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Protein

Major heat shock 70 kDa protein Ab

Gene

Hsp70Ab

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: UniProtKB
  • response to hypoxia Source: FlyBase
  • response to unfolded protein Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Ab
Short name:
Heat shock protein 70Ab
Alternative name(s):
HSP70-87A7
Gene namesi
Name:Hsp70Ab
Synonyms:Hsp70A
ORF Names:CG18743
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013276. Hsp70Ab.

Subcellular locationi

GO - Cellular componenti

  • microtubule associated complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Major heat shock 70 kDa protein AbPRO_0000078330Add
BLAST

Proteomic databases

PaxDbiP02825.
PRIDEiP02825.

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.

Gene expression databases

BgeeiFBgn0013275.
GenevisibleiP02825. DM.

Interactioni

Protein-protein interaction databases

BioGridi69381. 41 interactions.
71511. 51 interactions.
IntActiP02825. 4 interactions.
STRINGi7227.FBpp0081986.

Structurei

3D structure databases

ProteinModelPortaliP02825.
SMRiP02825. Positions 2-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
InParanoidiP02825.
KOiK03283.
OrthoDBiEOG091G03SF.
PhylomeDBiP02825.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKGER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA DEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQD
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYA DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQA
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNDTIRWLDS NTTAEKEEFD HKLEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAGAGGPG ANCGQQAGGF GGYSGPTVEE VD
Length:642
Mass (Da):70,160
Last modified:April 13, 2004 - v3
Checksum:iEC08E94412E27F84
GO

Sequence cautioni

The sequence CAA23495 differs from that shown. Reason: Frameshift at positions 31, 58, 91 and 99. Curated
The sequence CAA23495 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA23496 differs from that shown. Reason: Frameshift at position 506. Curated
The sequence CAA23496 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501D → E in AAA28640 (PubMed:6795353).Curated
Sequence conflicti128 – 1281A → AA in AAA28640 (PubMed:6795353).Curated
Sequence conflicti128 – 1281A → AA in CAA23495 (PubMed:6255408).Curated
Sequence conflicti530 – 5301H → R in AAA28640 (PubMed:6795353).Curated
Sequence conflicti530 – 5301H → R in CAA23496 (PubMed:6255408).Curated
Sequence conflicti534 – 5341I → V in AAA28640 (PubMed:6795353).Curated
Sequence conflicti534 – 5341I → V in CAA23496 (PubMed:6255408).Curated
Sequence conflicti543 – 5453YVF → HVL in AAA28640 (PubMed:6795353).Curated
Sequence conflicti543 – 5453YVF → HVL in CAA23496 (PubMed:6255408).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti189 – 1891E → G in strain: B28. 1 Publication
Natural varianti194 – 1941I → N in strain: Z(H)1. 1 Publication
Natural varianti262 – 2621R → G in strain: 122. 1 Publication
Natural varianti489 – 4891K → R in strain: FrV3-1. 1 Publication
Natural varianti567 – 5671V → D in strain: 56H8. 1 Publication
Natural varianti573 – 5731D → G in strain: 122. 1 Publication
Natural varianti636 – 6361P → R in strain: B28. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01103 Genomic DNA. Translation: AAA28640.1.
AF295939 Genomic DNA. Translation: AAG26893.1.
AF295940 Genomic DNA. Translation: AAG26894.1.
AF295941 Genomic DNA. Translation: AAG26895.1.
AF295942 Genomic DNA. Translation: AAG26896.1.
AF295943 Genomic DNA. Translation: AAG26897.1.
AF295944 Genomic DNA. Translation: AAG26898.1.
AF295945 Genomic DNA. Translation: AAG26899.1.
AF350460 Genomic DNA. Translation: AAK30217.1.
AF350461 Genomic DNA. Translation: AAK30218.1.
AF350462 Genomic DNA. Translation: AAK30219.1.
AF350463 Genomic DNA. Translation: AAK30220.1.
AF350464 Genomic DNA. Translation: AAK30221.1.
AF350465 Genomic DNA. Translation: AAK30222.1.
AF350466 Genomic DNA. Translation: AAK30223.1.
AF350467 Genomic DNA. Translation: AAK30224.1.
AE014297 Genomic DNA. Translation: AAG22148.2.
V00213 Genomic DNA. Translation: CAA23495.1. Sequence problems.
V00214 Genomic DNA. Translation: CAA23496.1. Sequence problems.
PIRiA03308.
RefSeqiNP_524798.2. NM_080059.3.
NP_731651.1. NM_169441.2.
UniGeneiDm.23375.
Dm.31247.

Genome annotation databases

EnsemblMetazoaiFBtr0082482; FBpp0081956; FBgn0013276.
FBtr0082512; FBpp0081986; FBgn0013275.
GeneIDi44920.
48581.
KEGGidme:Dmel_CG18743.
dme:Dmel_CG31366.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01103 Genomic DNA. Translation: AAA28640.1.
AF295939 Genomic DNA. Translation: AAG26893.1.
AF295940 Genomic DNA. Translation: AAG26894.1.
AF295941 Genomic DNA. Translation: AAG26895.1.
AF295942 Genomic DNA. Translation: AAG26896.1.
AF295943 Genomic DNA. Translation: AAG26897.1.
AF295944 Genomic DNA. Translation: AAG26898.1.
AF295945 Genomic DNA. Translation: AAG26899.1.
AF350460 Genomic DNA. Translation: AAK30217.1.
AF350461 Genomic DNA. Translation: AAK30218.1.
AF350462 Genomic DNA. Translation: AAK30219.1.
AF350463 Genomic DNA. Translation: AAK30220.1.
AF350464 Genomic DNA. Translation: AAK30221.1.
AF350465 Genomic DNA. Translation: AAK30222.1.
AF350466 Genomic DNA. Translation: AAK30223.1.
AF350467 Genomic DNA. Translation: AAK30224.1.
AE014297 Genomic DNA. Translation: AAG22148.2.
V00213 Genomic DNA. Translation: CAA23495.1. Sequence problems.
V00214 Genomic DNA. Translation: CAA23496.1. Sequence problems.
PIRiA03308.
RefSeqiNP_524798.2. NM_080059.3.
NP_731651.1. NM_169441.2.
UniGeneiDm.23375.
Dm.31247.

3D structure databases

ProteinModelPortaliP02825.
SMRiP02825. Positions 2-609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi69381. 41 interactions.
71511. 51 interactions.
IntActiP02825. 4 interactions.
STRINGi7227.FBpp0081986.

Proteomic databases

PaxDbiP02825.
PRIDEiP02825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082482; FBpp0081956; FBgn0013276.
FBtr0082512; FBpp0081986; FBgn0013275.
GeneIDi44920.
48581.
KEGGidme:Dmel_CG18743.
dme:Dmel_CG31366.

Organism-specific databases

CTDi44920.
48581.
FlyBaseiFBgn0013276. Hsp70Ab.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
InParanoidiP02825.
KOiK03283.
OrthoDBiEOG091G03SF.
PhylomeDBiP02825.

Miscellaneous databases

PROiP02825.

Gene expression databases

BgeeiFBgn0013275.
GenevisibleiP02825. DM.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP71_DROME
AccessioniPrimary (citable) accession number: P02825
Secondary accession number(s): Q95NG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 13, 2004
Last modified: September 7, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

There are two copies of the gene coding for this protein at chromosome locus 87A7.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.