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Protein

Osteocalcin

Gene

BGLAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Calcium 3By similarity1
Metal bindingi72Calcium 2By similarity1
Metal bindingi75Calcium 1By similarity1
Metal bindingi75Calcium 2By similarity1
Metal bindingi81Calcium 1By similarity1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • hydroxyapatite binding Source: UniProtKB
  • structural constituent of bone Source: UniProtKB
  • structural molecule activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processBiomineralization
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-159740 Gamma-carboxylation of protein precursors
R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORiP02818

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000242252.1
HGNCiHGNC:1043 BGLAP
MIMi112260 gene
neXtProtiNX_P02818

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi632
OpenTargetsiENSG00000242252
PharmGKBiPA25345

Chemistry databases

DrugBankiDB05260 Gallium nitrate
DB03847 Gamma-Carboxy-Glutamic Acid
DB00170 Menadione
DB01022 Phylloquinone

Polymorphism and mutation databases

BioMutaiBGLAP
DMDMi129253

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23CuratedAdd BLAST23
PropeptideiPRO_000001108624 – 511 PublicationAdd BLAST28
ChainiPRO_000001108752 – 100OsteocalcinAdd BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei684-carboxyglutamate; partialPROSITE-ProRule annotation1 Publication1
Modified residuei724-carboxyglutamatePROSITE-ProRule annotation1 Publication1
Disulfide bondi74 ↔ 80
Modified residuei754-carboxyglutamatePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei60Not hydroxylated1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP02818
PeptideAtlasiP02818
PRIDEiP02818

Miscellaneous databases

PMAP-CutDBiP02818

Expressioni

Gene expression databases

BgeeiENSG00000242252
CleanExiHS_BGLAP
GenevisibleiP02818 HS

Interactioni

Protein-protein interaction databases

BioGridi1071017 interactors.
IntActiP02818 1 interactor.
STRINGi9606.ENSP00000357255

Structurei

3D structure databases

ProteinModelPortaliP02818
SMRiP02818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 98GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z Eukaryota
ENOG410ZS6W LUCA
GeneTreeiENSGT00410000026290
HOGENOMiHOG000115820
InParanoidiP02818
OMAiNCDELAD
OrthoDBiEOG091G13UG
PhylomeDBiP02818
TreeFamiTF330920

Family and domain databases

InterProiView protein in InterPro
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR002384 Osteocalcin/MGP
PRINTSiPR00002 GLABONE
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SUPFAMiSSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR
60 70 80 90 100
RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):10,963
Last modified:August 1, 1990 - v2
Checksum:i4DF2A0A80849CB71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 34Missing in CAA27763 (PubMed:3019668).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03874394R → Q1 PublicationCorresponds to variant dbSNP:rs34702397Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53698 mRNA Translation: CAA37736.1
X51699 mRNA Translation: CAA35996.1
X04143 Genomic DNA Translation: CAA27763.1
DQ007079 Genomic DNA Translation: AAY16981.1
AL135927 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52986.1
BC113432 mRNA Translation: AAI13433.1
BC113434 mRNA Translation: AAI13435.1
CCDSiCCDS1134.1
PIRiS12652 GEHU
RefSeqiNP_954642.1, NM_199173.5
UniGeneiHs.654541

Genome annotation databases

EnsembliENST00000368272; ENSP00000357255; ENSG00000242252
GeneIDi632
KEGGihsa:632
UCSCiuc001fnt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOSTCN_HUMAN
AccessioniPrimary (citable) accession number: P02818
Secondary accession number(s): Q5TCK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: February 28, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome