P02878 (MPAA5_AMBEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Pollen allergen Amb a 5 Alternative name(s): Allergen Amb a V Allergen Ra5 Allergen=Amb a 5
Organism	Ambrosia artemisiifolia var. elatior (Short ragweed) (Ambrosia elatior)
Taxonomic identifier	4215 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Ambrosia › Ambrosia artemisiifolia

Protein attributes

Sequence length	45 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer.
Allergenic properties	Causes an allergic reaction in human.

Ontologies

Keywords
Disease	Allergen
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 45	45	Pollen allergen Amb a 5		PRO_0000096552
Amino acid modifications
	Disulfide bond	4 ↔ 39
	Disulfide bond	11 ↔ 26
	Disulfide bond	18 ↔ 32
	Disulfide bond	19 ↔ 43
Natural variations
	Natural variant	2	1	V → L in 33% of the molecules.

Sequences

	Sequence		Length	Mass (Da)
	P02878 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 92870A6D4CBCCA7C	FASTA	45	4,979
	10 20 30 40 LVPCAWAGNV CGEKRAYCCS DPGRYCPWQV VCYESSEICS KKCGK

References

[1]	"The amino acid sequence of ragweed pollen allergen Ra5." Mole L.E., Goodfriend L., Lapkoff C.B., Kehoe J.M., Capra J.D. Biochemistry 14:1216-1220(1975) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Pollen.
[2]	"Proton resonance assignments and three-dimensional solution structure of the ragweed allergen Amb a V by nuclear magnetic resonance spectroscopy." Metzler W.J., Valentine K., Roebber M., Marsh D.G., Mueller L. Biochemistry 31:8697-8705(1992) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.

Cross-references

Sequence databases
PIR	ARRA5. A03371.
3D structure databases
ProteinModelPortal	P02878.
ModBase	Search...
Protein family/group databases
Allergome	28. Amb a 5. 3069. Amb a 5.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.160.80. 1 hit.
InterPro	IPR005611. Amb_V_allergen. [Graphical view]
Pfam	PF03913. Amb_V_allergen. 1 hit. [Graphical view]
PIRSF	PIRSF002697. Amb_V_allergen. 1 hit.
ProDom	PD018950. Amb_V_allergen. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00816. Amb_V_allergen. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPAA5_AMBEL

Accession

Primary (citable) accession number: P02878

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program