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Protein

Outer membrane protein A

Gene

ompA

Organism
Shigella dysenteriae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Conjugation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene namesi
Name:ompA
OrganismiShigella dysenteriae
Taxonomic identifieri622 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 40Beta strandedSequence analysisAdd BLAST14
Transmembranei55 – 67Beta strandedSequence analysisAdd BLAST13
Transmembranei70 – 85Beta strandedSequence analysisAdd BLAST16
Transmembranei97 – 107Beta strandedSequence analysisAdd BLAST11
Transmembranei111 – 126Beta strandedSequence analysisAdd BLAST16
Transmembranei147 – 158Beta strandedSequence analysisAdd BLAST12
Transmembranei164 – 180Beta strandedSequence analysisAdd BLAST17
Transmembranei186 – 197Beta strandedSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002010122 – 351Outer membrane protein AAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi316 ↔ 328By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP02935.

Interactioni

Subunit structurei

Monomer.Curated

Structurei

3D structure databases

ProteinModelPortaliP02935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati206 – 20712
Repeati208 – 20922
Repeati210 – 21132
Repeati212 – 21342
Domaini215 – 343OmpA-likePROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni206 – 2134 X 2 AA tandem repeats of A-P8

Sequence similaritiesi

Belongs to the OmpA family.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTAIAITV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFIDNNGP
60 70 80 90 100
THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL
110 120 130 140 150
TAKLGYPITD DLDVYTRLGG MVWRADTKAH NNVTGESEKN HDTGVSPVFA
160 170 180 190 200
GGVEWAITPE IATRLEYQWT NNIGDAHTIG TRPDNGLLSL GVSYRFGQGE
210 220 230 240 250
AAPVVAPAPA PAPEVQTKHF TLKSDVLFNF NKATLKPEGQ AALDQLYSQL
260 270 280 290 300
SNLDPKDGSV VVLGYTDRIG SDAYNQGLSE RRAQSVVDYL ISKGIPADKI
310 320 330 340 350
SARGMGESNP VTGNTCDNVK QRAALIDCLA PDRRVEIEVK GIKDVVTQPQ

A
Length:351
Mass (Da):37,741
Last modified:July 21, 1986 - v1
Checksum:i1499AA5F5395B35B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01344 Genomic DNA. Translation: CAA24638.1.
PIRiA03435. MMEBAD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01344 Genomic DNA. Translation: CAA24638.1.
PIRiA03435. MMEBAD.

3D structure databases

ProteinModelPortaliP02935.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP02935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPA_SHIDY
AccessioniPrimary (citable) accession number: P02935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.