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P02883

- THM1_THADA

UniProt

P02883 - THM1_THADA

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Protein
Thaumatin-1
Gene
N/A
Organism
Thaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.

Keywords - Molecular functioni

Taste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Thaumatin-1
Alternative name(s):
Thaumatin I
OrganismiThaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Taxonomic identifieri4621 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMarantaceaeThaumatococcus

Subcellular locationi

Cytoplasmic vesicle
Note: Thaumatin accumulates in vesicle-like organelles.

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Protein family/group databases

Allergomei9233. Tha da TLP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Thaumatin-1
PRO_0000096221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi9 ↔ 2041 Publication
Disulfide bondi56 ↔ 661 Publication
Disulfide bondi71 ↔ 771 Publication
Disulfide bondi121 ↔ 1931 Publication
Disulfide bondi126 ↔ 1771 Publication
Disulfide bondi134 ↔ 1451 Publication
Disulfide bondi149 ↔ 1581 Publication
Disulfide bondi159 ↔ 1641 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76
Beta strandi9 – 113
Beta strandi13 – 186
Beta strandi20 – 3112
Beta strandi36 – 405
Beta strandi47 – 559
Beta strandi62 – 654
Beta strandi67 – 693
Beta strandi74 – 763
Beta strandi87 – 948
Beta strandi97 – 1037
Beta strandi108 – 1103
Beta strandi112 – 1209
Beta strandi124 – 1263
Helixi130 – 1334
Helixi136 – 1383
Beta strandi143 – 1453
Helixi148 – 1525
Helixi155 – 1584
Turni159 – 1613
Helixi168 – 1769
Beta strandi180 – 1834
Beta strandi191 – 1944
Beta strandi199 – 2046

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KWNX-ray1.20A1-207[»]
1LR2X-ray1.80A1-207[»]
1LR3X-ray1.80A1-207[»]
1LXZX-ray1.25A1-207[»]
1LY0X-ray1.36A1-207[»]
1PP3X-ray1.60A/B1-207[»]
1RQWX-ray1.05A1-207[»]
1THIX-ray3.20A1-207[»]
1THUX-ray2.60A1-207[»]
1THVX-ray1.75A1-207[»]
1THWX-ray1.75A1-207[»]
2A7IX-ray1.75X1-207[»]
2BLRX-ray1.40A1-206[»]
2BLUX-ray1.40A1-206[»]
2D8OX-ray2.38A1-207[»]
2D8PX-ray2.30A1-207[»]
2G4YX-ray1.98A1-207[»]
2OQNX-ray1.90A1-207[»]
2PE7X-ray1.46A1-207[»]
2VHKX-ray0.94A1-206[»]
2VHRX-ray0.95A1-207[»]
2VI1X-ray1.04A1-207[»]
2VI2X-ray1.08A1-207[»]
2VI3X-ray0.98A1-207[»]
2VI4X-ray1.10A1-207[»]
2VU6X-ray0.95A1-207[»]
2VU7X-ray1.08A1-207[»]
2WBZX-ray1.60A1-206[»]
3AL7X-ray1.10A1-207[»]
3ALDX-ray1.10A1-207[»]
3DZNX-ray1.51A1-207[»]
3DZPX-ray1.51A1-207[»]
3DZRX-ray1.51A1-207[»]
3E0AX-ray1.51A1-207[»]
3E3SX-ray1.73A1-207[»]
3N02X-ray1.50A1-206[»]
3N03X-ray1.50A1-206[»]
3QY5X-ray1.25A1-207[»]
3V7VX-ray2.30A1-207[»]
3V82X-ray2.30A1-207[»]
3V84X-ray2.30A1-207[»]
3V87X-ray2.30A1-207[»]
3V88X-ray2.30A1-207[»]
3V8AX-ray2.30A1-207[»]
3VCEX-ray2.30A1-207[»]
3VCGX-ray2.30A1-207[»]
3VCHX-ray2.30A1-207[»]
3VCIX-ray2.30A1-207[»]
3VCJX-ray2.30A1-207[»]
3VCKX-ray2.30A1-207[»]
3VHFX-ray1.39A1-207[»]
3VHGX-ray1.00A1-207[»]
3VJQX-ray1.00A1-207[»]
3ZEJX-ray1.55A1-207[»]
4AXRX-ray1.38A1-207[»]
4AXUX-ray1.38A1-206[»]
4BALX-ray1.30A1-207[»]
4BARX-ray1.20A1-207[»]
4DC5X-ray1.48A1-207[»]
4DC6X-ray1.48A1-207[»]
4DIYX-ray1.98A1-207[»]
4DIZX-ray1.98A1-207[»]
4DJ0X-ray1.98A1-207[»]
4DJ1X-ray1.98A1-207[»]
4EK0X-ray1.52A1-207[»]
4EKAX-ray1.55A1-207[»]
4EKBX-ray1.52A1-207[»]
4EKHX-ray1.75A1-207[»]
4EKOX-ray1.52A1-207[»]
4EKTX-ray1.75A1-207[»]
4EL2X-ray1.52A1-207[»]
4EL3X-ray1.95A1-207[»]
4EL7X-ray1.52A1-207[»]
4ELAX-ray2.00A1-207[»]
ProteinModelPortaliP02883.
SMRiP02883. Positions 1-207.

