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Protein

Uteroglobin

Gene

SCGB1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Uteroglobin binds progesterone specifically and with high affinity. It may regulate progesterone concentrations reaching the blastocyst. It is also a potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPhospholipase A2 inhibitor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Blastokinin
Secretoglobin family 1A member 1
Gene namesi
Name:SCGB1A1
Synonyms:UGB, UGL
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000003636922 – 91Uteroglobin1 PublicationAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24Interchain (with C-90)1 Publication
Disulfide bondi90Interchain (with C-24)1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Synthesized in the uterus and lung.

Inductioni

By progesterone.

Gene expression databases

BgeeiENSOCUG00000014249

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000012245

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 36Combined sources12
Helixi39 – 47Combined sources9
Helixi53 – 66Combined sources14
Helixi71 – 85Combined sources15
Helixi88 – 90Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UTGX-ray1.34A22-91[»]
2UTGX-ray1.64A/B22-91[»]
ProteinModelPortaliP02779
SMRiP02779
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02779

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459 Eukaryota
ENOG4111966 LUCA
GeneTreeiENSGT00530000064300
HOGENOMiHOG000220914
HOVERGENiHBG018062
InParanoidiP02779
OMAiASAEICP
OrthoDBiEOG091G15B2
TreeFamiTF338407

Family and domain databases

CDDicd00633 Secretoglobin, 1 hit
InterProiView protein in InterPro
IPR016126 Secretoglobin
IPR035960 Secretoglobin_sf
IPR000329 Uteroglobin
PfamiView protein in Pfam
PF01099 Uteroglobin, 1 hit
PRINTSiPR00486 UTEROGLOBIN
SUPFAMiSSF48201 SSF48201, 1 hit
PROSITEiView protein in PROSITE
PS51311 SCGB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAITLALV TLALLCSPAS AGICPRFAHV IENLLLGTPS SYETSLKEFE
60 70 80 90
PDDTMKDAGM QMKKVLDSLP QTTRENIMKL TEKIVKSPLC M
Length:91
Mass (Da):9,983
Last modified:July 21, 1986 - v1
Checksum:i0C1978AAE5D550CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6T → F AA sequence (PubMed:571719).Curated1
Sequence conflicti16C → G AA sequence (PubMed:571719).Curated1
Sequence conflicti46L → V in AAA31500 (PubMed:6287481).Curated1
Sequence conflicti67 – 68DS → NT in AAA31499 (PubMed:6156676).Curated2
Sequence conflicti82E → Q AA sequence (PubMed:568483).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01657 mRNA Translation: AAA31497.1
J00689, J00688 Genomic DNA Translation: AAA31495.1
X01423 Genomic DNA Translation: CAA25669.1
M32012, M25090 Genomic DNA Translation: AAA31500.1
M27564 mRNA Translation: AAA31496.1
M25057 Genomic DNA Translation: AAA31498.1
M25038 mRNA Translation: AAA31499.1
PIRiA92391 UGRB
RefSeqiNP_001075706.1, NM_001082237.1
UniGeneiOcu.1976

Genome annotation databases

EnsembliENSOCUT00000014246; ENSOCUP00000012245; ENSOCUG00000014249
GeneIDi100009053
KEGGiocu:100009053

Similar proteinsi

Entry informationi

Entry nameiUTER_RABIT
AccessioniPrimary (citable) accession number: P02779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health