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P02808

- STAT_HUMAN

UniProt

P02808 - STAT_HUMAN

Protein

Statherin

Gene

STATH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.

    GO - Molecular functioni

    1. extracellular matrix constituent, lubricant activity Source: UniProtKB
    2. hydroxyapatite binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. structural constituent of tooth enamel Source: UniProtKB

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. negative regulation of bone mineralization Source: UniProtKB
    3. ossification Source: ProtInc
    4. saliva secretion Source: UniProtKB

    Keywords - Biological processi

    Biomineralization

    Protein family/group databases

    TCDBi1.C.79.1.2. the channel-forming histatin antimicrobial peptide (histatin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Statherin
    Gene namesi
    Name:STATH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11369. STATH.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36187.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 6243StatherinPRO_0000022422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Phosphoserine1 Publication
    Modified residuei22 – 221Phosphoserine1 Publication
    Cross-linki25 ↔ 58Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-39
    Cross-linki25 ↔ 56Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-37

    Post-translational modificationi

    Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva.
    Sulfated on tyrosine residues.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Sulfation

    Proteomic databases

    MaxQBiP02808.
    PaxDbiP02808.
    PeptideAtlasiP02808.
    PRIDEiP02808.

    PTM databases

    PhosphoSiteiP02808.

    Expressioni

    Tissue specificityi

    Secreted by parotid and submandibular glands.

    Gene expression databases

    BgeeiP02808.
    CleanExiHS_STATH.
    GenevestigatoriP02808.

    Organism-specific databases

    HPAiHPA044569.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MUC7Q8TAX72EBI-738687,EBI-738582

    Protein-protein interaction databases

    BioGridi112656. 1 interaction.
    IntActiP02808. 1 interaction.
    STRINGi9606.ENSP00000246895.

    Structurei

    3D structure databases

    ProteinModelPortaliP02808.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 256Hydroxyapatite-binding; inhibits crystal growth
    Regioni38 – 6225Hydrophobic; inhibits precipitation of calcium phosphate saltsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the histatin/statherin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG255838.
    HOGENOMiHOG000293326.
    InParanoidiP02808.
    KOiK13914.
    OMAiEIATERW.
    OrthoDBiEOG7J183D.
    PhylomeDBiP02808.
    TreeFamiTF341588.

    Family and domain databases

    InterProiIPR005575. Statherin.
    [Graphical view]
    PfamiPF03875. Statherin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002565. Statherin. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Both isoforms can occur with the Phe-62 deletion.

    Isoform 1 (identifier: P02808-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKFLVFAFIL ALMVSMIGAD SSEEKFLRRI GRFGYGYGPY QPVPEQPLYP   50
    QPYQPQYQQY TF 62
    Length:62
    Mass (Da):7,304
    Last modified:July 1, 1989 - v2
    Checksum:iCFE32EC235CA3A22
    GO
    Isoform 2 (identifier: P02808-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         25-34: Missing.

    Show »
    Length:52
    Mass (Da):6,073
    Checksum:iC94F2FE112DAA733
    GO

    Mass spectrometryi

    Molecular mass is 5380.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22.1 Publication
    Molecular mass is 5363.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22 and transglutamine cross-link.1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621Missing.1 Publication
    VAR_069065

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei25 – 3410Missing in isoform 2. CuratedVSP_045744

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18078 mRNA. Translation: AAA60594.1.
    M18371 mRNA. Translation: AAA60600.1.
    M32639 Genomic DNA. Translation: AAA60593.1.
    AK311812 mRNA. Translation: BAG34755.1.
    AC063956 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05604.1.
    CH471057 Genomic DNA. Translation: EAX05605.1.
    BC067219 mRNA. Translation: AAH67219.1.
    CCDSiCCDS33998.1. [P02808-2]
    CCDS3533.1. [P02808-1]
    PIRiJH0153. SBHUP.
    RefSeqiNP_001009181.1. NM_001009181.1. [P02808-2]
    NP_003145.1. NM_003154.2. [P02808-1]
    UniGeneiHs.654495.

    Genome annotation databases

    EnsembliENST00000246895; ENSP00000246895; ENSG00000126549. [P02808-1]
    ENST00000381060; ENSP00000370448; ENSG00000126549. [P02808-2]
    GeneIDi6779.
    KEGGihsa:6779.
    UCSCiuc003heu.1. human. [P02808-1]
    uc003hev.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M18078 mRNA. Translation: AAA60594.1 .
    M18371 mRNA. Translation: AAA60600.1 .
    M32639 Genomic DNA. Translation: AAA60593.1 .
    AK311812 mRNA. Translation: BAG34755.1 .
    AC063956 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05604.1 .
    CH471057 Genomic DNA. Translation: EAX05605.1 .
    BC067219 mRNA. Translation: AAH67219.1 .
    CCDSi CCDS33998.1. [P02808-2 ]
    CCDS3533.1. [P02808-1 ]
    PIRi JH0153. SBHUP.
    RefSeqi NP_001009181.1. NM_001009181.1. [P02808-2 ]
    NP_003145.1. NM_003154.2. [P02808-1 ]
    UniGenei Hs.654495.

    3D structure databases

    ProteinModelPortali P02808.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112656. 1 interaction.
    IntActi P02808. 1 interaction.
    STRINGi 9606.ENSP00000246895.

    Protein family/group databases

    TCDBi 1.C.79.1.2. the channel-forming histatin antimicrobial peptide (histatin) family.

    PTM databases

    PhosphoSitei P02808.

    Proteomic databases

    MaxQBi P02808.
    PaxDbi P02808.
    PeptideAtlasi P02808.
    PRIDEi P02808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246895 ; ENSP00000246895 ; ENSG00000126549 . [P02808-1 ]
    ENST00000381060 ; ENSP00000370448 ; ENSG00000126549 . [P02808-2 ]
    GeneIDi 6779.
    KEGGi hsa:6779.
    UCSCi uc003heu.1. human. [P02808-1 ]
    uc003hev.1. human.

    Organism-specific databases

    CTDi 6779.
    GeneCardsi GC04P070861.
    HGNCi HGNC:11369. STATH.
    HPAi HPA044569.
    MIMi 184470. gene.
    neXtProti NX_P02808.
    PharmGKBi PA36187.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255838.
    HOGENOMi HOG000293326.
    InParanoidi P02808.
    KOi K13914.
    OMAi EIATERW.
    OrthoDBi EOG7J183D.
    PhylomeDBi P02808.
    TreeFami TF341588.

    Miscellaneous databases

    ChiTaRSi STATH. human.
    GeneWikii STATH.
    GenomeRNAii 6779.
    NextBioi 26462.
    PROi P02808.
    SOURCEi Search...

    Gene expression databases

    Bgeei P02808.
    CleanExi HS_STATH.
    Genevestigatori P02808.

    Family and domain databases

    InterProi IPR005575. Statherin.
    [Graphical view ]
    Pfami PF03875. Statherin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002565. Statherin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva."
      Sabatinai L., Carlock L., Johnson G., Azen E.
      Am. J. Hum. Genet. 41:1048-1060(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence."
      Dickinson D.P., Ridall A.L., Levine M.J.
      Biochem. Biophys. Res. Commun. 149:784-790(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Structure and sequence determination of the gene encoding human salivary statherin."
      Sabatini L.M., He Y.-Z., Azen E.A.
      Gene 89:245-251(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thyroid.
    8. "Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva."
      Schlesinger D.H., Hay D.I.
      J. Biol. Chem. 252:1689-1695(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-62 (ISOFORM 1), PHOSPHORYLATION AT SER-21 AND SER-22.
    9. "Multiple forms of statherin in human salivary secretions."
      Jensen J.L., Lamkin M.S., Troxler R.F., Oppenheim F.G.
      Arch. Oral Biol. 36:529-534(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-62 (ISOFORMS 1 AND 2), VARIANT PHE-62 DEL, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides."
      Oppenheim F.G., Hay D.I., Smith D.J., Offner G.D., Troxler R.F.
      J. Dent. Res. 66:462-466(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE OF 1-16.
    11. Cited for: PROTEIN SEQUENCE OF 20-62 (ISOFORM 1), SULFATION.
    12. "HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2."
      Cabras T., Inzitari R., Fanali C., Scarano E., Patamia M., Sanna M.T., Pisano E., Giardina B., Castagnola M., Messana I.
      J. Sep. Sci. 29:2600-2608(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TRANSGLUTAMINATION, MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSTAT_HUMAN
    AccessioniPrimary (citable) accession number: P02808
    Secondary accession number(s): A6NKE9, B2R4F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3