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P02871 (LEC_VICFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Favin
Alternative name(s):
Lectin

Cleaved into the following 2 chains:

  1. Favin beta chain
  2. Favin alpha chain
OrganismVicia faba (Broad bean) (Faba vulgaris)
Taxonomic identifier3906 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterodimer of an alpha and a beta chain.

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Sequence similarities

Belongs to the leguminous lectin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Favin beta chain
PRO_0000017648
Chain183 – 23351Favin alpha chain
PRO_0000017649

Sites

Metal binding1201Manganese By similarity
Metal binding1221Calcium By similarity
Metal binding1221Manganese By similarity
Metal binding1241Calcium; via carbonyl oxygen By similarity
Metal binding1261Calcium By similarity
Metal binding1301Calcium By similarity
Metal binding1301Manganese By similarity
Metal binding1371Manganese By similarity

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Ref.1

Secondary structure

............................................ 233
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02871 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 341F96AF7D477B00

FASTA23325,509
        10         20         30         40         50         60 
TDEITSFSIP KFRPDQPNLI FQGGGYTTKE KLTLTKAVKN TVGRALYSLP IHIWDSETGN 

        70         80         90        100        110        120 
VADFTTTFIF VIDAPNGYNV ADGFTFFIAP VDTKPQTGGG YLGVFNGKDY DKTAQTVAVE 

       130        140        150        160        170        180 
FDTFYNAAWD PSNGKRHIGI DVNTIKSIST KSWNLQNGEE AHVAISFNAT TNVLSVTLLY 

       190        200        210        220        230 
PNLTGYTLSE VVPLKDVVPE WVRIGFSATT GAEYATHEVL SWTFLSELTG PSN 

« Hide

References

[1]"Amino acid sequence and variant forms of favin, a lectin from Vicia faba."
Hopp T.P., Hemperly J.J., Cunningham B.A.
J. Biol. Chem. 257:4473-4483(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-182, SEQUENCE REVISION.
[2]"Favin versus concanavalin A: circularly permuted amino acid sequences."
Cunningham B.A., Hemperly J.J., Hopp T.P., Edelman G.M.
Proc. Natl. Acad. Sci. U.S.A. 76:3218-3222(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-182.
[3]"The chemical characterization of favin, a lectin isolated from Vicia faba."
Hemperly J.J., Hopp T.P., Becker J.W., Cunningham B.A.
J. Biol. Chem. 254:6803-6810(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 183-233.
[4]"Three-dimensional structure of favin: saccharide binding-cyclic permutation in leguminous lectins."
Reeke G.N. Jr., Becker J.W.
Science 234:1108-1111(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

Cross-references

Sequence databases

PIRFVVFBA. A92369.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B7YX-ray3.00A/C1-182[»]
B/D183-233[»]
ProteinModelPortalP02871.
SMRP02871. Positions 2-229.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR016363. Lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02871.

Entry information

Entry nameLEC_VICFA
AccessionPrimary (citable) accession number: P02871
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references