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P02830 (HXA7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox-1.1
Homeobox protein M6-12
Short name=M6
Gene names
Name:Hoxa7
Synonyms:Hox-1.1, Hoxa-7
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Homeobox protein Hox-A7
PRO_0000200072

Regions

DNA binding129 – 18860Homeobox
Motif118 – 1236Antp-type hexapeptide
Compositional bias156 – 1594Poly-Arg
Compositional bias211 – 22919Asp/Glu-rich (highly acidic)
Compositional bias215 – 22915Poly-Glu

Experimental info

Sequence conflict43 – 453GAG → APA in AAA37833. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P02830 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: D36E6BD61D8D5C6F

FASTA22925,682
        10         20         30         40         50         60 
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST VPGLYNVNSP 

        70         80         90        100        110        120 
LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC DKADEGVLHG PAEASFRIYP 

       130        140        150        160        170        180 
WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EIAHALCLTE RQIKIWFQNR 

       190        200        210        220 
RMKWKKEHKD ESQAPTAAPE DAVPSVSTAA DKADEEEEEE EEEEEEEEE

« Hide

References

« Hide 'large scale' references
[1]"Primary structure and nuclear localization of a murine homeodomain protein."
Kessel M., Schulze F., Fibi M., Gruss P.
Proc. Natl. Acad. Sci. U.S.A. 84:5306-5310(1987) [PubMed: 2885847] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Organization, sequence and regulation of expression of the murine Hoxa-7 gene."
Parikh H., Shah S., Hilt D., Peterkofsky A.
Gene 154:237-242(1995) [PubMed: 7890170] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Colon.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells."
Colberg-Poley A.M., Voss S.D., Chowdhury K., Gruss P.
Nature 314:713-718(1985) [PubMed: 2986010] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 126-229.
[6]"Sequential expression of murine homeo box genes during F9 EC cell differentiation."
Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
EMBO J. 5:2209-2215(1986) [PubMed: 2877873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 129-197.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M17192 mRNA. Translation: AAA37833.1.
U15972 Genomic DNA. Translation: AAC52160.1.
AK033500 mRNA. Translation: BAC28323.1.
BC131978 mRNA. Translation: AAI31979.1.
BC132643 mRNA. Translation: AAI32644.1.
IPIIPI00113735.
PIRA03314.
A28329.
RefSeqNP_034585.1. NM_010455.2.
UniGeneMm.294826.

3D structure databases

ProteinModelPortalP02830.
SMRP02830. Positions 133-188.
ModBaseSearch...

Protein-protein interaction databases

IntActP02830. 1 interaction.
MINTMINT-1172633.
STRINGP02830.

Proteomic databases

PRIDEP02830.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236.
GeneID15404.
KEGGmmu:15404.
UCSCuc009byj.1. mouse.

Organism-specific databases

CTD3204.
MGIMGI:96179. Hoxa7.

Phylogenomic databases

HOGENOMHBG715745.
HOVERGENHBG016849.
InParanoidP02830.
OMAHKDEGPT.
OrthoDBEOG4W9J4Z.
PhylomeDBP02830.

Gene expression databases

ArrayExpressP02830.
BgeeP02830.
CleanExMM_HOXA7.
GenevestigatorP02830.
GermOnlineENSMUSG00000038236. Mus musculus.

Family and domain databases

InterProIPR001356. Homeobox.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KOK09307.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288110.
SOURCESearch...

Entry information

Entry nameHXA7_MOUSE
AccessionPrimary (citable) accession number: P02830
Secondary accession number(s): A2RS54, Q544P0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: December 14, 2011
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents