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Protein

Uteroglobin

Gene

SCGB1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Uteroglobin binds progesterone specifically and with high affinity. It may regulate progesterone concentrations reaching the blastocyst. It is also a potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Blastokinin
Secretoglobin family 1A member 1
Gene namesi
Name:SCGB1A1
Synonyms:UGB, UGL
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000003636922 – 91Uteroglobin1 PublicationAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24Interchain (with C-90)1 Publication
Disulfide bondi90Interchain (with C-24)1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Synthesized in the uterus and lung.

Inductioni

By progesterone.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000012245.

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 36Combined sources12
Helixi39 – 47Combined sources9
Helixi53 – 66Combined sources14
Helixi71 – 85Combined sources15
Helixi88 – 90Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTGX-ray1.34A22-91[»]
2UTGX-ray1.64A/B22-91[»]
ProteinModelPortaliP02779.
SMRiP02779.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02779.

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP02779.
OMAiASAEICP.
OrthoDBiEOG091G15B2.
TreeFamiTF338407.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAITLALV TLALLCSPAS AGICPRFAHV IENLLLGTPS SYETSLKEFE
60 70 80 90
PDDTMKDAGM QMKKVLDSLP QTTRENIMKL TEKIVKSPLC M
Length:91
Mass (Da):9,983
Last modified:July 21, 1986 - v1
Checksum:i0C1978AAE5D550CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6T → F AA sequence (PubMed:571719).Curated1
Sequence conflicti16C → G AA sequence (PubMed:571719).Curated1
Sequence conflicti46L → V in AAA31500 (PubMed:6287481).Curated1
Sequence conflicti67 – 68DS → NT in AAA31499 (PubMed:6156676).Curated2
Sequence conflicti82E → Q AA sequence (PubMed:568483).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01657 mRNA. Translation: AAA31497.1.
J00689, J00688 Genomic DNA. Translation: AAA31495.1.
X01423 Genomic DNA. Translation: CAA25669.1.
M32012, M25090 Genomic DNA. Translation: AAA31500.1.
M27564 mRNA. Translation: AAA31496.1.
M25057 Genomic DNA. Translation: AAA31498.1.
M25038 mRNA. Translation: AAA31499.1.
PIRiA92391. UGRB.
RefSeqiNP_001075706.1. NM_001082237.1.
UniGeneiOcu.1976.

Genome annotation databases

EnsembliENSOCUT00000014246; ENSOCUP00000012245; ENSOCUG00000014249.
GeneIDi100009053.
KEGGiocu:100009053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01657 mRNA. Translation: AAA31497.1.
J00689, J00688 Genomic DNA. Translation: AAA31495.1.
X01423 Genomic DNA. Translation: CAA25669.1.
M32012, M25090 Genomic DNA. Translation: AAA31500.1.
M27564 mRNA. Translation: AAA31496.1.
M25057 Genomic DNA. Translation: AAA31498.1.
M25038 mRNA. Translation: AAA31499.1.
PIRiA92391. UGRB.
RefSeqiNP_001075706.1. NM_001082237.1.
UniGeneiOcu.1976.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTGX-ray1.34A22-91[»]
2UTGX-ray1.64A/B22-91[»]
ProteinModelPortaliP02779.
SMRiP02779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000012245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000014246; ENSOCUP00000012245; ENSOCUG00000014249.
GeneIDi100009053.
KEGGiocu:100009053.

Organism-specific databases

CTDi7356.

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP02779.
OMAiASAEICP.
OrthoDBiEOG091G15B2.
TreeFamiTF338407.

Miscellaneous databases

EvolutionaryTraceiP02779.

Family and domain databases

CDDicd00633. Secretoglobin. 1 hit.
InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTER_RABIT
AccessioniPrimary (citable) accession number: P02779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.