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Protein

Favin

Gene
N/A
Organism
Vicia faba (Broad bean) (Faba vulgaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120ManganeseBy similarity1
Metal bindingi122CalciumBy similarity1
Metal bindingi122ManganeseBy similarity1
Metal bindingi124Calcium; via carbonyl oxygenBy similarity1
Metal bindingi126CalciumBy similarity1
Metal bindingi130CalciumBy similarity1
Metal bindingi130ManganeseBy similarity1
Metal bindingi137ManganeseBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Favin
Alternative name(s):
Lectin
Cleaved into the following 2 chains:
OrganismiVicia faba (Broad bean) (Faba vulgaris)
Taxonomic identifieri3906 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000176481 – 182Favin beta chainAdd BLAST182
ChainiPRO_0000017649183 – 233Favin alpha chainAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.1 Publication

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi19 – 23Combined sources5
Beta strandi29 – 35Combined sources7
Beta strandi37 – 40Combined sources4
Beta strandi42 – 49Combined sources8
Turni56 – 58Combined sources3
Beta strandi63 – 73Combined sources11
Beta strandi83 – 90Combined sources8
Helixi99 – 101Combined sources3
Turni102 – 104Combined sources3
Beta strandi112 – 114Combined sources3
Beta strandi117 – 122Combined sources6
Turni127 – 129Combined sources3
Beta strandi137 – 146Combined sources10
Beta strandi148 – 152Combined sources5
Beta strandi161 – 168Combined sources8
Turni169 – 172Combined sources4
Beta strandi173 – 179Combined sources7
Beta strandi185 – 191Combined sources7
Helixi194 – 196Combined sources3
Beta strandi200 – 209Combined sources10
Beta strandi211 – 213Combined sources3
Beta strandi216 – 227Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7YX-ray3.00A/C1-182[»]
B/D183-233[»]
ProteinModelPortaliP02871.
SMRiP02871.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02871.

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TDEITSFSIP KFRPDQPNLI FQGGGYTTKE KLTLTKAVKN TVGRALYSLP
60 70 80 90 100
IHIWDSETGN VADFTTTFIF VIDAPNGYNV ADGFTFFIAP VDTKPQTGGG
110 120 130 140 150
YLGVFNGKDY DKTAQTVAVE FDTFYNAAWD PSNGKRHIGI DVNTIKSIST
160 170 180 190 200
KSWNLQNGEE AHVAISFNAT TNVLSVTLLY PNLTGYTLSE VVPLKDVVPE
210 220 230
WVRIGFSATT GAEYATHEVL SWTFLSELTG PSN
Length:233
Mass (Da):25,509
Last modified:July 21, 1986 - v1
Checksum:i341F96AF7D477B00
GO

Sequence databases

PIRiA92369. FVVFBA.

Cross-referencesi

Sequence databases

PIRiA92369. FVVFBA.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7YX-ray3.00A/C1-182[»]
B/D183-233[»]
ProteinModelPortaliP02871.
SMRiP02871.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02871.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. L-lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEC_VICFA
AccessioniPrimary (citable) accession number: P02871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.