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Protein

Larval cuticle protein 1

Gene

Lcp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the larval cuticle.

GO - Molecular functioni

  • structural constituent of chitin-based larval cuticle Source: FlyBase

GO - Biological processi

  • chitin-based cuticle development Source: FlyBase
  • larval chitin-based cuticle development Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Larval cuticle protein 1
Alternative name(s):
Larval cuticle protein I
Gene namesi
Name:Lcp1
ORF Names:CG11650
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0002531. Lcp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000000638717 – 130Larval cuticle protein 1Add BLAST114

Proteomic databases

PaxDbiP02839.

Expressioni

Gene expression databases

BgeeiFBgn0002531.
ExpressionAtlasiP02839. differential.
GenevisibleiP02839. DM.

Interactioni

Protein-protein interaction databases

BioGridi61670. 7 interactors.
DIPiDIP-18177N.
IntActiP02839. 1 interactor.
MINTiMINT-303922.
STRINGi7227.FBpp0305735.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 104Chitin-binding type R&RPROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 108Pro-rich7

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JPG1. Eukaryota.
ENOG41119AX. LUCA.
GeneTreeiENSGT00900000141325.
InParanoidiP02839.
OMAiIAMICAV.
OrthoDBiEOG091G0KRD.
PhylomeDBiP02839.

Family and domain databases

InterProiView protein in InterPro
IPR031311. CHIT_BIND_RR_consensus.
IPR000618. Insect_cuticle.
PfamiView protein in Pfam
PF00379. Chitin_bind_4. 1 hit.
PROSITEiView protein in PROSITE
PS00233. CHIT_BIND_RR_1. 1 hit.
PS51155. CHIT_BIND_RR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKFVMICAV LGLAVANPPV PHSLGRSEDV HADVLSQSDD VRADGFDSSL
60 70 80 90 100
HTSNGIEQAA SGDAHGNIHG NFGWISPEGE HVEVKYVANE NGYQPSGAWI
110 120 130
PTPPPIPEAI ARAVAWLESH PPAPEHPRHH
Length:130
Mass (Da):13,921
Last modified:November 2, 2001 - v3
Checksum:i0A20F5B9D2DC3F4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Q → R in CAA23487 (PubMed:6817923).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00202 Genomic DNA. Translation: CAA23487.1.
AE013599 Genomic DNA. Translation: AAF59096.1.
PIRiA03328. UCFF1L.
A25299.
RefSeqiNP_001260801.1. NM_001273872.2.
NP_476619.1. NM_057271.4.

Genome annotation databases

EnsemblMetazoaiFBtr0088763; FBpp0087841; FBgn0002531.
FBtr0333557; FBpp0305735; FBgn0002531.
GeneIDi35817.
KEGGidme:Dmel_CG11650.

Similar proteinsi

Entry informationi

Entry nameiLCP1_DROME
AccessioniPrimary (citable) accession number: P02839
Secondary accession number(s): Q24290, Q9V4S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 2, 2001
Last modified: October 25, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase