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Protein

C-X-C motif chemokine 10

Gene

CXCL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

GO - Molecular functioni

  • cAMP-dependent protein kinase regulator activity Source: ProtInc
  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • heparin binding Source: UniProtKB
  • receptor binding Source: ProtInc

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • blood circulation Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular response to heat Source: Ensembl
  • cellular response to lipopolysaccharide Source: MGI
  • chemokine-mediated signaling pathway Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • defense response to virus Source: Ensembl
  • endothelial cell activation Source: CACAO
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • killing of cells of other organism Source: UniProtKB
  • muscle organ development Source: ProtInc
  • negative regulation of angiogenesis Source: Ensembl
  • negative regulation of myoblast differentiation Source: Ensembl
  • negative regulation of myoblast fusion Source: Ensembl
  • positive regulation of cAMP-mediated signaling Source: UniProtKB
  • positive regulation of cAMP metabolic process Source: UniProtKB
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of monocyte chemotaxis Source: CACAO
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • positive regulation of T cell migration Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB
  • regulation of endothelial tube morphogenesis Source: CACAO
  • regulation of T cell chemotaxis Source: CACAO
  • response to auditory stimulus Source: Ensembl
  • response to cold Source: Ensembl
  • response to gamma radiation Source: Ensembl
  • response to vitamin D Source: Ensembl
  • signal transduction Source: ProtInc
  • T cell chemotaxis Source: UniProtKB

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6783783. Interleukin-10 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name:
Gamma-IP10
Short name:
IP-10
Small-inducible cytokine B10
Cleaved into the following chain:
Gene namesi
Name:CXCL10
Synonyms:INP10, SCYB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169245.5.
HGNCiHGNC:10637. CXCL10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3627.
OpenTargetsiENSG00000169245.
PharmGKBiPA35568.

Chemistry databases

ChEMBLiCHEMBL3712964.
DrugBankiDB04487. N-Methylleucine.

Polymorphism and mutation databases

BioMutaiCXCL10.
DMDMi21542456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000000510122 – 98C-X-C motif chemokine 10Add BLAST77
ChainiPRO_000000510222 – 94CXCL10(1-73)Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26Citrulline; by PAD21 Publication1
Disulfide bondi30 ↔ 57
Disulfide bondi32 ↔ 74

Post-translational modificationi

CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

MaxQBiP02778.
PaxDbiP02778.
PeptideAtlasiP02778.
PRIDEiP02778.

PTM databases

iPTMnetiP02778.
PhosphoSitePlusiP02778.

Expressioni

Inductioni

By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Gene expression databases

BgeeiENSG00000169245.
CleanExiHS_CXCL10.
ExpressionAtlasiP02778. baseline and differential.
GenevisibleiP02778. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-7815386,EBI-2871277

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109839. 2 interactors.
DIPiDIP-5893N.
IntActiP02778. 2 interactors.
MINTiMINT-91448.
STRINGi9606.ENSP00000305651.

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni42 – 44Combined sources3
Beta strandi45 – 51Combined sources7
Beta strandi57 – 59Combined sources3
Beta strandi61 – 66Combined sources6
Turni67 – 69Combined sources3
Beta strandi72 – 75Combined sources4
Beta strandi77 – 79Combined sources3
Helixi80 – 88Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LV9NMR-A22-98[»]
1O7YX-ray3.00A/B/C/D22-98[»]
1O7ZX-ray1.92A/B22-98[»]
1O80X-ray2.00A/B22-98[»]
ProteinModelPortaliP02778.
SMRiP02778.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02778.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP02778.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG091G0YSL.
PhylomeDBiP02778.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI
60 70 80 90
IPASQFCPRV EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP
Length:98
Mass (Da):10,881
Last modified:June 20, 2002 - v2
Checksum:i44AE51967C58DDFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93R → M in CAA26370 (PubMed:3925348).Curated1

Mass spectrometryi

Molecular mass is 8641.8 Da from positions 22 - 98. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02530 mRNA. Translation: CAA26370.1.
BC010954 mRNA. Translation: AAH10954.1.
CCDSiCCDS43240.1.
PIRiA03243. TGHUGI.
RefSeqiNP_001556.2. NM_001565.3.
UniGeneiHs.632586.

Genome annotation databases

EnsembliENST00000306602; ENSP00000305651; ENSG00000169245.
GeneIDi3627.
KEGGihsa:3627.
UCSCiuc003hjl.5. human.

Similar proteinsi

Entry informationi

Entry nameiCXL10_HUMAN
AccessioniPrimary (citable) accession number: P02778
Secondary accession number(s): Q96QJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 20, 2002
Last modified: September 27, 2017
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families