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Protein

Statherin

Gene

STATH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.

GO - Molecular functioni

  • extracellular matrix constituent, lubricant activity Source: UniProtKB
  • hydroxyapatite binding Source: UniProtKB
  • structural constituent of tooth enamel Source: UniProtKB

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • defense response to bacterium Source: InterPro
  • negative regulation of bone mineralization Source: UniProtKB
  • ossification Source: ProtInc
  • saliva secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126549-MONOMER.

Protein family/group databases

TCDBi1.C.79.1.2. the channel-forming histatin antimicrobial peptide (histatin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Statherin
Gene namesi
Name:STATH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:11369. STATH.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6779.
OpenTargetsiENSG00000126549.
ENSG00000282891.
PharmGKBiPA36187.

Polymorphism and mutation databases

BioMutaiSTATH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000002242220 – 62StatherinAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Phosphoserine1 Publication1
Modified residuei22Phosphoserine1 Publication1
Cross-linki25 ↔ 58Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-39
Cross-linki25 ↔ 56Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-37

Post-translational modificationi

Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva.
Sulfated on tyrosine residues.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiP02808.
PaxDbiP02808.
PeptideAtlasiP02808.
PRIDEiP02808.
TopDownProteomicsiP02808-1. [P02808-1]
P02808-2. [P02808-2]

PTM databases

iPTMnetiP02808.
PhosphoSitePlusiP02808.

Expressioni

Tissue specificityi

Secreted by parotid and submandibular glands.

Gene expression databases

BgeeiENSG00000126549.
CleanExiHS_STATH.
GenevisibleiP02808. HS.

Organism-specific databases

HPAiHPA044569.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MUC7Q8TAX72EBI-738687,EBI-738582

Protein-protein interaction databases

BioGridi112656. 3 interactors.
IntActiP02808. 1 interactor.
STRINGi9606.ENSP00000246895.

Structurei

3D structure databases

ProteinModelPortaliP02808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 25Hydroxyapatite-binding; inhibits crystal growth6
Regioni38 – 62Hydrophobic; inhibits precipitation of calcium phosphate saltsAdd BLAST25

Sequence similaritiesi

Belongs to the histatin/statherin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KCI1. Eukaryota.
ENOG4110NY1. LUCA.
GeneTreeiENSGT00390000011757.
HOGENOMiHOG000293326.
InParanoidiP02808.
KOiK13914.
OMAiGPYQPFV.
OrthoDBiEOG091G1BYD.
PhylomeDBiP02808.
TreeFamiTF341588.

Family and domain databases

InterProiIPR030773. Histatin/statherin.
IPR005575. Statherin.
[Graphical view]
PANTHERiPTHR15057. PTHR15057. 1 hit.
PfamiPF03875. Statherin. 1 hit.
[Graphical view]
PIRSFiPIRSF002565. Statherin. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Both isoforms can occur with the Phe-62 deletion.
Isoform 1 (identifier: P02808-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFLVFAFIL ALMVSMIGAD SSEEKFLRRI GRFGYGYGPY QPVPEQPLYP
60
QPYQPQYQQY TF
Length:62
Mass (Da):7,304
Last modified:July 1, 1989 - v2
Checksum:iCFE32EC235CA3A22
GO
Isoform 2 (identifier: P02808-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-34: Missing.

Show »
Length:52
Mass (Da):6,073
Checksum:iC94F2FE112DAA733
GO

Mass spectrometryi

Molecular mass is 5380.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22.1 Publication
Molecular mass is 5363.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22 and transglutamine cross-link.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06906562Missing .1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04574425 – 34Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18078 mRNA. Translation: AAA60594.1.
M18371 mRNA. Translation: AAA60600.1.
M32639 Genomic DNA. Translation: AAA60593.1.
AK311812 mRNA. Translation: BAG34755.1.
AC063956 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05604.1.
CH471057 Genomic DNA. Translation: EAX05605.1.
BC067219 mRNA. Translation: AAH67219.1.
CCDSiCCDS33998.1. [P02808-2]
CCDS3533.1. [P02808-1]
PIRiJH0153. SBHUP.
RefSeqiNP_001009181.1. NM_001009181.1. [P02808-2]
NP_003145.1. NM_003154.2. [P02808-1]
UniGeneiHs.654495.

Genome annotation databases

EnsembliENST00000246895; ENSP00000246895; ENSG00000126549. [P02808-1]
ENST00000381060; ENSP00000370448; ENSG00000126549. [P02808-2]
ENST00000615994; ENSP00000484341; ENSG00000126549. [P02808-1]
ENST00000634727; ENSP00000489107; ENSG00000282891. [P02808-2]
ENST00000635437; ENSP00000489569; ENSG00000282891. [P02808-1]
ENST00000635686; ENSP00000489243; ENSG00000282891. [P02808-1]
GeneIDi6779.
KEGGihsa:6779.
UCSCiuc003heu.2. human. [P02808-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18078 mRNA. Translation: AAA60594.1.
M18371 mRNA. Translation: AAA60600.1.
M32639 Genomic DNA. Translation: AAA60593.1.
AK311812 mRNA. Translation: BAG34755.1.
AC063956 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05604.1.
CH471057 Genomic DNA. Translation: EAX05605.1.
BC067219 mRNA. Translation: AAH67219.1.
CCDSiCCDS33998.1. [P02808-2]
CCDS3533.1. [P02808-1]
PIRiJH0153. SBHUP.
RefSeqiNP_001009181.1. NM_001009181.1. [P02808-2]
NP_003145.1. NM_003154.2. [P02808-1]
UniGeneiHs.654495.

3D structure databases

ProteinModelPortaliP02808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112656. 3 interactors.
IntActiP02808. 1 interactor.
STRINGi9606.ENSP00000246895.

Protein family/group databases

TCDBi1.C.79.1.2. the channel-forming histatin antimicrobial peptide (histatin) family.

PTM databases

iPTMnetiP02808.
PhosphoSitePlusiP02808.

Polymorphism and mutation databases

BioMutaiSTATH.

Proteomic databases

MaxQBiP02808.
PaxDbiP02808.
PeptideAtlasiP02808.
PRIDEiP02808.
TopDownProteomicsiP02808-1. [P02808-1]
P02808-2. [P02808-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246895; ENSP00000246895; ENSG00000126549. [P02808-1]
ENST00000381060; ENSP00000370448; ENSG00000126549. [P02808-2]
ENST00000615994; ENSP00000484341; ENSG00000126549. [P02808-1]
ENST00000634727; ENSP00000489107; ENSG00000282891. [P02808-2]
ENST00000635437; ENSP00000489569; ENSG00000282891. [P02808-1]
ENST00000635686; ENSP00000489243; ENSG00000282891. [P02808-1]
GeneIDi6779.
KEGGihsa:6779.
UCSCiuc003heu.2. human. [P02808-1]

Organism-specific databases

CTDi6779.
DisGeNETi6779.
GeneCardsiSTATH.
HGNCiHGNC:11369. STATH.
HPAiHPA044569.
MIMi184470. gene.
neXtProtiNX_P02808.
OpenTargetsiENSG00000126549.
ENSG00000282891.
PharmGKBiPA36187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCI1. Eukaryota.
ENOG4110NY1. LUCA.
GeneTreeiENSGT00390000011757.
HOGENOMiHOG000293326.
InParanoidiP02808.
KOiK13914.
OMAiGPYQPFV.
OrthoDBiEOG091G1BYD.
PhylomeDBiP02808.
TreeFamiTF341588.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126549-MONOMER.

Miscellaneous databases

ChiTaRSiSTATH. human.
GeneWikiiSTATH.
GenomeRNAii6779.
PROiP02808.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126549.
CleanExiHS_STATH.
GenevisibleiP02808. HS.

Family and domain databases

InterProiIPR030773. Histatin/statherin.
IPR005575. Statherin.
[Graphical view]
PANTHERiPTHR15057. PTHR15057. 1 hit.
PfamiPF03875. Statherin. 1 hit.
[Graphical view]
PIRSFiPIRSF002565. Statherin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTAT_HUMAN
AccessioniPrimary (citable) accession number: P02808
Secondary accession number(s): A6NKE9, B2R4F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.