Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetracycline resistance protein

Gene

tet

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H+ antiporter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Antiport, Hydrogen ion transport, Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.3.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Tetracycline resistance protein
Alternative name(s):
Tetracycline efflux protein
Gene namesi
Name:tet
Synonyms:tet(K)
Encoded oniPlasmid pT1813 Publications
Plasmid pTP51 Publication
Plasmid pKH61 Publication
Plasmid pKH12 Publications
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST
Transmembranei49 – 6820HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10020HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12723HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16223HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18823HelicalSequence analysisAdd
BLAST
Transmembranei201 – 21818HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24018HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28323HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31523HelicalSequence analysisAdd
BLAST
Transmembranei322 – 34423HelicalSequence analysisAdd
BLAST
Transmembranei348 – 37023HelicalSequence analysisAdd
BLAST
Transmembranei391 – 41323HelicalSequence analysisAdd
BLAST
Transmembranei428 – 45023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Tetracycline resistance proteinPRO_0000173384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93062.SAA0002.

Structurei

3D structure databases

ProteinModelPortaliP02983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108PCX. Bacteria.
ENOG410YSYS. LUCA.
KOiK08168.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLYKKFKG LFYSVLFWLC ILSFFSVLNE MVLNVSLPDI ANHFNTTPGI
60 70 80 90 100
TNWVNTAYML TFSIGTAVYG KLSDYINIKK LLIIGISLSC LGSLIAFIGH
110 120 130 140 150
NHFFILIFGR LVQGVGSAAF PSLIMVVVAR NITRKKQGKA FGFIGSIVAL
160 170 180 190 200
GEGLGPSIGG IIAHYIHWSY LLILPMITIV TIPFLIKVMV PGKSTKNTLD
210 220 230 240 250
IVGIVLMSIS IICFMLFTTN YNWTFLILFT IFFVIFIKHI SRVSNPFINP
260 270 280 290 300
KLGKNIPFML GLFSGGLIFS IVAGFISMVP YMMKTIYHVN VATIGNSVIF
310 320 330 340 350
PGTMSVIVFG YFGGFLVDRK GSLFVFILGS LSISISFLTI AFFVEFSMWL
360 370 380 390 400
TTFMFIFVMG GLSFTKTVIS KIVSSSLSEE EVASGMSLLN FTSFLSEGTG
410 420 430 440 450
IAIVGGLLSL QLINRKLVLE FINYSSGVYS NILVAMAILI ILCCLLTIIV

FKRSEKQFE
Length:459
Mass (Da):50,695
Last modified:August 31, 2004 - v3
Checksum:iFE53C55535372B41
GO

Sequence cautioni

The sequence AAA26034 differs from that shown. Reason: Frameshift at positions 265, 433, 442 and 453. Curated
The sequence AAA26035 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti361 – 3611G → E in AAA26034 (PubMed:6657777).Curated
Sequence conflicti438 – 4381I → N in AAA26034 (PubMed:6657777).Curated
Sequence conflicti443 – 4431C → S in AAA26034 (PubMed:6657777).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01764 Genomic DNA. Translation: AAA26034.1. Sequence problems.
J01764 Genomic DNA. Translation: AAA26035.1. Different initiation.
M23644 Genomic DNA. Translation: AAA98301.1.
M16217 Unassigned DNA. Translation: AAA19179.1.
U38428 Genomic DNA. Translation: AAB07712.1.
S67449 Genomic DNA. Translation: AAB28795.1.
U38656 Genomic DNA. Translation: AAB09660.1.
PIRiA04492. QQSACT.
S42238.
RefSeqiNP_040465.1. NC_001391.1.
NP_040470.1. NC_001393.1.
NP_040471.1. NC_001393.1.
NP_044360.1. NC_001763.1.
NP_053795.1. NC_001767.1.
WP_000492283.1. NZ_LNTF01000013.1.
WP_010889938.1. NC_001763.1.
WP_010889939.1. NC_001393.1.
YP_001649337.1. NC_010262.1.
YP_006937482.1. NC_013307.1.
YP_006937490.1. NC_013309.1.
YP_006937494.1. NC_013311.1.
YP_006937498.1. NC_013312.1.
YP_006937647.1. NC_013320.1.
YP_006937988.1. NC_013328.1.
YP_006938259.1. NC_013336.1.

Genome annotation databases

GeneIDi1263239.
13874621.
13874631.
13874637.
13874642.
13874797.
13875146.
13875424.
2598303.
3362018.
3362019.
4594902.
5850692.
KEGGipg:1263239.
pg:13874621.
pg:13874631.
pg:13874637.
pg:13874642.
pg:13874797.
pg:13875146.
pg:13875424.
pg:2598303.
pg:3362018.
pg:3362019.
pg:4594902.
pg:5850692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01764 Genomic DNA. Translation: AAA26034.1. Sequence problems.
J01764 Genomic DNA. Translation: AAA26035.1. Different initiation.
M23644 Genomic DNA. Translation: AAA98301.1.
M16217 Unassigned DNA. Translation: AAA19179.1.
U38428 Genomic DNA. Translation: AAB07712.1.
S67449 Genomic DNA. Translation: AAB28795.1.
U38656 Genomic DNA. Translation: AAB09660.1.
PIRiA04492. QQSACT.
S42238.
RefSeqiNP_040465.1. NC_001391.1.
NP_040470.1. NC_001393.1.
NP_040471.1. NC_001393.1.
NP_044360.1. NC_001763.1.
NP_053795.1. NC_001767.1.
WP_000492283.1. NZ_LNTF01000013.1.
WP_010889938.1. NC_001763.1.
WP_010889939.1. NC_001393.1.
YP_001649337.1. NC_010262.1.
YP_006937482.1. NC_013307.1.
YP_006937490.1. NC_013309.1.
YP_006937494.1. NC_013311.1.
YP_006937498.1. NC_013312.1.
YP_006937647.1. NC_013320.1.
YP_006937988.1. NC_013328.1.
YP_006938259.1. NC_013336.1.

3D structure databases

ProteinModelPortaliP02983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi93062.SAA0002.

Protein family/group databases

TCDBi2.A.1.3.6. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1263239.
13874621.
13874631.
13874637.
13874642.
13874797.
13875146.
13875424.
2598303.
3362018.
3362019.
4594902.
5850692.
KEGGipg:1263239.
pg:13874621.
pg:13874631.
pg:13874637.
pg:13874642.
pg:13874797.
pg:13875146.
pg:13875424.
pg:2598303.
pg:3362018.
pg:3362019.
pg:4594902.
pg:5850692.

Phylogenomic databases

eggNOGiENOG4108PCX. Bacteria.
ENOG410YSYS. LUCA.
KOiK08168.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCR_STAAU
AccessioniPrimary (citable) accession number: P02983
Secondary accession number(s): P03863, P14512, Q79CG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 31, 2004
Last modified: September 7, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.