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Protein

Thaumatin-2

Gene
N/A
Organism
Thaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.

Keywords - Molecular functioni

Taste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Thaumatin-2
Alternative name(s):
Thaumatin II
OrganismiThaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Taxonomic identifieri4621 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMarantaceaeThaumatococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Protein family/group databases

Allergomei9233. Tha da TLP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22CuratedAdd BLAST22
ChainiPRO_000003401723 – 229Thaumatin-2Add BLAST207
PropeptideiPRO_0000034018230 – 235Sequence analysis6

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 226PROSITE-ProRule annotation
Disulfide bondi78 ↔ 88PROSITE-ProRule annotation
Disulfide bondi93 ↔ 99PROSITE-ProRule annotation
Disulfide bondi143 ↔ 215PROSITE-ProRule annotation
Disulfide bondi148 ↔ 199PROSITE-ProRule annotation
Disulfide bondi156 ↔ 167PROSITE-ProRule annotation
Disulfide bondi171 ↔ 180PROSITE-ProRule annotation
Disulfide bondi181 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 29Combined sources6
Beta strandi31 – 33Combined sources3
Beta strandi35 – 40Combined sources6
Beta strandi42 – 53Combined sources12
Beta strandi58 – 62Combined sources5
Beta strandi69 – 80Combined sources12
Beta strandi84 – 91Combined sources8
Beta strandi96 – 98Combined sources3
Beta strandi109 – 116Combined sources8
Beta strandi119 – 125Combined sources7
Beta strandi130 – 132Combined sources3
Beta strandi134 – 143Combined sources10
Beta strandi146 – 148Combined sources3
Helixi152 – 155Combined sources4
Helixi158 – 160Combined sources3
Beta strandi165 – 167Combined sources3
Helixi170 – 174Combined sources5
Helixi177 – 180Combined sources4
Turni181 – 183Combined sources3
Helixi190 – 198Combined sources9
Beta strandi213 – 216Combined sources4
Beta strandi221 – 226Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AOKX-ray1.27A23-229[»]
3WOUX-ray0.99A23-229[»]
ProteinModelPortaliP02884.
SMRiP02884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATTCFFFL FPFLLLLTLS RAATFEIVNR CSYTVWAAAS KGDAALDAGG
60 70 80 90 100
RQLNSGESWT INVEPGTKGG KIWARTDCYF DDSGRGICRT GDCGGLLQCK
110 120 130 140 150
RFGRPPTTLA EFSLNQYGKD YIDISNIKGF NVPMDFSPTT RGCRGVRCAA
160 170 180 190 200
DIVGQCPAKL KAPGGGCNDA CTVFQTSEYC CTTGKCGPTE YSRFFKRLCP
210 220 230
DAFSYVLDKP TTVTCPGSSN YRVTFCPTAL ELEDE
Length:235
Mass (Da):25,523
Last modified:July 21, 1986 - v1
Checksum:i15E9DA82554D7A75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01209 mRNA. Translation: AAA93095.1.
PIRiA03378. QTTC2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01209 mRNA. Translation: AAA93095.1.
PIRiA03378. QTTC2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AOKX-ray1.27A23-229[»]
3WOUX-ray0.99A23-229[»]
ProteinModelPortaliP02884.
SMRiP02884.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei9233. Tha da TLP.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PANTHERiPTHR31048. PTHR31048. 1 hit.
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHM2_THADA
AccessioniPrimary (citable) accession number: P02884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.