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P02884

- THM2_THADA

UniProt

P02884 - THM2_THADA

Protein

Thaumatin-2

Gene
N/A
Organism
Thaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.

    Keywords - Molecular functioni

    Taste-modifying protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thaumatin-2
    Alternative name(s):
    Thaumatin II
    OrganismiThaumatococcus daniellii (Katemfe) (Phrynium daniellii)
    Taxonomic identifieri4621 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMarantaceaeThaumatococcus

    Subcellular locationi

    Cytoplasmic vesicle
    Note: Thaumatin accumulates in vesicle-like organelles.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Protein family/group databases

    Allergomei9233. Tha da TLP.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222CuratedAdd
    BLAST
    Chaini23 – 229207Thaumatin-2PRO_0000034017Add
    BLAST
    Propeptidei230 – 2356Sequence AnalysisPRO_0000034018

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 226PROSITE-ProRule annotation
    Disulfide bondi78 ↔ 88PROSITE-ProRule annotation
    Disulfide bondi93 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 215PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 199PROSITE-ProRule annotation
    Disulfide bondi156 ↔ 167PROSITE-ProRule annotation
    Disulfide bondi171 ↔ 180PROSITE-ProRule annotation
    Disulfide bondi181 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 296
    Beta strandi31 – 333
    Beta strandi35 – 406
    Beta strandi42 – 5312
    Beta strandi58 – 625
    Beta strandi69 – 8012
    Beta strandi84 – 918
    Beta strandi96 – 983
    Beta strandi109 – 1168
    Beta strandi119 – 1257
    Beta strandi130 – 1323
    Beta strandi134 – 14310
    Beta strandi146 – 1483
    Helixi152 – 1554
    Helixi158 – 1603
    Beta strandi165 – 1673
    Helixi170 – 1745
    Helixi177 – 1804
    Turni181 – 1833
    Helixi190 – 1989
    Beta strandi213 – 2164
    Beta strandi221 – 2266

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AOKX-ray1.27A23-229[»]
    ProteinModelPortaliP02884.
    SMRiP02884. Positions 23-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thaumatin family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.60.110.10. 1 hit.
    InterProiIPR001938. Thaumatin.
    IPR017949. Thaumatin_CS.
    [Graphical view]
    PfamiPF00314. Thaumatin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002703. Thaumatin. 1 hit.
    PRINTSiPR00347. THAUMATIN.
    SMARTiSM00205. THN. 1 hit.
    [Graphical view]
    SUPFAMiSSF49870. SSF49870. 1 hit.
    PROSITEiPS00316. THAUMATIN_1. 1 hit.
    PS51367. THAUMATIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02884-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATTCFFFL FPFLLLLTLS RAATFEIVNR CSYTVWAAAS KGDAALDAGG    50
    RQLNSGESWT INVEPGTKGG KIWARTDCYF DDSGRGICRT GDCGGLLQCK 100
    RFGRPPTTLA EFSLNQYGKD YIDISNIKGF NVPMDFSPTT RGCRGVRCAA 150
    DIVGQCPAKL KAPGGGCNDA CTVFQTSEYC CTTGKCGPTE YSRFFKRLCP 200
    DAFSYVLDKP TTVTCPGSSN YRVTFCPTAL ELEDE 235
    Length:235
    Mass (Da):25,523
    Last modified:July 21, 1986 - v1
    Checksum:i15E9DA82554D7A75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01209 mRNA. Translation: AAA93095.1.
    PIRiA03378. QTTC2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01209 mRNA. Translation: AAA93095.1 .
    PIRi A03378. QTTC2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AOK X-ray 1.27 A 23-229 [» ]
    ProteinModelPortali P02884.
    SMRi P02884. Positions 23-229.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 9233. Tha da TLP.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.110.10. 1 hit.
    InterProi IPR001938. Thaumatin.
    IPR017949. Thaumatin_CS.
    [Graphical view ]
    Pfami PF00314. Thaumatin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002703. Thaumatin. 1 hit.
    PRINTSi PR00347. THAUMATIN.
    SMARTi SM00205. THN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49870. SSF49870. 1 hit.
    PROSITEi PS00316. THAUMATIN_1. 1 hit.
    PS51367. THAUMATIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNA encoding the sweet-tasting plant protein thaumatin and its expression in Escherichia coli."
      Edens L., Heslinga L., Klok R., Ledeboer A.M., Maat J., Toonen M.Y., Visser C., Verrips C.T.
      Gene 18:1-12(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTHM2_THADA
    AccessioniPrimary (citable) accession number: P02884
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3