Reviewed, UniProtKB/Swiss-Prot P02878 (MPAA5_AMBEL)

Names and origin

Protein names	Recommended name:     Pollen allergen Amb a 5 Alternative name(s):     Allergen Amb a V     Allergen Ra5     Allergen=Amb a 5
Organism	Ambrosia artemisiifolia var. elatior (Short ragweed)
Taxonomic identifier	4215 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae › Ambrosia

Protein attributes

Sequence length	45 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Monomer.
Allergenic properties	Causes an allergic reaction in human.

Ontologies

Keywords
Disease	Allergen
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 45	45	Pollen allergen Amb a 5		PRO_0000096552
Amino acid modifications
	Disulfide bond	4 ↔ 39
	Disulfide bond	11 ↔ 26
	Disulfide bond	18 ↔ 32
	Disulfide bond	19 ↔ 43
Natural variations
	Natural variant	2	1	V → L in 33% of the molecules.

Sequences

	Sequence		Length	Mass (Da)
	P02878-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 92870A6D4CBCCA7C	FASTA	45	4,979
	10 20 30 40 LVPCAWAGNV CGEKRAYCCS DPGRYCPWQV VCYESSEICS KKCGK

References

[1]	"The amino acid sequence of ragweed pollen allergen Ra5." Mole L.E., Goodfriend L., Lapkoff C.B., Kehoe J.M., Capra J.D. Biochemistry 14:1216-1220(1975) [PubMed: 1122277] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pollen.
[2]	"Proton resonance assignments and three-dimensional solution structure of the ragweed allergen Amb a V by nuclear magnetic resonance spectroscopy." Metzler W.J., Valentine K., Roebber M., Marsh D.G., Mueller L. Biochemistry 31:8697-8705(1992) [PubMed: 1390654] [Abstract] Cited for: STRUCTURE BY NMR.

Cross-references

Sequence databases
PIR	ARRA5. A03371.
3D structure databases
HSSP	HSSP built from PDB template 1BBG based on UniProtKB P10414.
ModBase	Search...
Family and domain databases
InterPro	IPR005611. Amb_V_allergen. [Graphical view]
Pfam	PF03913. Amb_V_allergen. 1 hit. [Graphical view]
PIRSF	PIRSF002697. Amb_V_allergen. 1 hit.
ProDom	PD018950. Amb_V_allergen. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00816. Amb_V_allergen. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPAA5_AMBEL

Accession

Primary (citable) accession number: P02878

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	March 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)