Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Osteocalcin

Gene

BGLAP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Calcium 11 Publication1
Metal bindingi72Calcium 21 Publication1
Metal bindingi75Calcium 21 Publication1
Metal bindingi75Calcium 31 Publication1
Metal bindingi81Calcium 31 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
PropeptideiPRO_000001108424 – 511 PublicationAdd BLAST28
ChainiPRO_000001108552 – 100Osteocalcin1 PublicationAdd BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei604-hydroxyproline1 Publication1
Modified residuei684-carboxyglutamatePROSITE-ProRule annotation2 Publications1
Modified residuei724-carboxyglutamatePROSITE-ProRule annotation2 Publications1
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation1 Publication
Modified residuei754-carboxyglutamatePROSITE-ProRule annotation2 Publications1

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Proteomic databases

PaxDbiP02820.
PRIDEiP02820.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047703.

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 75Combined sources7
Helixi78 – 87Combined sources10
Helixi89 – 97Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3MNMR-A52-100[»]
4MZZX-ray1.88A/B68-100[»]
ProteinModelPortaliP02820.
SMRiP02820.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02820.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 98GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
HOGENOMiHOG000115820.
InParanoidiP02820.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPMLLALL ALATLCLAGR ADAKPGDAES GKGAAFVSKQ EGSEVVKRLR
60 70 80 90 100
RYLDHWLGAP APYPDPLEPK REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):11,042
Last modified:August 1, 1990 - v2
Checksum:i73015D1681B26219
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53699 mRNA. Translation: CAA37737.1.
X51700 mRNA. Translation: CAA35997.1.
EF673278 Genomic DNA. Translation: ABU88822.1.
PIRiS12653. GEBO.
RefSeqiNP_776674.1. NM_174249.2.
UniGeneiBt.4055.

Genome annotation databases

GeneIDi281646.
KEGGibta:281646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53699 mRNA. Translation: CAA37737.1.
X51700 mRNA. Translation: CAA35997.1.
EF673278 Genomic DNA. Translation: ABU88822.1.
PIRiS12653. GEBO.
RefSeqiNP_776674.1. NM_174249.2.
UniGeneiBt.4055.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3MNMR-A52-100[»]
4MZZX-ray1.88A/B68-100[»]
ProteinModelPortaliP02820.
SMRiP02820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047703.

Proteomic databases

PaxDbiP02820.
PRIDEiP02820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281646.
KEGGibta:281646.

Organism-specific databases

CTDi632.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
HOGENOMiHOG000115820.
InParanoidiP02820.

Miscellaneous databases

EvolutionaryTraceiP02820.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTCN_BOVIN
AccessioniPrimary (citable) accession number: P02820
Secondary accession number(s): A7YEW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.