UniProtKB - P02818 (OSTCN_HUMAN)
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Protein
Osteocalcin
Gene
BGLAP
Organism
Homo sapiens (Human)
Status
Functioni
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 68 | Calcium 3By similarity | 1 | |
Metal bindingi | 72 | Calcium 2By similarity | 1 | |
Metal bindingi | 75 | Calcium 1By similarity | 1 | |
Metal bindingi | 75 | Calcium 2By similarity | 1 | |
Metal bindingi | 81 | Calcium 1By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- hydroxyapatite binding Source: UniProtKB
- structural constituent of bone Source: UniProtKB
- structural molecule activity Source: ProtInc
GO - Biological processi
- bone development Source: Ensembl
- bone mineralization Source: UniProtKB
- cell adhesion Source: UniProtKB
- cell aging Source: Ensembl
- cellular response to growth factor stimulus Source: Ensembl
- cellular response to vitamin D Source: Ensembl
- ER to Golgi vesicle-mediated transport Source: Reactome
- odontogenesis Source: Ensembl
- osteoblast development Source: Ensembl
- osteoblast differentiation Source: BHF-UCL
- peptidyl-glutamic acid carboxylation Source: Reactome
- regulation of bone mineralization Source: InterPro
- regulation of bone resorption Source: UniProtKB
- regulation of osteoclast differentiation Source: UniProtKB
- response to activity Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to gravity Source: Ensembl
- response to hydroxyisoflavone Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to testosterone Source: Ensembl
- response to vitamin D Source: BHF-UCL
- response to vitamin K Source: Ensembl
- response to zinc ion Source: Ensembl
- signal peptide processing Source: Reactome
- skeletal system development Source: ProtInc
Keywordsi
Biological process | Biomineralization |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-8940973 RUNX2 regulates osteoblast differentiation |
SIGNORi | P02818 |
Names & Taxonomyi
Protein namesi | Recommended name: OsteocalcinAlternative name(s): Bone Gla protein Short name: BGP Gamma-carboxyglutamic acid-containing protein |
Gene namesi | Name:BGLAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000242252.1 |
HGNCi | HGNC:1043 BGLAP |
MIMi | 112260 gene |
neXtProti | NX_P02818 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 632 |
OpenTargetsi | ENSG00000242252 |
PharmGKBi | PA25345 |
Chemistry databases
DrugBanki | DB05260 Gallium nitrate DB03847 Gamma-Carboxy-Glutamic Acid DB00170 Menadione DB01022 Phylloquinone |
Polymorphism and mutation databases
BioMutai | BGLAP |
DMDMi | 129253 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | CuratedAdd BLAST | 23 | |
PropeptideiPRO_0000011086 | 24 – 51 | 1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000011087 | 52 – 100 | OsteocalcinAdd BLAST | 49 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 68 | 4-carboxyglutamate; partialPROSITE-ProRule annotation1 Publication | 1 | |
Modified residuei | 72 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 | |
Disulfide bondi | 74 ↔ 80 | |||
Modified residuei | 75 | 4-carboxyglutamatePROSITE-ProRule annotation1 Publication | 1 |
Post-translational modificationi
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 60 | Not hydroxylated1 Publication | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acidProteomic databases
PaxDbi | P02818 |
PeptideAtlasi | P02818 |
PRIDEi | P02818 |
Miscellaneous databases
PMAP-CutDBi | P02818 |
Interactioni
Protein-protein interaction databases
BioGridi | 1071017 interactors. |
IntActi | P02818 1 interactor. |
STRINGi | 9606.ENSP00000357255 |
Structurei
3D structure databases
ProteinModelPortali | P02818 |
SMRi | P02818 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 98 | GlaPROSITE-ProRule annotationAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the osteocalcin/matrix Gla protein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410J11Z Eukaryota ENOG410ZS6W LUCA |
GeneTreei | ENSGT00410000026290 |
HOGENOMi | HOG000115820 |
InParanoidi | P02818 |
OMAi | NCDELAD |
OrthoDBi | EOG091G13UG |
PhylomeDBi | P02818 |
TreeFami | TF330920 |
Family and domain databases
InterProi | View protein in InterPro IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR002384 Osteocalcin/MGP |
PRINTSi | PR00002 GLABONE |
SMARTi | View protein in SMART SM00069 GLA, 1 hit |
SUPFAMi | SSF57630 SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P02818-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR
60 70 80 90 100
RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 – 34 | Missing in CAA27763 (PubMed:3019668).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038743 | 94 | R → Q1 PublicationCorresponds to variant dbSNP:rs34702397Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53698 mRNA Translation: CAA37736.1 X51699 mRNA Translation: CAA35996.1 X04143 Genomic DNA Translation: CAA27763.1 DQ007079 Genomic DNA Translation: AAY16981.1 AL135927 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52986.1 BC113432 mRNA Translation: AAI13433.1 BC113434 mRNA Translation: AAI13435.1 |
CCDSi | CCDS1134.1 |
PIRi | S12652 GEHU |
RefSeqi | NP_954642.1, NM_199173.5 |
UniGenei | Hs.654541 |
Genome annotation databases
Ensembli | ENST00000368272; ENSP00000357255; ENSG00000242252 |
GeneIDi | 632 |
KEGGi | hsa:632 |
UCSCi | uc001fnt.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | OSTCN_HUMAN | |
Accessioni | P02818Primary (citable) accession number: P02818 Secondary accession number(s): Q5TCK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | August 1, 1990 | |
Last modified: | February 28, 2018 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |