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P02805 (MT1_SCYSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1

Short name=MT-1
Alternative name(s):
Metallothionein-I
Short name=MT-I
OrganismScylla serrata (Mud crab)
Taxonomic identifier6761 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeScylla

Protein attributes

Sequence length58 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.

Sequence similarities

Belongs to the metallothionein superfamily. Type 3 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5858Metallothionein-1
PRO_0000197340

Regions

Region1 – 2828Beta
Region29 – 5830Alpha

Sites

Metal binding41Divalent metal cation; cluster B
Metal binding51Divalent metal cation; cluster B
Metal binding91Divalent metal cation; cluster B
Metal binding111Divalent metal cation; cluster B
Metal binding161Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding221Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding271Divalent metal cation; cluster B
Metal binding301Divalent metal cation; cluster A
Metal binding331Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding391Divalent metal cation; cluster A
Metal binding451Divalent metal cation; cluster A
Metal binding491Divalent metal cation; cluster A
Metal binding531Divalent metal cation; cluster A
Metal binding551Divalent metal cation; cluster A
Metal binding561Divalent metal cation; cluster A

Sequences

Sequence LengthMass (Da)Tools
P02805 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: CE8A24C590B027B8

FASTA586,001
        10         20         30         40         50 
PGPCCNDKCV CKEGGCKEGC QCTSCRCSPC EKCSSGCKCA NKEECSKTCS KACSCCPT 

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References

[1]"Crab metallothionein. Primary structures of metallothioneins 1 and 2."
Lerch K., Ammer D., Olafson R.W.
J. Biol. Chem. 257:2420-2426(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRSMKD1S. A03283.

3D structure databases

ProteinModelPortalP02805.
SMRP02805. Positions 1-58.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view]
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00858. MTCRUSTACEAN.
SUPFAMSSF57868. SSF57868. 2 hits.
ProtoNetSearch...

Entry information

Entry nameMT1_SCYSE
AccessionPrimary (citable) accession number: P02805
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries