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Reviewed, UniProtKB/Swiss-Prot P02802 (MT1_MOUSE)

Last modified November 24, 2009. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Metallothionein-1
      Short name=MT-1
Alternative name(s):
    Metallothionein-I
      Short name=MT-I
Gene names
Name: Mt1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-1
PRO_0000197206

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Cluster B
Metal binding71Cluster B
Metal binding131Cluster B
Metal binding151Cluster B
Metal binding191Cluster B
Metal binding211Cluster B
Metal binding241Cluster B
Metal binding261Cluster B
Metal binding291Cluster B
Metal binding331Cluster A
Metal binding341Cluster A
Metal binding361Cluster A
Metal binding371Cluster A
Metal binding411Cluster A
Metal binding441Cluster A
Metal binding481Cluster A
Metal binding501Cluster A
Metal binding571Cluster A
Metal binding591Cluster A
Metal binding601Cluster A

Amino acid modifications

Modified residue11N-acetylmethionine Ref.1

Experimental info

Sequence conflict231N → D AA sequence Ref.1
Sequence conflict321S → G Ref.4

Secondary structure

........... 61
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02802-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 4B3754EC759C0ADB

FASTA616,018
        10         20         30         40         50         60 
MDPNCSCSTG GSCTCTSSCA CKNCKCTSCK KSCCSCCPVG CSKCAQGCVC KGAADKCTCC 


A 

« Hide

References

« Hide 'large scale' references
[1]"Mouse liver metallothioneins. Complete amino acid sequence of metallothionein-I."
Huang I.-Y., Yoshida A., Tsunoo H., Nakajima H.
J. Biol. Chem. 252:8217-8221(1977) [PubMed: 914867] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Liver.
[2]"Structure of mouse metallothionein-I gene and its mRNA."
Glanville N., Durnam D.M., Palmiter R.D.
Nature 292:267-269(1981) [PubMed: 7254320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Isolation and characterization of the mouse metallothionein-I gene."
Durnam D.M., Perrin F., Gannon F., Palmiter R.D.
Proc. Natl. Acad. Sci. U.S.A. 77:6511-6515(1980) [PubMed: 6935664] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[4]"Cloning and sequencing of cDNA for mouse liver metallothionein-I."
Mbikay M., Maiti I.B., Thirion J.-P.
Biochem. Biophys. Res. Commun. 103:825-832(1981) [PubMed: 6277322] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Production of a bifunctional hybrid molecule B72.3/metallothionein-1 by protein engineering."
Xiang J., Koropatnick J., Qi Y., Luo X., Moyana T., Li K., Chen Y.
Immunology 78:574-581(1993) [PubMed: 8495976] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[8]"Three-dimensional solution structure of mouse [Cd7]-metallothionein-1 by homonuclear and heteronuclear NMR spectroscopy."
Zangger K., Oez G., Otvos J.D., Armitage I.M.
Protein Sci. 8:2630-2638(1999) [PubMed: 10631978] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

S62785 mRNA. Translation: AAB26768.1.
J00605 Genomic DNA. Translation: AAA39527.2.
AK018727 mRNA. Translation: BAC25563.1.
BC036990 mRNA. Translation: AAH36990.1.
IPIIPI00113696.
PIRSMMSI. A93261.
RefSeqNP_038630.1.
UniGeneMm.192991

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1DFSNMR-A31-61[»]
1DFTNMR-A1-30[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP02802.

PTM databases

PhosphoSiteP02802.

Proteomic databases

PRIDEP02802.

Genome annotation databases

EnsemblENSMUST00000034215; ENSMUSP00000034215; ENSMUSG00000031765; Mus musculus. [Genome view]
GeneID17748.
KEGGmmu:17748.
UCSCuc009mvw.1. mouse.

Organism-specific databases

CTD17748.
MGIMGI:97171. Mt1.

Phylogenomic databases

HOVERGENP02802.

Gene expression databases

ArrayExpressP02802.
BgeeP02802.
CleanExMM_MT1.
GenevestigatorP02802.
GermOnlineENSMUSG00000031765. Mus musculus.

Family and domain databases

InterProIPR017854. Metallothionein_sfam.
IPR003019. Metallothionein_sfam_euk.
IPR000006. Metallothionein_vert.
IPR018064. Metallothionein_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio292401.
SOURCESearch...

Entry information

Entry nameMT1_MOUSE
AccessionPrimary (citable) accession number: P02802
Secondary accession number(s): Q64485
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 24, 2009
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents