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P02808 (STAT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Statherin
Gene names
Name:STATH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length62 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.

Subcellular location

Secreted.

Tissue specificity

Secreted by parotid and submandibular glands.

Post-translational modification

Substrate for transglutaminase-2. More than 95% of the cyclized peptide is cyclo-statherin Q-37, and less than 5% is cyclo-statherin Q-39. Cyclized forms account for about 1% of total statherin in saliva.

Sulfated on tyrosine residues.

Sequence similarities

Belongs to the histatin/statherin family.

Mass spectrometry

Molecular mass is 5380.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22. Ref.12

Molecular mass is 5363.0±0.3 Da from positions 20 - 62. Determined by ESI. With phosphorylated Ser-21 and Ser-22 and transglutamine cross-link. Ref.12

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MUC7Q8TAX72EBI-738687,EBI-738582

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Both isoforms can occur with the Phe-62 deletion.
Isoform 1 (identifier: P02808-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P02808-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-34: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.8 Ref.9 Ref.10 Ref.11
Chain20 – 6243Statherin
PRO_0000022422

Regions

Region20 – 256Hydroxyapatite-binding; inhibits crystal growth
Region38 – 6225Hydrophobic; inhibits precipitation of calcium phosphate salts

Amino acid modifications

Modified residue211Phosphoserine Ref.8
Modified residue221Phosphoserine Ref.8
Cross-link25 ↔ 58Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-39
Cross-link25 ↔ 56Isoglutamyl lysine isopeptide (Lys-Gln); in form cyclo-statherin Q-37

Natural variations

Alternative sequence25 – 3410Missing in isoform 2.
VSP_045744
Natural variant621Missing. Ref.9
VAR_069065

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: CFE32EC235CA3A22

FASTA627,304
        10         20         30         40         50         60 
MKFLVFAFIL ALMVSMIGAD SSEEKFLRRI GRFGYGYGPY QPVPEQPLYP QPYQPQYQQY 


TF 

« Hide

Isoform 2 [UniParc].

Checksum: C94F2FE112DAA733
Show »

FASTA526,073

References

« Hide 'large scale' references
[1]"cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva."
Sabatinai L., Carlock L., Johnson G., Azen E.
Am. J. Hum. Genet. 41:1048-1060(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence."
Dickinson D.P., Ridall A.L., Levine M.J.
Biochem. Biophys. Res. Commun. 149:784-790(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Structure and sequence determination of the gene encoding human salivary statherin."
Sabatini L.M., He Y.-Z., Azen E.A.
Gene 89:245-251(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Trachea.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thyroid.
[8]"Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva."
Schlesinger D.H., Hay D.I.
J. Biol. Chem. 252:1689-1695(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-62 (ISOFORM 1), PHOSPHORYLATION AT SER-21 AND SER-22.
[9]"Multiple forms of statherin in human salivary secretions."
Jensen J.L., Lamkin M.S., Troxler R.F., Oppenheim F.G.
Arch. Oral Biol. 36:529-534(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-62 (ISOFORMS 1 AND 2), VARIANT PHE-62 DEL, IDENTIFICATION BY MASS SPECTROMETRY.
[10]"Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides."
Oppenheim F.G., Hay D.I., Smith D.J., Offner G.D., Troxler R.F.
J. Dent. Res. 66:462-466(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE OF 1-16.
[11]"Tyrosine sulfation of statherin."
Kasinathan C., Gandhi N., Ramaprasad P., Sundaram P., Ramasubbu N.
Int. J. Biol. Sci. 3:237-241(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-62 (ISOFORM 1), SULFATION.
[12]"HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2."
Cabras T., Inzitari R., Fanali C., Scarano E., Patamia M., Sanna M.T., Pisano E., Giardina B., Castagnola M., Messana I.
J. Sep. Sci. 29:2600-2608(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TRANSGLUTAMINATION, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18078 mRNA. Translation: AAA60594.1.
M18371 mRNA. Translation: AAA60600.1.
M32639 Genomic DNA. Translation: AAA60593.1.
AK311812 mRNA. Translation: BAG34755.1.
AC063956 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05604.1.
CH471057 Genomic DNA. Translation: EAX05605.1.
BC067219 mRNA. Translation: AAH67219.1.
PIRSBHUP. JH0153.
RefSeqNP_001009181.1. NM_001009181.1.
NP_003145.1. NM_003154.2.
UniGeneHs.654495.

3D structure databases

ProteinModelPortalP02808.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112656. 1 interaction.
IntActP02808. 1 interaction.
STRING9606.ENSP00000246895.

Protein family/group databases

TCDB1.C.79.1.2. the channel-forming histatin antimicrobial peptide (histatin) family.

PTM databases

PhosphoSiteP02808.

Proteomic databases

PaxDbP02808.
PeptideAtlasP02808.
PRIDEP02808.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000246895; ENSP00000246895; ENSG00000126549. [P02808-1]
ENST00000381060; ENSP00000370448; ENSG00000126549. [P02808-2]
GeneID6779.
KEGGhsa:6779.
UCSCuc003heu.1. human. [P02808-1]

Organism-specific databases

CTD6779.
GeneCardsGC04P070861.
HGNCHGNC:11369. STATH.
HPAHPA044569.
MIM184470. gene.
neXtProtNX_P02808.
PharmGKBPA36187.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG255838.
HOGENOMHOG000293326.
InParanoidP02808.
KOK13914.
OMANRYPATW.
OrthoDBEOG7J183D.
TreeFamTF341588.

Gene expression databases

BgeeP02808.
CleanExHS_STATH.
GenevestigatorP02808.

Family and domain databases

InterProIPR005575. Statherin.
[Graphical view]
PfamPF03875. Statherin. 1 hit.
[Graphical view]
PIRSFPIRSF002565. Statherin. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSTATH. human.
GeneWikiSTATH.
GenomeRNAi6779.
NextBio26462.
PROP02808.
SOURCESearch...

Entry information

Entry nameSTAT_HUMAN
AccessionPrimary (citable) accession number: P02808
Secondary accession number(s): A6NKE9, B2R4F8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM