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Protein

Histidine transport ATP-binding protein HisP

Gene

hisP

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system.3 Publications

Enzyme regulationi

ATPase activity is slightly increased in the presence of HisM and HisQ, and strongly increased when HisJ is also present.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processAmino-acid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-2373-MONOMER

Protein family/group databases

TCDBi3.A.1.3.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport ATP-binding protein HisP
Gene namesi
Name:hisP
Ordered Locus Names:STM2351
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication
  • Note: Binds much more tightly to the membrane in the presence of HisQ and HisM.

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923421 – 258Histidine transport ATP-binding protein HisPAdd BLAST258

Proteomic databases

PaxDbiP02915
PRIDEiP02915

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).4 Publications

Protein-protein interaction databases

STRINGi99287.STM2351

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Beta strandi19 – 29Combined sources11
Beta strandi34 – 38Combined sources5
Helixi45 – 52Combined sources8
Beta strandi59 – 65Combined sources7
Beta strandi72 – 74Combined sources3
Beta strandi78 – 83Combined sources6
Helixi85 – 94Combined sources10
Beta strandi95 – 98Combined sources4
Helixi110 – 120Combined sources11
Helixi126 – 139Combined sources14
Helixi144 – 147Combined sources4
Helixi151 – 153Combined sources3
Helixi156 – 169Combined sources14
Beta strandi173 – 179Combined sources7
Turni180 – 183Combined sources4
Helixi186 – 188Combined sources3
Helixi189 – 201Combined sources13
Beta strandi206 – 209Combined sources4
Helixi213 – 219Combined sources7
Beta strandi221 – 227Combined sources7
Beta strandi230 – 235Combined sources6
Helixi237 – 242Combined sources6
Helixi247 – 258Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B0UX-ray1.50A1-258[»]
ProteinModelPortaliP02915
SMRiP02915
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02915

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 253ABC transporterPROSITE-ProRule annotationAdd BLAST247

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4108JEH Bacteria
COG4598 LUCA
KOiK10017
OMAiLFFKLRD
PhylomeDBiP02915

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR030679 ABC_ATPase_HisP-typ
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PIRSFiPIRSF039085 ABC_ATPase_HisP, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P02915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSENKLHVI DLHKRYGGHE VLKGVSLQAR AGDVISIIGS SGSGKSTFLR
60 70 80 90 100
CINFLEKPSE GAIIVNGQNI NLVRDKDGQL KVADKNQLRL LRTRLTMVFQ
110 120 130 140 150
HFNLWSHMTV LENVMEAPIQ VLGLSKHDAR ERALKYLAKV GIDERAQGKY
160 170 180 190 200
PVHLSGGQQQ RVSIARALAM EPDVLLFDEP TSALDPELVG EVLRIMQQLA
210 220 230 240 250
EEGKTMVVVT HEMGFARHVS SHVIFLHQGK IEEEGDPEQV FGNPQSPRLQ

QFLKGSLK
Length:258
Mass (Da):28,771
Last modified:July 21, 1986 - v1
Checksum:iD7646F4DA43C62F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01373 Genomic DNA Translation: CAA24662.1
J01805 Genomic DNA Translation: AAA75581.1
AE006468 Genomic DNA Translation: AAL21252.1
PIRiA03412 QREBPT
RefSeqiNP_461293.1, NC_003197.2
WP_000986775.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21252; AAL21252; STM2351
GeneIDi1253873
KEGGistm:STM2351
PATRICifig|99287.12.peg.2488

Similar proteinsi

Entry informationi

Entry nameiHISP_SALTY
AccessioniPrimary (citable) accession number: P02915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health