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P02877

- HEVE_HEVBR

UniProt

P02877 - HEVE_HEVBR

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Protein

Pro-hevein

Gene
HEV1
Organism
Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

N-acetyl-D-glucosamine / N-acetyl-D-neuraminic acid binding lectin. Can inhibit fungal growth.

GO - Molecular functioni

  1. chitin binding Source: UniProtKB-KW

GO - Biological processi

  1. defense response to bacterium Source: InterPro
  2. defense response to fungus Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Chitin-binding

Protein family/group databases

CAZyiCBM18. Carbohydrate-Binding Module Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-hevein
Alternative name(s):
Major hevein
Cleaved into the following 2 chains:
Alternative name(s):
Allergen: Hev b 6
Gene namesi
Name:HEV1
OrganismiHevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Taxonomic identifieri3981 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeCrotonoideaeMicrandreaeHevea

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei390. Hev b 6.
391. Hev b 6.01.
392. Hev b 6.02.
393. Hev b 6.03.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17173 PublicationsAdd
BLAST
Chaini18 – 204187Pro-heveinPRO_0000005280Add
BLAST
Chaini18 – 6043HeveinPRO_0000005281Add
BLAST
Propeptidei61 – 666PRO_0000005282
Chaini67 – 204138Win-like proteinPRO_0000005283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 351 Publication
Disulfide bondi29 ↔ 411 Publication
Disulfide bondi34 ↔ 481 Publication
Disulfide bondi54 ↔ 581 Publication
Disulfide bondi96 ↔ 128 By similarity
Disulfide bondi117 ↔ 151 By similarity
Disulfide bondi131 ↔ 187 By similarity

Post-translational modificationi

Proteolytically processed to yield the two chains of the mature protein.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Laticifer.

Structurei

Secondary structure

1
204
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 244
Helixi30 – 323
Beta strandi37 – 393
Beta strandi41 – 444
Helixi45 – 484
Helixi50 – 523

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HEVNMR-A18-60[»]
1Q9BX-ray1.50A18-60[»]
1T0WNMR-A18-49[»]
1WKXX-ray1.70A18-60[»]
ProteinModelPortaliP02877.
SMRiP02877. Positions 18-60, 70-189.

Miscellaneous databases

EvolutionaryTraceiP02877.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 6043Chitin-binding type-1Add
BLAST
Domaini68 – 189122BarwinAdd
BLAST

Sequence similaritiesi

Contains 1 barwin domain.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
3.30.60.10. 1 hit.
InterProiIPR001153. Barwin.
IPR014733. Barwin-like_endoglucanase.
IPR018226. Barwin_CS.
IPR001002. Chitin-bd_1.
IPR018371. Chitin-binding_1_CS.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF00967. Barwin. 1 hit.
PF00187. Chitin_bind_1. 1 hit.
[Graphical view]
PRINTSiPR00602. BARWIN.
PR00451. CHITINBINDNG.
ProDomiPD004535. Barwin. 1 hit.
PD000609. Chitin_bd_1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00270. ChtBD1. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
SSF57016. SSF57016. 1 hit.
PROSITEiPS00771. BARWIN_1. 1 hit.
PS00772. BARWIN_2. 1 hit.
PS51174. BARWIN_3. 1 hit.
PS00026. CHIT_BIND_I_1. 1 hit.
PS50941. CHIT_BIND_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02877-1 [UniParc]FASTAAdd to Basket

