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P02830

- HXA7_MOUSE

UniProt

P02830 - HXA7_MOUSE

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Protein

Homeobox protein Hox-A7

Gene
Hoxa7, Hox-1.1, Hoxa-7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi129 – 18860HomeoboxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. anterior/posterior pattern specification Source: MGI
  3. embryonic skeletal system morphogenesis Source: MGI
  4. negative regulation of cell-matrix adhesion Source: Ensembl
  5. negative regulation of keratinocyte differentiation Source: Ensembl
  6. negative regulation of leukocyte migration Source: Ensembl
  7. negative regulation of monocyte differentiation Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. stem cell differentiation Source: MGI
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox-1.1
Homeobox protein M6-12
Short name:
M6
Gene namesi
Name:Hoxa7
Synonyms:Hox-1.1, Hoxa-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96179. Hoxa7.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Homeobox protein Hox-A7PRO_0000200072Add
BLAST

Proteomic databases

PRIDEiP02830.

Expressioni

Gene expression databases

ArrayExpressiP02830.
BgeeiP02830.
CleanExiMM_HOXA7.
GenevestigatoriP02830.

Interactioni

Protein-protein interaction databases

BioGridi200372. 1 interaction.
IntActiP02830. 1 interaction.
MINTiMINT-1172633.

Structurei

3D structure databases

ProteinModelPortaliP02830.
SMRiP02830. Positions 133-188.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi118 – 1236Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1594Poly-Arg
Compositional biasi211 – 22919Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi215 – 22915Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00730000110212.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiA2RS54.
KOiK09307.
OMAiHKDEGPA.
PhylomeDBiP02830.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02830-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST    50
VPGLYNVNSP LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC 100
DKADEGVLHG PAEASFRIYP WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF 150
NRYLTRRRRI EIAHALCLTE RQIKIWFQNR RMKWKKEHKD ESQAPTAAPE 200
DAVPSVSTAA DKADEEEEEE EEEEEEEEE 229
Length:229
Mass (Da):25,682
Last modified:February 1, 1996 - v2
Checksum:iD36E6BD61D8D5C6F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 453GAG → APA in AAA37833. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17192 mRNA. Translation: AAA37833.1.
U15972 Genomic DNA. Translation: AAC52160.1.
AK033500 mRNA. Translation: BAC28323.1.
BC131978 mRNA. Translation: AAI31979.1.
BC132643 mRNA. Translation: AAI32644.1.
CCDSiCCDS20145.1.
PIRiA03314.
A28329.
RefSeqiNP_034585.1. NM_010455.2.
XP_006505672.1. XM_006505609.1.
XP_006505673.1. XM_006505610.1.
UniGeneiMm.294826.

Genome annotation databases

EnsembliENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236.
GeneIDi15404.
KEGGimmu:15404.
UCSCiuc009byj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17192 mRNA. Translation: AAA37833.1 .
U15972 Genomic DNA. Translation: AAC52160.1 .
AK033500 mRNA. Translation: BAC28323.1 .
BC131978 mRNA. Translation: AAI31979.1 .
BC132643 mRNA. Translation: AAI32644.1 .
CCDSi CCDS20145.1.
PIRi A03314.
A28329.
RefSeqi NP_034585.1. NM_010455.2.
XP_006505672.1. XM_006505609.1.
XP_006505673.1. XM_006505610.1.
UniGenei Mm.294826.

3D structure databases

ProteinModelPortali P02830.
SMRi P02830. Positions 133-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200372. 1 interaction.
IntActi P02830. 1 interaction.
MINTi MINT-1172633.

Proteomic databases

PRIDEi P02830.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048715 ; ENSMUSP00000048648 ; ENSMUSG00000038236 .
GeneIDi 15404.
KEGGi mmu:15404.
UCSCi uc009byj.1. mouse.

Organism-specific databases

CTDi 3204.
MGIi MGI:96179. Hoxa7.

Phylogenomic databases

eggNOGi NOG238660.
GeneTreei ENSGT00730000110212.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi A2RS54.
KOi K09307.
OMAi HKDEGPA.
PhylomeDBi P02830.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288110.
PROi P02830.
SOURCEi Search...

Gene expression databases

ArrayExpressi P02830.
Bgeei P02830.
CleanExi MM_HOXA7.
Genevestigatori P02830.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and nuclear localization of a murine homeodomain protein."
    Kessel M., Schulze F., Fibi M., Gruss P.
    Proc. Natl. Acad. Sci. U.S.A. 84:5306-5310(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Organization, sequence and regulation of expression of the murine Hoxa-7 gene."
    Parikh H., Shah S., Hilt D., Peterkofsky A.
    Gene 154:237-242(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells."
    Colberg-Poley A.M., Voss S.D., Chowdhury K., Gruss P.
    Nature 314:713-718(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 126-229.
  6. "Sequential expression of murine homeo box genes during F9 EC cell differentiation."
    Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
    EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 129-197.

Entry informationi

Entry nameiHXA7_MOUSE
AccessioniPrimary (citable) accession number: P02830
Secondary accession number(s): A2RS54, Q544P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi