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P02830

- HXA7_MOUSE

UniProt

P02830 - HXA7_MOUSE

Protein

Homeobox protein Hox-A7

Gene

Hoxa7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi129 – 18860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. anterior/posterior pattern specification Source: MGI
    3. embryonic skeletal system morphogenesis Source: MGI
    4. negative regulation of cell-matrix adhesion Source: Ensembl
    5. negative regulation of keratinocyte differentiation Source: Ensembl
    6. negative regulation of leukocyte migration Source: Ensembl
    7. negative regulation of monocyte differentiation Source: Ensembl
    8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. stem cell differentiation Source: MGI
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A7
    Alternative name(s):
    Homeobox protein Hox-1.1
    Homeobox protein M6-12
    Short name:
    M6
    Gene namesi
    Name:Hoxa7
    Synonyms:Hox-1.1, Hoxa-7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96179. Hoxa7.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Homeobox protein Hox-A7PRO_0000200072Add
    BLAST

    Proteomic databases

    PRIDEiP02830.

    Expressioni

    Gene expression databases

    ArrayExpressiP02830.
    BgeeiP02830.
    CleanExiMM_HOXA7.
    GenevestigatoriP02830.

    Interactioni

    Protein-protein interaction databases

    BioGridi200372. 1 interaction.
    IntActiP02830. 1 interaction.
    MINTiMINT-1172633.

    Structurei

    3D structure databases

    ProteinModelPortaliP02830.
    SMRiP02830. Positions 133-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi118 – 1236Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 1594Poly-Arg
    Compositional biasi211 – 22919Asp/Glu-rich (highly acidic)Add
    BLAST
    Compositional biasi215 – 22915Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238660.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiA2RS54.
    KOiK09307.
    OMAiHKDEGPA.
    PhylomeDBiP02830.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P02830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST    50
    VPGLYNVNSP LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC 100
    DKADEGVLHG PAEASFRIYP WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF 150
    NRYLTRRRRI EIAHALCLTE RQIKIWFQNR RMKWKKEHKD ESQAPTAAPE 200
    DAVPSVSTAA DKADEEEEEE EEEEEEEEE 229
    Length:229
    Mass (Da):25,682
    Last modified:February 1, 1996 - v2
    Checksum:iD36E6BD61D8D5C6F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 453GAG → APA in AAA37833. (PubMed:2885847)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17192 mRNA. Translation: AAA37833.1.
    U15972 Genomic DNA. Translation: AAC52160.1.
    AK033500 mRNA. Translation: BAC28323.1.
    BC131978 mRNA. Translation: AAI31979.1.
    BC132643 mRNA. Translation: AAI32644.1.
    CCDSiCCDS20145.1.
    PIRiA03314.
    A28329.
    RefSeqiNP_034585.1. NM_010455.2.
    XP_006505672.1. XM_006505609.1.
    XP_006505673.1. XM_006505610.1.
    UniGeneiMm.294826.

    Genome annotation databases

    EnsembliENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236.
    GeneIDi15404.
    KEGGimmu:15404.
    UCSCiuc009byj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17192 mRNA. Translation: AAA37833.1 .
    U15972 Genomic DNA. Translation: AAC52160.1 .
    AK033500 mRNA. Translation: BAC28323.1 .
    BC131978 mRNA. Translation: AAI31979.1 .
    BC132643 mRNA. Translation: AAI32644.1 .
    CCDSi CCDS20145.1.
    PIRi A03314.
    A28329.
    RefSeqi NP_034585.1. NM_010455.2.
    XP_006505672.1. XM_006505609.1.
    XP_006505673.1. XM_006505610.1.
    UniGenei Mm.294826.

    3D structure databases

    ProteinModelPortali P02830.
    SMRi P02830. Positions 133-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200372. 1 interaction.
    IntActi P02830. 1 interaction.
    MINTi MINT-1172633.

    Proteomic databases

    PRIDEi P02830.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048715 ; ENSMUSP00000048648 ; ENSMUSG00000038236 .
    GeneIDi 15404.
    KEGGi mmu:15404.
    UCSCi uc009byj.1. mouse.

    Organism-specific databases

    CTDi 3204.
    MGIi MGI:96179. Hoxa7.

    Phylogenomic databases

    eggNOGi NOG238660.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi A2RS54.
    KOi K09307.
    OMAi HKDEGPA.
    PhylomeDBi P02830.
    TreeFami TF316310.

    Miscellaneous databases

    NextBioi 288110.
    PROi P02830.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02830.
    Bgeei P02830.
    CleanExi MM_HOXA7.
    Genevestigatori P02830.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and nuclear localization of a murine homeodomain protein."
      Kessel M., Schulze F., Fibi M., Gruss P.
      Proc. Natl. Acad. Sci. U.S.A. 84:5306-5310(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Organization, sequence and regulation of expression of the murine Hoxa-7 gene."
      Parikh H., Shah S., Hilt D., Peterkofsky A.
      Gene 154:237-242(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells."
      Colberg-Poley A.M., Voss S.D., Chowdhury K., Gruss P.
      Nature 314:713-718(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 126-229.
    6. "Sequential expression of murine homeo box genes during F9 EC cell differentiation."
      Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
      EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 129-197.

    Entry informationi

    Entry nameiHXA7_MOUSE
    AccessioniPrimary (citable) accession number: P02830
    Secondary accession number(s): A2RS54, Q544P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3