Skip Header

Contribute Send feedback
Read comments (?) or add your own

P02803 (MT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1

Short name=MT-1
Alternative name(s):
Metallothionein-I
Short name=MT-I
Gene names
Name:Mt1
Synonyms:Mt1a
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-1
PRO_0000197221

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Divalent metal cation; cluster B
Metal binding71Divalent metal cation; cluster B
Metal binding131Divalent metal cation; cluster B
Metal binding151Divalent metal cation; cluster B
Metal binding191Divalent metal cation; cluster B
Metal binding211Divalent metal cation; cluster B
Metal binding241Divalent metal cation; cluster B
Metal binding261Divalent metal cation; cluster B
Metal binding291Divalent metal cation; cluster B
Metal binding331Divalent metal cation; cluster A
Metal binding341Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding411Divalent metal cation; cluster A
Metal binding441Divalent metal cation; cluster A
Metal binding481Divalent metal cation; cluster A
Metal binding501Divalent metal cation; cluster A
Metal binding571Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A
Metal binding601Divalent metal cation; cluster A

Amino acid modifications

Modified residue11N-acetylmethionine Ref.1

Sequences

Sequence LengthMass (Da)Tools
P02803 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 4460B3720B9ABC18

FASTA616,006
        10         20         30         40         50         60 
MDPNCSCSTG GSCTCSSSCG CKNCKCTSCK KSCCSCCPVG CSKCAQGCVC KGASDKCTCC 


A 

« Hide

References

« Hide 'large scale' references
[1]"Structural characterization of the isoforms of neonatal and adult rat liver metallothionein."
Winge D.R., Nielson K.B., Zeikus R.D., Gray W.R.
J. Biol. Chem. 259:11419-11425(1984) [PubMed: 6470004] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Rat metallothionein-1 structural gene and three pseudogenes, one of which contains 5'-regulatory sequences."
Andersen R.D., Birren B.W., Taplitz S.J., Herschman H.R.
Mol. Cell. Biol. 6:302-314(1986) [PubMed: 3023830] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence."
Andersen R.D., Birren B.W., Ganz T., Piletz J.E., Herschman H.R.
DNA 2:15-22(1983) [PubMed: 6687866] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]"Rat metallothionein multigene family."
Andersen R.D., Taplitz S.J., Birren B.W., Bristol G., Herschman H.R.
Experientia Suppl. 52:373-384(1987) [PubMed: 2959527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[6]"Cloning of metallothionein cDNA from neonatal rat liver."
Mercer J.F.B., Hudson P.J.
Biosci. Rep. 2:761-768(1982) [PubMed: 6184083] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-61.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00750 mRNA. Translation: AAA41590.1.
M11794 Genomic DNA. Translation: AAA41641.1.
BC058442 mRNA. Translation: AAH58442.1.
M24327 mRNA. Translation: AAA41589.1.
IPIIPI00192524.
PIRSMRT1. A93079.
RefSeqNP_620181.1. NM_138826.4.
UniGeneRn.54397.

3D structure databases

ProteinModelPortalP02803.
SMRP02803. Positions 1-61.
ModBaseSearch...

Protein-protein interaction databases

STRINGP02803.

PTM databases

PhosphoSiteP02803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000038212; ENSRNOP00000030623; ENSRNOG00000025764.
ENSRNOT00000057898; ENSRNOP00000054706; ENSRNOG00000038047.
GeneID24567.
KEGGrno:24567.
UCSCAY341880. rat.

Organism-specific databases

CTD4489.
RGD3117. Mt1a.

Phylogenomic databases

eggNOGmaNOG21730.
HOVERGENHBG095667.
InParanoidP02803.
OMASCKCKNC.

Gene expression databases

GenevestigatorP02803.
GermOnlineENSRNOG00000038047. Rattus norvegicus.

Family and domain databases

InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
KOK14739.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. Metallothionein_sfam. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603706.

Entry information

Entry nameMT1_RAT
AccessionPrimary (citable) accession number: P02803
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families