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P02883

- THM1_THADA

UniProt

P02883 - THM1_THADA

Protein

Thaumatin-1

Gene
N/A
Organism
Thaumatococcus daniellii (Katemfe) (Phrynium daniellii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.

    Keywords - Molecular functioni

    Taste-modifying protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thaumatin-1
    Alternative name(s):
    Thaumatin I
    OrganismiThaumatococcus daniellii (Katemfe) (Phrynium daniellii)
    Taxonomic identifieri4621 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesMarantaceaeThaumatococcus

    Subcellular locationi

    Cytoplasmic vesicle
    Note: Thaumatin accumulates in vesicle-like organelles.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Protein family/group databases

    Allergomei9233. Tha da TLP.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Thaumatin-1PRO_0000096221Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi9 ↔ 2041 PublicationPROSITE-ProRule annotation
    Disulfide bondi56 ↔ 661 PublicationPROSITE-ProRule annotation
    Disulfide bondi71 ↔ 771 PublicationPROSITE-ProRule annotation
    Disulfide bondi121 ↔ 1931 PublicationPROSITE-ProRule annotation
    Disulfide bondi126 ↔ 1771 PublicationPROSITE-ProRule annotation
    Disulfide bondi134 ↔ 1451 PublicationPROSITE-ProRule annotation
    Disulfide bondi149 ↔ 1581 PublicationPROSITE-ProRule annotation
    Disulfide bondi159 ↔ 1641 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 76
    Beta strandi9 – 113
    Beta strandi13 – 186
    Beta strandi20 – 3112
    Beta strandi36 – 405
    Beta strandi47 – 559
    Beta strandi62 – 654
    Beta strandi67 – 693
    Beta strandi74 – 763
    Beta strandi87 – 948
    Beta strandi97 – 1037
    Beta strandi108 – 1103
    Beta strandi112 – 1209
    Beta strandi124 – 1263
    Helixi130 – 1334
    Helixi136 – 1383
    Beta strandi143 – 1453
    Helixi148 – 1525
    Helixi155 – 1584
    Turni159 – 1613
    Helixi168 – 1769
    Beta strandi180 – 1834
    Beta strandi191 – 1944
    Beta strandi199 – 2046

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KWNX-ray1.20A1-207[»]
    1LR2X-ray1.80A1-207[»]
    1LR3X-ray1.80A1-207[»]
    1LXZX-ray1.25A1-207[»]
    1LY0X-ray1.36A1-207[»]
    1PP3X-ray1.60A/B1-207[»]
    1RQWX-ray1.05A1-207[»]
    1THIX-ray3.20A1-207[»]
    1THUX-ray2.60A1-207[»]
    1THVX-ray1.75A1-207[»]
    1THWX-ray1.75A1-207[»]
    2A7IX-ray1.75X1-207[»]
    2BLRX-ray1.40A1-206[»]
    2BLUX-ray1.40A1-206[»]
    2D8OX-ray2.38A1-207[»]
    2D8PX-ray2.30A1-207[»]
    2G4YX-ray1.98A1-207[»]
    2OQNX-ray1.90A1-207[»]
    2PE7X-ray1.46A1-207[»]
    2VHKX-ray0.94A1-206[»]
    2VHRX-ray0.95A1-207[»]
    2VI1X-ray1.04A1-207[»]
    2VI2X-ray1.08A1-207[»]
    2VI3X-ray0.98A1-207[»]
    2VI4X-ray1.10A1-207[»]
    2VU6X-ray0.95A1-207[»]
    2VU7X-ray1.08A1-207[»]
    2WBZX-ray1.60A1-206[»]
    3AL7X-ray1.10A1-207[»]
    3ALDX-ray1.10A1-207[»]
    3DZNX-ray1.51A1-207[»]
    3DZPX-ray1.51A1-207[»]
    3DZRX-ray1.51A1-207[»]
    3E0AX-ray1.51A1-207[»]
    3E3SX-ray1.73A1-207[»]
    3N02X-ray1.50A1-206[»]
    3N03X-ray1.50A1-206[»]
    3QY5X-ray1.25A1-207[»]
    3V7VX-ray2.30A1-207[»]
    3V82X-ray2.30A1-207[»]
    3V84X-ray2.30A1-207[»]
    3V87X-ray2.30A1-207[»]
    3V88X-ray2.30A1-207[»]
    3V8AX-ray2.30A1-207[»]
    3VCEX-ray2.30A1-207[»]
    3VCGX-ray2.30A1-207[»]
    3VCHX-ray2.30A1-207[»]
    3VCIX-ray2.30A1-207[»]
    3VCJX-ray2.30A1-207[»]
    3VCKX-ray2.30A1-207[»]
    3VHFX-ray1.39A1-207[»]
    3VHGX-ray1.00A1-207[»]
    3VJQX-ray1.00A1-207[»]
    3ZEJX-ray1.55A1-207[»]
    4AXRX-ray1.38A1-207[»]
    4AXUX-ray1.38A1-206[»]
    4BALX-ray1.30A1-207[»]
    4BARX-ray1.20A1-207[»]
    4DC5X-ray1.48A1-207[»]
    4DC6X-ray1.48A1-207[»]
    4DIYX-ray1.98A1-207[»]
    4DIZX-ray1.98A1-207[»]
    4DJ0X-ray1.98A1-207[»]
    4DJ1X-ray1.98A1-207[»]
    4EK0X-ray1.52A1-207[»]
    4EKAX-ray1.55A1-207[»]
    4EKBX-ray1.52A1-207[»]
    4EKHX-ray1.75A1-207[»]
    4EKOX-ray1.52A1-207[»]
    4EKTX-ray1.75A1-207[»]
    4EL2X-ray1.52A1-207[»]
    4EL3X-ray1.95A1-207[»]
    4EL7X-ray1.52A1-207[»]
    4ELAX-ray2.00A1-207[»]
    ProteinModelPortaliP02883.
    SMRiP02883. Positions 1-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02883.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thaumatin family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.60.110.10. 1 hit.
    InterProiIPR001938. Thaumatin.
    IPR017949. Thaumatin_CS.
    [Graphical view]
    PfamiPF00314. Thaumatin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002703. Thaumatin. 1 hit.
    PRINTSiPR00347. THAUMATIN.
    SMARTiSM00205. THN. 1 hit.
    [Graphical view]
    SUPFAMiSSF49870. SSF49870. 1 hit.
    PROSITEiPS00316. THAUMATIN_1. 1 hit.
    PS51367. THAUMATIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P02883-1 [UniParc]FASTAAdd to Basket

    « Hide

    ATFEIVNRCS YTVWAAASKG DAALDAGGRQ LNSGESWTIN VEPGTNGGKI    50
    WARTDCYFDD SGSGICKTGD CGGLLRCKRF GRPPTTLAEF SLNQYGKDYI 100
    DISNIKGFNV PMNFSPTTRG CRGVRCAADI VGQCPAKLKA PGGGCNDACT 150
    VFQTSEYCCT TGKCGPTEYS RFFKRLCPDA FSYVLDKPTT VTCPGSSNYR 200
    VTFCPTA 207
    Length:207
    Mass (Da):22,204
    Last modified:July 21, 1986 - v1
    Checksum:i9C3288F1873FB32B
    GO

    Sequence databases

    PIRiA03377. QTTC1.

    Cross-referencesi

    Sequence databases

    PIRi A03377. QTTC1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KWN X-ray 1.20 A 1-207 [» ]
    1LR2 X-ray 1.80 A 1-207 [» ]
    1LR3 X-ray 1.80 A 1-207 [» ]
    1LXZ X-ray 1.25 A 1-207 [» ]
    1LY0 X-ray 1.36 A 1-207 [» ]
    1PP3 X-ray 1.60 A/B 1-207 [» ]
    1RQW X-ray 1.05 A 1-207 [» ]
    1THI X-ray 3.20 A 1-207 [» ]
    1THU X-ray 2.60 A 1-207 [» ]
    1THV X-ray 1.75 A 1-207 [» ]
    1THW X-ray 1.75 A 1-207 [» ]
    2A7I X-ray 1.75 X 1-207 [» ]
    2BLR X-ray 1.40 A 1-206 [» ]
    2BLU X-ray 1.40 A 1-206 [» ]
    2D8O X-ray 2.38 A 1-207 [» ]
    2D8P X-ray 2.30 A 1-207 [» ]
    2G4Y X-ray 1.98 A 1-207 [» ]
    2OQN X-ray 1.90 A 1-207 [» ]
    2PE7 X-ray 1.46 A 1-207 [» ]
    2VHK X-ray 0.94 A 1-206 [» ]
    2VHR X-ray 0.95 A 1-207 [» ]
    2VI1 X-ray 1.04 A 1-207 [» ]
    2VI2 X-ray 1.08 A 1-207 [» ]
    2VI3 X-ray 0.98 A 1-207 [» ]
    2VI4 X-ray 1.10 A 1-207 [» ]
    2VU6 X-ray 0.95 A 1-207 [» ]
    2VU7 X-ray 1.08 A 1-207 [» ]
    2WBZ X-ray 1.60 A 1-206 [» ]
    3AL7 X-ray 1.10 A 1-207 [» ]
    3ALD X-ray 1.10 A 1-207 [» ]
    3DZN X-ray 1.51 A 1-207 [» ]
    3DZP X-ray 1.51 A 1-207 [» ]
    3DZR X-ray 1.51 A 1-207 [» ]
    3E0A X-ray 1.51 A 1-207 [» ]
    3E3S X-ray 1.73 A 1-207 [» ]
    3N02 X-ray 1.50 A 1-206 [» ]
    3N03 X-ray 1.50 A 1-206 [» ]
    3QY5 X-ray 1.25 A 1-207 [» ]
    3V7V X-ray 2.30 A 1-207 [» ]
    3V82 X-ray 2.30 A 1-207 [» ]
    3V84 X-ray 2.30 A 1-207 [» ]
    3V87 X-ray 2.30 A 1-207 [» ]
    3V88 X-ray 2.30 A 1-207 [» ]
    3V8A X-ray 2.30 A 1-207 [» ]
    3VCE X-ray 2.30 A 1-207 [» ]
    3VCG X-ray 2.30 A 1-207 [» ]
    3VCH X-ray 2.30 A 1-207 [» ]
    3VCI X-ray 2.30 A 1-207 [» ]
