ID OMPA_SHIDY Reviewed; 351 AA. AC P02935; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 27-MAR-2024, entry version 117. DE RecName: Full=Outer membrane protein A {ECO:0000255|HAMAP-Rule:MF_00842}; DE AltName: Full=Outer membrane porin A {ECO:0000255|HAMAP-Rule:MF_00842}; DE Flags: Precursor; GN Name=ompA {ECO:0000255|HAMAP-Rule:MF_00842}; OS Shigella dysenteriae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Shigella. OX NCBI_TaxID=622; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6283478; DOI=10.1093/nar/10.7.2367; RA Braun G., Cole S.T.; RT "The nucleotide sequence coding for major outer membrane protein OmpA of RT Shigella dysenteriae."; RL Nucleic Acids Res. 10:2367-2378(1982). CC -!- FUNCTION: With TolR probably plays a role in maintaining the position CC of the peptidoglycan cell wall in the periplasm. Acts as a porin with CC low permeability that allows slow penetration of small solutes; an CC internal gate slows down solute passage. {ECO:0000255|HAMAP- CC Rule:MF_00842}. CC -!- FUNCTION: Required for conjugation with F-type plasmids; probably CC serves as the mating receptor on recipient cells. {ECO:0000255|HAMAP- CC Rule:MF_00842}. CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000255|HAMAP-Rule:MF_00842}. CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP- CC Rule:MF_00842}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_00842}. CC -!- DOMAIN: The extracellular loops are most variable in sequence, and in CC some bacteria confer sensitivity to phage and/or colicins. CC {ECO:0000255|HAMAP-Rule:MF_00842}. CC -!- SIMILARITY: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. CC OmpA family. {ECO:0000255|HAMAP-Rule:MF_00842}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V01344; CAA24638.1; -; Genomic_DNA. DR PIR; A03435; MMEBAD. DR RefSeq; WP_005020288.1; NZ_UAUQ01000016.1. DR AlphaFoldDB; P02935; -. DR BMRB; P02935; -. DR SMR; P02935; -. DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW. DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-UniRule. DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-UniRule. DR CDD; cd07185; OmpA_C-like; 1. DR Gene3D; 2.40.160.20; -; 1. DR Gene3D; 3.30.1330.60; OmpA-like domain; 1. DR HAMAP; MF_00842; OmpA; 1. DR InterPro; IPR011250; OMP/PagP_b-brl. DR InterPro; IPR006664; OMP_bac. DR InterPro; IPR002368; OmpA. DR InterPro; IPR006665; OmpA-like. DR InterPro; IPR006690; OMPA-like_CS. DR InterPro; IPR036737; OmpA-like_sf. DR InterPro; IPR000498; OmpA-like_TM_dom. DR PANTHER; PTHR30329:SF23; LIPOPROTEIN YIAD-RELATED; 1. DR PANTHER; PTHR30329; STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX; 1. DR Pfam; PF00691; OmpA; 1. DR Pfam; PF01389; OmpA_membrane; 1. DR PRINTS; PR01021; OMPADOMAIN. DR PRINTS; PR01022; OUTRMMBRANEA. DR SUPFAM; SSF56925; OMPA-like; 1. DR SUPFAM; SSF103088; OmpA-like; 1. DR PROSITE; PS01068; OMPA_1; 1. DR PROSITE; PS51123; OMPA_2; 1. PE 3: Inferred from homology; KW Cell outer membrane; Conjugation; Disulfide bond; Ion transport; Membrane; KW Porin; Repeat; Signal; Transmembrane; Transmembrane beta strand; Transport. FT SIGNAL 1..21 FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT CHAIN 22..351 FT /note="Outer membrane protein A" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT /id="PRO_0000020101" FT TRANSMEM 27..37 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 55..66 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 70..78 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 96..107 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 112..120 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 147..156 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 161..168 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT TRANSMEM 187..195 FT /note="Beta stranded" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT REPEAT 206..207 FT /note="1" FT REPEAT 208..209 FT /note="2" FT REPEAT 210..211 FT /note="3" FT REPEAT 212..213 FT /note="4" FT DOMAIN 215..343 FT /note="OmpA-like" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT REGION 206..213 FT /note="4 X 2 AA tandem repeats of A-P" FT SITE 73 FT /note="Part of salt bridge gating mechanism" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT SITE 164 FT /note="Part of salt bridge gating mechanism" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" FT DISULFID 316..328 FT /evidence="ECO:0000255|HAMAP-Rule:MF_00842" SQ SEQUENCE 351 AA; 37741 MW; 1499AA5F5395B35B CRC64; MKKTAIAITV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFIDNNGP THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL TAKLGYPITD DLDVYTRLGG MVWRADTKAH NNVTGESEKN HDTGVSPVFA GGVEWAITPE IATRLEYQWT NNIGDAHTIG TRPDNGLLSL GVSYRFGQGE AAPVVAPAPA PAPEVQTKHF TLKSDVLFNF NKATLKPEGQ AALDQLYSQL SNLDPKDGSV VVLGYTDRIG SDAYNQGLSE RRAQSVVDYL ISKGIPADKI SARGMGESNP VTGNTCDNVK QRAALIDCLA PDRRVEIEVK GIKDVVTQPQ A //