P02935 (OMPA_SHIDY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer membrane protein A

Alternative name(s):
Outer membrane protein II

Gene names

Name:

ompA

Organism

Shigella dysenteriae

Taxonomic identifier

622 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.
Subunit structure	Monomer Probable.
Subcellular location	Cell outer membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the OmpA family. Contains 1 OmpA-like domain.

Ontologies

Keywords
Biological process	Conjugation Ion transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane beta strand
Molecular function	Porin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	conjugation Inferred from electronic annotation. Source: UniProtKB-KW ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	porin activity Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 351	330	Outer membrane protein A		PRO_0000020101
Regions
	Transmembrane	27 – 40	14	Beta stranded; Potential
	Transmembrane	55 – 67	13	Beta stranded; Potential
	Transmembrane	70 – 85	16	Beta stranded; Potential
	Transmembrane	97 – 107	11	Beta stranded; Potential
	Transmembrane	111 – 126	16	Beta stranded; Potential
	Transmembrane	147 – 158	12	Beta stranded; Potential
	Transmembrane	164 – 180	17	Beta stranded; Potential
	Transmembrane	186 – 197	12	Beta stranded; Potential
	Repeat	206 – 207	2	1
	Repeat	208 – 209	2	2
	Repeat	210 – 211	2	3
	Repeat	212 – 213	2	4
	Domain	215 – 343	129	OmpA-like
	Region	206 – 213	8	4 X 2 AA tandem repeats of A-P
Amino acid modifications
	Disulfide bond	316 ↔ 328		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P02935 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 1499AA5F5395B35B	FASTA	351	37,741
	10 20 30 40 50 60 MKKTAIAITV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFIDNNGP THENQLGAGA 70 80 90 100 110 120 FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL TAKLGYPITD DLDVYTRLGG 130 140 150 160 170 180 MVWRADTKAH NNVTGESEKN HDTGVSPVFA GGVEWAITPE IATRLEYQWT NNIGDAHTIG 190 200 210 220 230 240 TRPDNGLLSL GVSYRFGQGE AAPVVAPAPA PAPEVQTKHF TLKSDVLFNF NKATLKPEGQ 250 260 270 280 290 300 AALDQLYSQL SNLDPKDGSV VVLGYTDRIG SDAYNQGLSE RRAQSVVDYL ISKGIPADKI 310 320 330 340 350 SARGMGESNP VTGNTCDNVK QRAALIDCLA PDRRVEIEVK GIKDVVTQPQ A

References

[1]	"The nucleotide sequence coding for major outer membrane protein OmpA of Shigella dysenteriae." Braun G., Cole S.T. Nucleic Acids Res. 10:2367-2378(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	V01344 Genomic DNA. Translation: CAA24638.1.
PIR	MMEBAD. A03435.
3D structure databases
ProteinModelPortal	P02935.
SMR	P02935. Positions 22-202.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.40.160.20. 1 hit. 3.30.1330.60. 1 hit.
InterPro	IPR011250. OMP/PagP_b-brl. IPR006664. OMP_bac. IPR002368. OmpA. IPR006690. OMPA-like_CS. IPR000498. OmpA-like_TM_dom. IPR006665. OmpA/MotB_C. [Graphical view]
Pfam	PF00691. OmpA. 1 hit. PF01389. OmpA_membrane. 1 hit. [Graphical view]
PRINTS	PR01021. OMPADOMAIN. PR01022. OUTRMMBRANEA.
SUPFAM	SSF103088. OmpA/MotB_C. 1 hit. SSF56925. SSF56925. 1 hit.
PROSITE	PS01068. OMPA_1. 1 hit. PS51123. OMPA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OMPA_SHIDY

Accession

Primary (citable) accession number: P02935

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program