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Protein

Homeobox protein Hox-A3

Gene

Hoxa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • anterior/posterior pattern specification Source: MGI
  • blood vessel remodeling Source: MGI
  • cartilage development Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • glossopharyngeal nerve morphogenesis Source: MGI
  • organ formation Source: MGI
  • organ morphogenesis Source: MGI
  • parathyroid gland development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • specification of organ position Source: MGI
  • thymus development Source: MGI
  • thyroid gland development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-1.5
Homeobox protein MO-10
Gene namesi
Name:Hoxa3
Synonyms:Hox-1.5, Hoxa-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96175. Hoxa3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Homeobox protein Hox-A3PRO_0000200044Add
BLAST

Proteomic databases

PRIDEiP02831.

PTM databases

PhosphoSiteiP02831.

Expressioni

Developmental stagei

Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.1 Publication

Gene expression databases

BgeeiP02831.
CleanExiMM_HOXA3.
ExpressionAtlasiP02831. baseline and differential.
GenevisibleiP02831. MM.

Interactioni

Protein-protein interaction databases

BioGridi200368. 1 interaction.
STRINGi10090.ENSMUSP00000110077.

Structurei

3D structure databases

ProteinModelPortaliP02831.
SMRiP02831. Positions 167-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi156 – 1616Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 13860Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP02831.
KOiK09303.
OMAiHIQGSPV.
OrthoDBiEOG754HPS.
PhylomeDBiP02831.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA
60 70 80 90 100
CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP
110 120 130 140 150
PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP
160 170 180 190 200
TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT
210 220 230 240 250
SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD
260 270 280 290 300
QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
310 320 330 340 350
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL
360 370 380 390 400
QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG
410 420 430 440
TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL
Length:443
Mass (Da):46,430
Last modified:November 1, 1997 - v2
Checksum:i6C0E184B0F6F2D40
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851S → G (Ref. 4) Curated
Sequence conflicti185 – 1851S → G (PubMed:6091896).Curated
Sequence conflicti195 – 1951A → G (Ref. 4) Curated
Sequence conflicti195 – 1951A → G (PubMed:6091896).Curated
Sequence conflicti201 – 2022SA → RP (Ref. 4) Curated
Sequence conflicti201 – 2022SA → RP (PubMed:6091896).Curated
Sequence conflicti218 – 2181C → M (Ref. 4) Curated
Sequence conflicti218 – 2181C → M (PubMed:6091896).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11717 mRNA. Translation: CAA72404.1.
BC096612 mRNA. Translation: AAH96612.1.
U56399 mRNA. Translation: AAC52778.1.
K02591 Genomic DNA. Translation: AAA37822.1.
CCDSiCCDS20140.1.
PIRiI49746.
RefSeqiNP_034582.1. NM_010452.3.
UniGeneiMm.483277.
Mm.71533.

Genome annotation databases

EnsembliENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560.
GeneIDi15400.
KEGGimmu:15400.
UCSCiuc009bya.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11717 mRNA. Translation: CAA72404.1.
BC096612 mRNA. Translation: AAH96612.1.
U56399 mRNA. Translation: AAC52778.1.
K02591 Genomic DNA. Translation: AAA37822.1.
CCDSiCCDS20140.1.
PIRiI49746.
RefSeqiNP_034582.1. NM_010452.3.
UniGeneiMm.483277.
Mm.71533.

3D structure databases

ProteinModelPortaliP02831.
SMRiP02831. Positions 167-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200368. 1 interaction.
STRINGi10090.ENSMUSP00000110077.

PTM databases

PhosphoSiteiP02831.

Proteomic databases

PRIDEiP02831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560.
GeneIDi15400.
KEGGimmu:15400.
UCSCiuc009bya.2. mouse.

Organism-specific databases

CTDi3200.
MGIiMGI:96175. Hoxa3.

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP02831.
KOiK09303.
OMAiHIQGSPV.
OrthoDBiEOG754HPS.
PhylomeDBiP02831.
TreeFamiTF315938.

Miscellaneous databases

NextBioi288094.
PROiP02831.
SOURCEiSearch...

Gene expression databases

BgeeiP02831.
CleanExiMM_HOXA3.
ExpressionAtlasiP02831. baseline and differential.
GenevisibleiP02831. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hofmann M., Boehm T.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Sequence and expression of the murine Hoxd-3 homeobox gene."
    Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
    Strain: ICR X Swiss Webster.
  4. "Structural and functional aspects of the mammalian homeo-box sequences."
    Ruddle F.H., Hart C.P., McGinnis W.
    Trends Genet. 1:48-51(1985)
    Cited for: NUCLEOTIDE SEQUENCE OF 185-258.
  5. "Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila."
    McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.
    Cell 38:675-680(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
  6. Cited for: DNA-BINDING.
  7. "Expression of the murine homeo box gene Hox 1.5 during embryogenesis."
    Fainsod A., Awgulewitsch A., Ruddle F.H.
    Dev. Biol. 124:125-133(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHXA3_MOUSE
AccessioniPrimary (citable) accession number: P02831
Secondary accession number(s): Q4V9Z8, Q61197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.