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Protein

Secretoglobin family 2A member 2

Gene

Scgb2a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of prostatein which is the major secretory glycoprotein of ventral prostate gland. Steroid-binding protein; can bind non-polar steroids, cholesterol and a group of small proline-rich peptides.

GO - Molecular functioni

GO - Biological processi

  • protein tetramerization Source: RGD
Complete GO annotation...

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 2A member 2
Alternative name(s):
C3.1
Prostatein peptide C3
Prostatic steroid-binding protein C3
Gene namesi
Name:Scgb2a2
Synonyms:Psbpc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi735031. Scgb2a2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003637719 – 95Secretoglobin family 2A member 2Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP02780.
PRIDEiP02780.

PTM databases

iPTMnetiP02780.
PhosphoSitePlusiP02780.

Expressioni

Tissue specificityi

Highly expressed in ventral prostate.1 Publication

Inductioni

Androgen dependent, as shown by the decrease in the level of the protein following castration.1 Publication

Gene expression databases

ExpressionAtlasiP02780. differential.
GenevisibleiP02780. RN.

Interactioni

Subunit structurei

Prostatein is composed of three different peptides called C1, C2 and C3. These form covalent C1:C3 (F) and C2:C3 (S) heterodimers whose non-covalent association forms tetrameric (C1:C3/C3:C2) prostatein molecules.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066848.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JEU0. Eukaryota.
ENOG4111A32. LUCA.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiP02780.
OMAiLHCYADS.
OrthoDBiEOG091G16OV.
PhylomeDBiP02780.
TreeFamiTF338521.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVFLFLLV TIPICCYASG SGCSILDEVI RGTINSTVTL HDYMKLVKPY
60 70 80 90
VQDHFTEKAV KQFKQCFLDQ TDKTLENVGV MMEAIFNSES CQQPS
Length:95
Mass (Da):10,731
Last modified:July 21, 1986 - v1
Checksum:iF7F7F1A0C882E375
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53D → A in AAA41965 (PubMed:1537831).Curated1
Sequence conflicti79G → S (PubMed:6190812).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01257, V01258, V01259 Genomic DNA. Translation: CAB76237.1.
V01263 mRNA. Translation: CAA24577.1.
M71245 Genomic DNA. Translation: AAA41965.1.
BC062401 mRNA. Translation: AAH62401.1.
PIRiA92395. BORT3.
RefSeqiNP_976078.1. NM_203333.2.
XP_017445787.1. XM_017590298.1.
UniGeneiRn.103180.

Genome annotation databases

EnsembliENSRNOT00000031612; ENSRNOP00000037869; ENSRNOG00000023151.
ENSRNOT00000072584; ENSRNOP00000066848; ENSRNOG00000020305.
GeneIDi25010.
361725.
KEGGirno:361725.
UCSCiRGD:735031. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01257, V01258, V01259 Genomic DNA. Translation: CAB76237.1.
V01263 mRNA. Translation: CAA24577.1.
M71245 Genomic DNA. Translation: AAA41965.1.
BC062401 mRNA. Translation: AAH62401.1.
PIRiA92395. BORT3.
RefSeqiNP_976078.1. NM_203333.2.
XP_017445787.1. XM_017590298.1.
UniGeneiRn.103180.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066848.

PTM databases

iPTMnetiP02780.
PhosphoSitePlusiP02780.

Proteomic databases

PaxDbiP02780.
PRIDEiP02780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031612; ENSRNOP00000037869; ENSRNOG00000023151.
ENSRNOT00000072584; ENSRNOP00000066848; ENSRNOG00000020305.
GeneIDi25010.
361725.
KEGGirno:361725.
UCSCiRGD:735031. rat.

Organism-specific databases

CTDi4250.
RGDi735031. Scgb2a2.

Phylogenomic databases

eggNOGiENOG410JEU0. Eukaryota.
ENOG4111A32. LUCA.
GeneTreeiENSGT00390000013802.
HOGENOMiHOG000294150.
HOVERGENiHBG005021.
InParanoidiP02780.
OMAiLHCYADS.
OrthoDBiEOG091G16OV.
PhylomeDBiP02780.
TreeFamiTF338521.

Miscellaneous databases

PROiP02780.

Gene expression databases

ExpressionAtlasiP02780. differential.
GenevisibleiP02780. RN.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSG2A2_RAT
AccessioniPrimary (citable) accession number: P02780
Secondary accession number(s): Q63463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.