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P02805

- MT1_SCYSE

UniProt

P02805 - MT1_SCYSE

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Protein

Metallothionein-1

Gene
N/A
Organism
Scylla serrata (Mud crab)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi4 – 41Divalent metal cation; cluster B
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi9 – 91Divalent metal cation; cluster B
Metal bindingi11 – 111Divalent metal cation; cluster B
Metal bindingi16 – 161Divalent metal cation; cluster B
Metal bindingi20 – 201Divalent metal cation; cluster B
Metal bindingi22 – 221Divalent metal cation; cluster B
Metal bindingi25 – 251Divalent metal cation; cluster B
Metal bindingi27 – 271Divalent metal cation; cluster B
Metal bindingi30 – 301Divalent metal cation; cluster A
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi39 – 391Divalent metal cation; cluster A
Metal bindingi45 – 451Divalent metal cation; cluster A
Metal bindingi49 – 491Divalent metal cation; cluster A
Metal bindingi53 – 531Divalent metal cation; cluster A
Metal bindingi55 – 551Divalent metal cation; cluster A
Metal bindingi56 – 561Divalent metal cation; cluster A

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
OrganismiScylla serrata (Mud crab)
Taxonomic identifieri6761 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeScylla

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Metallothionein-1PRO_0000197340Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP02805.
SMRiP02805. Positions 1-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828BetaAdd
BLAST
Regioni29 – 5830AlphaAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view]
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

P02805 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
PGPCCNDKCV CKEGGCKEGC QCTSCRCSPC EKCSSGCKCA NKEECSKTCS

KACSCCPT
Length:58
Mass (Da):6,001
Last modified:July 21, 1986 - v1
Checksum:iCE8A24C590B027B8
GO

Sequence databases

PIRiA03283. SMKD1S.

Cross-referencesi

Sequence databases

PIRi A03283. SMKD1S.

3D structure databases

ProteinModelPortali P02805.
SMRi P02805. Positions 1-58.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view ]
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00858. MTCRUSTACEAN.
SUPFAMi SSF57868. SSF57868. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Crab metallothionein. Primary structures of metallothioneins 1 and 2."
    Lerch K., Ammer D., Olafson R.W.
    J. Biol. Chem. 257:2420-2426(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiMT1_SCYSE
AccessioniPrimary (citable) accession number: P02805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3