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P02805

- MT1_SCYSE

UniProt

P02805 - MT1_SCYSE

Protein

Metallothionein-1

Gene
N/A
Organism
Scylla serrata (Mud crab)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi4 – 41Divalent metal cation; cluster B
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi9 – 91Divalent metal cation; cluster B
    Metal bindingi11 – 111Divalent metal cation; cluster B
    Metal bindingi16 – 161Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi22 – 221Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi27 – 271Divalent metal cation; cluster B
    Metal bindingi30 – 301Divalent metal cation; cluster A
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi39 – 391Divalent metal cation; cluster A
    Metal bindingi45 – 451Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi53 – 531Divalent metal cation; cluster A
    Metal bindingi55 – 551Divalent metal cation; cluster A
    Metal bindingi56 – 561Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1
    Short name:
    MT-1
    Alternative name(s):
    Metallothionein-I
    Short name:
    MT-I
    OrganismiScylla serrata (Mud crab)
    Taxonomic identifieri6761 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeScylla

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5858Metallothionein-1PRO_0000197340Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP02805.
    SMRiP02805. Positions 1-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 5830AlphaAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002045. Metalthion_3_crustacean.
    IPR017854. Metalthion_dom.
    IPR003019. Metalthion_sfam_euk.
    [Graphical view]
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00858. MTCRUSTACEAN.
    SUPFAMiSSF57868. SSF57868. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P02805-1 [UniParc]FASTAAdd to Basket

    « Hide

    PGPCCNDKCV CKEGGCKEGC QCTSCRCSPC EKCSSGCKCA NKEECSKTCS   50
    KACSCCPT 58
    Length:58
    Mass (Da):6,001
    Last modified:July 21, 1986 - v1
    Checksum:iCE8A24C590B027B8
    GO

    Sequence databases

    PIRiA03283. SMKD1S.

    Cross-referencesi

    Sequence databases

    PIRi A03283. SMKD1S.

    3D structure databases

    ProteinModelPortali P02805.
    SMRi P02805. Positions 1-58.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002045. Metalthion_3_crustacean.
    IPR017854. Metalthion_dom.
    IPR003019. Metalthion_sfam_euk.
    [Graphical view ]
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00858. MTCRUSTACEAN.
    SUPFAMi SSF57868. SSF57868. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Crab metallothionein. Primary structures of metallothioneins 1 and 2."
      Lerch K., Ammer D., Olafson R.W.
      J. Biol. Chem. 257:2420-2426(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiMT1_SCYSE
    AccessioniPrimary (citable) accession number: P02805
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3