Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-A7

Gene

Hoxa7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi129 – 188HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox-1.1
Homeobox protein M6-12
Short name:
M6
Gene namesi
Name:Hoxa7
Synonyms:Hox-1.1, Hoxa-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96179 Hoxa7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000721 – 229Homeobox protein Hox-A7Add BLAST229

Proteomic databases

MaxQBiP02830
PaxDbiP02830
PRIDEiP02830

PTM databases

PhosphoSitePlusiP02830

Expressioni

Gene expression databases

BgeeiENSMUSG00000038236
CleanExiMM_HOXA7
ExpressionAtlasiP02830 baseline and differential
GenevisibleiP02830 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2003721 interactor.
IntActiP02830 1 interactor.
STRINGi10090.ENSMUSP00000048648

Structurei

3D structure databases

ProteinModelPortaliP02830
SMRiP02830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi118 – 123Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 159Poly-Arg4
Compositional biasi211 – 229Asp/Glu-rich (highly acidic)Add BLAST19
Compositional biasi215 – 229Poly-GluAdd BLAST15

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP02830
KOiK09307
OMAiWKKEHKD
OrthoDBiEOG091G09XD
PhylomeDBiP02830
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P02830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST
60 70 80 90 100
VPGLYNVNSP LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC
110 120 130 140 150
DKADEGVLHG PAEASFRIYP WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF
160 170 180 190 200
NRYLTRRRRI EIAHALCLTE RQIKIWFQNR RMKWKKEHKD ESQAPTAAPE
210 220
DAVPSVSTAA DKADEEEEEE EEEEEEEEE
Length:229
Mass (Da):25,682
Last modified:February 1, 1996 - v2
Checksum:iD36E6BD61D8D5C6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 45GAG → APA in AAA37833 (PubMed:2885847).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17192 mRNA Translation: AAA37833.1
U15972 Genomic DNA Translation: AAC52160.1
AK033500 mRNA Translation: BAC28323.1
BC131978 mRNA Translation: AAI31979.1
BC132643 mRNA Translation: AAI32644.1
CCDSiCCDS20145.1
PIRiA03314
A28329
RefSeqiNP_034585.1, NM_010455.2
UniGeneiMm.294826

Genome annotation databases

EnsembliENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236
GeneIDi15404
KEGGimmu:15404
UCSCiuc009byj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHXA7_MOUSE
AccessioniPrimary (citable) accession number: P02830
Secondary accession number(s): A2RS54, Q544P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome