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P02818

- OSTCN_HUMAN

UniProt

P02818 - OSTCN_HUMAN

Protein

Osteocalcin

Gene

BGLAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei60 – 601Not hydroxylated
    Metal bindingi68 – 681Calcium 3By similarity
    Metal bindingi72 – 721Calcium 2By similarity
    Metal bindingi75 – 751Calcium 1By similarity
    Metal bindingi75 – 751Calcium 2By similarity
    Metal bindingi81 – 811Calcium 1By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. hydroxyapatite binding Source: UniProtKB
    3. structural constituent of bone Source: UniProtKB
    4. structural molecule activity Source: ProtInc

    GO - Biological processi

    1. bone development Source: Ensembl
    2. bone mineralization Source: UniProtKB
    3. cell adhesion Source: UniProtKB
    4. cell aging Source: Ensembl
    5. cellular response to growth factor stimulus Source: Ensembl
    6. cellular response to vitamin D Source: Ensembl
    7. odontogenesis Source: UniProtKB
    8. osteoblast development Source: Ensembl
    9. osteoblast differentiation Source: BHF-UCL
    10. regulation of bone mineralization Source: InterPro
    11. regulation of bone resorption Source: UniProtKB
    12. regulation of osteoclast differentiation Source: UniProtKB
    13. response to activity Source: Ensembl
    14. response to drug Source: Ensembl
    15. response to estrogen Source: Ensembl
    16. response to ethanol Source: Ensembl
    17. response to glucocorticoid Source: Ensembl
    18. response to gravity Source: Ensembl
    19. response to hydroxyisoflavone Source: Ensembl
    20. response to mechanical stimulus Source: Ensembl
    21. response to testosterone Source: Ensembl
    22. response to vitamin D Source: BHF-UCL
    23. response to vitamin K Source: Ensembl
    24. response to zinc ion Source: Ensembl
    25. skeletal system development Source: ProtInc

    Keywords - Biological processi

    Biomineralization

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteocalcin
    Alternative name(s):
    Bone Gla protein
    Short name:
    BGP
    Gamma-carboxyglutamic acid-containing protein
    Gene namesi
    Name:BGLAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1043. BGLAP.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. membrane-bounded vesicle Source: Ensembl
    6. perikaryon Source: Ensembl
    7. rough endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25345.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323CuratedAdd
    BLAST
    Propeptidei24 – 51281 PublicationPRO_0000011086Add
    BLAST
    Chaini52 – 10049OsteocalcinPRO_0000011087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei68 – 6814-carboxyglutamate; partial1 PublicationPROSITE-ProRule annotation
    Modified residuei72 – 7214-carboxyglutamate1 PublicationPROSITE-ProRule annotation
    Disulfide bondi74 ↔ 80
    Modified residuei75 – 7514-carboxyglutamate1 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.1 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

    Proteomic databases

    PaxDbiP02818.
    PeptideAtlasiP02818.
    PRIDEiP02818.

    Miscellaneous databases

    PMAP-CutDBP02818.

    Expressioni

    Gene expression databases

    BgeeiP02818.
    CleanExiHS_BGLAP.
    GenevestigatoriP02818.

    Interactioni

    Protein-protein interaction databases

    BioGridi107101. 1 interaction.
    STRINGi9606.ENSP00000357255.

    Structurei

    3D structure databases

    ProteinModelPortaliP02818.
    SMRiP02818. Positions 68-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 9847GlaPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72046.
    HOGENOMiHOG000115820.
    OMAiPKREVCE.
    OrthoDBiEOG7VDXRQ.
    PhylomeDBiP02818.
    TreeFamiTF330920.

    Family and domain databases

    InterProiIPR000294. GLA_domain.
    IPR002384. Osteocalcin/MGP.
    [Graphical view]
    PfamiPF00594. Gla. 1 hit.
    [Graphical view]
    PRINTSiPR00002. GLABONE.
    SMARTiSM00069. GLA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57630. SSF57630. 1 hit.
    PROSITEiPS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02818-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR    50
    RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV 100
    Length:100
    Mass (Da):10,963
    Last modified:August 1, 1990 - v2
    Checksum:i4DF2A0A80849CB71
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 342Missing in CAA27763. (PubMed:3019668)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941R → Q.1 Publication
    Corresponds to variant rs34702397 [ dbSNP | Ensembl ].
    VAR_038743

