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Protein

Monellin chain A

Gene
N/A
Organism
Dioscoreophyllum cumminsii (Serendipity berry) (Rhopalandria cumminsii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Taste-modifying protein; intensely sweet-tasting protein.

Keywords - Molecular functioni

Taste-modifying protein

Names & Taxonomyi

Protein namesi
Recommended name:
Monellin chain A
Alternative name(s):
Monellin chain I
OrganismiDioscoreophyllum cumminsii (Serendipity berry) (Rhopalandria cumminsii)
Taxonomic identifieri3457 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesMenispermaceaeTinosporoideaeDioscoreophyllum

Pathology & Biotechi

Biotechnological usei

Natural monellin has not been mass marketed to the food industry, primarily due to the challenge of large-scale purification of the protein which is relatively sensitive to heat or acid treatment.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071651 – 45Monellin chain AAdd BLAST45

Interactioni

Subunit structurei

Heterodimer of an A chain and a B chain.

Protein-protein interaction databases

MINTiMINT-1542282.

Structurei

Secondary structure

145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 15Combined sources12
Beta strandi18 – 27Combined sources10
Turni28 – 30Combined sources3
Beta strandi33 – 39Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FA3NMR-A1-45[»]
1FUWNMR-A2-42[»]
1IV7X-ray1.82A/B1-45[»]
1IV9X-ray1.90A/B1-45[»]
1KRLX-ray1.90A/C2-45[»]
1M9GNMR-A1-45[»]
1MNLNMR-A1-45[»]
2GPKmodel-B2-45[»]
3MONX-ray2.80A/C/E/G2-45[»]
3PXMX-ray1.80A/B2-45[»]
3PYJX-ray2.00A2-45[»]
3Q2PX-ray2.34A/B/C/D2-45[»]
4MONX-ray2.30A/C1-45[»]
5LC6X-ray1.70A/B1-45[»]
5LC7X-ray1.55A/B1-45[»]
ProteinModelPortaliP02881.
SMRiP02881.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02881.

Family & Domainsi

Family and domain databases

InterProiIPR015283. Monellin.
IPR000828. Monellin_A.
[Graphical view]
PfamiPF09200. Monellin. 1 hit.
[Graphical view]
PRINTSiPR00630. MONELLINA.

Sequencei

Sequence statusi: Complete.

P02881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
FREIKGYEYQ LYVYASDKLF RADISEDYKT RGRKLLRFNG PVPPP
Length:45
Mass (Da):5,398
Last modified:July 21, 1986 - v1
Checksum:iE086DF18521EC5B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → N AA sequence (PubMed:962914).Curated1
Sequence conflicti26 – 27ED → QN AA sequence (PubMed:962914).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1Missing in 90% of the chains. 1

Sequence databases

PIRiJH0209. MLDIA.

Cross-referencesi

Sequence databases

PIRiJH0209. MLDIA.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FA3NMR-A1-45[»]
1FUWNMR-A2-42[»]
1IV7X-ray1.82A/B1-45[»]
1IV9X-ray1.90A/B1-45[»]
1KRLX-ray1.90A/C2-45[»]
1M9GNMR-A1-45[»]
1MNLNMR-A1-45[»]
2GPKmodel-B2-45[»]
3MONX-ray2.80A/C/E/G2-45[»]
3PXMX-ray1.80A/B2-45[»]
3PYJX-ray2.00A2-45[»]
3Q2PX-ray2.34A/B/C/D2-45[»]
4MONX-ray2.30A/C1-45[»]
5LC6X-ray1.70A/B1-45[»]
5LC7X-ray1.55A/B1-45[»]
ProteinModelPortaliP02881.
SMRiP02881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1542282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02881.

Family and domain databases

InterProiIPR015283. Monellin.
IPR000828. Monellin_A.
[Graphical view]
PfamiPF09200. Monellin. 1 hit.
[Graphical view]
PRINTSiPR00630. MONELLINA.
ProtoNetiSearch...

Entry informationi

Entry nameiMONA_DIOCU
AccessioniPrimary (citable) accession number: P02881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.