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Protein

Salivary acidic proline-rich phosphoprotein 1/2

Gene

PRH1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Enzyme and pathway databases

SIGNORiP02810.

Names & Taxonomyi

Protein namesi
Recommended name:
Salivary acidic proline-rich phosphoprotein 1/2
Alternative name(s):
Db-s
PRP-1/PRP-2
Parotid acidic protein
Short name:
Pa
Parotid double-band protein
Parotid isoelectric focusing variant protein
Short name:
PIF-S
Parotid proline-rich protein 1/2
Pr1/Pr2
Protein C
Cleaved into the following 3 chains:
Gene namesi
Name:PRH1
AND
Name:PRH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9366. PRH1.
HGNC:9367. PRH2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi24 – 241S → A: Decreased phosphorylation by FAM20C; when associated with A-38. 1 Publication
Mutagenesisi38 – 381S → A: Decreased phosphorylation by FAM20C; when associated with A-24. 1 Publication

Organism-specific databases

PharmGKBiPA33738.

Polymorphism and mutation databases

BioMutaiPRH1.
DMDMi131008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16167 PublicationsAdd
BLAST
Chaini17 – 166150Salivary acidic proline-rich phosphoprotein 1/2PRO_0000022137Add
BLAST
Chaini17 – 122106Salivary acidic proline-rich phosphoprotein 3/4PRO_0000022138Add
BLAST
Chaini123 – 16644Peptide P-CPRO_0000022139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Pyrrolidone carboxylic acid1 Publication
Modified residuei24 – 241Phosphoserine; by FAM20C3 Publications
Modified residuei33 – 331Phosphoserine; alternate1 Publication
Glycosylationi33 – 331O-linked (GlcA); alternate1 Publication
Modified residuei38 – 381Phosphoserine; by FAM20C; alternate4 Publications
Glycosylationi38 – 381O-linked (GlcA); alternate1 Publication

Post-translational modificationi

Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.1 Publication
An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP02810.
MaxQBiP02810.
PaxDbiP02810.
PeptideAtlasiP02810.
PRIDEiP02810.
TopDownProteomicsiP02810.

PTM databases

iPTMnetiP02810.
PhosphoSiteiP02810.

Expressioni

Gene expression databases

BgeeiENSG00000134551.
CleanExiHS_PRH2.
GenevisibleiP02810. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MUC7Q8TAX72EBI-738601,EBI-738582

Protein-protein interaction databases

IntActiP02810. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP02810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 4630Inhibits hydroxyapatite formation, binds to hydroxyapatite and calciumAdd
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IUYX. Eukaryota.
ENOG4110PRV. LUCA.
InParanoidiP02810.
KOiK13910.
OrthoDBiEOG091G1ACT.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 1 hit.
[Graphical view]
SMARTiSM01412. Pro-rich. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLILLSVAL LAFSSAQDLD EDVSQEDVPL VISDGGDSEQ FIDEERQGPP
60 70 80 90 100
LGGQQSQPSA GDGNQDDGPQ QGPPQQGGQQ QQGPPPPQGK PQGPPQQGGH
110 120 130 140 150
PPPPQGRPQG PPQQGGHPRP PRGRPQGPPQ QGGHQQGPPP PPPGKPQGPP
160
PQGGRPQGPP QGQSPQ
Length:166
Mass (Da):17,016
Last modified:July 1, 1989 - v2
Checksum:iA7DF62BF94E3C3EF
GO

Sequence cautioni

The sequence AAI28193 differs from that shown. Reason: Erroneous termination at position 167. Translated as stop.Curated
The sequence AAI41917 differs from that shown. Reason: Erroneous termination at position 167. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411F → P AA sequence (Ref. 11) Curated

Polymorphismi

Sequence shown is that of allele PRH2-2, also known as PR-2; Allele PRH2-1 is also known as PR-1 or protein C, and allele PRH2-3 as PR-1'. The PRH1-DB allele (about 16% of the population) has an insertion of 21 repeated amino acids compared to the more frequent PRH1-PIF allele (68%). In contrast to all other PRH1 and PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201D → N in allele PRH1-PIF, allele PRH1-PA and allele PRH1-DB.
Corresponds to variant rs1130404 [ dbSNP | Ensembl ].
VAR_005563
Natural varianti42 – 421I → L in allele PRH1-PA and allele PRH1-DB.
Corresponds to variant rs2923234 [ dbSNP | Ensembl ].
VAR_023240
Natural varianti66 – 661D → N in allele PRH2-1. 1 Publication
Corresponds to variant rs1049112 [ dbSNP | Ensembl ].
VAR_005564
Natural varianti97 – 971Q → QGGQQQQGPPPPQGKPQGPP QQ in allele PRH1-DB.
VAR_023241
Natural varianti119 – 1191R → C in allele PRH1-PA; interferes with proteolytic cleavage at Arg-122.
VAR_023242
Natural varianti163 – 1631Q → K in allele PRH2-3. 1 Publication
Corresponds to variant rs74062407 [ dbSNP | Ensembl ].
VAR_005565

