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Reviewed, UniProtKB/Swiss-Prot P02798 (MT2_MOUSE)

Last modified December 15, 2009. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Metallothionein-2
      Short name=MT-2
Alternative name(s):
    Metallothionein-II
      Short name=MT-II
Gene names
Name: Mt2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-2
PRO_0000197207

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Cluster B
Metal binding71Cluster B
Metal binding131Cluster B
Metal binding151Cluster B
Metal binding191Cluster B
Metal binding211Cluster B
Metal binding241Cluster B
Metal binding261Cluster B
Metal binding291Cluster B
Metal binding331Cluster A
Metal binding341Cluster A
Metal binding361Cluster A
Metal binding371Cluster A
Metal binding411Cluster A
Metal binding441Cluster A
Metal binding481Cluster A
Metal binding501Cluster A
Metal binding571Cluster A
Metal binding591Cluster A
Metal binding601Cluster A

Amino acid modifications

Modified residue11N-acetylmethionine Ref.1
Modified residue511N6-acetyllysine By similarity

Experimental info

Sequence conflict521E → Q AA sequence Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P02798-1 [UniParc].

Last modified August 1, 1991. Version 2.
Checksum: A20D1311166672EC

FASTA616,115
        10         20         30         40         50         60 
MDPNCSCASD GSCSCAGACK CKQCKCTSCK KSCCSCCPVG CAKCSQGCIC KEASDKCSCC 


A

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References

« Hide 'large scale' references
[1]"Complete amino acid sequence of mouse liver metallothionein-II."
Huang I.-Y., Kimura M., Hata A., Tsunoo H., Yoshida A.
J. Biochem. 89:1839-1845(1981) [PubMed: 7287658] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"Regulation, linkage, and sequence of mouse metallothionein I and II genes."
Searle P.F., Davison B.L., Stuart G.W., Wilkie T.M., Norstedt G., Palmiter R.D.
Mol. Cell. Biol. 4:1221-1230(1984) [PubMed: 6095054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
+Additional computationally mapped references.

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Cross-references

Sequence databases

K02236 Genomic DNA. Translation: AAA39528.1.
AK002567 mRNA. Translation: BAB22192.1.
BC031758 mRNA. Translation: AAH31758.1.
IPIIPI00113240.
PIRSMMS2. A03275.
I57572.
RefSeqNP_032656.1.
UniGeneMm.147226

3D structure databases

SMRP02798. Positions 1-61.
ModBaseSearch...

Protein-protein interaction databases

STRINGP02798.

PTM databases

PhosphoSiteP02798.

Proteomic databases

PRIDEP02798.

Genome annotation databases

EnsemblENSMUST00000034214; ENSMUSP00000034214; ENSMUSG00000031762; Mus musculus. [Genome view]
GeneID17750.
KEGGmmu:17750.
UCSCuc009mvv.1. mouse.

Organism-specific databases

CTD17750.
MGIMGI:97172. Mt2.

Phylogenomic databases

HOVERGENP02798.
InParanoidP02798.
OMASQGCICK.

Gene expression databases

ArrayExpressP02798.
BgeeP02798.
CleanExMM_MT2.
GenevestigatorP02798.
GermOnlineENSMUSG00000031762. Mus musculus.

Family and domain databases

InterProIPR017854. Metallothionein_sfam.
IPR003019. Metallothionein_sfam_euk.
IPR000006. Metallothionein_vert.
IPR018064. Metallothionein_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio292411.
SOURCESearch...

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Entry information

Entry nameMT2_MOUSE
AccessionPrimary (citable) accession number: P02798
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1991
Last modified: December 15, 2009
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents