF02796. HTH_7. 1 hit.
PF00239. Resolvase. 1 hit.
[Graphical view]
SMARTiSM00857. Resolvase. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF53041. SSF53041. 1 hit.
PROSITEiPS00397. RECOMBINASES_1. 1 hit.
PS00398. RECOMBINASES_2. 1 hit.
PS51736. RECOMBINASES_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P03013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIGYIRVS TIDQNIDLQR NALTSANCDR IFEDRISGKI ANRPGLKRAL
60 70 80 90 100
KYVNKGDTLV VWKLDRLGRS VKNLVALISE LHERGAHFHS LTDSIDTSSA
110 120 130 140 150
MGRFFFHVMS ALAEMERELI VERTLAGLAA ARAQGRLGGR PRAINKHEQE
160 170 180 190
QISRLLEKGH PRQQLAIIFG IGVSTLYRYF PASRIKKRMN
Length:190
Mass (Da):21,426
Last modified:January 23, 2002 - v2
Checksum:i3599962ADE1748E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841R → S (PubMed:6933466).Curated
Sequence conflicti184 – 1841R → S (PubMed:6271461).Curated
Sequence conflicti184 – 1841R → S (PubMed:6251543).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01801 Genomic DNA. Translation: AAA27073.1.
V01370 Genomic DNA. Translation: CAA24654.1.
M12292 Genomic DNA. Translation: AAA27140.1.
AE006468 Genomic DNA. Translation: AAL21658.1.
PIRiA03544. JWEBT.
RefSeqiNP_461699.1. NC_003197.1.
WP_000190912.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21658; AAL21658; STM2772.
GeneIDi1254295.
KEGGistm:STM2772.
PATRICi32384214. VBISalEnt20916_2924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01801 Genomic DNA. Translation: AAA27073.1.
V01370 Genomic DNA. Translation: CAA24654.1.
M12292 Genomic DNA. Translation: AAA27140.1.
AE006468 Genomic DNA. Translation: AAL21658.1.
PIRiA03544. JWEBT.
RefSeqiNP_461699.1. NC_003197.1.
WP_000190912.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HCRX-ray2.30A139-190[»]
1IJWX-ray2.40C139-190[»]
1JJ6X-ray2.30C139-190[»]
1JJ8X-ray2.75C139-190[»]
1JKOX-ray2.24C139-190[»]
1JKPX-ray2.80C139-190[»]
1JKQX-ray2.86C139-190[»]
1JKRX-ray2.28C139-190[»]
ProteinModelPortaliP03013.
SMRiP03013. Positions 139-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2772.

Proteomic databases

PaxDbiP03013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21658; AAL21658; STM2772.
GeneIDi1254295.
KEGGistm:STM2772.
PATRICi32384214. VBISalEnt20916_2924.

Phylogenomic databases

eggNOGiENOG4108C33. Bacteria.
COG1961. LUCA.
HOGENOMiHOG000275578.
OMAiKGDEQSN.
PhylomeDBiP03013.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2789-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP03013.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.1390. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006118. Recombinase_CS.
IPR006119. Resolv_N.
IPR006120. Resolvase_HTH_dom.
[Graphical view]
PfamiPF02796. HTH_7. 1 hit.
PF00239. Resolvase. 1 hit.
[Graphical view]
SMARTiSM00857. Resolvase. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF53041. SSF53041. 1 hit.
PROSITEiPS00397. RECOMBINASES_1. 1 hit.
PS00398. RECOMBINASES_2. 1 hit.
PS51736. RECOMBINASES_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIN_SALTY
AccessioniPrimary (citable) accession number: P03013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2002
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.