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Protein

Histidine transport ATP-binding protein HisP

Gene

hisP

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system.3 Publications

Enzyme regulationi

ATPase activity is slightly increased in the presence of HisM and HisQ, and strongly increased when HisJ is also present.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.3.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport ATP-binding protein HisP
Gene namesi
Name:hisP
Ordered Locus Names:STM2351
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication

  • Note: Binds much more tightly to the membrane in the presence of HisQ and HisM.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923421 – 258Histidine transport ATP-binding protein HisPAdd BLAST258

Proteomic databases

PaxDbiP02915.
PRIDEiP02915.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).4 Publications

Protein-protein interaction databases

STRINGi99287.STM2351.

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Beta strandi19 – 29Combined sources11
Beta strandi34 – 38Combined sources5
Helixi45 – 52Combined sources8
Beta strandi59 – 65Combined sources7
Beta strandi72 – 74Combined sources3
Beta strandi78 – 83Combined sources6
Helixi85 – 94Combined sources10
Beta strandi95 – 98Combined sources4
Helixi110 – 120Combined sources11
Helixi126 – 139Combined sources14
Helixi144 – 147Combined sources4
Helixi151 – 153Combined sources3
Helixi156 – 169Combined sources14
Beta strandi173 – 179Combined sources7
Turni180 – 183Combined sources4
Helixi186 – 188Combined sources3
Helixi189 – 201Combined sources13
Beta strandi206 – 209Combined sources4
Helixi213 – 219Combined sources7
Beta strandi221 – 227Combined sources7
Beta strandi230 – 235Combined sources6
Helixi237 – 242Combined sources6
Helixi247 – 258Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0UX-ray1.50A1-258[»]
ProteinModelPortaliP02915.
SMRiP02915.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 253ABC transporterPROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JEH. Bacteria.
COG4598. LUCA.
KOiK10017.
OMAiYLIVTKE.
PhylomeDBiP02915.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSENKLHVI DLHKRYGGHE VLKGVSLQAR AGDVISIIGS SGSGKSTFLR
60 70 80 90 100
CINFLEKPSE GAIIVNGQNI NLVRDKDGQL KVADKNQLRL LRTRLTMVFQ
110 120 130 140 150
HFNLWSHMTV LENVMEAPIQ VLGLSKHDAR ERALKYLAKV GIDERAQGKY
160 170 180 190 200
PVHLSGGQQQ RVSIARALAM EPDVLLFDEP TSALDPELVG EVLRIMQQLA
210 220 230 240 250
EEGKTMVVVT HEMGFARHVS SHVIFLHQGK IEEEGDPEQV FGNPQSPRLQ

QFLKGSLK
Length:258
Mass (Da):28,771
Last modified:July 21, 1986 - v1
Checksum:iD7646F4DA43C62F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01373 Genomic DNA. Translation: CAA24662.1.
J01805 Genomic DNA. Translation: AAA75581.1.
AE006468 Genomic DNA. Translation: AAL21252.1.
PIRiA03412. QREBPT.
RefSeqiNP_461293.1. NC_003197.1.
WP_000986775.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21252; AAL21252; STM2351.
GeneIDi1253873.
KEGGistm:STM2351.
PATRICi32383317. VBISalEnt20916_2488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01373 Genomic DNA. Translation: CAA24662.1.
J01805 Genomic DNA. Translation: AAA75581.1.
AE006468 Genomic DNA. Translation: AAL21252.1.
PIRiA03412. QREBPT.
RefSeqiNP_461293.1. NC_003197.1.
WP_000986775.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0UX-ray1.50A1-258[»]
ProteinModelPortaliP02915.
SMRiP02915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2351.

Protein family/group databases

TCDBi3.A.1.3.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP02915.
PRIDEiP02915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21252; AAL21252; STM2351.
GeneIDi1253873.
KEGGistm:STM2351.
PATRICi32383317. VBISalEnt20916_2488.

Phylogenomic databases

eggNOGiENOG4108JEH. Bacteria.
COG4598. LUCA.
KOiK10017.
OMAiYLIVTKE.
PhylomeDBiP02915.

Miscellaneous databases

EvolutionaryTraceiP02915.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030679. ABC_ATPase_HisP-typ.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039085. ABC_ATPase_HisP. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISP_SALTY
AccessioniPrimary (citable) accession number: P02915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.