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P02778

- CXL10_HUMAN

UniProt

P02778 - CXL10_HUMAN

Protein

C-X-C motif chemokine 10

Gene

CXCL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

    GO - Molecular functioni

    1. cAMP-dependent protein kinase regulator activity Source: ProtInc
    2. chemokine activity Source: UniProtKB
    3. CXCR3 chemokine receptor binding Source: UniProtKB
    4. heparin binding Source: UniProt
    5. protein binding Source: IntAct
    6. receptor binding Source: ProtInc

    GO - Biological processi

    1. blood circulation Source: ProtInc
    2. cell-cell signaling Source: ProtInc
    3. cell surface receptor signaling pathway Source: ProtInc
    4. cellular response to heat Source: Ensembl
    5. cellular response to lipopolysaccharide Source: MGI
    6. chemokine-mediated signaling pathway Source: UniProt
    7. chemotaxis Source: UniProtKB
    8. defense response to virus Source: Ensembl
    9. G-protein coupled receptor signaling pathway Source: UniProtKB
    10. immune response Source: Ensembl
    11. inflammatory response Source: ProtInc
    12. muscle organ development Source: ProtInc
    13. negative regulation of angiogenesis Source: Ensembl
    14. positive regulation of cAMP-mediated signaling Source: UniProtKB
    15. positive regulation of cAMP metabolic process Source: UniProtKB
    16. positive regulation of cell proliferation Source: ProtInc
    17. positive regulation of leukocyte chemotaxis Source: Ensembl
    18. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    19. positive regulation of T cell migration Source: MGI
    20. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    21. protein secretion Source: Ensembl
    22. regulation of cell proliferation Source: UniProtKB
    23. regulation of protein kinase activity Source: GOC
    24. response to auditory stimulus Source: Ensembl
    25. response to cold Source: Ensembl
    26. response to gamma radiation Source: Ensembl
    27. response to vitamin D Source: Ensembl
    28. signal transduction Source: ProtInc
    29. T cell chemotaxis Source: UniProt

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 10
    Alternative name(s):
    10 kDa interferon gamma-induced protein
    Short name:
    Gamma-IP10
    Short name:
    IP-10
    Small-inducible cytokine B10
    Cleaved into the following chain:
    Gene namesi
    Name:CXCL10
    Synonyms:INP10, SCYB10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10637. CXCL10.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: BHF-UCL
    3. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35568.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21213 PublicationsAdd
    BLAST
    Chaini22 – 9877C-X-C motif chemokine 10PRO_0000005101Add
    BLAST
    Chaini22 – 9473CXCL10(1-73)PRO_0000005102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261Citrulline; by PAD21 Publication
    Disulfide bondi30 ↔ 57
    Disulfide bondi32 ↔ 74

    Post-translational modificationi

    CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.

    Keywords - PTMi

    Citrullination, Disulfide bond

    Proteomic databases

    MaxQBiP02778.
    PaxDbiP02778.
    PRIDEiP02778.

    PTM databases

    PhosphoSiteiP02778.

    Expressioni

    Inductioni

    By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

    Gene expression databases

    BgeeiP02778.
    CleanExiHS_CXCL10.
    GenevestigatoriP02778.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DPP4P274872EBI-7815386,EBI-2871277

    Protein-protein interaction databases

    BioGridi109839. 2 interactions.
    DIPiDIP-5893N.
    IntActiP02778. 2 interactions.
    MINTiMINT-91448.
    STRINGi9606.ENSP00000305651.

    Structurei

    Secondary structure

    1
    98
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni42 – 443
    Beta strandi45 – 517
    Beta strandi57 – 593
    Beta strandi61 – 666
    Turni67 – 693
    Beta strandi72 – 754
    Beta strandi77 – 793
    Helixi80 – 889

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LV9NMR-A22-98[»]
    1O7YX-ray3.00A/B/C/D22-98[»]
    1O7ZX-ray1.92A/B22-98[»]
    1O80X-ray2.00A/B22-98[»]
    ProteinModelPortaliP02778.
    SMRiP02778. Positions 30-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02778.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47968.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiP02778.
    KOiK12671.
    OMAiSQSCPRV.
    OrthoDBiEOG7HHWVH.
    PhylomeDBiP02778.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR027220. Chemokine_CXCL10.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF5. PTHR10179:SF5. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02778-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI   50
    IPASQFCPRV EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP 98
    Length:98
    Mass (Da):10,881
    Last modified:June 20, 2002 - v2
    Checksum:i44AE51967C58DDFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931R → M in CAA26370. (PubMed:3925348)Curated

