BGLAP

Functionⁱ

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	68	Calcium 3By similarity	1
Metal bindingⁱ	72	Calcium 2By similarity	1
Metal bindingⁱ	75	Calcium 1By similarity	1
Metal bindingⁱ	75	Calcium 2By similarity	1
Metal bindingⁱ	81	Calcium 1By similarity	1

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
hydroxyapatite binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
structural constituent of bone
Source: UniProtKB
Non-traceable author statementⁱ
- 12467198
structural molecule activity
Source: ProtInc
Non-traceable author statementⁱ
- 10486212

Complete GO annotation...

GO - Biological processⁱ

bone development Source: Ensembl
bone mineralization
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
cell adhesion
Source: UniProtKB
Non-traceable author statementⁱ
- 12202187
cell aging Source: Ensembl
cellular response to growth factor stimulus Source: Ensembl
cellular response to vitamin D Source: Ensembl
ER to Golgi vesicle-mediated transport Source: Reactome
odontogenesis Source: Ensembl
osteoblast development Source: Ensembl
osteoblast differentiation
Source: BHF-UCL
Inferred from expression patternⁱ
- 17023519
peptidyl-glutamic acid carboxylation Source: Reactome
regulation of bone mineralization Source: InterPro
regulation of bone resorption
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
regulation of osteoclast differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 10486212
response to activity Source: Ensembl
response to drug Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to glucocorticoid Source: Ensembl
response to gravity Source: Ensembl
response to hydroxyisoflavone Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to testosterone Source: Ensembl
response to vitamin D
Source: BHF-UCL
Inferred from expression patternⁱ
- 17023519
response to vitamin K Source: Ensembl
response to zinc ion Source: Ensembl
signal peptide processing Source: Reactome
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 10865224

Complete GO annotation...

Keywordsⁱ

Biological process	Biomineralization
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-159740. Gamma-carboxylation of protein precursors. R-HSA-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus. R-HSA-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
SIGNORⁱ	P02818.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Osteocalcin Alternative name(s): Bone Gla protein Short name: BGP Gamma-carboxyglutamic acid-containing protein
Gene namesⁱ	Name:BGLAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1043. BGLAP.

HGNCⁱ

HGNC:1043. BGLAP.

Subcellular locationⁱ

Secreted

GO - Cellular componentⁱ

cytoplasm
Source: UniProtKB
Inferred from direct assayⁱ
- 11856645
dendrite Source: Ensembl
endoplasmic reticulum lumen Source: Reactome
extracellular space Source: Ensembl
Golgi lumen Source: Reactome
perikaryon Source: Ensembl
rough endoplasmic reticulum Source: Ensembl
vesicle Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	632.
Open Targets More...OpenTargetsⁱ	ENSG00000242252.
PharmGKBⁱ	PA25345.

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB05260. Gallium nitrate. DB03847. Gamma-Carboxy-Glutamic Acid. DB00170. Menadione. DB01022. Phylloquinone.

DrugBankⁱ

DB05260. Gallium nitrate.
DB03847. Gamma-Carboxy-Glutamic Acid.
DB00170. Menadione.
DB01022. Phylloquinone.

Polymorphism and mutation databases

BioMutaⁱ	BGLAP.
DMDMⁱ	129253.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	CuratedAdd BLAST	23
PropeptideⁱPRO_0000011086	24 – 51	1 PublicationAdd BLAST	28
ChainⁱPRO_0000011087	52 – 100	OsteocalcinAdd BLAST	49

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	68	4-carboxyglutamate; partialPROSITE-ProRule annotation1 Publication	1
Modified residueⁱ	72	4-carboxyglutamatePROSITE-ProRule annotation1 Publication	1
Disulfide bondⁱ	74 ↔ 80
Modified residueⁱ	75	4-carboxyglutamatePROSITE-ProRule annotation1 Publication	1

Post-translational modificationⁱ

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	60	Not hydroxylated1 Publication		1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbⁱ	P02818.
PeptideAtlas More...PeptideAtlasⁱ	P02818.
PRIDEⁱ	P02818.

Miscellaneous databases

PMAP-CutDBⁱ	P02818.

PMAP-CutDBⁱ

P02818.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000242252.
CleanExⁱ	HS_BGLAP.
Genevisibleⁱ	P02818. HS.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107101. 7 interactors.
IntActⁱ	P02818. 1 interactor.
STRINGⁱ	9606.ENSP00000357255.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P02818.
SMRⁱ	P02818.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	52 – 98	GlaPROSITE-ProRule annotationAdd BLAST		47

Sequence similaritiesⁱ

Belongs to the osteocalcin/matrix Gla protein family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J11Z. Eukaryota. ENOG410ZS6W. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000026290.
HOGENOMⁱ	HOG000115820.
InParanoidⁱ	P02818.
OMAⁱ	NCDELAD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13UG.
PhylomeDBⁱ	P02818.
TreeFamⁱ	TF330920.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000294. GLA_domain. IPR002384. Osteocalcin/MGP.
PRINTSⁱ	PR00002. GLABONE.
SMARTⁱ	View protein in SMART SM00069. GLA. 1 hit.
SUPFAMⁱ	SSF57630. SSF57630. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00011. GLA_1. 1 hit. PS50998. GLA_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P02818-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR 
        60         70         80         90        100
RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

Length:100

Mass (Da):10,963

Last modified:August 1, 1990 - v2

Checksum:ⁱ4DF2A0A80849CB71

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	33 – 34	Missing in CAA27763 (PubMed:3019668).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038743	94	R → Q1 PublicationCorresponds to variant dbSNP:rs34702397Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53698 mRNA. Translation: CAA37736.1. X51699 mRNA. Translation: CAA35996.1. X04143 Genomic DNA. Translation: CAA27763.1. DQ007079 Genomic DNA. Translation: AAY16981.1. AL135927 Genomic DNA. No translation available. CH471121 Genomic DNA. Translation: EAW52986.1. BC113432 mRNA. Translation: AAI13433.1. BC113434 mRNA. Translation: AAI13435.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1134.1.
PIRⁱ	S12652. GEHU.
NCBI Reference Sequences More...RefSeqⁱ	NP_954642.1. NM_199173.5.
UniGeneⁱ	Hs.654541.

Genome annotation databases

Ensemblⁱ	ENST00000368272; ENSP00000357255; ENSG00000242252.
GeneIDⁱ	632.
KEGGⁱ	hsa:632.
UCSC genome browser More...UCSCⁱ	uc001fnt.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P02818	P84349 A1YG30	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo)	100	UniRef100_P02818	Cluster: Osteocalcin	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P02818	P84349 A1YG30 A2D670 A2D4U1 A2T6K4 G7MDZ1 A0A0D9S4Y6 P02819 P84348 P84350 +10	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo) Macaca mulatta (Rhesus macaque) Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey) Macaca nemestrina (Pig-tailed macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pan troglodytes (Chimpanzee) Pongo pygmaeus (Bornean orangutan) And more	100	UniRef90_P02818	Cluster: Osteocalcin	21

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P02818	P04640 L9KAX9 UPI0003315177 B7ZS46 P40147 UPI00074FF2B5 P02820 UPI00042CD2A3 UPI00084705C3 UPI000A1B8103 +100	Rattus norvegicus (Rat) Tupaia chinensis (Chinese tree shrew) Sorex araneus (Eurasian common shrew) (European shrew) Xenopus laevis (African clawed frog) Gekko japonicus (Schlegel's Japanese gecko) Bos taurus (Bovine) Bubalus bubalis (Domestic water buffalo) Capra hircus (Goat) Odocoileus virginianus texanus Bison bison bison And more	99	UniRef50_P04640	Cluster: Osteocalcin	111

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Osteocalcin entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53698 mRNA. Translation: CAA37736.1. X51699 mRNA. Translation: CAA35996.1. X04143 Genomic DNA. Translation: CAA27763.1. DQ007079 Genomic DNA. Translation: AAY16981.1. AL135927 Genomic DNA. No translation available. CH471121 Genomic DNA. Translation: EAW52986.1. BC113432 mRNA. Translation: AAI13433.1. BC113434 mRNA. Translation: AAI13435.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1134.1.
PIRⁱ	S12652. GEHU.
NCBI Reference Sequences More...RefSeqⁱ	NP_954642.1. NM_199173.5.
UniGeneⁱ	Hs.654541.

3D structure databases

ProteinModelPortalⁱ	P02818.
SMRⁱ	P02818.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107101. 7 interactors.
IntActⁱ	P02818. 1 interactor.
STRINGⁱ	9606.ENSP00000357255.

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB05260. Gallium nitrate. DB03847. Gamma-Carboxy-Glutamic Acid. DB00170. Menadione. DB01022. Phylloquinone.

DrugBankⁱ

DB05260. Gallium nitrate.
DB03847. Gamma-Carboxy-Glutamic Acid.
DB00170. Menadione.
DB01022. Phylloquinone.

Polymorphism and mutation databases

BioMutaⁱ	BGLAP.
DMDMⁱ	129253.

Proteomic databases

PaxDbⁱ	P02818.
PeptideAtlas More...PeptideAtlasⁱ	P02818.
PRIDEⁱ	P02818.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	632.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368272; ENSP00000357255; ENSG00000242252.
GeneIDⁱ	632.
KEGGⁱ	hsa:632.
UCSC genome browser More...UCSCⁱ	uc001fnt.4. human.

Organism-specific databases

CTDⁱ	632.
DisGeNET More...DisGeNETⁱ	632.
GeneCardsⁱ	BGLAP.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1043. BGLAP.
MIMⁱ	112260. gene.
neXtProtⁱ	NX_P02818.
Open Targets More...OpenTargetsⁱ	ENSG00000242252.
PharmGKBⁱ	PA25345.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J11Z. Eukaryota. ENOG410ZS6W. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000026290.
HOGENOMⁱ	HOG000115820.
InParanoidⁱ	P02818.
OMAⁱ	NCDELAD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13UG.
PhylomeDBⁱ	P02818.
TreeFamⁱ	TF330920.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-159740. Gamma-carboxylation of protein precursors. R-HSA-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus. R-HSA-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.
SIGNORⁱ	P02818.

Miscellaneous databases

GeneWikiⁱ	Osteocalcin.
GenomeRNAiⁱ	632.
PMAP-CutDBⁱ	P02818.
Protein Ontology More...PROⁱ	PR:P02818.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000242252.
CleanExⁱ	HS_BGLAP.
Genevisibleⁱ	P02818. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000294. GLA_domain. IPR002384. Osteocalcin/MGP.
PRINTSⁱ	PR00002. GLABONE.
SMARTⁱ	View protein in SMART SM00069. GLA. 1 hit.
SUPFAMⁱ	SSF57630. SSF57630. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00011. GLA_1. 1 hit. PS50998. GLA_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OSTCN_HUMAN
Accessionⁱ	P02818Primary (citable) accession number: P02818 Secondary accession number(s): Q5TCK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 1, 1990
	Last modified:	August 30, 2017
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02818 (OSTCN_HUMAN)

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Osteocalcin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Proteomic databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