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Protein

Metallothionein-2

Gene

MT2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1 Publication1
Metal bindingi7Divalent metal cation; cluster B1 Publication1
Metal bindingi13Divalent metal cation; cluster B1 Publication1
Metal bindingi15Divalent metal cation; cluster B1 Publication1
Metal bindingi19Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi24Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi29Divalent metal cation; cluster B1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1
Metal bindingi41Divalent metal cation; cluster A1
Metal bindingi44Divalent metal cation; cluster A1
Metal bindingi48Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1
Metal bindingi60Divalent metal cation; cluster A1

GO - Molecular functioni

  • drug binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cellular copper ion homeostasis Source: ProtInc
  • cellular response to drug Source: UniProtKB
  • cellular response to erythropoietin Source: UniProtKB
  • cellular response to interleukin-3 Source: UniProtKB
  • cellular response to zinc ion Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • negative regulation of growth Source: UniProtKB
  • response to metal ion Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125148-MONOMER.
ReactomeiR-HSA-5661231. Metallothioneins bind metals.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein-2A
Metallothionein-II
Short name:
MT-II
Gene namesi
Name:MT2A
Synonyms:CES1, MT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7406. MT2A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4502.
OpenTargetsiENSG00000125148.
PharmGKBiPA31214.

Chemistry databases

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

Polymorphism and mutation databases

BioMutaiMT2A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972451 – 61Metallothionein-2Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP02795.
MaxQBiP02795.
PaxDbiP02795.
PeptideAtlasiP02795.
PRIDEiP02795.
TopDownProteomicsiP02795.

PTM databases

iPTMnetiP02795.
PhosphoSitePlusiP02795.

Expressioni

Gene expression databases

BgeeiENSG00000125148.
CleanExiHS_CES1.
HS_MT2A.
ExpressionAtlasiP02795. baseline and differential.
GenevisibleiP02795. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXorf40AQ8TE692EBI-996616,EBI-996609
GPR50Q135852EBI-996616,EBI-8550965
PRKD1Q151397EBI-996616,EBI-1181072
SPINK7P580627EBI-996616,EBI-1182445

Protein-protein interaction databases

BioGridi110608. 15 interactors.
DIPiDIP-35232N.
IntActiP02795. 18 interactors.
MINTiMINT-2836376.
STRINGi9606.ENSP00000245185.

Structurei

Secondary structure

161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi27 – 29Combined sources3
Beta strandi35 – 37Combined sources3
Helixi42 – 44Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MHUNMR-A31-61[»]
2MHUNMR-A1-30[»]
ProteinModelPortaliP02795.
SMRiP02795.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02795.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG094456.
InParanoidiP02795.
KOiK14739.
OMAiNCSCATR.
PhylomeDBiP02795.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCAAG DSCTCAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC
60
KGASDKCSCC A
Length:61
Mass (Da):6,042
Last modified:July 21, 1986 - v1
Checksum:i7B0A7E1F99843078
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02584042A → V.1 PublicationCorresponds to variant rs35109646dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00271 Genomic DNA. Translation: AAA59583.1.
V00594 mRNA. Translation: CAA23841.1.
M26637 mRNA. Translation: AAA59584.1. Sequence problems.
S52379 mRNA. Translation: AAB24908.1.
X97260 mRNA. Translation: CAA65915.1.
BT007315 mRNA. Translation: AAP35979.1.
DQ370420 Genomic DNA. Translation: ABC79300.1.
BC007034 mRNA. Translation: AAH07034.1.
BC070289 mRNA. Translation: AAH70289.1.
CCDSiCCDS10763.1.
PIRiA03271. SMHU2.
I63131.
RefSeqiNP_005944.1. NM_005953.3.
UniGeneiHs.534330.

Genome annotation databases

EnsembliENST00000245185; ENSP00000245185; ENSG00000125148.
GeneIDi4502.
KEGGihsa:4502.
UCSCiuc002ejh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00271 Genomic DNA. Translation: AAA59583.1.
V00594 mRNA. Translation: CAA23841.1.
M26637 mRNA. Translation: AAA59584.1. Sequence problems.
S52379 mRNA. Translation: AAB24908.1.
X97260 mRNA. Translation: CAA65915.1.
BT007315 mRNA. Translation: AAP35979.1.
DQ370420 Genomic DNA. Translation: ABC79300.1.
BC007034 mRNA. Translation: AAH07034.1.
BC070289 mRNA. Translation: AAH70289.1.
CCDSiCCDS10763.1.
PIRiA03271. SMHU2.
I63131.
RefSeqiNP_005944.1. NM_005953.3.
UniGeneiHs.534330.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MHUNMR-A31-61[»]
2MHUNMR-A1-30[»]
ProteinModelPortaliP02795.
SMRiP02795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110608. 15 interactors.
DIPiDIP-35232N.
IntActiP02795. 18 interactors.
MINTiMINT-2836376.
STRINGi9606.ENSP00000245185.

Chemistry databases

DrugBankiDB00958. Carboplatin.
DB00515. Cisplatin.
DB00526. Oxaliplatin.

PTM databases

iPTMnetiP02795.
PhosphoSitePlusiP02795.

Polymorphism and mutation databases

BioMutaiMT2A.

Proteomic databases

EPDiP02795.
MaxQBiP02795.
PaxDbiP02795.
PeptideAtlasiP02795.
PRIDEiP02795.
TopDownProteomicsiP02795.

Protocols and materials databases

DNASUi4502.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245185; ENSP00000245185; ENSG00000125148.
GeneIDi4502.
KEGGihsa:4502.
UCSCiuc002ejh.4. human.

Organism-specific databases

CTDi4502.
DisGeNETi4502.
GeneCardsiMT2A.
HGNCiHGNC:7406. MT2A.
MIMi156360. gene.
neXtProtiNX_P02795.
OpenTargetsiENSG00000125148.
PharmGKBiPA31214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
GeneTreeiENSGT00730000110883.
HOGENOMiHOG000236262.
HOVERGENiHBG094456.
InParanoidiP02795.
KOiK14739.
OMAiNCSCATR.
PhylomeDBiP02795.
TreeFamiTF336054.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125148-MONOMER.
ReactomeiR-HSA-5661231. Metallothioneins bind metals.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiMT2A. human.
EvolutionaryTraceiP02795.
GeneWikiiMetallothionein_2A.
GenomeRNAii4502.
PROiP02795.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125148.
CleanExiHS_CES1.
HS_MT2A.
ExpressionAtlasiP02795. baseline and differential.
GenevisibleiP02795. HS.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT2_HUMAN
AccessioniPrimary (citable) accession number: P02795
Secondary accession number(s): Q14823, Q2HXR9, Q53XT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This metallothionein binds zinc.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.