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P02871

- LEC_VICFA

UniProt

P02871 - LEC_VICFA

Protein

Favin

Gene
N/A
Organism
Vicia faba (Broad bean) (Faba vulgaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201ManganeseBy similarity
    Metal bindingi122 – 1221CalciumBy similarity
    Metal bindingi122 – 1221ManganeseBy similarity
    Metal bindingi124 – 1241Calcium; via carbonyl oxygenBy similarity
    Metal bindingi126 – 1261CalciumBy similarity
    Metal bindingi130 – 1301CalciumBy similarity
    Metal bindingi130 – 1301ManganeseBy similarity
    Metal bindingi137 – 1371ManganeseBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Calcium, Lectin, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Favin
    Alternative name(s):
    Lectin
    Cleaved into the following 2 chains:
    OrganismiVicia faba (Broad bean) (Faba vulgaris)
    Taxonomic identifieri3906 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Favin beta chainPRO_0000017648Add
    BLAST
    Chaini183 – 23351Favin alpha chainPRO_0000017649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi168 – 1681N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.1 Publication

    Structurei

    Secondary structure

    1
    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 117
    Beta strandi19 – 235
    Beta strandi29 – 357
    Beta strandi37 – 404
    Beta strandi42 – 498
    Turni56 – 583
    Beta strandi63 – 7311
    Beta strandi83 – 908
    Helixi99 – 1013
    Turni102 – 1043
    Beta strandi112 – 1143
    Beta strandi117 – 1226
    Turni127 – 1293
    Beta strandi137 – 14610
    Beta strandi148 – 1525
    Beta strandi161 – 1688
    Turni169 – 1724
    Beta strandi173 – 1797
    Beta strandi185 – 1917
    Helixi194 – 1963
    Beta strandi200 – 20910
    Beta strandi211 – 2133
    Beta strandi216 – 22712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B7YX-ray3.00A/C1-182[»]
    B/D183-233[»]
    ProteinModelPortaliP02871.
    SMRiP02871. Positions 2-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02871.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the leguminous lectin family.Curated

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR016363. Lectin.
    IPR000985. Lectin_LegA_CS.
    IPR019825. Lectin_legB_Mn/Ca_BS.
    IPR001220. Legume_lectin_dom.
    [Graphical view]
    PfamiPF00139. Lectin_legB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
    PS00307. LECTIN_LEGUME_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02871-1 [UniParc]FASTAAdd to Basket

    « Hide

    TDEITSFSIP KFRPDQPNLI FQGGGYTTKE KLTLTKAVKN TVGRALYSLP    50
    IHIWDSETGN VADFTTTFIF VIDAPNGYNV ADGFTFFIAP VDTKPQTGGG 100
    YLGVFNGKDY DKTAQTVAVE FDTFYNAAWD PSNGKRHIGI DVNTIKSIST 150
    KSWNLQNGEE AHVAISFNAT TNVLSVTLLY PNLTGYTLSE VVPLKDVVPE 200
    WVRIGFSATT GAEYATHEVL SWTFLSELTG PSN 233
    Length:233
    Mass (Da):25,509
    Last modified:July 21, 1986 - v1
    Checksum:i341F96AF7D477B00
    GO

    Sequence databases

    PIRiA92369. FVVFBA.

    Cross-referencesi

    Sequence databases

    PIRi A92369. FVVFBA.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B7Y X-ray 3.00 A/C 1-182 [» ]
    B/D 183-233 [» ]
    ProteinModelPortali P02871.
    SMRi P02871. Positions 2-229.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P02871.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR016363. Lectin.
    IPR000985. Lectin_LegA_CS.
    IPR019825. Lectin_legB_Mn/Ca_BS.
    IPR001220. Legume_lectin_dom.
    [Graphical view ]
    Pfami PF00139. Lectin_legB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002690. L-type_lectin_plant. 1 hit.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00308. LECTIN_LEGUME_ALPHA. 1 hit.
    PS00307. LECTIN_LEGUME_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence and variant forms of favin, a lectin from Vicia faba."
      Hopp T.P., Hemperly J.J., Cunningham B.A.
      J. Biol. Chem. 257:4473-4483(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-182, SEQUENCE REVISION.
    2. "Favin versus concanavalin A: circularly permuted amino acid sequences."
      Cunningham B.A., Hemperly J.J., Hopp T.P., Edelman G.M.
      Proc. Natl. Acad. Sci. U.S.A. 76:3218-3222(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-182.
    3. "The chemical characterization of favin, a lectin isolated from Vicia faba."
      Hemperly J.J., Hopp T.P., Becker J.W., Cunningham B.A.
      J. Biol. Chem. 254:6803-6810(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 183-233.
    4. "Three-dimensional structure of favin: saccharide binding-cyclic permutation in leguminous lectins."
      Reeke G.N. Jr., Becker J.W.
      Science 234:1108-1111(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

    Entry informationi

    Entry nameiLEC_VICFA
    AccessioniPrimary (citable) accession number: P02871
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3