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P02884

- THM2_THADA

UniProt

P02884 - THM2_THADA

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Protein

Thaumatin-2

Gene
N/A
Organism
Thaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.

Keywords - Molecular functioni

Taste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Thaumatin-2
Alternative name(s):
Thaumatin II
OrganismiThaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Taxonomic identifieri4621 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMarantaceaeThaumatococcus

Subcellular locationi

Cytoplasmic vesicle
Note: Thaumatin accumulates in vesicle-like organelles.

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Protein family/group databases

Allergomei9233. Tha da TLP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222CuratedAdd
BLAST
Chaini23 – 229207Thaumatin-2PRO_0000034017Add
BLAST
Propeptidei230 – 2356Sequence AnalysisPRO_0000034018

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 226PROSITE-ProRule annotation
Disulfide bondi78 ↔ 88PROSITE-ProRule annotation
Disulfide bondi93 ↔ 99PROSITE-ProRule annotation
Disulfide bondi143 ↔ 215PROSITE-ProRule annotation
Disulfide bondi148 ↔ 199PROSITE-ProRule annotation
Disulfide bondi156 ↔ 167PROSITE-ProRule annotation
Disulfide bondi171 ↔ 180PROSITE-ProRule annotation
Disulfide bondi181 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
235
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 296Combined sources
Beta strandi31 – 333Combined sources
Beta strandi35 – 406Combined sources
Beta strandi42 – 5312Combined sources
Beta strandi58 – 625Combined sources
Beta strandi69 – 8012Combined sources
Beta strandi84 – 918Combined sources
Beta strandi96 – 983Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi119 – 1257Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi134 – 14310Combined sources
Beta strandi146 – 1483Combined sources
Helixi152 – 1554Combined sources
Helixi158 – 1603Combined sources
Beta strandi165 – 1673Combined sources
Helixi170 – 1745Combined sources
Helixi177 – 1804Combined sources
Turni181 – 1833Combined sources
Helixi190 – 1989Combined sources
Beta strandi213 – 2164Combined sources
Beta strandi221 – 2266Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AOKX-ray1.27A23-229[»]
ProteinModelPortaliP02884.
SMRiP02884. Positions 23-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02884-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATTCFFFL FPFLLLLTLS RAATFEIVNR CSYTVWAAAS KGDAALDAGG
60 70 80 90 100
RQLNSGESWT INVEPGTKGG KIWARTDCYF DDSGRGICRT GDCGGLLQCK
110 120 130 140 150
RFGRPPTTLA EFSLNQYGKD YIDISNIKGF NVPMDFSPTT RGCRGVRCAA
160 170 180 190 200
DIVGQCPAKL KAPGGGCNDA CTVFQTSEYC CTTGKCGPTE YSRFFKRLCP
210 220 230
DAFSYVLDKP TTVTCPGSSN YRVTFCPTAL ELEDE
Length:235
Mass (Da):25,523
Last modified:July 21, 1986 - v1
Checksum:i15E9DA82554D7A75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01209 mRNA. Translation: AAA93095.1.
PIRiA03378. QTTC2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01209 mRNA. Translation: AAA93095.1 .
PIRi A03378. QTTC2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AOK X-ray 1.27 A 23-229 [» ]
ProteinModelPortali P02884.
SMRi P02884. Positions 23-229.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 9233. Tha da TLP.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.110.10. 1 hit.
InterProi IPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view ]
PANTHERi PTHR31048. PTHR31048. 1 hit.
Pfami PF00314. Thaumatin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002703. Thaumatin. 1 hit.
PRINTSi PR00347. THAUMATIN.
SMARTi SM00205. THN. 1 hit.
[Graphical view ]
SUPFAMi SSF49870. SSF49870. 1 hit.
PROSITEi PS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of cDNA encoding the sweet-tasting plant protein thaumatin and its expression in Escherichia coli."
    Edens L., Heslinga L., Klok R., Ledeboer A.M., Maat J., Toonen M.Y., Visser C., Verrips C.T.
    Gene 18:1-12(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTHM2_THADA
AccessioniPrimary (citable) accession number: P02884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3