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Protein

Osteocalcin

Gene

BGLAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei60 – 601Not hydroxylated
Metal bindingi68 – 681Calcium 3By similarity
Metal bindingi72 – 721Calcium 2By similarity
Metal bindingi75 – 751Calcium 1By similarity
Metal bindingi75 – 751Calcium 2By similarity
Metal bindingi81 – 811Calcium 1By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. hydroxyapatite binding Source: UniProtKB
  3. structural constituent of bone Source: UniProtKB
  4. structural molecule activity Source: ProtInc

GO - Biological processi

  1. bone development Source: Ensembl
  2. bone mineralization Source: UniProtKB
  3. cell adhesion Source: UniProtKB
  4. cell aging Source: Ensembl
  5. cellular response to growth factor stimulus Source: Ensembl
  6. cellular response to vitamin D Source: Ensembl
  7. odontogenesis Source: Ensembl
  8. osteoblast development Source: Ensembl
  9. osteoblast differentiation Source: BHF-UCL
  10. regulation of bone mineralization Source: InterPro
  11. regulation of bone resorption Source: UniProtKB
  12. regulation of osteoclast differentiation Source: UniProtKB
  13. response to activity Source: Ensembl
  14. response to drug Source: Ensembl
  15. response to estrogen Source: Ensembl
  16. response to ethanol Source: Ensembl
  17. response to glucocorticoid Source: Ensembl
  18. response to gravity Source: Ensembl
  19. response to hydroxyisoflavone Source: Ensembl
  20. response to mechanical stimulus Source: Ensembl
  21. response to testosterone Source: Ensembl
  22. response to vitamin D Source: BHF-UCL
  23. response to vitamin K Source: Ensembl
  24. response to zinc ion Source: Ensembl
  25. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1043. BGLAP.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. dendrite Source: Ensembl
  3. extracellular space Source: Ensembl
  4. Golgi apparatus Source: Ensembl
  5. membrane-bounded vesicle Source: Ensembl
  6. perikaryon Source: Ensembl
  7. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 51281 PublicationPRO_0000011086Add
BLAST
Chaini52 – 10049OsteocalcinPRO_0000011087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 6814-carboxyglutamate; partial1 PublicationPROSITE-ProRule annotation
Modified residuei72 – 7214-carboxyglutamate1 PublicationPROSITE-ProRule annotation
Disulfide bondi74 ↔ 80
Modified residuei75 – 7514-carboxyglutamate1 PublicationPROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.1 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP02818.
PeptideAtlasiP02818.
PRIDEiP02818.

Miscellaneous databases

PMAP-CutDBP02818.

Expressioni

Gene expression databases

BgeeiP02818.
CleanExiHS_BGLAP.
GenevestigatoriP02818.

Interactioni

Protein-protein interaction databases

BioGridi107101. 1 interaction.
STRINGi9606.ENSP00000357255.

Structurei

3D structure databases

ProteinModelPortaliP02818.
SMRiP02818. Positions 68-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 9847GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72046.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP02818.
OMAiPKREVCE.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP02818.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR
60 70 80 90 100
RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):10,963
Last modified:August 1, 1990 - v2
Checksum:i4DF2A0A80849CB71
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 342Missing in CAA27763 (PubMed:3019668).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941R → Q.1 Publication
Corresponds to variant rs34702397 [ dbSNP | Ensembl ].
VAR_038743

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53698 mRNA. Translation: CAA37736.1.
X51699 mRNA. Translation: CAA35996.1.
X04143 Genomic DNA. Translation: CAA27763.1.
DQ007079 Genomic DNA. Translation: AAY16981.1.
AL135927 Genomic DNA. Translation: CAI15541.1.
CH471121 Genomic DNA. Translation: EAW52986.1.
BC113432 mRNA. Translation: AAI13433.1.
BC113434 mRNA. Translation: AAI13435.1.
CCDSiCCDS1134.1.
PIRiS12652. GEHU.
RefSeqiNP_954642.1. NM_199173.4.
UniGeneiHs.654541.

Genome annotation databases

EnsembliENST00000368272; ENSP00000357255; ENSG00000242252.
GeneIDi632.
KEGGihsa:632.
UCSCiuc001fnt.3. human.

Polymorphism databases

DMDMi129253.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Osteocalcin entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53698 mRNA. Translation: CAA37736.1.
X51699 mRNA. Translation: CAA35996.1.
X04143 Genomic DNA. Translation: CAA27763.1.
DQ007079 Genomic DNA. Translation: AAY16981.1.
AL135927 Genomic DNA. Translation: CAI15541.1.
CH471121 Genomic DNA. Translation: EAW52986.1.
BC113432 mRNA. Translation: AAI13433.1.
BC113434 mRNA. Translation: AAI13435.1.
CCDSiCCDS1134.1.
PIRiS12652. GEHU.
RefSeqiNP_954642.1. NM_199173.4.
UniGeneiHs.654541.

3D structure databases

ProteinModelPortaliP02818.
SMRiP02818. Positions 68-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107101. 1 interaction.
STRINGi9606.ENSP00000357255.

Chemistry

DrugBankiDB05260. Gallium nitrate.
DB00170. Menadione.
DB01022. Phylloquinone.

Polymorphism databases

DMDMi129253.

Proteomic databases

PaxDbiP02818.
PeptideAtlasiP02818.
PRIDEiP02818.

Protocols and materials databases

DNASUi632.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368272; ENSP00000357255; ENSG00000242252.
GeneIDi632.
KEGGihsa:632.
UCSCiuc001fnt.3. human.

Organism-specific databases

CTDi632.
GeneCardsiGC01P156211.
HGNCiHGNC:1043. BGLAP.
MIMi112260. gene.
neXtProtiNX_P02818.
PharmGKBiPA25345.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72046.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
InParanoidiP02818.
OMAiPKREVCE.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP02818.
TreeFamiTF330920.

Miscellaneous databases

GeneWikiiOsteocalcin.
GenomeRNAii632.
NextBioi2554.
PMAP-CutDBP02818.
PROiP02818.
SOURCEiSearch...

Gene expression databases

BgeeiP02818.
CleanExiHS_BGLAP.
GenevestigatoriP02818.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cDNA and derived amino acid sequences of human and bovine bone Gla protein."
    Kiefer M.C., Saphire A.C.S., Bauer D.M., Barr P.J.
    Nucleic Acids Res. 18:1909-1909(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones."
    Celeste A.J., Buecker J.L., Kriz R., Wang E.A., Wozney J.M.
    EMBO J. 5:1885-1890(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. SeattleSNPs variation discovery resource
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-94.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue."
    Poser J.W., Esch F.S., Ling N.C., Price P.A.
    J. Biol. Chem. 255:8685-8691(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 52-100, GAMMA-CARBOXYGLUTAMATION AT GLU-68; GLU-72 AND GLU-75, ABSENCE OF HYDROXYLATION AT PRO-60.

Entry informationi

Entry nameiOSTCN_HUMAN
AccessioniPrimary (citable) accession number: P02818
Secondary accession number(s): Q5TCK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: January 7, 2015
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.