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Protein

Homeotic protein antennapedia

Gene

Antp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi297 – 356HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase

GO - Biological processi

  • anterior/posterior axis specification Source: UniProtKB
  • heart development Source: FlyBase
  • lymph gland development Source: FlyBase
  • midgut development Source: FlyBase
  • muscle cell fate specification Source: FlyBase
  • neuroblast development Source: FlyBase
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • specification of segmental identity, antennal segment Source: FlyBase
  • specification of segmental identity, thorax Source: UniProtKB
  • ventral cord development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP02833.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein antennapedia
Gene namesi
Name:Antp
ORF Names:CG1028
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0260642. Antp.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002591 – 378Homeotic protein antennapediaAdd BLAST378

Proteomic databases

PaxDbiP02833.
PRIDEiP02833.

Expressioni

Gene expression databases

BgeeiFBgn0260642.
ExpressionAtlasiP02833. baseline.
GenevisibleiP02833. DM.

Interactioni

Protein-protein interaction databases

BioGridi66033. 24 interactors.
DIPiDIP-51405N.
IntActiP02833. 2 interactors.
MINTiMINT-763892.
STRINGi7227.FBpp0081161.

Structurei

Secondary structure

1378
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi299 – 301Combined sources3
Helixi306 – 318Combined sources13
Helixi324 – 334Combined sources11
Helixi338 – 353Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHDNMR-P297-363[»]
1HOMNMR-A297-363[»]
1KZ0NMR-A339-354[»]
1KZ5NMR-A339-354[»]
1OMQNMR-A339-354[»]
1SANNMR-A303-363[»]
2HOANMR-A297-363[»]
4XICX-ray2.69A/D297-356[»]
4XIDX-ray2.70A/D297-356[»]
5JLWX-ray2.09A/D297-356[»]
5JLXX-ray2.75A/D297-356[»]
9ANTX-ray2.40A/B296-356[»]
ProteinModelPortaliP02833.
SMRiP02833.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02833.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi283 – 288Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 81Gln-rich (OPA repeat)6
Compositional biasi110 – 155Gln-rich (OPA repeat)Add BLAST46

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000142851.
InParanoidiP02833.
KOiK09311.
OMAiHNMGMYG.
OrthoDBiEOG091G09XD.
PhylomeDBiP02833.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02833-1) [UniParc]FASTAAdd to basket
Also known as: A, B, I, J

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNAN
60 70 80 90 100
HQGNMPYPRF PPYDRMPYYN GQGMDQQQQH QVYSRPDSPS SQVGGVMPQA
110 120 130 140 150
QTNGQLGVPQ QQQQQQQQPS QNQQQQQAQQ APQQLQQQLP QVTQQVTHPQ
160 170 180 190 200
QQQQQPVVYA SCKLQAAVGG LGMVPEGGSP PLVDQMSGHH MNAQMTLPHH
210 220 230 240 250
MGHPQAQLGY TDVGVPDVTE VHQNHHNMGM YQQQSGVPPV GAPPQGMMHQ
260 270 280 290 300
GQGPPQMHQG HPGQHTPPSQ NPNSQSSGMP SPLYPWMRSQ FGKCQERKRG
310 320 330 340 350
RQTYTRYQTL ELEKEFHFNR YLTRRRRIEI AHALCLTERQ IKIWFQNRRM
360 370
KWKKENKTKG EPGSGGEGDE ITPPNSPQ
Length:378
Mass (Da):42,760
Last modified:November 1, 1988 - v1
Checksum:iD653232A8622D055
GO
Isoform 2 (identifier: P02833-2) [UniParc]FASTAAdd to basket
Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     296-297: ER → GK
     298-378: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):32,844
Checksum:iA88C5435ABD619B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300G → E in AAA79241 (PubMed:2416463).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008097296 – 297ER → GK in isoform 2. 1 Publication2
Alternative sequenceiVSP_008098298 – 378Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03790, X03791 Genomic DNA. Translation: CAA27417.1.
M20704 mRNA. Translation: AAA70214.1.
M20705 mRNA. Translation: AAA70216.1.
AE001572 Genomic DNA. Translation: AAD19793.1.
AE014297 Genomic DNA. Translation: AAG22205.3.
AE014297 Genomic DNA. Translation: AAS65111.1.
AY060407 mRNA. Translation: AAL25446.1.
M14496 Genomic DNA. Translation: AAA28376.1.
K01948 Genomic DNA. Translation: AAA28373.1. Sequence problems.
M12009 mRNA. Translation: AAA79241.1.
PIRiA23450. A25399.
RefSeqiNP_996167.1. NM_206445.1. [P02833-1]
NP_996168.1. NM_206446.1. [P02833-1]
NP_996170.1. NM_206448.1. [P02833-1]
NP_996175.1. NM_206453.1. [P02833-1]
NP_996176.1. NM_206454.1. [P02833-2]
UniGeneiDm.3803.

