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Protein

Metallothionein-1

Gene

Mt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi7Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi15Divalent metal cation; cluster B1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5661231. Metallothioneins bind metals.
R-RNO-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:Mt1
Synonyms:Mt1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3117. Mt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972211 – 61Metallothionein-1Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02803.
PRIDEiP02803.

PTM databases

iPTMnetiP02803.
PhosphoSitePlusiP02803.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025764.
ExpressionAtlasiP02803. differential.
GenevisibleiP02803. RN.

Structurei

3D structure databases

ProteinModelPortaliP02803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG095667.
InParanoidiP02803.
KOiK14739.
OMAiSCACKNC.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCSTG GSCTCSSSCG CKNCKCTSCK KSCCSCCPVG CSKCAQGCVC
60
KGASDKCTCC A
Length:61
Mass (Da):6,006
Last modified:July 21, 1986 - v1
Checksum:i4460B3720B9ABC18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00750 mRNA. Translation: AAA41590.1.
M11794 Genomic DNA. Translation: AAA41641.1.
BC058442 mRNA. Translation: AAH58442.1.
M24327 mRNA. Translation: AAA41589.1.
PIRiA93079. SMRT1.
RefSeqiNP_620181.1. NM_138826.4.
UniGeneiRn.16133.
Rn.54397.

Genome annotation databases

EnsembliENSRNOT00000057898; ENSRNOP00000054706; ENSRNOG00000038047.
GeneIDi24567.
KEGGirno:24567.
UCSCiRGD:3117. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00750 mRNA. Translation: AAA41590.1.
M11794 Genomic DNA. Translation: AAA41641.1.
BC058442 mRNA. Translation: AAH58442.1.
M24327 mRNA. Translation: AAA41589.1.
PIRiA93079. SMRT1.
RefSeqiNP_620181.1. NM_138826.4.
UniGeneiRn.16133.
Rn.54397.

3D structure databases

ProteinModelPortaliP02803.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP02803.
PhosphoSitePlusiP02803.

Proteomic databases

PaxDbiP02803.
PRIDEiP02803.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057898; ENSRNOP00000054706; ENSRNOG00000038047.
GeneIDi24567.
KEGGirno:24567.
UCSCiRGD:3117. rat.

Organism-specific databases

CTDi17748.
RGDi3117. Mt1.

Phylogenomic databases

GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG095667.
InParanoidiP02803.
KOiK14739.
OMAiSCACKNC.
TreeFamiTF336054.

Enzyme and pathway databases

ReactomeiR-RNO-5661231. Metallothioneins bind metals.
R-RNO-877300. Interferon gamma signaling.

Miscellaneous databases

PROiP02803.

Gene expression databases

BgeeiENSRNOG00000025764.
ExpressionAtlasiP02803. differential.
GenevisibleiP02803. RN.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_RAT
AccessioniPrimary (citable) accession number: P02803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.