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Protein

Homeobox protein Hox-A7

Gene

Hoxa7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi129 – 18860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A7
Alternative name(s):
Homeobox protein Hox-1.1
Homeobox protein M6-12
Short name:
M6
Gene namesi
Name:Hoxa7
Synonyms:Hox-1.1, Hoxa-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96179. Hoxa7.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Homeobox protein Hox-A7PRO_0000200072Add
BLAST

Proteomic databases

PRIDEiP02830.

Expressioni

Gene expression databases

BgeeiP02830.
CleanExiMM_HOXA7.
ExpressionAtlasiP02830. baseline and differential.
GenevestigatoriP02830.

Interactioni

Protein-protein interaction databases

BioGridi200372. 1 interaction.
IntActiP02830. 1 interaction.
MINTiMINT-1172633.

Structurei

3D structure databases

ProteinModelPortaliP02830.
SMRiP02830. Positions 133-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi118 – 1236Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1594Poly-Arg
Compositional biasi211 – 22919Asp/Glu-rich (highly acidic)Add
BLAST
Compositional biasi215 – 22915Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP02830.
KOiK09307.
OMAiHKDEGPT.
PhylomeDBiP02830.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST
60 70 80 90 100
VPGLYNVNSP LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC
110 120 130 140 150
DKADEGVLHG PAEASFRIYP WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF
160 170 180 190 200
NRYLTRRRRI EIAHALCLTE RQIKIWFQNR RMKWKKEHKD ESQAPTAAPE
210 220
DAVPSVSTAA DKADEEEEEE EEEEEEEEE
Length:229
Mass (Da):25,682
Last modified:February 1, 1996 - v2
Checksum:iD36E6BD61D8D5C6F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 453GAG → APA in AAA37833 (PubMed:2885847).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17192 mRNA. Translation: AAA37833.1.
U15972 Genomic DNA. Translation: AAC52160.1.
AK033500 mRNA. Translation: BAC28323.1.
BC131978 mRNA. Translation: AAI31979.1.
BC132643 mRNA. Translation: AAI32644.1.
CCDSiCCDS20145.1.
PIRiA03314.
A28329.
RefSeqiNP_034585.1. NM_010455.2.
XP_006505672.1. XM_006505609.2.
XP_006505673.1. XM_006505610.1.
UniGeneiMm.294826.

Genome annotation databases

EnsembliENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236.
GeneIDi15404.
KEGGimmu:15404.
UCSCiuc009byj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17192 mRNA. Translation: AAA37833.1.
U15972 Genomic DNA. Translation: AAC52160.1.
AK033500 mRNA. Translation: BAC28323.1.
BC131978 mRNA. Translation: AAI31979.1.
BC132643 mRNA. Translation: AAI32644.1.
CCDSiCCDS20145.1.
PIRiA03314.
A28329.
RefSeqiNP_034585.1. NM_010455.2.
XP_006505672.1. XM_006505609.2.
XP_006505673.1. XM_006505610.1.
UniGeneiMm.294826.

3D structure databases

ProteinModelPortaliP02830.
SMRiP02830. Positions 133-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200372. 1 interaction.
IntActiP02830. 1 interaction.
MINTiMINT-1172633.

Proteomic databases

PRIDEiP02830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048715; ENSMUSP00000048648; ENSMUSG00000038236.
GeneIDi15404.
KEGGimmu:15404.
UCSCiuc009byj.1. mouse.

Organism-specific databases

CTDi3204.
MGIiMGI:96179. Hoxa7.

Phylogenomic databases

eggNOGiNOG238660.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP02830.
KOiK09307.
OMAiHKDEGPT.
PhylomeDBiP02830.
TreeFamiTF316310.

Miscellaneous databases

NextBioi288110.
PROiP02830.
SOURCEiSearch...

Gene expression databases

BgeeiP02830.
CleanExiMM_HOXA7.
ExpressionAtlasiP02830. baseline and differential.
GenevestigatoriP02830.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and nuclear localization of a murine homeodomain protein."
    Kessel M., Schulze F., Fibi M., Gruss P.
    Proc. Natl. Acad. Sci. U.S.A. 84:5306-5310(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Organization, sequence and regulation of expression of the murine Hoxa-7 gene."
    Parikh H., Shah S., Hilt D., Peterkofsky A.
    Gene 154:237-242(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells."
    Colberg-Poley A.M., Voss S.D., Chowdhury K., Gruss P.
    Nature 314:713-718(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 126-229.
  6. "Sequential expression of murine homeo box genes during F9 EC cell differentiation."
    Breier G., Bucan M., Francke U., Colberg-Poley A.M., Gruss P.
    EMBO J. 5:2209-2215(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 129-197.

Entry informationi

Entry nameiHXA7_MOUSE
AccessioniPrimary (citable) accession number: P02830
Secondary accession number(s): A2RS54, Q544P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.