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P02871

- LEC_VICFA

UniProt

P02871 - LEC_VICFA

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Protein

Favin

Gene
N/A
Organism
Vicia faba (Broad bean) (Faba vulgaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201ManganeseBy similarity
Metal bindingi122 – 1221CalciumBy similarity
Metal bindingi122 – 1221ManganeseBy similarity
Metal bindingi124 – 1241Calcium; via carbonyl oxygenBy similarity
Metal bindingi126 – 1261CalciumBy similarity
Metal bindingi130 – 1301CalciumBy similarity
Metal bindingi130 – 1301ManganeseBy similarity
Metal bindingi137 – 1371ManganeseBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Lectin, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Favin
Alternative name(s):
Lectin
Cleaved into the following 2 chains:
OrganismiVicia faba (Broad bean) (Faba vulgaris)
Taxonomic identifieri3906 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaeVicia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Favin beta chainPRO_0000017648Add
BLAST
Chaini183 – 23351Favin alpha chainPRO_0000017649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi168 – 1681N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.1 Publication

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 117
Beta strandi19 – 235
Beta strandi29 – 357
Beta strandi37 – 404
Beta strandi42 – 498
Turni56 – 583
Beta strandi63 – 7311
Beta strandi83 – 908
Helixi99 – 1013
Turni102 – 1043
Beta strandi112 – 1143
Beta strandi117 – 1226
Turni127 – 1293
Beta strandi137 – 14610
Beta strandi148 – 1525
Beta strandi161 – 1688
Turni169 – 1724
Beta strandi173 – 1797
Beta strandi185 – 1917
Helixi194 – 1963
Beta strandi200 – 20910
Beta strandi211 – 2133
Beta strandi216 – 22712

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B7YX-ray3.00A/C1-182[»]
B/D183-233[»]
ProteinModelPortaliP02871.
SMRiP02871. Positions 2-229.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02871.

Family & Domainsi

Sequence similaritiesi

Belongs to the leguminous lectin family.Curated

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR016363. Lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
[Graphical view]
PIRSFiPIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
TDEITSFSIP KFRPDQPNLI FQGGGYTTKE KLTLTKAVKN TVGRALYSLP
60 70 80 90 100
IHIWDSETGN VADFTTTFIF VIDAPNGYNV ADGFTFFIAP VDTKPQTGGG
110 120 130 140 150
YLGVFNGKDY DKTAQTVAVE FDTFYNAAWD PSNGKRHIGI DVNTIKSIST
160 170 180 190 200
KSWNLQNGEE AHVAISFNAT TNVLSVTLLY PNLTGYTLSE VVPLKDVVPE
210 220 230
WVRIGFSATT GAEYATHEVL SWTFLSELTG PSN
Length:233
Mass (Da):25,509
Last modified:July 21, 1986 - v1
Checksum:i341F96AF7D477B00
GO

Sequence databases

PIRiA92369. FVVFBA.

Cross-referencesi

Sequence databases

PIRi A92369. FVVFBA.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B7Y X-ray 3.00 A/C 1-182 [» ]
B/D 183-233 [» ]
ProteinModelPortali P02871.
SMRi P02871. Positions 2-229.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P02871.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR016363. Lectin.
IPR000985. Lectin_LegA_CS.
IPR019825. Lectin_legB_Mn/Ca_BS.
IPR001220. Legume_lectin_dom.
[Graphical view ]
Pfami PF00139. Lectin_legB. 1 hit.
[Graphical view ]
PIRSFi PIRSF002690. L-type_lectin_plant. 1 hit.
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00308. LECTIN_LEGUME_ALPHA. 1 hit.
PS00307. LECTIN_LEGUME_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence and variant forms of favin, a lectin from Vicia faba."
    Hopp T.P., Hemperly J.J., Cunningham B.A.
    J. Biol. Chem. 257:4473-4483(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-182, SEQUENCE REVISION.
  2. "Favin versus concanavalin A: circularly permuted amino acid sequences."
    Cunningham B.A., Hemperly J.J., Hopp T.P., Edelman G.M.
    Proc. Natl. Acad. Sci. U.S.A. 76:3218-3222(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-182.
  3. "The chemical characterization of favin, a lectin isolated from Vicia faba."
    Hemperly J.J., Hopp T.P., Becker J.W., Cunningham B.A.
    J. Biol. Chem. 254:6803-6810(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 183-233.
  4. "Three-dimensional structure of favin: saccharide binding-cyclic permutation in leguminous lectins."
    Reeke G.N. Jr., Becker J.W.
    Science 234:1108-1111(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH GLUCOSE.

Entry informationi

Entry nameiLEC_VICFA
AccessioniPrimary (citable) accession number: P02871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds one manganese (or another transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3