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Protein

Segmentation protein fushi tarazu

Gene

ftz

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in determining neuronal identity, may be directly involved in specifying identity of individual neurons. Required during embryogenesis for the process of body segmentation. Homeotic protein, required in alternating segment primordia, it specifies the correct number of segments.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi254 – 313HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • blastoderm segmentation Source: FlyBase
  • cell fate specification Source: FlyBase
  • central nervous system development Source: FlyBase
  • germ cell migration Source: FlyBase
  • gonadal mesoderm development Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • periodic partitioning by pair rule gene Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • posterior head segmentation Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • segmentation Source: FlyBase
  • trunk segmentation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Pair-rule protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP02835.

Names & Taxonomyi

Protein namesi
Recommended name:
Segmentation protein fushi tarazu
Gene namesi
Name:ftz
ORF Names:CG2047
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001077. ftz.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi208P → L in allele Ual2; half-life is increased. 1 Publication1
Mutagenesisi212P → L in allele Ual1; half-life is increased. 1 Publication1
Mutagenesisi212P → S in allele Ual3; half-life is increased. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490621 – 410Segmentation protein fushi tarazuAdd BLAST410

Post-translational modificationi

Phosphorylated at as many as 16 sites.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02835.
PRIDEiP02835.

PTM databases

iPTMnetiP02835.

Expressioni

Tissue specificityi

Expressed early in development in a striped pattern at the blastoderm stage. Later expressed in a specific subset of neuronal precursor cells, neurons and glia in the developing CNS. Between 5 and 6 hours of development, found in the midline precursor-2 cells in a segmentally repeating pattern. Expression in many other neuronal precursors follows and reaches a second peak of abundance at 9 hours of development. Expressed in the hindgut between 11-15 hours of development.

Developmental stagei

Expressed during embryonic development.1 Publication

Gene expression databases

BgeeiFBgn0001077.
GenevisibleiP02835. DM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ftz-f1P332443EBI-125786,EBI-160447

Protein-protein interaction databases

BioGridi66032. 15 interactors.
DIPiDIP-18500N.
IntActiP02835. 4 interactors.
MINTiMINT-156974.
STRINGi7227.FBpp0081139.

Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi108 – 113Combined sources6
Helixi263 – 273Combined sources11
Helixi281 – 290Combined sources10
Helixi295 – 305Combined sources11
Helixi315 – 317Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FTZNMR-A253-321[»]
2XHSX-ray2.80B107-115[»]
ProteinModelPortaliP02835.
SMRiP02835.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02835.

Family & Domainsi

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
InParanoidiP02835.
KOiK09311.
OMAiCKDSKRT.
OrthoDBiEOG091G04SL.
PhylomeDBiP02835.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005567. FTZ_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF03867. FTZ. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTNSQSHY SYADNMNMYN MYHPHSLPPT YYDNSGSNAY YQNTSNYQGY
60 70 80 90 100
YPQESYSESC YYYNNQEQVT TQTVPPVQPT TPPPKATKRK AEDDAASIIA
110 120 130 140 150
AVEERPSTLR ALLTNPVKKL KYTPDYFYTT VEQVKKAPAV STKVTASPAP
160 170 180 190 200
SYDQEYVTVP TPSASEDVDY LDVYSPQSQT QKLKNGDFAT PPPTTPTSLP
210 220 230 240 250
PLEGISTPPQ SPGEKSSSAV SQEINHRIVT APNGAGDFNW SHIEETLASD
260 270 280 290 300
CKDSKRTRQT YTRYQTLELE KEFHFNRYIT RRRRIDIANA LSLSERQIKI
310 320 330 340 350
WFQNRRMKSK KDRTLDSSPE HCGAGYTAML PPLEATSTAT TGAPSVPVPM
360 370 380 390 400
YHHHQTTAAY PAYSHSHSHG YGLLNDYPQQ QTHQQYDAYP QQYQHQCSYQ
410
QHPQDLYHLS
Length:410
Mass (Da):46,479
Last modified:November 25, 2002 - v2
Checksum:i517154F3DAF8262F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47Y → YHSY in CAA25408 (PubMed:6330566).Curated1
Sequence conflicti141S → T in CAA25408 (PubMed:6330566).Curated1
Sequence conflicti247 – 249LAS → MLT in AAA28372 (PubMed:6327065).Curated3
Sequence conflicti395H → Q in CAA25408 (PubMed:6330566).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00854 Genomic DNA. Translation: CAA25408.1.
AE014297 Genomic DNA. Translation: AAF54081.1.
BT022173 mRNA. Translation: AAY51567.1.
AE001572 Genomic DNA. Translation: AAD19794.1.
X78905 Genomic DNA. Translation: CAA55518.1.
K01947 Genomic DNA. Translation: AAA28372.1.
PIRiA93334. WJFFFT.
RefSeqiNP_477498.1. NM_058150.3.
UniGeneiDm.24032.

Genome annotation databases

EnsemblMetazoaiFBtr0081625; FBpp0081139; FBgn0001077.
GeneIDi40834.
KEGGidme:Dmel_CG2047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00854 Genomic DNA. Translation: CAA25408.1.
AE014297 Genomic DNA. Translation: AAF54081.1.
BT022173 mRNA. Translation: AAY51567.1.
AE001572 Genomic DNA. Translation: AAD19794.1.
X78905 Genomic DNA. Translation: CAA55518.1.
K01947 Genomic DNA. Translation: AAA28372.1.
PIRiA93334. WJFFFT.
RefSeqiNP_477498.1. NM_058150.3.
UniGeneiDm.24032.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FTZNMR-A253-321[»]
2XHSX-ray2.80B107-115[»]
ProteinModelPortaliP02835.
SMRiP02835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66032. 15 interactors.
DIPiDIP-18500N.
IntActiP02835. 4 interactors.
MINTiMINT-156974.
STRINGi7227.FBpp0081139.

PTM databases

iPTMnetiP02835.

Proteomic databases

PaxDbiP02835.
PRIDEiP02835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081625; FBpp0081139; FBgn0001077.
GeneIDi40834.
KEGGidme:Dmel_CG2047.

Organism-specific databases

CTDi40834.
FlyBaseiFBgn0001077. ftz.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
InParanoidiP02835.
KOiK09311.
OMAiCKDSKRT.
OrthoDBiEOG091G04SL.
PhylomeDBiP02835.

Enzyme and pathway databases

SignaLinkiP02835.

Miscellaneous databases

EvolutionaryTraceiP02835.
GenomeRNAii40834.
PROiP02835.

Gene expression databases

BgeeiFBgn0001077.
GenevisibleiP02835. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR005567. FTZ_N.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF03867. FTZ. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTZ_DROME
AccessioniPrimary (citable) accession number: P02835
Secondary accession number(s): O96929, Q4V6Y3, Q9V3W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 25, 2002
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

'Fushi tarazu' means 'segment deficient' in Japanese. Flies lacking ftz exhibit embryos with half the usual number of body segments.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.