Miscellaneous databases

EvolutionaryTraceiP02883.

Family & Domainsi

Sequence similaritiesi

Belongs to the thaumatin family.

Family and domain databases

Gene3Di2.60.110.10. 1 hit.
InterProiIPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view]
PfamiPF00314. Thaumatin. 1 hit.
[Graphical view]
PIRSFiPIRSF002703. Thaumatin. 1 hit.
PRINTSiPR00347. THAUMATIN.
SMARTiSM00205. THN. 1 hit.
[Graphical view]
SUPFAMiSSF49870. SSF49870. 1 hit.
PROSITEiPS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02883-1 [UniParc]FASTAAdd to Basket

« Hide

ATFEIVNRCS YTVWAAASKG DAALDAGGRQ LNSGESWTIN VEPGTNGGKI    50
WARTDCYFDD SGSGICKTGD CGGLLRCKRF GRPPTTLAEF SLNQYGKDYI 100
DISNIKGFNV PMNFSPTTRG CRGVRCAADI VGQCPAKLKA PGGGCNDACT 150
VFQTSEYCCT TGKCGPTEYS RFFKRLCPDA FSYVLDKPTT VTCPGSSNYR 200
VTFCPTA 207
Length:207
Mass (Da):22,204
Last modified:July 21, 1986 - v1
Checksum:i9C3288F1873FB32B
GO

Sequence databases

PIRiA03377. QTTC1.

Cross-referencesi

Sequence databases

PIRi A03377. QTTC1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KWN X-ray 1.20 A 1-207 [» ]
1LR2 X-ray 1.80 A 1-207 [» ]
1LR3 X-ray 1.80 A 1-207 [» ]
1LXZ X-ray 1.25 A 1-207 [» ]
1LY0 X-ray 1.36 A 1-207 [» ]
1PP3 X-ray 1.60 A/B 1-207 [» ]
1RQW X-ray 1.05 A 1-207 [» ]
1THI X-ray 3.20 A 1-207 [» ]
1THU X-ray 2.60 A 1-207 [» ]
1THV X-ray 1.75 A 1-207 [» ]
1THW X-ray 1.75 A 1-207 [» ]
2A7I X-ray 1.75 X 1-207 [» ]
2BLR X-ray 1.40 A 1-206 [» ]
2BLU X-ray 1.40 A 1-206 [» ]
2D8O X-ray 2.38 A 1-207 [» ]
2D8P X-ray 2.30 A 1-207 [» ]
2G4Y X-ray 1.98 A 1-207 [» ]
2OQN X-ray 1.90 A 1-207 [» ]
2PE7 X-ray 1.46 A 1-207 [» ]
2VHK X-ray 0.94 A 1-206 [» ]
2VHR X-ray 0.95 A 1-207 [» ]
2VI1 X-ray 1.04 A 1-207 [» ]
2VI2 X-ray 1.08 A 1-207 [» ]
2VI3 X-ray 0.98 A 1-207 [» ]
2VI4 X-ray 1.10 A 1-207 [» ]
2VU6 X-ray 0.95 A 1-207 [» ]
2VU7 X-ray 1.08 A 1-207 [» ]
2WBZ X-ray 1.60 A 1-206 [» ]
3AL7 X-ray 1.10 A 1-207 [» ]
3ALD X-ray 1.10 A 1-207 [» ]
3DZN X-ray 1.51 A 1-207 [» ]
3DZP X-ray 1.51 A 1-207 [» ]
3DZR X-ray 1.51 A 1-207 [» ]
3E0A X-ray 1.51 A 1-207 [» ]
3E3S X-ray 1.73 A 1-207 [» ]
3N02 X-ray 1.50 A 1-206 [» ]
3N03 X-ray 1.50 A 1-206 [» ]
3QY5 X-ray 1.25 A 1-207 [» ]
3V7V X-ray 2.30 A 1-207 [» ]
3V82 X-ray 2.30 A 1-207 [» ]
3V84 X-ray 2.30 A 1-207 [» ]
3V87 X-ray 2.30 A 1-207 [» ]
3V88 X-ray 2.30 A 1-207 [» ]
3V8A X-ray 2.30 A 1-207 [» ]
3VCE X-ray 2.30 A 1-207 [» ]
3VCG X-ray 2.30 A 1-207 [» ]
3VCH X-ray 2.30 A 1-207 [» ]
3VCI X-ray 2.30 A 1-207 [» ]
3VCJ X-ray 2.30 A 1-207 [» ]
3VCK X-ray 2.30 A 1-207 [» ]
3VHF X-ray 1.39 A 1-207 [» ]
3VHG X-ray 1.00 A 1-207 [» ]
3VJQ X-ray 1.00 A 1-207 [» ]
3ZEJ X-ray 1.55 A 1-207 [» ]
4AXR X-ray 1.38 A 1-207 [» ]
4AXU X-ray 1.38 A 1-206 [» ]
4BAL X-ray 1.30 A 1-207 [» ]
4BAR X-ray 1.20 A 1-207 [» ]
4DC5 X-ray 1.48 A 1-207 [» ]
4DC6 X-ray 1.48 A 1-207 [» ]
4DIY X-ray 1.98 A 1-207 [» ]
4DIZ X-ray 1.98 A 1-207 [» ]
4DJ0 X-ray 1.98 A 1-207 [» ]
4DJ1 X-ray 1.98 A 1-207 [» ]
4EK0 X-ray 1.52 A 1-207 [» ]
4EKA X-ray 1.55 A 1-207 [» ]
4EKB X-ray 1.52 A 1-207 [» ]
4EKH X-ray 1.75 A 1-207 [» ]
4EKO X-ray 1.52 A 1-207 [» ]
4EKT X-ray 1.75 A 1-207 [» ]
4EL2 X-ray 1.52 A 1-207 [» ]
4EL3 X-ray 1.95 A 1-207 [» ]
4EL7 X-ray 1.52 A 1-207 [» ]
4ELA X-ray 2.00 A 1-207 [» ]
ProteinModelPortali P02883.
SMRi P02883. Positions 1-207.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 9233. Tha da TLP.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P02883.

Family and domain databases

Gene3Di 2.60.110.10. 1 hit.
InterProi IPR001938. Thaumatin.
IPR017949. Thaumatin_CS.
[Graphical view ]
Pfami PF00314. Thaumatin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002703. Thaumatin. 1 hit.
PRINTSi PR00347. THAUMATIN.
SMARTi SM00205. THN. 1 hit.
[Graphical view ]
SUPFAMi SSF49870. SSF49870. 1 hit.
PROSITEi PS00316. THAUMATIN_1. 1 hit.
PS51367. THAUMATIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  3. "X-ray analysis of new crystal forms of the sweet protein thaumatin."
    McPherson A., Weickmann J.
    J. Biomol. Struct. Dyn. 7:1053-1060(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  4. "Crystal structure of a sweet tasting protein thaumatin I, at 1.65-A resolution."
    Ogata C.M., Gordon P.F., de Vos A.M., Kim S.-H.
    J. Mol. Biol. 228:893-908(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

Entry informationi

Entry nameiTHM1_THADA
AccessioniPrimary (citable) accession number: P02883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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