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53698 mRNA. Translation: CAA37736.1.
    X51699 mRNA. Translation: CAA35996.1.
    X04143 Genomic DNA. Translation: CAA27763.1.
    DQ007079 Genomic DNA. Translation: AAY16981.1.
    AL135927 Genomic DNA. Translation: CAI15541.1.
    CH471121 Genomic DNA. Translation: EAW52986.1.
    BC113432 mRNA. Translation: AAI13433.1.
    BC113434 mRNA. Translation: AAI13435.1.
    CCDSiCCDS1134.1.
    PIRiS12652. GEHU.
    RefSeqiNP_954642.1. NM_199173.4.
    UniGeneiHs.654541.

    Genome annotation databases

    EnsembliENST00000368272; ENSP00000357255; ENSG00000242252.
    GeneIDi632.
    KEGGihsa:632.
    UCSCiuc001fnt.3. human.

    Polymorphism databases

    DMDMi129253.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Osteocalcin entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53698 mRNA. Translation: CAA37736.1 .
    X51699 mRNA. Translation: CAA35996.1 .
    X04143 Genomic DNA. Translation: CAA27763.1 .
    DQ007079 Genomic DNA. Translation: AAY16981.1 .
    AL135927 Genomic DNA. Translation: CAI15541.1 .
    CH471121 Genomic DNA. Translation: EAW52986.1 .
    BC113432 mRNA. Translation: AAI13433.1 .
    BC113434 mRNA. Translation: AAI13435.1 .
    CCDSi CCDS1134.1.
    PIRi S12652. GEHU.
    RefSeqi NP_954642.1. NM_199173.4.
    UniGenei Hs.654541.

    3D structure databases

    ProteinModelPortali P02818.
    SMRi P02818. Positions 68-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107101. 1 interaction.
    STRINGi 9606.ENSP00000357255.

    Chemistry

    DrugBanki DB01022. Phytonadione.

    Polymorphism databases

    DMDMi 129253.

    Proteomic databases

    PaxDbi P02818.
    PeptideAtlasi P02818.
    PRIDEi P02818.

    Protocols and materials databases

    DNASUi 632.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368272 ; ENSP00000357255 ; ENSG00000242252 .
    GeneIDi 632.
    KEGGi hsa:632.
    UCSCi uc001fnt.3. human.

    Organism-specific databases

    CTDi 632.
    GeneCardsi GC01P156211.
    HGNCi HGNC:1043. BGLAP.
    MIMi 112260. gene.
    neXtProti NX_P02818.
    PharmGKBi PA25345.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72046.
    HOGENOMi HOG000115820.
    OMAi PKREVCE.
    OrthoDBi EOG7VDXRQ.
    PhylomeDBi P02818.
    TreeFami TF330920.

    Miscellaneous databases

    GeneWikii Osteocalcin.
    GenomeRNAii 632.
    NextBioi 2554.
    PMAP-CutDB P02818.
    PROi P02818.
    SOURCEi Search...

    Gene expression databases

    Bgeei P02818.
    CleanExi HS_BGLAP.
    Genevestigatori P02818.

    Family and domain databases

    InterProi IPR000294. GLA_domain.
    IPR002384. Osteocalcin/MGP.
    [Graphical view ]
    Pfami PF00594. Gla. 1 hit.
    [Graphical view ]
    PRINTSi PR00002. GLABONE.
    SMARTi SM00069. GLA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57630. SSF57630. 1 hit.
    PROSITEi PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA and derived amino acid sequences of human and bovine bone Gla protein."
      Kiefer M.C., Saphire A.C.S., Bauer D.M., Barr P.J.
      Nucleic Acids Res. 18:1909-1909(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones."
      Celeste A.J., Buecker J.L., Kriz R., Wang E.A., Wozney J.M.
      EMBO J. 5:1885-1890(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. SeattleSNPs variation discovery resource
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-94.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue."
      Poser J.W., Esch F.S., Ling N.C., Price P.A.
      J. Biol. Chem. 255:8685-8691(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 52-100, GAMMA-CARBOXYGLUTAMATION AT GLU-68; GLU-72 AND GLU-75, ABSENCE OF HYDROXYLATION AT PRO-60.

    Entry informationi

    Entry nameiOSTCN_HUMAN
    AccessioniPrimary (citable) accession number: P02818
    Secondary accession number(s): Q5TCK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3