Reviewed, UniProtKB/Swiss-Prot P02830 (HXA7_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A7
Alternative name(s):
    Hox-1.1
    M6-12
      Short name=M6

Gene names

Name:	Hoxa7
Synonyms:	Hox-1.1, Hoxa-7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	anterior/posterior pattern formation Inferred from genetic interaction. Source: MGI embryonic skeletal system morphogenesis Inferred from genetic interaction. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from direct assay. Source: MGI transcription repressor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Gmnn	O88513	1	EBI-445978,EBI-445922

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Homeobox protein Hox-A7		PRO_0000200072
Regions
	DNA binding	129 – 188	60	Homeobox
	Motif	118 – 123	6	Antp-type hexapeptide
	Compositional bias	156 – 159	4	Poly-Arg
	Compositional bias	211 – 229	19	Asp/Glu-rich (highly acidic)
	Compositional bias	215 – 229	15	Poly-Glu
Experimental info
	Sequence conflict	43 – 45	3	GAG → APA in AAA37833. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P02830-1 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: D36E6BD61D8D5C6F	FASTA	229	25,682
	10 20 30 40 50 60 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST VPGLYNVNSP 70 80 90 100 110 120 LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC DKADEGVLHG PAEASFRIYP 130 140 150 160 170 180 WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EIAHALCLTE RQIKIWFQNR 190 200 210 220 RMKWKKEHKD ESQAPTAAPE DAVPSVSTAA DKADEEEEEE EEEEEEEEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure and nuclear localization of a murine homeodomain protein." Kessel M., Schulze F., Fibi M., Gruss P. Proc. Natl. Acad. Sci. U.S.A. 84:5306-5310(1987) [PubMed: 2885847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Organization, sequence and regulation of expression of the murine Hoxa-7 gene." Parikh H., Shah S., Hilt D., Peterkofsky A. Gene 154:237-242(1995) [PubMed: 7890170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Colon.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells." Colberg-Poley A.M., Voss S.D., Chowdhury K., Gruss P. Nature 314:713-718(1985) [PubMed: 2986010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 126-229.
[6]	"Sequential expression of murine homeo box genes during F9 EC cell differentiation." Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P. EMBO J. 5:2209-2215(1986) [PubMed: 2877873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 129-197.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M17192 mRNA. Translation: AAA37833.1. U15972 Genomic DNA. Translation: AAC52160.1. AK033500 mRNA. Translation: BAC28323.1. BC131978 mRNA. Translation: AAI31979.1. BC132643 mRNA. Translation: AAI32644.1.
IPI	IPI00113735.
PIR	A03314. A28329.
RefSeq	NP_034585.1.
UniGene	Mm.294826
3D structure databases
SMR	P02830. Positions 129-193.
ModBase	Search...
Protein-protein interaction databases
IntAct	P02830. 1 interaction.
STRING	P02830.
Proteomic databases
PRIDE	P02830.
Genome annotation databases
Ensembl	ENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236; Mus musculus. [Genome view]
GeneID	15404.
KEGG	mmu:15404.
UCSC	uc009byj.1. mouse.
Organism-specific databases
CTD	15404.
MGI	MGI:96179. Hoxa7.
Phylogenomic databases
HOGENOM	P02830.
HOVERGEN	P02830.
OMA	HKDEGPT
OrthoDB	EOG9WM7CV
Gene expression databases
ArrayExpress	P02830.
Bgee	P02830.
CleanEx	MM_HOXA7.
Genevestigator	P02830.
GermOnline	ENSMUSG00000038236. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288110.
SOURCE	Search...

Entry information

Entry name

HXA7_MOUSE

Accession

Primary (citable) accession number: P02830
Secondary accession number(s): A2RS54, Q544P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	February 1, 1996
Last modified:	November 24, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)