    3VCJ X-ray 2.30 A 1-207 [» ]
    3VCK X-ray 2.30 A 1-207 [» ]
    3VHF X-ray 1.39 A 1-207 [» ]
    3VHG X-ray 1.00 A 1-207 [» ]
    3VJQ X-ray 1.00 A 1-207 [» ]
    3ZEJ X-ray 1.55 A 1-207 [» ]
    4AXR X-ray 1.38 A 1-207 [» ]
    4AXU X-ray 1.38 A 1-206 [» ]
    4BAL X-ray 1.30 A 1-207 [» ]
    4BAR X-ray 1.20 A 1-207 [» ]
    4DC5 X-ray 1.48 A 1-207 [» ]
    4DC6 X-ray 1.48 A 1-207 [» ]
    4DIY X-ray 1.98 A 1-207 [» ]
    4DIZ X-ray 1.98 A 1-207 [» ]
    4DJ0 X-ray 1.98 A 1-207 [» ]
    4DJ1 X-ray 1.98 A 1-207 [» ]
    4EK0 X-ray 1.52 A 1-207 [» ]
    4EKA X-ray 1.55 A 1-207 [» ]
    4EKB X-ray 1.52 A 1-207 [» ]
    4EKH X-ray 1.75 A 1-207 [» ]
    4EKO X-ray 1.52 A 1-207 [» ]
    4EKT X-ray 1.75 A 1-207 [» ]
    4EL2 X-ray 1.52 A 1-207 [» ]
    4EL3 X-ray 1.95 A 1-207 [» ]
    4EL7 X-ray 1.52 A 1-207 [» ]
    4ELA X-ray 2.00 A 1-207 [» ]
    ProteinModelPortali P02883.
    SMRi P02883. Positions 1-207.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 9233. Tha da TLP.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P02883.

    Family and domain databases

    Gene3Di 2.60.110.10. 1 hit.
    InterProi IPR001938. Thaumatin.
    IPR017949. Thaumatin_CS.
    [Graphical view ]
    Pfami PF00314. Thaumatin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002703. Thaumatin. 1 hit.
    PRINTSi PR00347. THAUMATIN.
    SMARTi SM00205. THN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49870. SSF49870. 1 hit.
    PROSITEi PS00316. THAUMATIN_1. 1 hit.
    PS51367. THAUMATIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    3. "X-ray analysis of new crystal forms of the sweet protein thaumatin."
      McPherson A., Weickmann J.
      J. Biomol. Struct. Dyn. 7:1053-1060(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    4. "Crystal structure of a sweet tasting protein thaumatin I, at 1.65-A resolution."
      Ogata C.M., Gordon P.F., de Vos A.M., Kim S.-H.
      J. Mol. Biol. 228:893-908(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

    Entry informationi

    Entry nameiTHM1_THADA
    AccessioniPrimary (citable) accession number: P02883
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3