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P02831

- HXA3_MOUSE

UniProt

P02831 - HXA3_MOUSE

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Protein

Homeobox protein Hox-A3

Gene

Hoxa3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi192 – 25160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. HMG box domain binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. anterior/posterior pattern specification Source: MGI
  3. blood vessel remodeling Source: MGI
  4. cartilage development Source: MGI
  5. embryonic skeletal system development Source: MGI
  6. embryonic skeletal system morphogenesis Source: MGI
  7. glossopharyngeal nerve morphogenesis Source: MGI
  8. organ formation Source: MGI
  9. organ morphogenesis Source: MGI
  10. parathyroid gland development Source: MGI
  11. positive regulation of cell proliferation Source: MGI
  12. specification of organ position Source: MGI
  13. thymus development Source: MGI
  14. thyroid gland development Source: MGI
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-1.5
Homeobox protein MO-10
Gene namesi
Name:Hoxa3
Synonyms:Hox-1.5, Hoxa-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96175. Hoxa3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Homeobox protein Hox-A3PRO_0000200044Add
BLAST

Proteomic databases

PRIDEiP02831.

PTM databases

PhosphoSiteiP02831.

Expressioni

Developmental stagei

Expressed in a spatially restricted manner in embryos 8.5 dpc, expression is limited to the CNS with an anterior boundary in the hindbrain and extending posteriorly through caudal regions of the spinal cord. The same spatial expression is seen in embryos 9.5 to 12.5 dpc.1 Publication

Gene expression databases

BgeeiP02831.
CleanExiMM_HOXA3.
ExpressionAtlasiP02831. baseline and differential.
GenevestigatoriP02831.

Interactioni

Protein-protein interaction databases

BioGridi200368. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP02831.
SMRiP02831. Positions 167-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi156 – 1616Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 13860Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP02831.
KOiK09303.
OMAiHIQGSPV.
OrthoDBiEOG754HPS.
PhylomeDBiP02831.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02831-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA
60 70 80 90 100
CSLQSPASAG GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP
110 120 130 140 150
PAPQPPQPPP QPPAPTPAAP PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP
160 170 180 190 200
TVGKQIFPWM KESRQNTKQK TSGSSSGESC AGDKSPPGQA SSKRARTAYT
210 220 230 240 250
SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF QNRRMKYKKD
260 270 280 290 300
QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
310 320 330 340 350
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL
360 370 380 390 400
QGNGSYGTPH LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG
410 420 430 440
TGPLGSGHHH GPGPGEPHPT YTDLTAHHPS QGRIQEAPKL THL
Length:443
Mass (Da):46,430
Last modified:November 1, 1997 - v2
Checksum:i6C0E184B0F6F2D40
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851S → G1 PublicationCurated
Sequence conflicti185 – 1851S → G(PubMed:6091896)Curated
Sequence conflicti195 – 1951A → G1 PublicationCurated
Sequence conflicti195 – 1951A → G(PubMed:6091896)Curated
Sequence conflicti201 – 2022SA → RP1 PublicationCurated
Sequence conflicti201 – 2022SA → RP(PubMed:6091896)Curated
Sequence conflicti218 – 2181C → M1 PublicationCurated
Sequence conflicti218 – 2181C → M(PubMed:6091896)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11717 mRNA. Translation: CAA72404.1.
BC096612 mRNA. Translation: AAH96612.1.
U56399 mRNA. Translation: AAC52778.1.
K02591 Genomic DNA. Translation: AAA37822.1.
CCDSiCCDS20140.1.
PIRiI49746.
RefSeqiNP_034582.1. NM_010452.3.
UniGeneiMm.483277.
Mm.71533.

Genome annotation databases

EnsembliENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560.
GeneIDi15400.
KEGGimmu:15400.
UCSCiuc009bya.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11717 mRNA. Translation: CAA72404.1 .
BC096612 mRNA. Translation: AAH96612.1 .
U56399 mRNA. Translation: AAC52778.1 .
K02591 Genomic DNA. Translation: AAA37822.1 .
CCDSi CCDS20140.1.
PIRi I49746.
RefSeqi NP_034582.1. NM_010452.3.
UniGenei Mm.483277.
Mm.71533.

3D structure databases

ProteinModelPortali P02831.
SMRi P02831. Positions 167-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200368. 1 interaction.

PTM databases

PhosphoSitei P02831.

Proteomic databases

PRIDEi P02831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114434 ; ENSMUSP00000110077 ; ENSMUSG00000079560 .
GeneIDi 15400.
KEGGi mmu:15400.
UCSCi uc009bya.2. mouse.

Organism-specific databases

CTDi 3200.
MGIi MGI:96175. Hoxa3.

Phylogenomic databases

eggNOGi NOG284589.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000252944.
HOVERGENi HBG107984.
InParanoidi P02831.
KOi K09303.
OMAi HIQGSPV.
OrthoDBi EOG754HPS.
PhylomeDBi P02831.
TreeFami TF315938.

Miscellaneous databases

NextBioi 288094.
PROi P02831.
SOURCEi Search...

Gene expression databases

Bgeei P02831.
CleanExi MM_HOXA3.
ExpressionAtlasi P02831. baseline and differential.
Genevestigatori P02831.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hofmann M., Boehm T.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Sequence and expression of the murine Hoxd-3 homeobox gene."
    Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
    Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
    Strain: ICR X Swiss Webster.
  4. "Structural and functional aspects of the mammalian homeo-box sequences."
    Ruddle F.H., Hart C.P., McGinnis W.
    Trends Genet. 1:48-51(1985)
    Cited for: NUCLEOTIDE SEQUENCE OF 185-258.
  5. "Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila."
    McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.
    Cell 38:675-680(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
  6. Cited for: DNA-BINDING.
  7. "Expression of the murine homeo box gene Hox 1.5 during embryogenesis."
    Fainsod A., Awgulewitsch A., Ruddle F.H.
    Dev. Biol. 124:125-133(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHXA3_MOUSE
AccessioniPrimary (citable) accession number: P02831
Secondary accession number(s): Q4V9Z8, Q61197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3