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Protein

Metallothionein-2

Gene

MT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Miscellaneous

This metallothionein binds zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1 Publication1
Metal bindingi7Divalent metal cation; cluster B1 Publication1
Metal bindingi13Divalent metal cation; cluster B1 Publication1
Metal bindingi15Divalent metal cation; cluster B1 Publication1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • drug binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cellular copper ion homeostasis Source: ProtInc
  • cellular response to drug Source: UniProtKB
  • cellular response to erythropoietin Source: UniProtKB
  • cellular response to interleukin-3 Source: UniProtKB
  • cellular response to zinc ion Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • negative regulation of growth Source: UniProtKB
  • response to metal ion Source: Reactome

Keywordsi

LigandMetal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals
R-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein-2A
Metallothionein-II
Short name:
MT-II
Gene namesi
Name:MT2A
Synonyms:CES1, MT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000125148.6
HGNCiHGNC:7406 MT2A
MIMi156360 gene
neXtProtiNX_P02795

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4502
OpenTargetsiENSG00000125148
PharmGKBiPA31214

Chemistry databases

DrugBankiDB00958 Carboplatin
DB00515 Cisplatin
DB00526 Oxaliplatin

Polymorphism and mutation databases

BioMutaiMT2A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972451 – 61Metallothionein-2Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP02795
MaxQBiP02795
PaxDbiP02795
PeptideAtlasiP02795
PRIDEiP02795
TopDownProteomicsiP02795

PTM databases

iPTMnetiP02795
PhosphoSitePlusiP02795

Expressioni

Gene expression databases

BgeeiENSG00000125148
CleanExiHS_CES1
HS_MT2A
ExpressionAtlasiP02795 baseline and differential
GenevisibleiP02795 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11060819 interactors.
DIPiDIP-35232N
IntActiP02795 20 interactors.
MINTiP02795
STRINGi9606.ENSP00000245185

Structurei

Secondary structure

161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi27 – 29Combined sources3
Beta strandi35 – 37Combined sources3
Helixi42 – 44Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MHUNMR-A31-61[»]
2MHUNMR-A1-30[»]
ProteinModelPortaliP02795
SMRiP02795
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02795

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1 Eukaryota
ENOG41113QR LUCA
GeneTreeiENSGT00730000110883
HOGENOMiHOG000236262
HOVERGENiHBG094456
InParanoidiP02795
KOiK14739
OMAiCKKSCCT
PhylomeDBiP02795
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.101 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P02795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCAAG DSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC
60
KGASDKCSCC A
Length:61
Mass (Da):6,042
Last modified:July 21, 1986 - v1
Checksum:i7B0A7E1F99843078
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02584042A → V1 PublicationCorresponds to variant dbSNP:rs35109646Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00271 Genomic DNA Translation: AAA59583.1
V00594 mRNA Translation: CAA23841.1
M26637 mRNA Translation: AAA59584.1 Sequence problems.
S52379 mRNA Translation: AAB24908.1
X97260 mRNA Translation: CAA65915.1
BT007315 mRNA Translation: AAP35979.1
DQ370420 Genomic DNA Translation: ABC79300.1
BC007034 mRNA Translation: AAH07034.1
BC070289 mRNA Translation: AAH70289.1
CCDSiCCDS10763.1
PIRiA03271 SMHU2
I63131
RefSeqiNP_005944.1, NM_005953.3
UniGeneiHs.534330

Genome annotation databases

EnsembliENST00000245185; ENSP00000245185; ENSG00000125148
GeneIDi4502
KEGGihsa:4502
UCSCiuc002ejh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMT2_HUMAN
AccessioniPrimary (citable) accession number: P02795
Secondary accession number(s): Q14823, Q2HXR9, Q53XT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome