P02805 (MT1_SCYSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Metallothionein-1 Short name=MT-1 Alternative name(s): Metallothionein-I Short name=MT-I
Organism	Scylla serrata (Mud crab)
Taxonomic identifier	6761 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Crustacea › Malacostraca › Eumalacostraca › Eucarida › Decapoda › Pleocyemata › Brachyura › Eubrachyura › Heterotremata › Portunoidea › Portunidae › Scylla

Protein attributes

Sequence length	58 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.
Sequence similarities	Belongs to the metallothionein superfamily. Type 3 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 58	58	Metallothionein-1		PRO_0000197340
Regions
	Region	1 – 28	28	Beta
	Region	29 – 58	30	Alpha
Sites
	Metal binding	4	1	Divalent metal cation; cluster B
	Metal binding	5	1	Divalent metal cation; cluster B
	Metal binding	9	1	Divalent metal cation; cluster B
	Metal binding	11	1	Divalent metal cation; cluster B
	Metal binding	16	1	Divalent metal cation; cluster B
	Metal binding	20	1	Divalent metal cation; cluster B
	Metal binding	22	1	Divalent metal cation; cluster B
	Metal binding	25	1	Divalent metal cation; cluster B
	Metal binding	27	1	Divalent metal cation; cluster B
	Metal binding	30	1	Divalent metal cation; cluster A
	Metal binding	33	1	Divalent metal cation; cluster A
	Metal binding	37	1	Divalent metal cation; cluster A
	Metal binding	39	1	Divalent metal cation; cluster A
	Metal binding	45	1	Divalent metal cation; cluster A
	Metal binding	49	1	Divalent metal cation; cluster A
	Metal binding	53	1	Divalent metal cation; cluster A
	Metal binding	55	1	Divalent metal cation; cluster A
	Metal binding	56	1	Divalent metal cation; cluster A

Sequences

	Sequence		Length	Mass (Da)
	P02805 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: CE8A24C590B027B8	FASTA	58	6,001
	10 20 30 40 50 PGPCCNDKCV CKEGGCKEGC QCTSCRCSPC EKCSSGCKCA NKEECSKTCS KACSCCPT

References

[1]	"Crab metallothionein. Primary structures of metallothioneins 1 and 2." Lerch K., Ammer D., Olafson R.W. J. Biol. Chem. 257:2420-2426(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	SMKD1S. A03283.
3D structure databases
ProteinModelPortal	P02805.
SMR	P02805. Positions 1-58.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002045. Metalthion_3_crustacean. IPR017854. Metalthion_dom. IPR003019. Metalthion_sfam_euk. [Graphical view]
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00858. MTCRUSTACEAN.
SUPFAM	SSF57868. Metallothionein_sfam. 2 hits.
ProtoNet	Search...

Entry information

Entry name

MT1_SCYSE

Accession

Primary (citable) accession number: P02805

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)