Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P02883 (THM1_THADA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thaumatin-1
Alternative name(s):
Thaumatin I
OrganismThaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Taxonomic identifier4621 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMarantaceaeThaumatococcus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.

Subcellular location

Cytoplasmic vesicle. Note: Thaumatin accumulates in vesicle-like organelles.

Sequence similarities

Belongs to the thaumatin family.

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
   Molecular functionTaste-modifying protein
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Thaumatin-1
PRO_0000096221

Amino acid modifications

Disulfide bond9 ↔ 204 Ref.2
Disulfide bond56 ↔ 66 Ref.2
Disulfide bond71 ↔ 77 Ref.2
Disulfide bond121 ↔ 193 Ref.2
Disulfide bond126 ↔ 177 Ref.2
Disulfide bond134 ↔ 145 Ref.2
Disulfide bond149 ↔ 158 Ref.2
Disulfide bond159 ↔ 164 Ref.2

Secondary structure

................................................ 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02883 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 9C3288F1873FB32B

FASTA20722,204
        10         20         30         40         50         60 
ATFEIVNRCS YTVWAAASKG DAALDAGGRQ LNSGESWTIN VEPGTNGGKI WARTDCYFDD 

        70         80         90        100        110        120 
SGSGICKTGD CGGLLRCKRF GRPPTTLAEF SLNQYGKDYI DISNIKGFNV PMNFSPTTRG 

       130        140        150        160        170        180 
CRGVRCAADI VGQCPAKLKA PGGGCNDACT VFQTSEYCCT TGKCGPTEYS RFFKRLCPDA 

       190        200 
FSYVLDKPTT VTCPGSSNYR VTFCPTA 

« Hide

References

[1]"The complete amino-acid sequence of the sweet protein thaumatin I."
Iyengar R.B., Smits P., van der Ouderaa F., van der Wel H., van Brouwershaven J., Ravestein P., Richters G., van Wassenaar P.D.
Eur. J. Biochem. 96:193-204(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Three-dimensional structure of thaumatin I, an intensely sweet protein."
de Vos A.M., Hatada M., van der Wel H., Krabbendam H., Peerdeman A.F., Kim S.-H.
Proc. Natl. Acad. Sci. U.S.A. 82:1406-1409(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[3]"X-ray analysis of new crystal forms of the sweet protein thaumatin."
McPherson A., Weickmann J.
J. Biomol. Struct. Dyn. 7:1053-1060(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
[4]"Crystal structure of a sweet tasting protein thaumatin I, at 1.65-A resolution."
Ogata C.M., Gordon P.F., de Vos A.M., Kim S.-H.
J. Mol. Biol. 228:893-908(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRQTTC1. A03377.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KWNX-ray1.20A1-207[»]
1LR2X-ray1.80A1-207[»]
1LR3X-ray1.80A1-207[»]
1LXZX-ray1.25A1-207[»]
1LY0X-ray1.36A1-207[»]
1PP3X-ray1.60A/B1-207[»]
1RQWX-ray1.05A1-207[»]
1THIX-ray3.20A1-207[»]
1THUX-ray2.60A1-207[»]
1THVX-ray1.75A1-207[»]
1THWX-ray1.75A1-207[»]
2A7IX-ray1.75X1-207[»]
2BLRX-ray1.40A1-206[»]
2BLUX-ray1.40A1-206[»]
2D8OX-ray2.38A1-207[»]
2D8PX-ray2.30A1-207[»]
2G4YX-ray1.98A1-207[»]
2OQNX-ray1.90A1-207[»]
2PE7X-ray1.46A1-207[»]
2VHKX-ray0.94A1-206[»]
2VHRX-ray0.95A1-207[»]
2VI1X-ray1.04A1-207[»]
2VI2X-ray1.08A1-207[»]
2VI3X-ray0.98A1-207[»]
2VI4X-ray1.10A1-207[»]
2VU6X-ray0.95A1-207[»]
2VU7X-ray1.08A1-207[»]
2WBZX-ray1.60A1-206[»]
3AL7X-ray1.10A1-207[»]
3ALDX-ray1.10A1-207[»]
3DZNX-ray1.51A1-207[»]
3DZPX-ray1.51A1-207[»]
3DZRX-ray1.51A1-207[»]
3E0AX-ray1.51A1-207[»]
3E3SX-ray1.73A1-207[»]
3N02X-ray1.50A1-206[»]
3N03X-ray1.50A1-206[»]
3QY5X-ray1.25A1-207[»]
3V7VX-ray2.30A1-207[»]
3V82X-ray2.30A1-207[»]
3V84X-ray2.30A1-207[»]
3V87X-ray2.30A1-207[»]
3V88X-ray2.30A1-207[»]
3V8AX-ray2.30A1-207[»]
3VCEX-ray2.30A1-207[»]
3VCGX-ray2.30A1-207[»]
3VCHX-ray2.30A1-207[»]
3VCIX-ray2.30A1-207[»]
3VCJX-ray2.30A1-207[»]
3VCKX-ray2.30A1-207[»]
3VHFX-ray1.39A1-207[»]
3VHGX-ray1.00A1-207[»]
3VJQX-ray1.00A1-207[»]
3ZEJX-ray1.55A1-207[»]
4AXRX-ray1.38A1-207[»]
4AXUX-ray1.38A1-206[»]
4BALX-ray1.30A1-207[»]
4BARX-ray1.20A1-207[»]
4DC5X-ray1.48A1-207[»]
4DC6X-ray1.48A1-207[»]
4DIYX-ray1.98A1-207[»]
4DIZX-ray1.98A1-207[»]
4DJ0X-ray1.98A1-207[»]
4DJ1X-ray1.98A1-207[»]
4EK0X-ray1.52A1-207[»]
4EKAX-ray1.55A1-207[»]
4EKBX-ray1.52A1-207[»]
4EKHX-ray1.75A1-207[»]
4EKOX-ray1.52A1-207[»]
4EKTX-ray1.75A1-207[»]
4EL2X-ray1.52A1-207[»]
4EL3X-ray1.95A1-207[»]
4EL7X-ray1.52A1-207[»]
4ELAX-ray2.00A1-207[»]
ProteinModelPortalP02883.
SMRP02883. Positions 1-207.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome9233. Tha da TLP.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.110.10. 1 hit.
InterProIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PfamPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFPIRSF002703. Thaumatin. 1 hit.
PRINTSPR00347. THAUMATIN.
SMARTSM00205. THN. 1 hit.
[Graphical view]
SUPFAMSSF49870. SSF49870. 1 hit.
PROSITEPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02883.

Entry information

Entry nameTHM1_THADA
AccessionPrimary (citable) accession number: P02883
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references