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Protein

Secretoglobin family 2A member 2

Gene

Scgb2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of prostatein which is the major secretory glycoprotein of ventral prostate gland. Steroid-binding protein; can bind non-polar steroids, cholesterol and a group of small proline-rich peptides.

GO - Molecular functioni

GO - Biological processi

  • androgen receptor signaling pathway Source: RGD
  • protein tetramerization Source: RGD

Keywordsi

LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 2A member 2
Alternative name(s):
C3.1
Prostatein peptide C3
Prostatic steroid-binding protein C3
Gene namesi
Name:Scgb2a2
Synonyms:Psbpc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi735031. Scgb2a2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003637719 – 95Secretoglobin family 2A member 2Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP02780.
PRIDEiP02780.

PTM databases

iPTMnetiP02780.
PhosphoSitePlusiP02780.

Expressioni

Tissue specificityi

Highly expressed in ventral prostate.1 Publication

Inductioni

Androgen dependent, as shown by the decrease in the level of the protein following castration.1 Publication

Gene expression databases

BgeeiENSRNOG00000020305.
ExpressionAtlasiP02780. baseline.
GenevisibleiP02780. RN.

Interactioni

Subunit structurei

Prostatein is composed of three different peptides called C1, C2 and C3. These form covalent C1:C3 (F) and C2:C3 (S) heterodimers whose non-covalent association forms tetrameric (C1:C3/C3:C2) prostatein molecules.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066848.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEU0. Eukaryota.
ENOG4111A32. LUCA.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiP02780.
OMAiLHCYADS.
OrthoDBiEOG091G16OV.
PhylomeDBiP02780.
TreeFamiTF338521.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
Gene3Di1.10.210.10. 1 hit.
InterProiView protein in InterPro
IPR016126. Secretoglobin.
IPR035960. Secretoglobin_sf.
PfamiView protein in Pfam
PF01099. Uteroglobin. 1 hit.
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiView protein in PROSITE
PS51311. SCGB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVFLFLLV TIPICCYASG SGCSILDEVI RGTINSTVTL HDYMKLVKPY
60 70 80 90
VQDHFTEKAV KQFKQCFLDQ TDKTLENVGV MMEAIFNSES CQQPS
Length:95
Mass (Da):10,731
Last modified:July 21, 1986 - v1
Checksum:iF7F7F1A0C882E375
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53D → A in AAA41965 (PubMed:1537831).Curated1
Sequence conflicti79G → S (PubMed:6190812).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01257, V01258, V01259 Genomic DNA. Translation: CAB76237.1.
V01263 mRNA. Translation: CAA24577.1.
M71245 Genomic DNA. Translation: AAA41965.1.
BC062401 mRNA. Translation: AAH62401.1.
PIRiA92395. BORT3.
RefSeqiNP_976078.1. NM_203333.2.
XP_017445787.1. XM_017590298.1.
UniGeneiRn.103180.

Genome annotation databases

EnsembliENSRNOT00000031612; ENSRNOP00000037869; ENSRNOG00000023151.
ENSRNOT00000072584; ENSRNOP00000066848; ENSRNOG00000020305.
GeneIDi25010.
361725.
KEGGirno:25010.
rno:361725.
UCSCiRGD:735031. rat.

Similar proteinsi

Entry informationi

Entry nameiSG2A2_RAT
AccessioniPrimary (citable) accession number: P02780
Secondary accession number(s): Q63463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families