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P02831

- HXA3_MOUSE

UniProt

P02831 - HXA3_MOUSE

Protein

Homeobox protein Hox-A3

Gene

Hoxa3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. HMG box domain binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. anterior/posterior pattern specification Source: MGI
    3. blood vessel remodeling Source: MGI
    4. cartilage development Source: MGI
    5. embryonic skeletal system development Source: MGI
    6. embryonic skeletal system morphogenesis Source: MGI
    7. glossopharyngeal nerve morphogenesis Source: MGI
    8. organ formation Source: MGI
    9. organ morphogenesis Source: MGI
    10. parathyroid gland development Source: MGI
    11. positive regulation of cell proliferation Source: MGI
    12. specification of organ position Source: MGI
    13. thymus development Source: MGI
    14. thyroid gland development Source: MGI
    15. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A3
    Alternative name(s):
    Homeobox protein Hox-1.5
    Homeobox protein MO-10
    Gene namesi
    Name:Hoxa3
    Synonyms:Hox-1.5, Hoxa-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96175. Hoxa3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Homeobox protein Hox-A3PRO_0000200044Add
    BLAST

    Proteomic databases

    PRIDEiP02831.

    PTM databases

    PhosphoSiteiP02831.

    Expressioni

    Developmental stagei

    Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.1 Publication

    Gene expression databases

    ArrayExpressiP02831.
    BgeeiP02831.
    CleanExiMM_HOXA3.
    GenevestigatoriP02831.

    Interactioni

    Protein-protein interaction databases

    BioGridi200368. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP02831.
    SMRiP02831. Positions 167-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi156 – 1616Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi79 – 13860Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG284589.
    GeneTreeiENSGT00750000117486.
    HOGENOMiHOG000252944.
    HOVERGENiHBG107984.
    InParanoidiP02831.
    KOiK09303.
    OMAiHIQGSPV.
    OrthoDBiEOG754HPS.
    PhylomeDBiP02831.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P02831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA    50
    CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP 100
    PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP 150
    TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT 200
    SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD 250
    QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK 300
    PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL 350
    QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG 400
    TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL 443
    Length:443
    Mass (Da):46,430
    Last modified:November 1, 1997 - v2
    Checksum:i6C0E184B0F6F2D40
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851S → G1 PublicationCurated
    Sequence conflicti185 – 1851S → G(PubMed:6091896)Curated
    Sequence conflicti195 – 1951A → G1 PublicationCurated
    Sequence conflicti195 – 1951A → G(PubMed:6091896)Curated
    Sequence conflicti201 – 2022SA → RP1 PublicationCurated
    Sequence conflicti201 – 2022SA → RP(PubMed:6091896)Curated
    Sequence conflicti218 – 2181C → M1 PublicationCurated
    Sequence conflicti218 – 2181C → M(PubMed:6091896)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11717 mRNA. Translation: CAA72404.1.
    BC096612 mRNA. Translation: AAH96612.1.
    U56399 mRNA. Translation: AAC52778.1.
    K02591 Genomic DNA. Translation: AAA37822.1.
    CCDSiCCDS20140.1.
    PIRiI49746.
    RefSeqiNP_034582.1. NM_010452.3.
    UniGeneiMm.483277.
    Mm.71533.

    Genome annotation databases

    EnsembliENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560.
    GeneIDi15400.
    KEGGimmu:15400.
    UCSCiuc009bya.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11717 mRNA. Translation: CAA72404.1 .
    BC096612 mRNA. Translation: AAH96612.1 .
    U56399 mRNA. Translation: AAC52778.1 .
    K02591 Genomic DNA. Translation: AAA37822.1 .
    CCDSi CCDS20140.1.
    PIRi I49746.
    RefSeqi NP_034582.1. NM_010452.3.
    UniGenei Mm.483277.
    Mm.71533.

    3D structure databases

    ProteinModelPortali P02831.
    SMRi P02831. Positions 167-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200368. 1 interaction.

    PTM databases

    PhosphoSitei P02831.

    Proteomic databases

    PRIDEi P02831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114434 ; ENSMUSP00000110077 ; ENSMUSG00000079560 .
    GeneIDi 15400.
    KEGGi mmu:15400.
    UCSCi uc009bya.2. mouse.

    Organism-specific databases

    CTDi 3200.
    MGIi MGI:96175. Hoxa3.

    Phylogenomic databases

    eggNOGi NOG284589.
    GeneTreei ENSGT00750000117486.
    HOGENOMi HOG000252944.
    HOVERGENi HBG107984.
    InParanoidi P02831.
    KOi K09303.
    OMAi HIQGSPV.
    OrthoDBi EOG754HPS.
    PhylomeDBi P02831.
    TreeFami TF315938.

    Miscellaneous databases

    NextBioi 288094.
    PROi P02831.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02831.
    Bgeei P02831.
    CleanExi MM_HOXA3.
    Genevestigatori P02831.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hofmann M., Boehm T.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "Sequence and expression of the murine Hoxd-3 homeobox gene."
      Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
      Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
      Strain: ICR X Swiss Webster.
    4. "Structural and functional aspects of the mammalian homeo-box sequences."
      Ruddle F.H., Hart C.P., McGinnis W.
      Trends Genet. 1:48-51(1985)
      Cited for: NUCLEOTIDE SEQUENCE OF 185-258.
    5. "Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila."
      McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.
      Cell 38:675-680(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
    6. Cited for: DNA-BINDING.
    7. "Expression of the murine homeo box gene Hox 1.5 during embryogenesis."
      Fainsod A., Awgulewitsch A., Ruddle F.H.
      Dev. Biol. 124:125-133(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHXA3_MOUSE
    AccessioniPrimary (citable) accession number: P02831
    Secondary accession number(s): Q4V9Z8, Q61197
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3