BGLAP

Functionⁱ

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	68	Calcium 3By similarity	1
Metal bindingⁱ	72	Calcium 2By similarity	1
Metal bindingⁱ	75	Calcium 1By similarity	1
Metal bindingⁱ	75	Calcium 2By similarity	1
Metal bindingⁱ	81	Calcium 1By similarity	1

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
hydroxyapatite binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
structural constituent of bone
Source: UniProtKB
Non-traceable author statementⁱ
- 12467198
structural molecule activity
Source: ProtInc
Non-traceable author statementⁱ
- 10486212

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone development Source: Ensembl
bone mineralization
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
cell adhesion
Source: UniProtKB
Non-traceable author statementⁱ
- 12202187
cell aging Source: Ensembl
cellular response to growth factor stimulus Source: Ensembl
cellular response to vitamin D Source: Ensembl
ER to Golgi vesicle-mediated transport Source: Reactome
odontogenesis Source: Ensembl
osteoblast development Source: Ensembl
osteoblast differentiation
Source: BHF-UCL
Inferred from expression patternⁱ
- 17023519
peptidyl-glutamic acid carboxylation Source: Reactome
regulation of bone mineralization Source: InterPro
regulation of bone resorption
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
regulation of osteoclast differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
response to activity Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to glucocorticoid Source: Ensembl
response to gravity Source: Ensembl
response to hydroxyisoflavone Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to testosterone Source: Ensembl
response to vitamin D
Source: BHF-UCL
Inferred from expression patternⁱ
- 17023519
response to vitamin K Source: Ensembl
response to zinc ion Source: Ensembl
signal peptide processing Source: Reactome
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 10865224

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Biomineralization
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORⁱ	P02818

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Osteocalcin Alternative name(s): Bone Gla protein Short name: BGP Gamma-carboxyglutamic acid-containing protein
Gene namesⁱ	Name:BGLAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000242252.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1043 BGLAP
MIMⁱ	112260 gene
neXtProtⁱ	NX_P02818

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	632
Open Targets More...OpenTargetsⁱ	ENSG00000242252
PharmGKBⁱ	PA25345

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB05260 Gallium nitrate DB03847 Gamma-Carboxy-Glutamic Acid DB00170 Menadione DB01022 Phylloquinone

DrugBankⁱ

DB05260 Gallium nitrate
DB03847 Gamma-Carboxy-Glutamic Acid
DB00170 Menadione
DB01022 Phylloquinone

Polymorphism and mutation databases

BioMutaⁱ	BGLAP
DMDMⁱ	129253

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	CuratedAdd BLAST	23
PropeptideⁱPRO_0000011086	24 – 51	1 PublicationAdd BLAST	28
ChainⁱPRO_0000011087	52 – 100	OsteocalcinAdd BLAST	49

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	68	4-carboxyglutamate; partialPROSITE-ProRule annotation1 Publication	1
Modified residueⁱ	72	4-carboxyglutamatePROSITE-ProRule annotation1 Publication	1
Disulfide bondⁱ	74 ↔ 80
Modified residueⁱ	75	4-carboxyglutamatePROSITE-ProRule annotation1 Publication	1

Post-translational modificationⁱ

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	60	Not hydroxylated1 Publication		1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbⁱ	P02818
PeptideAtlas More...PeptideAtlasⁱ	P02818
PRIDEⁱ	P02818

Miscellaneous databases

PMAP-CutDBⁱ	P02818

PMAP-CutDBⁱ

P02818

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000242252
CleanExⁱ	HS_BGLAP
Genevisibleⁱ	P02818 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	1071017 interactors.
IntActⁱ	P02818 1 interactor.
STRINGⁱ	9606.ENSP00000357255

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P02818
SMRⁱ	P02818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	52 – 98	GlaPROSITE-ProRule annotationAdd BLAST		47

Sequence similaritiesⁱ

Belongs to the osteocalcin/matrix Gla protein family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J11Z Eukaryota ENOG410ZS6W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000026290
HOGENOMⁱ	HOG000115820
InParanoidⁱ	P02818
OMAⁱ	NCDELAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13UG
PhylomeDBⁱ	P02818
TreeFamⁱ	TF330920

Family and domain databases

InterProⁱ	View protein in InterPro IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR002384 Osteocalcin/MGP
PRINTSⁱ	PR00002 GLABONE
SMARTⁱ	View protein in SMART SM00069 GLA, 1 hit
SUPFAMⁱ	SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02818-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR 
        60         70         80         90        100
RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

Length:100

Mass (Da):10,963

Last modified:August 1, 1990 - v2

Checksum:ⁱ4DF2A0A80849CB71

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	33 – 34	Missing in CAA27763 (PubMed:3019668).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038743	94	R → Q1 PublicationCorresponds to variant dbSNP:rs34702397Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53698 mRNA Translation: CAA37736.1 X51699 mRNA Translation: CAA35996.1 X04143 Genomic DNA Translation: CAA27763.1 DQ007079 Genomic DNA Translation: AAY16981.1 AL135927 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52986.1 BC113432 mRNA Translation: AAI13433.1 BC113434 mRNA Translation: AAI13435.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1134.1
PIRⁱ	S12652 GEHU
NCBI Reference Sequences More...RefSeqⁱ	NP_954642.1, NM_199173.5
UniGeneⁱ	Hs.654541

Genome annotation databases

Ensemblⁱ	ENST00000368272; ENSP00000357255; ENSG00000242252
GeneIDⁱ	632
KEGGⁱ	hsa:632
UCSC genome browser More...UCSCⁱ	uc001fnt.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P02818	P84349 A1YG30	Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo)	100	UniRef100_P02818	Cluster: Osteocalcin	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P02818	P84349 A1YG30 A2D670 A2D4U1 A2T6K4 G7MDZ1 A0A0D9S4Y6 P02819 P84348 P84350 +14	Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo) Macaca mulatta (Rhesus macaque) Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey) Macaca nemestrina (Pig-tailed macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pan troglodytes (Chimpanzee) Pongo pygmaeus (Bornean orangutan) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) And more	100	UniRef90_P02818	Cluster: Osteocalcin	25

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P02818	P84349 A1YG30 A0A2K5PPJ8 A0A2K6QIM5 A0A2K6JMA1 A0A2K5IE86 G7NV82 U3EBX3 P84348 A0A2I3GHP2 +108	Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo) Cebus capucinus imitator Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Colobus angolensis palliatus (Peters' Angolan colobus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	100	UniRef50_P02818	Cluster: Osteocalcin	119

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Osteocalcin entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53698 mRNA Translation: CAA37736.1 X51699 mRNA Translation: CAA35996.1 X04143 Genomic DNA Translation: CAA27763.1 DQ007079 Genomic DNA Translation: AAY16981.1 AL135927 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52986.1 BC113432 mRNA Translation: AAI13433.1 BC113434 mRNA Translation: AAI13435.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1134.1
PIRⁱ	S12652 GEHU
NCBI Reference Sequences More...RefSeqⁱ	NP_954642.1, NM_199173.5
UniGeneⁱ	Hs.654541

3D structure databases

ProteinModelPortalⁱ	P02818
SMRⁱ	P02818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1071017 interactors.
IntActⁱ	P02818 1 interactor.
STRINGⁱ	9606.ENSP00000357255

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB05260 Gallium nitrate DB03847 Gamma-Carboxy-Glutamic Acid DB00170 Menadione DB01022 Phylloquinone

DrugBankⁱ

DB05260 Gallium nitrate
DB03847 Gamma-Carboxy-Glutamic Acid
DB00170 Menadione
DB01022 Phylloquinone

Polymorphism and mutation databases

BioMutaⁱ	BGLAP
DMDMⁱ	129253

Proteomic databases

PaxDbⁱ	P02818
PeptideAtlas More...PeptideAtlasⁱ	P02818
PRIDEⁱ	P02818

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	632
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368272; ENSP00000357255; ENSG00000242252
GeneIDⁱ	632
KEGGⁱ	hsa:632
UCSC genome browser More...UCSCⁱ	uc001fnt.4 human

Organism-specific databases

CTDⁱ	632
DisGeNET More...DisGeNETⁱ	632
EuPathDBⁱ	HostDB:ENSG00000242252.1
GeneCardsⁱ	BGLAP
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1043 BGLAP
MIMⁱ	112260 gene
neXtProtⁱ	NX_P02818
Open Targets More...OpenTargetsⁱ	ENSG00000242252
PharmGKBⁱ	PA25345
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J11Z Eukaryota ENOG410ZS6W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000026290
HOGENOMⁱ	HOG000115820
InParanoidⁱ	P02818
OMAⁱ	NCDELAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13UG
PhylomeDBⁱ	P02818
TreeFamⁱ	TF330920

Enzyme and pathway databases

Reactomeⁱ	R-HSA-159740 Gamma-carboxylation of protein precursors R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORⁱ	P02818

Miscellaneous databases

GeneWikiⁱ	Osteocalcin
GenomeRNAiⁱ	632
PMAP-CutDBⁱ	P02818
Protein Ontology More...PROⁱ	PR:P02818
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000242252
CleanExⁱ	HS_BGLAP
Genevisibleⁱ	P02818 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR002384 Osteocalcin/MGP
PRINTSⁱ	PR00002 GLABONE
SMARTⁱ	View protein in SMART SM00069 GLA, 1 hit
SUPFAMⁱ	SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OSTCN_HUMAN
Accessionⁱ	P02818Primary (citable) accession number: P02818 Secondary accession number(s): Q5TCK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 1, 1990
	Last modified:	February 28, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02818 (OSTCN_HUMAN)

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Osteocalcin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Proteomic databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