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Protein

Hemopexin

Gene

HPX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Iron (heme 1 axial ligand)By similarity1
Metal bindingi150Iron (heme 1 axial ligand)By similarity1
Metal bindingi236Iron (heme 2 axial ligand)By similarity1
Metal bindingi293Iron (heme 2 axial ligand)By similarity1

GO - Molecular functioni

  • heme transporter activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110169-MONOMER.
ReactomeiR-HSA-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemopexin
Alternative name(s):
Beta-1B-glycoprotein
Gene namesi
Name:HPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5171. HPX.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • endocytic vesicle lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3263.
OpenTargetsiENSG00000110169.
PharmGKBiPA29441.

Polymorphism and mutation databases

BioMutaiHPX.
DMDMi1708182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000002140624 – 462Hemopexin1 PublicationAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24O-linked (GalNAc...)3 Publications1
Glycosylationi29O-linked (GalNAc...)1 Publication1
Disulfide bondi50 ↔ 2311 Publication
Glycosylationi64N-linked (GlcNAc...) (complex)3 Publications1
Disulfide bondi149 ↔ 1541 Publication
Glycosylationi187N-linked (GlcNAc...) (complex)8 Publications1
Disulfide bondi188 ↔ 2001 Publication
Glycosylationi240N-linked (GlcNAc...)3 Publications1
Glycosylationi246N-linked (GlcNAc...)3 Publications1
Disulfide bondi257 ↔ 4601 Publication
Disulfide bondi366 ↔ 4081 Publication
Disulfide bondi418 ↔ 4351 Publication
Glycosylationi453N-linked (GlcNAc...) (complex)6 Publications1

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.9 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02790.
PeptideAtlasiP02790.
PRIDEiP02790.

2D gel databases

DOSAC-COBS-2DPAGEP02790.
REPRODUCTION-2DPAGEIPI00022488.
SWISS-2DPAGEP02790.

PTM databases

iPTMnetiP02790.
PhosphoSitePlusiP02790.
UniCarbKBiP02790.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000110169.
CleanExiHS_HPX.
ExpressionAtlasiP02790. baseline and differential.
GenevisibleiP02790. HS.

Organism-specific databases

HPAiCAB016725.

Interactioni

Subunit structurei

Interacts with HEV ORF3 protein. Interacts with FLVCR1.2 Publications

Protein-protein interaction databases

BioGridi109500. 10 interactors.
DIPiDIP-38339N.
IntActiP02790. 4 interactors.
STRINGi9606.ENSP00000265983.

Structurei

3D structure databases

ProteinModelPortaliP02790.
SMRiP02790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 93Hemopexin 1Add BLAST41
Repeati94 – 139Hemopexin 2Add BLAST46
Repeati140 – 184Hemopexin 3Add BLAST45
Repeati185 – 231Hemopexin 4Add BLAST47
Repeati259 – 304Hemopexin 5Add BLAST46
Repeati305 – 352Hemopexin 6Add BLAST48
Repeati357 – 396Hemopexin 7Add BLAST40
Repeati400 – 450Hemopexin 8Add BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 40O-glycosylated at one siteAdd BLAST11

Sequence similaritiesi

Belongs to the hemopexin family.Curated
Contains 8 hemopexin repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00390000009178.
HOGENOMiHOG000112887.
HOVERGENiHBG005956.
InParanoidiP02790.
KOiK18977.
OMAiAVECHRG.
OrthoDBiEOG091G052J.
PhylomeDBiP02790.
TreeFamiTF331201.

Family and domain databases

CDDicd00094. HX. 2 hits.
Gene3Di2.110.10.10. 2 hits.
InterProiIPR016358. Hemopexin.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
[Graphical view]
PfamiPF00045. Hemopexin. 5 hits.
[Graphical view]
PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
SMARTiSM00120. HX. 5 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC
60 70 80 90 100
SDGWSFDATT LDDNGTMLFF KGEFVWKSHK WDRELISERW KNFPSPVDAA
110 120 130 140 150
FRQGHNSVFL IKGDKVWVYP PEKKEKGYPK LLQDEFPGIP SPLDAAVECH
160 170 180 190 200
RGECQAEGVL FFQGDREWFW DLATGTMKER SWPAVGNCSS ALRWLGRYYC
210 220 230 240 250
FQGNQFLRFD PVRGEVPPRY PRDVRDYFMP CPGRGHGHRN GTGHGNSTHH
260 270 280 290 300
GPEYMRCSPH LVLSALTSDN HGATYAFSGT HYWRLDTSRD GWHSWPIAHQ
310 320 330 340 350
WPQGPSAVDA AFSWEEKLYL VQGTQVYVFL TKGGYTLVSG YPKRLEKEVG
360 370 380 390 400
TPHGIILDSV DAAFICPGSS RLHIMAGRRL WWLDLKSGAQ ATWTELPWPH
410 420 430 440 450
EKVDGALCME KSLGPNSCSA NGPGLYLIHG PNLYCYSDVE KLNAAKALPQ
460
PQNVTSLLGC TH
Length:462
Mass (Da):51,676
Last modified:October 1, 1996 - v2
Checksum:i054B44D0603763B8
GO

Sequence cautioni

The sequence CAA26382 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411K → R in BAG36404 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04713752D → N.Corresponds to variant rs10839564dbSNPEnsembl.1
Natural variantiVAR_03399083R → W.Corresponds to variant rs12117dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36803
, M36796, M36799, M36800, M36801, M36802 Genomic DNA. Translation: AAA58678.1.
AK313648 mRNA. Translation: BAG36404.1.
J03048 mRNA. Translation: AAA52704.1.
X02537 mRNA. Translation: CAA26382.1. Different initiation.
CCDSiCCDS7763.1.
PIRiI56456. OQHU.
RefSeqiNP_000604.1. NM_000613.2.
UniGeneiHs.426485.

Genome annotation databases

EnsembliENST00000265983; ENSP00000265983; ENSG00000110169.
GeneIDi3263.
KEGGihsa:3263.
UCSCiuc001mdg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36803
, M36796, M36799, M36800, M36801, M36802 Genomic DNA. Translation: AAA58678.1.
AK313648 mRNA. Translation: BAG36404.1.
J03048 mRNA. Translation: AAA52704.1.
X02537 mRNA. Translation: CAA26382.1. Different initiation.
CCDSiCCDS7763.1.
PIRiI56456. OQHU.
RefSeqiNP_000604.1. NM_000613.2.
UniGeneiHs.426485.

3D structure databases

ProteinModelPortaliP02790.
SMRiP02790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109500. 10 interactors.
DIPiDIP-38339N.
IntActiP02790. 4 interactors.
STRINGi9606.ENSP00000265983.

PTM databases

iPTMnetiP02790.
PhosphoSitePlusiP02790.
UniCarbKBiP02790.

Polymorphism and mutation databases

BioMutaiHPX.
DMDMi1708182.

2D gel databases

DOSAC-COBS-2DPAGEP02790.
REPRODUCTION-2DPAGEIPI00022488.
SWISS-2DPAGEP02790.

Proteomic databases

PaxDbiP02790.
PeptideAtlasiP02790.
PRIDEiP02790.

Protocols and materials databases

DNASUi3263.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265983; ENSP00000265983; ENSG00000110169.
GeneIDi3263.
KEGGihsa:3263.
UCSCiuc001mdg.3. human.

Organism-specific databases

CTDi3263.
DisGeNETi3263.
GeneCardsiHPX.
HGNCiHGNC:5171. HPX.
HPAiCAB016725.
MIMi142290. gene.
neXtProtiNX_P02790.
OpenTargetsiENSG00000110169.
PharmGKBiPA29441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00390000009178.
HOGENOMiHOG000112887.
HOVERGENiHBG005956.
InParanoidiP02790.
KOiK18977.
OMAiAVECHRG.
OrthoDBiEOG091G052J.
PhylomeDBiP02790.
TreeFamiTF331201.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110169-MONOMER.
ReactomeiR-HSA-2168880. Scavenging of heme from plasma.

Miscellaneous databases

ChiTaRSiHPX. human.
GeneWikiiHemopexin.
GenomeRNAii3263.
PROiP02790.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110169.
CleanExiHS_HPX.
ExpressionAtlasiP02790. baseline and differential.
GenevisibleiP02790. HS.

Family and domain databases

CDDicd00094. HX. 2 hits.
Gene3Di2.110.10.10. 2 hits.
InterProiIPR016358. Hemopexin.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
[Graphical view]
PfamiPF00045. Hemopexin. 5 hits.
[Graphical view]
PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
SMARTiSM00120. HX. 5 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMO_HUMAN
AccessioniPrimary (citable) accession number: P02790
Secondary accession number(s): B2R957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.