Genome annotation databases

EnsemblMetazoaiFBtr0081647; FBpp0081161; FBgn0260642. [P02833-1]
FBtr0081652; FBpp0081162; FBgn0260642. [P02833-1]
FBtr0081654; FBpp0089245; FBgn0260642. [P02833-1]
FBtr0081655; FBpp0089246; FBgn0260642. [P02833-1]
GeneIDi40835.
KEGGidme:Dmel_CG1028.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03790, X03791 Genomic DNA. Translation: CAA27417.1.
M20704 mRNA. Translation: AAA70214.1.
M20705 mRNA. Translation: AAA70216.1.
AE001572 Genomic DNA. Translation: AAD19793.1.
AE014297 Genomic DNA. Translation: AAG22205.3.
AE014297 Genomic DNA. Translation: AAS65111.1.
AY060407 mRNA. Translation: AAL25446.1.
M14496 Genomic DNA. Translation: AAA28376.1.
K01948 Genomic DNA. Translation: AAA28373.1. Sequence problems.
M12009 mRNA. Translation: AAA79241.1.
PIRiA23450. A25399.
RefSeqiNP_996167.1. NM_206445.1. [P02833-1]
NP_996168.1. NM_206446.1. [P02833-1]
NP_996170.1. NM_206448.1. [P02833-1]
NP_996175.1. NM_206453.1. [P02833-1]
NP_996176.1. NM_206454.1. [P02833-2]
UniGeneiDm.3803.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHDNMR-P297-363[»]
1HOMNMR-A297-363[»]
1KZ0NMR-A339-354[»]
1KZ5NMR-A339-354[»]
1OMQNMR-A339-354[»]
1SANNMR-A303-363[»]
2HOANMR-A297-363[»]
4XICX-ray2.69A/D297-356[»]
4XIDX-ray2.70A/D297-356[»]
5JLWX-ray2.09A/D297-356[»]
5JLXX-ray2.75A/D297-356[»]
9ANTX-ray2.40A/B296-356[»]
ProteinModelPortaliP02833.
SMRiP02833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66033. 24 interactors.
DIPiDIP-51405N.
IntActiP02833. 2 interactors.
MINTiMINT-763892.
STRINGi7227.FBpp0081161.

Proteomic databases

PaxDbiP02833.
PRIDEiP02833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081647; FBpp0081161; FBgn0260642. [P02833-1]
FBtr0081652; FBpp0081162; FBgn0260642. [P02833-1]
FBtr0081654; FBpp0089245; FBgn0260642. [P02833-1]
FBtr0081655; FBpp0089246; FBgn0260642. [P02833-1]
GeneIDi40835.
KEGGidme:Dmel_CG1028.

Organism-specific databases

CTDi40835.
FlyBaseiFBgn0260642. Antp.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000142851.
InParanoidiP02833.
KOiK09311.
OMAiHNMGMYG.
OrthoDBiEOG091G09XD.
PhylomeDBiP02833.

Enzyme and pathway databases

SignaLinkiP02833.

Miscellaneous databases

EvolutionaryTraceiP02833.
GenomeRNAii40835.
PROiP02833.

Gene expression databases

BgeeiFBgn0260642.
ExpressionAtlasiP02833. baseline.
GenevisibleiP02833. DM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANTP_DROME
AccessioniPrimary (citable) accession number: P02833
Secondary accession number(s): Q95SZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: November 30, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Loss of Antp results in altered development of the embryonic thoracic segments. Overexpression can cause antennae to be transformed into legs.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.