« Hide

MNIFIVVLLC LTGVAIAEQC GRQAGGKLCP NNLCCSQWGW CGSTDEYCSP    50
DHNCQSNCKD SGEGVGGGSA SNVLATYHLY NSQDHGWDLN AASAYCSTWD 100
ANKPYSWRSK YGWTAFCGPV GAHGQSSCGK CLSVTNTGTG AKTTVRIVDQ 150
CSNGGLDLDV NVFRQLDTDG KGYERGHITV NYQFVDCGDS FNPLFSVMKS 200
SVIN 204
Length:204
Mass (Da):21,859
Last modified:November 1, 1990 - v2
Checksum:iFBCEE57CDFC80569
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311N → D Possible deamidation.
Natural varianti73 – 731V → M.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36986 mRNA. Translation: AAA33357.1.
PIRiA38288. HVHV.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36986 mRNA. Translation: AAA33357.1 .
PIRi A38288. HVHV.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HEV NMR - A 18-60 [» ]
1Q9B X-ray 1.50 A 18-60 [» ]
1T0W NMR - A 18-49 [» ]
1WKX X-ray 1.70 A 18-60 [» ]
ProteinModelPortali P02877.
SMRi P02877. Positions 18-60, 70-189.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 390. Hev b 6.
391. Hev b 6.01.
392. Hev b 6.02.
393. Hev b 6.03.
CAZyi CBM18. Carbohydrate-Binding Module Family 18.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P02877.

Family and domain databases

Gene3Di 2.40.40.10. 1 hit.
3.30.60.10. 1 hit.
InterProi IPR001153. Barwin.
IPR014733. Barwin-like_endoglucanase.
IPR018226. Barwin_CS.
IPR001002. Chitin-bd_1.
IPR018371. Chitin-binding_1_CS.
IPR009009. RlpA-like_DPBB.
[Graphical view ]
Pfami PF00967. Barwin. 1 hit.
PF00187. Chitin_bind_1. 1 hit.
[Graphical view ]
PRINTSi PR00602. BARWIN.
PR00451. CHITINBINDNG.
ProDomi PD004535. Barwin. 1 hit.
PD000609. Chitin_bd_1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00270. ChtBD1. 1 hit.
[Graphical view ]
SUPFAMi SSF50685. SSF50685. 1 hit.
SSF57016. SSF57016. 1 hit.
PROSITEi PS00771. BARWIN_1. 1 hit.
PS00772. BARWIN_2. 1 hit.
PS51174. BARWIN_3. 1 hit.
PS00026. CHIT_BIND_I_1. 1 hit.
PS50941. CHIT_BIND_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Wound-induced accumulation of mRNA containing a hevein sequence in laticifers of rubber tree (Hevea brasiliensis)."
    Broekaert W.F., Lee H.I., Kush A., Chua N.H., Raikhel N.
    Proc. Natl. Acad. Sci. U.S.A. 87:7633-7637(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amino-acid sequence of hevein."
    Walujono K., Scholma R.A., Beintema J.J., Mariono A., Hahn A.M.
    (In) Proceedings of the international rubber conference, pp.2:518-531, Rubber Research Institute of Malaysia, Kuala Lumpur (1975)
    Cited for: PROTEIN SEQUENCE OF 18-60.
    Tissue: Latex.
  3. Beintema J.J.
    Submitted (JUN-1977) to the PIR data bank
    Cited for: SEQUENCE REVISION TO 51-52.
  4. "Co- and post-translational processing of the hevein preproprotein of latex of the rubber tree (Hevea brasiliensis)."
    Lee H.-I., Broekaert W.F., Raikhel N.V.
    J. Biol. Chem. 266:15944-15948(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-26 AND 67-77, PROTEOLYTIC PROCESSING.
    Tissue: Latex.
  5. "Characterization of latex allergenic components by capillary zone electrophoresis and N-terminal sequence analysis."
    Chen H.-D., Chen C.-L., Huang S.-W., Kung H.-F., Chen H.-C.
    J. Biomed. Sci. 5:421-427(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-35.
    Tissue: Latex.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 18-60.
  7. "Hevein: NMR assignment and assessment of solution-state folding for the agglutinin-toxin motif."
    Andersen N.H., Cao B., Rodriguez-Romero A., Arreguin B.
    Biochemistry 32:1407-1422(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 18-60, DISULFIDE BONDS.

Entry informationi

Entry nameiHEVE_HEVBR
AccessioniPrimary (citable) accession number: P02877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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