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Protein

Galactose-binding lectin

Gene
N/A
Organism
Arachis hypogaea (Peanut)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

D-galactose specific lectin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi144Manganese1
Metal bindingi146Calcium1
Metal bindingi146Manganese1
Metal bindingi148Calcium; via carbonyl oxygen1
Metal bindingi150Calcium1
Metal bindingi155Calcium1
Metal bindingi155Manganese1
Metal bindingi160Manganese1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-binding lectin
Alternative name(s):
Agglutinin
PNA
OrganismiArachis hypogaea (Peanut)
Taxonomic identifieri3818 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeDalbergieaeArachis

Pathology & Biotechi

Protein family/group databases

Allergomei1050. Ara h Agglutinin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001758324 – 273Galactose-binding lectinAdd BLAST250

Proteomic databases

PRIDEiP02872.

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 33Combined sources9
Beta strandi41 – 46Combined sources6
Beta strandi51 – 53Combined sources3
Beta strandi60 – 64Combined sources5
Beta strandi66 – 73Combined sources8
Turni80 – 82Combined sources3
Beta strandi87 – 97Combined sources11
Beta strandi100 – 103Combined sources4
Beta strandi107 – 114Combined sources8
Helixi126 – 128Combined sources3
Turni129 – 131Combined sources3
Beta strandi136 – 146Combined sources11
Helixi151 – 153Combined sources3
Beta strandi160 – 169Combined sources10
Beta strandi171 – 175Combined sources5
Beta strandi183 – 191Combined sources9
Turni192 – 195Combined sources4
Beta strandi196 – 202Combined sources7
Beta strandi204 – 206Combined sources3
Beta strandi208 – 214Combined sources7
Helixi217 – 220Combined sources4
Beta strandi223 – 232Combined sources10
Beta strandi235 – 237Combined sources3
Beta strandi240 – 252Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZWX-ray2.70A/B/C/D24-255[»]
1CIWX-ray2.70A/B/C/D24-259[»]
1CQ9X-ray3.50A/B/C/D24-259[»]
1CR7X-ray2.60A/B/C/D/E/F/G/H24-259[»]
1QF3X-ray2.80A/B/C/D24-259[»]
1RIRX-ray2.90A/B/C/D24-259[»]
1RITX-ray2.85A/B/C/D24-259[»]
1V6IX-ray2.15A/B/C/D24-255[»]
1V6JX-ray2.90A/B/C/D24-255[»]
1V6KX-ray2.40A/B/C/D24-255[»]
1V6LX-ray2.50A/B/C/D24-255[»]
1V6MX-ray2.70A/B/C/D/E/F/G/H24-255[»]
1V6NX-ray3.50A/B/C/D/E/F/G/H24-255[»]
1V6OX-ray3.00A/B/C/D/E/F/G/H24-255[»]
2DH1X-ray7.65A/B/C/D24-259[»]
2DV9X-ray2.48A/B/C/D24-259[»]
2DVAX-ray2.20A/B/C/D24-259[»]
2DVBX-ray2.25A/B/C/D24-259[»]
2DVDX-ray2.25A/B/C/D24-259[»]
2DVFX-ray2.74A/B/C/D24-259[»]
2DVGX-ray2.78A/B/C/D24-259[»]
2PELX-ray2.25A/B/C/D24-259[»]
2TEPX-ray2.50A/B/C/D24-259[»]
ProteinModelPortaliP02872.
SMRiP02872.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02872.

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPFCVFLTF FLLLAASSKK VDSAETVSFN FNSFSEGNPA INFQGDVTVL
60 70 80 90 100
SNGNIQLTNL NKVNSVGRVL YAMPVRIWSS ATGNVASFLT SFSFEMKDIK
110 120 130 140 150
DYDPADGIIF FIAPEDTQIP AGSIGGGTLG VSDTKGAGHF VGVEFDTYSN
160 170 180 190 200
SEYNDPPTDH VGIDVNSVDS VKTVPWNSVS GAVVKVTVIY DSSTKTLSVA
210 220 230 240 250
VTNDNGDITT IAQVVDLKAK LPERVKFGFS ASGSLGGRQI HLIRSWSFTS
260 270
TLITTTRRSI DNNEKKIMNM ASA
Length:273
Mass (Da):29,325
Last modified:October 1, 1996 - v3
Checksum:i05A0B1A8FAC7B159
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti115E → V in minor form. 1
Natural varianti172K → A in minor form. 1
Natural varianti185K → I in minor form. 1
Natural varianti235 – 236LG → RA in minor form. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42352 mRNA. Translation: AAB22817.1.
PIRiA03364. LNNPG.
S24044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S42352 mRNA. Translation: AAB22817.1.
PIRiA03364. LNNPG.
S24044.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZWX-ray2.70A/B/C/D24-255[»]
1CIWX-ray2.70A/B/C/D24-259[»]
1CQ9X-ray3.50A/B/C/D24-259[»]
1CR7X-ray2.60A/B/C/D/E/F/G/H24-259[»]
1QF3X-ray2.80A/B/C/D24-259[»]
1RIRX-ray2.90A/B/C/D24-259[»]
1RITX-ray2.85A/B/C/D24-259[»]
1V6IX-ray2.15A/B/C/D24-255[»]
1V6JX-ray2.90A/B/C/D24-255[»]
1V6KX-ray2.40A/B/C/D24-255[»]
1V6LX-ray2.50A/B/C/D24-255[»]
1V6MX-ray2.70A/B/C/D/E/F/G/H24-255[»]
1V6NX-ray3.50A/B/C/D/E/F/G/H24-255[»]
1V6OX-ray3.00A/B/C/D/E/F/G/H24-255[»]
2DH1X-ray7.65A/B/C/D24-259[»]
2DV9X-ray2.48A/B/C/D24-259[»]
2DVAX-ray2.20A/B/C/D24-259[»]
2DVBX-ray2.25A/B/C/D24-259[»]
2DVDX-ray2.25A/B/C/D24-259[»]
2DVFX-ray2.74A/B/C/D24-259[»]
2DVGX-ray2.78A/B/C/D24-259[»]
2PELX-ray2.25A/B/C/D24-259[»]
2TEPX-ray2.50A/B/C/D24-259[»]
ProteinModelPortaliP02872.
SMRiP02872.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1050. Ara h Agglutinin.

Proteomic databases

PRIDEiP02872.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02872.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLECG_ARAHY
AccessioniPrimary (citable) accession number: P02872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.