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P02935 (OMPA_SHIDY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene names
Name:ompA
OrganismShigella dysenteriae
Taxonomic identifier622 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.

Subunit structure

Monomer Probable.

Subcellular location

Cell outer membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the OmpA family.

Contains 1 OmpA-like domain.

Ontologies

Keywords
   Biological processConjugation
Ion transport
Transport
   Cellular componentCell outer membrane
Membrane
   DomainRepeat
Signal
Transmembrane
Transmembrane beta strand
   Molecular functionPorin
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processconjugation

Inferred from electronic annotation. Source: UniProtKB-KW

ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

pore complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionporin activity

Inferred from electronic annotation. Source: UniProtKB-KW

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 351330Outer membrane protein A
PRO_0000020101

Regions

Transmembrane27 – 4014Beta stranded; Potential
Transmembrane55 – 6713Beta stranded; Potential
Transmembrane70 – 8516Beta stranded; Potential
Transmembrane97 – 10711Beta stranded; Potential
Transmembrane111 – 12616Beta stranded; Potential
Transmembrane147 – 15812Beta stranded; Potential
Transmembrane164 – 18017Beta stranded; Potential
Transmembrane186 – 19712Beta stranded; Potential
Repeat206 – 20721
Repeat208 – 20922
Repeat210 – 21123
Repeat212 – 21324
Domain215 – 343129OmpA-like
Region206 – 21384 X 2 AA tandem repeats of A-P

Amino acid modifications

Disulfide bond316 ↔ 328 By similarity

Sequences

Sequence LengthMass (Da)Tools
P02935 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 1499AA5F5395B35B

FASTA35137,741
        10         20         30         40         50         60 
MKKTAIAITV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFIDNNGP THENQLGAGA 

        70         80         90        100        110        120 
FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL TAKLGYPITD DLDVYTRLGG 

       130        140        150        160        170        180 
MVWRADTKAH NNVTGESEKN HDTGVSPVFA GGVEWAITPE IATRLEYQWT NNIGDAHTIG 

       190        200        210        220        230        240 
TRPDNGLLSL GVSYRFGQGE AAPVVAPAPA PAPEVQTKHF TLKSDVLFNF NKATLKPEGQ 

       250        260        270        280        290        300 
AALDQLYSQL SNLDPKDGSV VVLGYTDRIG SDAYNQGLSE RRAQSVVDYL ISKGIPADKI 

       310        320        330        340        350 
SARGMGESNP VTGNTCDNVK QRAALIDCLA PDRRVEIEVK GIKDVVTQPQ A 

« Hide

References

[1]"The nucleotide sequence coding for major outer membrane protein OmpA of Shigella dysenteriae."
Braun G., Cole S.T.
Nucleic Acids Res. 10:2367-2378(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V01344 Genomic DNA. Translation: CAA24638.1.
PIRMMEBAD. A03435.

3D structure databases

ProteinModelPortalP02935.
SMRP02935. Positions 22-202.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
IPR006665. OmpA/MotB_C.
[Graphical view]
PfamPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOMPA_SHIDY
AccessionPrimary (citable) accession number: P02935
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families