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Protein

Uteroglobin

Gene

SCGB1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Uteroglobin binds progesterone specifically and with high affinity. It may regulate progesterone concentrations reaching the blastocyst. It is also a potent inhibitor of phospholipase A2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uteroglobin
Alternative name(s):
Blastokinin
Secretoglobin family 1A member 1
Gene namesi
Name:SCGB1A1
Synonyms:UGB, UGL
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21213 PublicationsAdd
BLAST
Chaini22 – 9170Uteroglobin1 PublicationPRO_0000036369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 – 24Interchain (with C-90)1 Publication
Disulfide bondi90 – 90Interchain (with C-24)1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Synthesized in the uterus and lung.

Inductioni

By progesterone.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000012245.

Structurei

Secondary structure

1
91
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 3612Combined sources
Helixi39 – 479Combined sources
Helixi53 – 6614Combined sources
Helixi71 – 8515Combined sources
Helixi88 – 903Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UTGX-ray1.34A22-91[»]
2UTGX-ray1.64A/B22-91[»]
ProteinModelPortaliP02779.
SMRiP02779. Positions 22-91.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02779.

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP02779.
OMAiASAEICP.
OrthoDBiEOG77T17C.
TreeFamiTF338407.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAITLALV TLALLCSPAS AGICPRFAHV IENLLLGTPS SYETSLKEFE
60 70 80 90
PDDTMKDAGM QMKKVLDSLP QTTRENIMKL TEKIVKSPLC M
Length:91
Mass (Da):9,983
Last modified:July 21, 1986 - v1
Checksum:i0C1978AAE5D550CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61T → F AA sequence (PubMed:571719).Curated
Sequence conflicti16 – 161C → G AA sequence (PubMed:571719).Curated
Sequence conflicti46 – 461L → V in AAA31500 (PubMed:6287481).Curated
Sequence conflicti67 – 682DS → NT in AAA31499 (PubMed:6156676).Curated
Sequence conflicti82 – 821E → Q AA sequence (PubMed:568483).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01657 mRNA. Translation: AAA31497.1.
J00689, J00688 Genomic DNA. Translation: AAA31495.1.
X01423 Genomic DNA. Translation: CAA25669.1.
M32012, M25090 Genomic DNA. Translation: AAA31500.1.
M27564 mRNA. Translation: AAA31496.1.
M25057 Genomic DNA. Translation: AAA31498.1.
M25038 mRNA. Translation: AAA31499.1.
PIRiA92391. UGRB.
RefSeqiNP_001075706.1. NM_001082237.1.
UniGeneiOcu.1976.

Genome annotation databases

EnsembliENSOCUT00000014246; ENSOCUP00000012245; ENSOCUG00000014249.
GeneIDi100009053.
KEGGiocu:100009053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01657 mRNA. Translation: AAA31497.1.
J00689, J00688 Genomic DNA. Translation: AAA31495.1.
X01423 Genomic DNA. Translation: CAA25669.1.
M32012, M25090 Genomic DNA. Translation: AAA31500.1.
M27564 mRNA. Translation: AAA31496.1.
M25057 Genomic DNA. Translation: AAA31498.1.
M25038 mRNA. Translation: AAA31499.1.
PIRiA92391. UGRB.
RefSeqiNP_001075706.1. NM_001082237.1.
UniGeneiOcu.1976.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UTGX-ray1.34A22-91[»]
2UTGX-ray1.64A/B22-91[»]
ProteinModelPortaliP02779.
SMRiP02779. Positions 22-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000012245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000014246; ENSOCUP00000012245; ENSOCUG00000014249.
GeneIDi100009053.
KEGGiocu:100009053.

Organism-specific databases

CTDi7356.

Phylogenomic databases

eggNOGiENOG410J459. Eukaryota.
ENOG4111966. LUCA.
GeneTreeiENSGT00530000064300.
HOGENOMiHOG000220914.
HOVERGENiHBG018062.
InParanoidiP02779.
OMAiASAEICP.
OrthoDBiEOG77T17C.
TreeFamiTF338407.

Miscellaneous databases

EvolutionaryTraceiP02779.

Family and domain databases

InterProiIPR016126. Secretoglobin.
IPR000329. Uteroglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
PRINTSiPR00486. UTEROGLOBIN.
SMARTiSM00096. UTG. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The rabbit uteroglobin gene. Structure and interaction with the progesterone receptor."
    Bailly A., Atger M., Atger P., Cerbon M.-A., Alizon M., Vu Hai M.T., Logeat F., Milgrom E.
    J. Biol. Chem. 258:10384-10389(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The uteroglobin gene region: hormonal regulation, repetitive elements and complete nucleotide sequence of the gene."
    Suske G., Wenz M., Cato A.C.B., Beato M.
    Nucleic Acids Res. 11:2257-2271(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Isolation and structure of the gene for the progesterone-inducible protein uteroglobin."
    Menne C., Suske G., Arnemann J., Wenz M., Cato A.C.B., Beato M.
    Proc. Natl. Acad. Sci. U.S.A. 79:4853-4857(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Hormonally regulated mammalian gene expression: steady-state level and nucleotide sequence of rabbit uteroglobin mRNA."
    Chandra T., Bullock D.W., Woo S.L.C.
    DNA 1:19-26(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Characterization and sequence analysis of interspersed repetitive DNA sequences transcribed in X.laevis embryos."
    Suske G., Menne C., Cato A., Wenz M., Beato M.
    Prog. Clin. Biol. Res. 85:139-146(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "N-terminal sequences of uteroglobin and its precursor."
    Atger M., Mercier J.-C., Haze G., Fridlansky F., Milgrom E.
    Biochem. J. 177:985-988(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-73.
  7. "Amino acid sequence of progesterone-induced rabbit uteroglobin."
    Ponstingl H., Nieto A., Beato M.
    Biochemistry 17:3908-3912(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-91.
  8. Cited for: PROTEIN SEQUENCE OF 22-91.
  9. Popp R.A., Foresman K.R., Wise L.D., Daniel J.C. Jr.
    Submitted (OCT-1982) to the PIR data bank
    Cited for: SEQUENCE REVISION TO 50-62 AND 67-71.
  10. "Primary structure of rabbit lung uteroglobin as deduced from the nucleotide sequence of a cDNA."
    de Haro M.S., Nieto A.
    FEBS Lett. 193:247-249(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-91.
  11. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-77.
  12. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-72.
  13. "Structure and refinement of the oxidized P21 form of uteroglobin at 1.64-A resolution."
    Bally R., Delettre J.
    J. Mol. Biol. 206:153-170(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS).
  14. "Refinement of the C222(1) crystal form of oxidized uteroglobin at 1.34-A resolution."
    Morize I., Surcouf E., Vaney M.C., Epelboin Y., Buehner M., Fridlansky F., Milgrom E., Mornon J.-P.
    J. Mol. Biol. 194:725-739(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.34 ANGSTROMS).
  15. "Conformation and molecular dynamics calculations on uteroglobin fragment 18-47."
    Improta S., Pastore A., Mammi S., Peggion E.
    Biopolymers 34:773-782(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 39-68.

Entry informationi

Entry nameiUTER_RABIT
AccessioniPrimary (citable) accession number: P02779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 11, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.