P02839 (LCP1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Larval cuticle protein 1

Alternative name(s):
Larval cuticle protein I

Gene names

Name:	Lcp1
ORF Names:	CG11650

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the larval cuticle.
Sequence similarities	Contains 1 chitin-binding type R&R domain.

Ontologies

Keywords
Cellular component	Cuticle
Domain	Signal
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	larval chitin-based cuticle development Inferred by curator PubMed 6168386. Source: FlyBase
Cellular_component	extracellular matrix Inferred from direct assay PubMed 6168386. Source: FlyBase
Molecular_function	structural constituent of chitin-based larval cuticle Inferred from direct assay PubMed 6168386. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
sxc	Q7KJA9	1	EBI-192994,EBI-122233

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16
	Chain	17 – 130	114	Larval cuticle protein 1		PRO_0000006387
Regions
	Domain	43 – 104	62	Chitin-binding type R&R
	Compositional bias	102 – 108	7	Pro-rich
Experimental info
	Sequence conflict	37	1	Q → R in CAA23487. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P02839 [UniParc]. Last modified November 2, 2001. Version 3. Checksum: 0A20F5B9D2DC3F4B	FASTA	130	13,921
	10 20 30 40 50 60 MFKFVMICAV LGLAVANPPV PHSLGRSEDV HADVLSQSDD VRADGFDSSL HTSNGIEQAA 70 80 90 100 110 120 SGDAHGNIHG NFGWISPEGE HVEVKYVANE NGYQPSGAWI PTPPPIPEAI ARAVAWLESH 130 PPAPEHPRHH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cuticle protein genes of Drosophila: structure, organization and evolution of four clustered genes." Snyder M., Hunkapiller M., Yuen D., Silvert D., Fristrom J., Davidson N. Cell 29:1027-1040(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE. Strain: Canton-S and Oregon-R. Tissue: Larva.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00202 Genomic DNA. Translation: CAA23487.1. AE013599 Genomic DNA. Translation: AAF59096.1.
PIR	UCFF1L. A03328. A25299.
RefSeq	NP_001260801.1. NM_001273872.1. NP_476619.1. NM_057271.3.
UniGene	Dm.21565.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-18177N.
IntAct	P02839. 1 interaction.
MINT	MINT-303922.
Proteomic databases
PaxDb	P02839.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0088763; FBpp0087841; FBgn0002531. FBtr0333557; FBpp0305735; FBgn0002531.
GeneID	35817.
KEGG	dme:Dmel_CG11650.
Organism-specific databases
CTD	3936.
FlyBase	FBgn0002531. Lcp1.
Phylogenomic databases
eggNOG	NOG321761.
GeneTree	ENSGT00700000104790.
InParanoid	P02839.
OMA	FVMICAV.
OrthoDB	EOG4547G4.
PhylomeDB	P02839.
Gene expression databases
Bgee	P02839.
GermOnline	CG11650. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000618. Insect_cuticle. [Graphical view]
Pfam	PF00379. Chitin_bind_4. 1 hit. [Graphical view]
PROSITE	PS00233. CHIT_BIND_RR_1. 1 hit. PS51155. CHIT_BIND_RR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	35817.
NextBio	795357.

Entry information

Entry name

LCP1_DROME

Accession

Primary (citable) accession number: P02839
Secondary accession number(s): Q24290, Q9V4S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	November 2, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project