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Protein

Ferritin light chain 1

Gene

Ftl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronPROSITE-ProRule annotation1
Metal bindingi57IronPROSITE-ProRule annotation1
Metal bindingi58IronPROSITE-ProRule annotation1
Metal bindingi61IronPROSITE-ProRule annotation1
Metal bindingi64IronPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: RGD
  • intracellular sequestering of iron ion Source: GO_Central
  • iron ion transport Source: InterPro
  • response to lead ion Source: RGD
Complete GO annotation...

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-917937. Iron uptake and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin light chain 1
Alternative name(s):
Ferritin L subunit 1
Gene namesi
Name:Ftl1
Synonyms:Ftl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 5

Organism-specific databases

RGDi61813. Ftl1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • intracellular ferritin complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010661 – 183Ferritin light chain 1Add BLAST183

Proteomic databases

PaxDbiP02793.
PRIDEiP02793.

2D gel databases

World-2DPAGE0004:P02793.

PTM databases

iPTMnetiP02793.
PhosphoSitePlusiP02793.

Expressioni

Tissue specificityi

In rat liver, the light chain is the major chain.

Gene expression databases

BgeeiENSRNOG00000020843.
GenevisibleiP02793. RN.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Protein-protein interaction databases

IntActiP02793. 2 interactors.
MINTiMINT-4580869.
STRINGi10116.ENSRNOP00000064683.

Structurei

3D structure databases

ProteinModelPortaliP02793.
SMRiP02793.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Domaini

The rat light chain has an octopeptide insertion after residue 158 compared with other light chains.

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410KDTW. Eukaryota.
ENOG4111Q1M. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiP02793.
KOiK13625.
OMAiAQDEWGR.
OrthoDBiEOG091G0J20.
PhylomeDBiP02793.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQIRQNYS TEVEAAVNRL VNLHLRASYT YLSLGFFFDR DDVALEGVGH
60 70 80 90 100
FFRELAEEKR EGAERLLKLQ NERGGRALFQ DVQKPSQDEW GKTLEAMEAA
110 120 130 140 150
LALEKNLNQA LLDLHALGSA RTDPHLCDFL ESHFLDKEVK LIKKMGNHLT
160 170 180
NLRRVAGPQP AQTGVAQASL GEYLFERLTL KHD
Length:183
Mass (Da):20,749
Last modified:January 23, 2007 - v3
Checksum:iE6AB306251D55106
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98E → K in AAA41154 (PubMed:6546756).Curated1
Sequence conflicti121 – 122RT → QA in AAA41154 (PubMed:6546756).Curated2
Sequence conflicti126L → F in AAA41152 (PubMed:1555892).Curated1
Sequence conflicti155V → W in AAA41154 (PubMed:6546756).Curated1
Sequence conflicti156A → Q in AAA41154 (PubMed:6546756).Curated1
Sequence conflicti156A → Q in AAA41155 (PubMed:3584116).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01930 mRNA. Translation: AAA41154.1.
J02741 Genomic DNA. Translation: AAA41155.1.
L01122 mRNA. Translation: AAA41152.1.
BC061525 mRNA. Translation: AAH61525.1.
BC086583 mRNA. Translation: AAH86583.1.
BC088756 mRNA. Translation: AAH88756.1.
PIRiA29575. FRRTL.
I54774.
RefSeqiNP_071945.3. NM_022500.4.
XP_002726683.1. XM_002726637.5.
XP_002729599.1. XM_002729553.5.
UniGeneiRn.119282.
Rn.1905.

Genome annotation databases

EnsembliENSRNOT00000028315; ENSRNOP00000028315; ENSRNOG00000020843.
ENSRNOT00000044711; ENSRNOP00000064683; ENSRNOG00000031506.
GeneIDi100360087.
29292.
KEGGirno:100360087.
rno:29292.
UCSCiRGD:61813. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01930 mRNA. Translation: AAA41154.1.
J02741 Genomic DNA. Translation: AAA41155.1.
L01122 mRNA. Translation: AAA41152.1.
BC061525 mRNA. Translation: AAH61525.1.
BC086583 mRNA. Translation: AAH86583.1.
BC088756 mRNA. Translation: AAH88756.1.
PIRiA29575. FRRTL.
I54774.
RefSeqiNP_071945.3. NM_022500.4.
XP_002726683.1. XM_002726637.5.
XP_002729599.1. XM_002729553.5.
UniGeneiRn.119282.
Rn.1905.

3D structure databases

ProteinModelPortaliP02793.
SMRiP02793.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02793. 2 interactors.
MINTiMINT-4580869.
STRINGi10116.ENSRNOP00000064683.

PTM databases

iPTMnetiP02793.
PhosphoSitePlusiP02793.

2D gel databases

World-2DPAGE0004:P02793.

Proteomic databases

PaxDbiP02793.
PRIDEiP02793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028315; ENSRNOP00000028315; ENSRNOG00000020843.
ENSRNOT00000044711; ENSRNOP00000064683; ENSRNOG00000031506.
GeneIDi100360087.
29292.
KEGGirno:100360087.
rno:29292.
UCSCiRGD:61813. rat.

Organism-specific databases

CTDi14325.
RGDi61813. Ftl1.

Phylogenomic databases

eggNOGiENOG410KDTW. Eukaryota.
ENOG4111Q1M. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiP02793.
KOiK13625.
OMAiAQDEWGR.
OrthoDBiEOG091G0J20.
PhylomeDBiP02793.
TreeFamiTF313885.

Enzyme and pathway databases

ReactomeiR-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-917937. Iron uptake and transport.

Miscellaneous databases

PROiP02793.

Gene expression databases

BgeeiENSRNOG00000020843.
GenevisibleiP02793. RN.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRIL1_RAT
AccessioniPrimary (citable) accession number: P02793
Secondary accession number(s): Q6P7T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.