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Protein

Submaxillary gland androgen-regulated protein 3B

Gene

SMR3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Submaxillary gland androgen-regulated protein 3B
Alternative name(s):
Proline-rich peptide P-B
Proline-rich protein 3
Cleaved into the following 2 chains:
Gene namesi
Name:SMR3B
Synonyms:PBII, PRL3, PROL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17326. SMR3B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33805.

Polymorphism and mutation databases

BioMutaiSMR3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 7957Submaxillary gland androgen-regulated protein 3BPRO_0000022112Add
BLAST
Peptidei30 – 4314Peptide D1APRO_0000022113Add
BLAST
Peptidei42 – 7938Peptide P-APRO_0000022114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Pyrrolidone carboxylic acid1 Publication

Post-translational modificationi

P-A and D1A are probably degradation products of P-B.

Keywords - PTMi

Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP02814.
PaxDbiP02814.
PeptideAtlasiP02814.
PRIDEiP02814.
TopDownProteomicsiP02814.

Expressioni

Tissue specificityi

Secreted into saliva by submaxillary gland. Not expressed in heart, brain, lung, liver, skeletal muscle, Kidney, pancreas or placenta.1 Publication

Gene expression databases

BgeeiP02814.
CleanExiHS_SMR3B.
GenevisibleiP02814. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-738612,EBI-741480
UBQLN1Q9UMX0-23EBI-738612,EBI-10173939

Protein-protein interaction databases

BioGridi116087. 7 interactions.
IntActiP02814. 4 interactions.
STRINGi9606.ENSP00000302400.

Structurei

3D structure databases

ProteinModelPortaliP02814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 7954Pro-richAdd
BLAST
Compositional biasi47 – 537Poly-Pro
Compositional biasi60 – 667Poly-Pro
Compositional biasi73 – 797Poly-Pro

Sequence similaritiesi

Belongs to the PROL1/PROL3 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00770000120960.
HOVERGENiHBG093969.
InParanoidiP02814.
OMAiPYGPGIF.

Family and domain databases

InterProiIPR026288. SMR-like.
[Graphical view]
PANTHERiPTHR14179. PTHR14179. 1 hit.
PfamiPF15621. PROL5-SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPQP FGPGFVPPPP
60 70
PPPYGPGRIP PPPPAPYGPG IFPPPPPQP
Length:79
Mass (Da):8,188
Last modified:May 27, 2002 - v2
Checksum:i7B10AE90E95BCB61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29833 mRNA. Translation: BAA06213.1.
AB031740 Genomic DNA. Translation: BAA88517.1.
CH471057 Genomic DNA. Translation: EAX05619.1.
BC015327 mRNA. Translation: AAH15327.1.
BC144529 mRNA. Translation: AAI44530.1.
CCDSiCCDS3540.1.
PIRiJX0321. PJHUSB.
RefSeqiNP_006676.1. NM_006685.3.
UniGeneiHs.650650.

Genome annotation databases

EnsembliENST00000304915; ENSP00000302400; ENSG00000171201.
ENST00000504825; ENSP00000423138; ENSG00000171201.
ENST00000614072; ENSP00000481313; ENSG00000171201.
GeneIDi10879.
KEGGihsa:10879.
UCSCiuc003hfh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29833 mRNA. Translation: BAA06213.1.
AB031740 Genomic DNA. Translation: BAA88517.1.
CH471057 Genomic DNA. Translation: EAX05619.1.
BC015327 mRNA. Translation: AAH15327.1.
BC144529 mRNA. Translation: AAI44530.1.
CCDSiCCDS3540.1.
PIRiJX0321. PJHUSB.
RefSeqiNP_006676.1. NM_006685.3.
UniGeneiHs.650650.

3D structure databases

ProteinModelPortaliP02814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116087. 7 interactions.
IntActiP02814. 4 interactions.
STRINGi9606.ENSP00000302400.

Polymorphism and mutation databases

BioMutaiSMR3B.

Proteomic databases

MaxQBiP02814.
PaxDbiP02814.
PeptideAtlasiP02814.
PRIDEiP02814.
TopDownProteomicsiP02814.

Protocols and materials databases

DNASUi10879.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304915; ENSP00000302400; ENSG00000171201.
ENST00000504825; ENSP00000423138; ENSG00000171201.
ENST00000614072; ENSP00000481313; ENSG00000171201.
GeneIDi10879.
KEGGihsa:10879.
UCSCiuc003hfh.3. human.

Organism-specific databases

CTDi10879.
GeneCardsiSMR3B.
H-InvDBHIX0037114.
HGNCiHGNC:17326. SMR3B.
MIMi611593. gene.
neXtProtiNX_P02814.
PharmGKBiPA33805.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00770000120960.
HOVERGENiHBG093969.
InParanoidiP02814.
OMAiPYGPGIF.

Miscellaneous databases

ChiTaRSiSMR3B. human.
GenomeRNAii10879.
NextBioi41311.
PROiP02814.
SOURCEiSearch...

Gene expression databases

BgeeiP02814.
CleanExiHS_SMR3B.
GenevisibleiP02814. HS.

Family and domain databases

InterProiIPR026288. SMR-like.
[Graphical view]
PANTHERiPTHR14179. PTHR14179. 1 hit.
PfamiPF15621. PROL5-SMR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequence analysis of cDNA coding for the precursor of the human salivary proline-rich peptide P-B."
    Isemura S., Saito E.
    J. Biochem. 115:1101-1106(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Submandibular gland.
  2. "Nucleotide sequence of gene PBII encoding salivary proline-rich protein P-B."
    Isemura S.
    J. Biochem. 127:393-398(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Duodenum.
  5. "Isolation and amino acid sequences of proline-rich peptides of human whole saliva."
    Isemura S., Saitoh E., Sanada K.
    J. Biochem. 86:79-86(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-79, PYROGLUTAMATE FORMATION AT GLN-23.
    Tissue: Saliva.
  6. "Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva."
    Ramasubbu N., Reddy M.S., Bergey E.J., Haraszthy G.G., Soni S.-D., Levine M.J.
    Biochem. J. 280:341-352(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-43.
    Tissue: Saliva.

Entry informationi

Entry nameiSMR3B_HUMAN
AccessioniPrimary (citable) accession number: P02814
Secondary accession number(s): B7ZMG7, Q9UBN0, Q9UCT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 27, 2002
Last modified: March 16, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.