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P02935

- OMPA_SHIDY

UniProt

P02935 - OMPA_SHIDY

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Protein
Outer membrane protein A
Gene
ompA
Organism
Shigella dysenteriae
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.

GO - Molecular functioni

  1. porin activity Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. conjugation Source: UniProtKB-KW
  2. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Conjugation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene namesi
Name:ompA
OrganismiShigella dysenteriae
Taxonomic identifieri622 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4014Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei55 – 6713Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei70 – 8516Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei97 – 10711Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei111 – 12616Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei147 – 15812Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei164 – 18017Beta stranded; Reviewed prediction
Add
BLAST
Transmembranei186 – 19712Beta stranded; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
  2. pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 351330Outer membrane protein A
PRO_0000020101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi316 ↔ 328 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer Inferred.

Structurei

3D structure databases

ProteinModelPortaliP02935.
SMRiP02935. Positions 22-202.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati206 – 20721
Repeati208 – 20922
Repeati210 – 21123
Repeati212 – 21324
Domaini215 – 343129OmpA-like
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 21384 X 2 AA tandem repeats of A-P

Sequence similaritiesi

Belongs to the OmpA family.
Contains 1 OmpA-like domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02935-1 [UniParc]FASTAAdd to Basket

« Hide

MKKTAIAITV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFIDNNGP    50
THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL 100
TAKLGYPITD DLDVYTRLGG MVWRADTKAH NNVTGESEKN HDTGVSPVFA 150
GGVEWAITPE IATRLEYQWT NNIGDAHTIG TRPDNGLLSL GVSYRFGQGE 200
AAPVVAPAPA PAPEVQTKHF TLKSDVLFNF NKATLKPEGQ AALDQLYSQL 250
SNLDPKDGSV VVLGYTDRIG SDAYNQGLSE RRAQSVVDYL ISKGIPADKI 300
SARGMGESNP VTGNTCDNVK QRAALIDCLA PDRRVEIEVK GIKDVVTQPQ 350
A 351
Length:351
Mass (Da):37,741
Last modified:July 21, 1986 - v1
Checksum:i1499AA5F5395B35B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01344 Genomic DNA. Translation: CAA24638.1.
PIRiA03435. MMEBAD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01344 Genomic DNA. Translation: CAA24638.1 .
PIRi A03435. MMEBAD.

3D structure databases

ProteinModelPortali P02935.
SMRi P02935. Positions 22-202.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProi IPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view ]
Pfami PF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view ]
PRINTSi PR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMi SSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEi PS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The nucleotide sequence coding for major outer membrane protein OmpA of Shigella dysenteriae."
    Braun G., Cole S.T.
    Nucleic Acids Res. 10:2367-2378(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiOMPA_SHIDY
AccessioniPrimary (citable) accession number: P02935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi