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Protein

Osteocalcin

Gene

BGLAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Calcium 11 Publication
Metal bindingi72 – 721Calcium 21 Publication
Metal bindingi75 – 751Calcium 21 Publication
Metal bindingi75 – 751Calcium 31 Publication
Metal bindingi81 – 811Calcium 31 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Propeptidei24 – 51281 PublicationPRO_0000011084Add
BLAST
Chaini52 – 10049Osteocalcin1 PublicationPRO_0000011085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 6014-hydroxyproline1 Publication
Modified residuei68 – 6814-carboxyglutamatePROSITE-ProRule annotation2 Publications
Modified residuei72 – 7214-carboxyglutamatePROSITE-ProRule annotation2 Publications
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation1 Publication
Modified residuei75 – 7514-carboxyglutamatePROSITE-ProRule annotation2 Publications

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Proteomic databases

PaxDbiP02820.
PRIDEiP02820.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047703.

Structurei

Secondary structure

1
100
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 757Combined sources
Helixi78 – 8710Combined sources
Helixi89 – 979Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3MNMR-A52-100[»]
4MZZX-ray1.88A/B68-100[»]
ProteinModelPortaliP02820.
SMRiP02820. Positions 69-100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02820.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 9847GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
HOGENOMiHOG000115820.
InParanoidiP02820.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPMLLALL ALATLCLAGR ADAKPGDAES GKGAAFVSKQ EGSEVVKRLR
60 70 80 90 100
RYLDHWLGAP APYPDPLEPK REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):11,042
Last modified:August 1, 1990 - v2
Checksum:i73015D1681B26219
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53699 mRNA. Translation: CAA37737.1.
X51700 mRNA. Translation: CAA35997.1.
EF673278 Genomic DNA. Translation: ABU88822.1.
PIRiS12653. GEBO.
RefSeqiNP_776674.1. NM_174249.2.
UniGeneiBt.4055.

Genome annotation databases

GeneIDi281646.
KEGGibta:281646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53699 mRNA. Translation: CAA37737.1.
X51700 mRNA. Translation: CAA35997.1.
EF673278 Genomic DNA. Translation: ABU88822.1.
PIRiS12653. GEBO.
RefSeqiNP_776674.1. NM_174249.2.
UniGeneiBt.4055.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Q3MNMR-A52-100[»]
4MZZX-ray1.88A/B68-100[»]
ProteinModelPortaliP02820.
SMRiP02820. Positions 69-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047703.

Proteomic databases

PaxDbiP02820.
PRIDEiP02820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281646.
KEGGibta:281646.

Organism-specific databases

CTDi632.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
HOGENOMiHOG000115820.
InParanoidiP02820.

Miscellaneous databases

EvolutionaryTraceiP02820.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTCN_BOVIN
AccessioniPrimary (citable) accession number: P02820
Secondary accession number(s): A7YEW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.