    Mass spectrometryi

    Molecular mass is 8641.8 Da from positions 22 - 98. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02530 mRNA. Translation: CAA26370.1.
    BC010954 mRNA. Translation: AAH10954.1.
    CCDSiCCDS43240.1.
    PIRiA03243. TGHUGI.
    RefSeqiNP_001556.2. NM_001565.3.
    UniGeneiHs.632586.

    Genome annotation databases

    EnsembliENST00000306602; ENSP00000305651; ENSG00000169245.
    GeneIDi3627.
    KEGGihsa:3627.
    UCSCiuc003hjl.4. human.

    Polymorphism databases

    DMDMi21542456.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL10 entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02530 mRNA. Translation: CAA26370.1 .
    BC010954 mRNA. Translation: AAH10954.1 .
    CCDSi CCDS43240.1.
    PIRi A03243. TGHUGI.
    RefSeqi NP_001556.2. NM_001565.3.
    UniGenei Hs.632586.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LV9 NMR - A 22-98 [» ]
    1O7Y X-ray 3.00 A/B/C/D 22-98 [» ]
    1O7Z X-ray 1.92 A/B 22-98 [» ]
    1O80 X-ray 2.00 A/B 22-98 [» ]
    ProteinModelPortali P02778.
    SMRi P02778. Positions 30-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109839. 2 interactions.
    DIPi DIP-5893N.
    IntActi P02778. 2 interactions.
    MINTi MINT-91448.
    STRINGi 9606.ENSP00000305651.

    PTM databases

    PhosphoSitei P02778.

    Polymorphism databases

    DMDMi 21542456.

    Proteomic databases

    MaxQBi P02778.
    PaxDbi P02778.
    PRIDEi P02778.

    Protocols and materials databases

    DNASUi 3627.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306602 ; ENSP00000305651 ; ENSG00000169245 .
    GeneIDi 3627.
    KEGGi hsa:3627.
    UCSCi uc003hjl.4. human.

    Organism-specific databases

    CTDi 3627.
    GeneCardsi GC04M076942.
    HGNCi HGNC:10637. CXCL10.
    MIMi 147310. gene.
    neXtProti NX_P02778.
    PharmGKBi PA35568.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47968.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi P02778.
    KOi K12671.
    OMAi SQSCPRV.
    OrthoDBi EOG7HHWVH.
    PhylomeDBi P02778.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P02778.
    GeneWikii CXCL10.
    GenomeRNAii 3627.
    NextBioi 14193.
    PROi P02778.
    SOURCEi Search...

    Gene expression databases

    Bgeei P02778.
    CleanExi HS_CXCL10.
    Genevestigatori P02778.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR027220. Chemokine_CXCL10.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF5. PTHR10179:SF5. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins."
      Luster A.D., Unkeless J.C., Ravetch J.V.
      Nature 315:672-676(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. "Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
      Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J.
      J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-51.
    4. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
      Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
      J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-29.
      Tissue: Keratinocyte.
    5. "Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity."
      Hensbergen P.J., van der Raaij-Helmer E.M.H., Dijkman R., van der Schors R.C., Werner-Felmayer G., Boorsma D.M., Scheper R.J., Willemze R., Tensen C.P.
      Eur. J. Biochem. 268:4992-4999(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-27; 60-67 AND 79-98, MASS SPECTROMETRY, IDENTIFICATION OF CXCL10(1-73).
      Tissue: Foreskin keratinocyte.
    6. "Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation."
      Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P., Van Damme J., Proost P.
      Blood 112:2648-2656(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CITRULLINATION AT ARG-26.
    7. "The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions."
      Booth V., Keizer D.W., Kamphuis M.B., Clark-Lewis I., Sykes B.D.
      Biochemistry 41:10418-10425(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 22-98.

    Entry informationi

    Entry nameiCXL10_HUMAN
    AccessioniPrimary (citable) accession number: P02778
    Secondary accession number(s): Q96QJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 162 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3