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03202 mRNA. Translation: AAA60183.1.
K03203 mRNA. Translation: AAA60184.1.
M13057 Genomic DNA. Translation: AAA98807.1.
M13058 Genomic DNA. Translation: AAA98808.1.
BX641094 mRNA. Translation: CAE46044.1.
CH471094 Genomic DNA. Translation: EAW96214.1.
CH471094 Genomic DNA. Translation: EAW96219.1.
BC095488 mRNA. Translation: AAH95488.1.
BC128192 mRNA. Translation: AAI28193.1. Sequence problems.
BC133676 mRNA. Translation: AAI33677.1.
BC136499 mRNA. Translation: AAI36500.1.
BC141916 mRNA. Translation: AAI41917.1. Sequence problems.
CCDSiCCDS8636.1.
PIRiA25372. PIHUSC.
B25372.
RefSeqiNP_001103683.1. NM_001110213.1.
NP_001278243.1. NM_001291314.1.
NP_001278244.1. NM_001291315.1.
UniGeneiHs.408153.
Hs.656965.
Hs.731575.

Genome annotation databases

EnsembliENST00000381847; ENSP00000371271; ENSG00000134551.
ENST00000396400; ENSP00000379682; ENSG00000134551.
ENST00000572141; ENSP00000458690; ENSG00000272803.
ENST00000575657; ENSP00000461041; ENSG00000272803.
ENST00000622570; ENSP00000481810; ENSG00000275679.
ENST00000622848; ENSP00000483458; ENSG00000275679.
GeneIDi5554.
5555.
KEGGihsa:5554.
hsa:5555.
UCSCiuc001qzi.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03202 mRNA. Translation: AAA60183.1.
K03203 mRNA. Translation: AAA60184.1.
M13057 Genomic DNA. Translation: AAA98807.1.
M13058 Genomic DNA. Translation: AAA98808.1.
BX641094 mRNA. Translation: CAE46044.1.
CH471094 Genomic DNA. Translation: EAW96214.1.
CH471094 Genomic DNA. Translation: EAW96219.1.
BC095488 mRNA. Translation: AAH95488.1.
BC128192 mRNA. Translation: AAI28193.1. Sequence problems.
BC133676 mRNA. Translation: AAI33677.1.
BC136499 mRNA. Translation: AAI36500.1.
BC141916 mRNA. Translation: AAI41917.1. Sequence problems.
CCDSiCCDS8636.1.
PIRiA25372. PIHUSC.
B25372.
RefSeqiNP_001103683.1. NM_001110213.1.
NP_001278243.1. NM_001291314.1.
NP_001278244.1. NM_001291315.1.
UniGeneiHs.408153.
Hs.656965.
Hs.731575.

3D structure databases

ProteinModelPortaliP02810.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02810. 3 interactions.

PTM databases

iPTMnetiP02810.
PhosphoSiteiP02810.

Polymorphism and mutation databases

BioMutaiPRH1.
DMDMi131008.

Proteomic databases

EPDiP02810.
MaxQBiP02810.
PaxDbiP02810.
PeptideAtlasiP02810.
PRIDEiP02810.
TopDownProteomicsiP02810.

Protocols and materials databases

DNASUi5554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381847; ENSP00000371271; ENSG00000134551.
ENST00000396400; ENSP00000379682; ENSG00000134551.
ENST00000572141; ENSP00000458690; ENSG00000272803.
ENST00000575657; ENSP00000461041; ENSG00000272803.
ENST00000622570; ENSP00000481810; ENSG00000275679.
ENST00000622848; ENSP00000483458; ENSG00000275679.
GeneIDi5554.
5555.
KEGGihsa:5554.
hsa:5555.
UCSCiuc001qzi.5. human.

Organism-specific databases

CTDi5554.
5555.
GeneCardsiPRH1.
PRH2.
H-InvDBHIX0026359.
HIX0026397.
HIX0079411.
HGNCiHGNC:9366. PRH1.
HGNC:9367. PRH2.
MIMi168730. gene.
168790. gene.
neXtProtiNX_P02810.
PharmGKBiPA33738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUYX. Eukaryota.
ENOG4110PRV. LUCA.
InParanoidiP02810.
KOiK13910.
OrthoDBiEOG091G1ACT.

Enzyme and pathway databases

SIGNORiP02810.

Miscellaneous databases

GeneWikiiPRH1.
PROiP02810.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134551.
CleanExiHS_PRH2.
GenevisibleiP02810. HS.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 1 hit.
[Graphical view]
SMARTiSM01412. Pro-rich. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRPC_HUMAN
AccessioniPrimary (citable) accession number: P02810
Secondary accession number(s): A2VCM0
, A3KN66, A5D902, B2RMW2, Q4VBP2, Q53XA2, Q6P2F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.