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Protein

Monellin chain A

Gene
N/A
Organism
Dioscoreophyllum cumminsii (Serendipity berry) (Rhopalandria cumminsii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Taste-modifying protein; intensely sweet-tasting protein.

Keywordsi

Molecular functionTaste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Monellin chain A
Alternative name(s):
Monellin chain I
OrganismiDioscoreophyllum cumminsii (Serendipity berry) (Rhopalandria cumminsii)
Taxonomic identifieri3457 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesMenispermaceaeChasmantheroideaeBurasaieaeDioscoreophyllum

Pathology & Biotechi

Biotechnological usei

Natural monellin has not been mass marketed to the food industry, primarily due to the challenge of large-scale purification of the protein which is relatively sensitive to heat or acid treatment.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071651 – 45Monellin chain AAdd BLAST45

Interactioni

Subunit structurei

Heterodimer of an A chain and a B chain.

Protein-protein interaction databases

MINTiP02881

Structurei

Secondary structure

145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 15Combined sources10
Beta strandi18 – 27Combined sources10
Turni28 – 30Combined sources3
Beta strandi33 – 39Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FA3NMR-A1-45[»]
1FUWNMR-A2-42[»]
1IV7X-ray1.82A/B1-45[»]
1IV9X-ray1.90A/B1-45[»]
1KRLX-ray1.90A/C2-45[»]
1M9GNMR-A1-45[»]
1MNLNMR-A1-45[»]
2GPKmodel-B2-45[»]
3MONX-ray2.80A/C/E/G2-45[»]
3PXMX-ray1.80A/B2-45[»]
3PYJX-ray2.00A2-45[»]
3Q2PX-ray2.34A/B/C/D2-45[»]
4MONX-ray2.30A/C1-45[»]
5LC6X-ray1.70A/B1-45[»]
5LC7X-ray1.55A/B1-45[»]
5O7KX-ray2.05A/B1-45[»]
5O7QX-ray1.72A/B1-45[»]
5O7RX-ray2.06A/B1-45[»]
5O7SX-ray2.02A/B1-45[»]
5XFUX-ray2.61A/B/C/D/E4-45[»]
5Z1PX-ray1.89A/B/C/D1-45[»]
ProteinModelPortaliP02881
SMRiP02881
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02881

Family & Domainsi

Family and domain databases

Gene3Di2.20.25.610, 1 hit
InterProiView protein in InterPro
IPR015283 Monellin
IPR000828 Monellin_A
IPR038580 Monellin_A_sf
PfamiView protein in Pfam
PF09200 Monellin, 1 hit
PRINTSiPR00630 MONELLINA

Sequencei

Sequence statusi: Complete.

P02881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
FREIKGYEYQ LYVYASDKLF RADISEDYKT RGRKLLRFNG PVPPP
Length:45
Mass (Da):5,398
Last modified:July 21, 1986 - v1
Checksum:iE086DF18521EC5B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → N AA sequence (PubMed:962914).Curated1
Sequence conflicti26 – 27ED → QN AA sequence (PubMed:962914).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1Missing in 90% of the chains. 1

Sequence databases

PIRiJH0209 MLDIA

Similar proteinsi

Entry informationi

Entry nameiMONA_DIOCU
AccessioniPrimary (citable) accession number: P02881
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
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Main funding by: National Institutes of Health