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P02935

- OMPA_SHIDY

UniProt

P02935 - OMPA_SHIDY

Protein

Outer membrane protein A

Gene

ompA

Organism
Shigella dysenteriae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    • Comment

    Functioni

    Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes By similarity.By similarity

    GO - Molecular functioni

    1. porin activity Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. conjugation Source: UniProtKB-KW
    2. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Porin

    Keywords - Biological processi

    Conjugation, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane protein A
    Alternative name(s):
    Outer membrane protein II
    Gene namesi
    Name:ompA
    OrganismiShigella dysenteriae
    Taxonomic identifieri622 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. pore complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 351330Outer membrane protein APRO_0000020101Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi316 ↔ 328By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliP02935.
    SMRiP02935. Positions 22-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4014Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei55 – 6713Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei70 – 8516Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei97 – 10711Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei111 – 12616Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei147 – 15812Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18017Beta strandedSequence AnalysisAdd
    BLAST
    Transmembranei186 – 19712Beta strandedSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati206 – 20721
    Repeati208 – 20922
    Repeati210 – 21123
    Repeati212 – 21324
    Domaini215 – 343129OmpA-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni206 – 21384 X 2 AA tandem repeats of A-P

    Sequence similaritiesi

    Belongs to the OmpA family.Curated
    Contains 1 OmpA-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane beta strand

    Family and domain databases

    Gene3Di2.40.160.20. 1 hit.
    3.30.1330.60. 1 hit.
    InterProiIPR011250. OMP/PagP_b-brl.
    IPR006664. OMP_bac.
    IPR002368. OmpA.
    IPR006690. OMPA-like_CS.
    IPR000498. OmpA-like_TM_dom.
    IPR006665. OmpA/MotB_C.
    [Graphical view]
    PfamiPF00691. OmpA. 1 hit.
    PF01389. OmpA_membrane. 1 hit.
    [Graphical view]
    PRINTSiPR01021. OMPADOMAIN.
    PR01022. OUTRMMBRANEA.
    SUPFAMiSSF103088. SSF103088. 1 hit.
    SSF56925. SSF56925. 1 hit.
    PROSITEiPS01068. OMPA_1. 1 hit.
    PS51123. OMPA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02935-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKTAIAITV ALAGFATVAQ AAPKDNTWYT GAKLGWSQYH DTGFIDNNGP    50
    THENQLGAGA FGGYQVNPYV GFEMGYDWLG RMPYKGSVEN GAYKAQGVQL 100
    TAKLGYPITD DLDVYTRLGG MVWRADTKAH NNVTGESEKN HDTGVSPVFA 150
    GGVEWAITPE IATRLEYQWT NNIGDAHTIG TRPDNGLLSL GVSYRFGQGE 200
    AAPVVAPAPA PAPEVQTKHF TLKSDVLFNF NKATLKPEGQ AALDQLYSQL 250
    SNLDPKDGSV VVLGYTDRIG SDAYNQGLSE RRAQSVVDYL ISKGIPADKI 300
    SARGMGESNP VTGNTCDNVK QRAALIDCLA PDRRVEIEVK GIKDVVTQPQ 350
    A 351
    Length:351
    Mass (Da):37,741
    Last modified:July 21, 1986 - v1
    Checksum:i1499AA5F5395B35B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01344 Genomic DNA. Translation: CAA24638.1.
    PIRiA03435. MMEBAD.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01344 Genomic DNA. Translation: CAA24638.1 .
    PIRi A03435. MMEBAD.

    3D structure databases

    ProteinModelPortali P02935.
    SMRi P02935. Positions 22-202.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.40.160.20. 1 hit.
    3.30.1330.60. 1 hit.
    InterProi IPR011250. OMP/PagP_b-brl.
    IPR006664. OMP_bac.
    IPR002368. OmpA.
    IPR006690. OMPA-like_CS.
    IPR000498. OmpA-like_TM_dom.
    IPR006665. OmpA/MotB_C.
    [Graphical view ]
    Pfami PF00691. OmpA. 1 hit.
    PF01389. OmpA_membrane. 1 hit.
    [Graphical view ]
    PRINTSi PR01021. OMPADOMAIN.
    PR01022. OUTRMMBRANEA.
    SUPFAMi SSF103088. SSF103088. 1 hit.
    SSF56925. SSF56925. 1 hit.
    PROSITEi PS01068. OMPA_1. 1 hit.
    PS51123. OMPA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence coding for major outer membrane protein OmpA of Shigella dysenteriae."
      Braun G., Cole S.T.
      Nucleic Acids Res. 10:2367-2378(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiOMPA_SHIDY
    AccessioniPrimary (citable) accession number: P02935
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3