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P02778

- CXL10_HUMAN

UniProt

P02778 - CXL10_HUMAN

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Protein

C-X-C motif chemokine 10

Gene

CXCL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.

GO - Molecular functioni

  1. cAMP-dependent protein kinase regulator activity Source: ProtInc
  2. chemokine activity Source: UniProtKB
  3. CXCR3 chemokine receptor binding Source: UniProtKB
  4. heparin binding Source: UniProt
  5. receptor binding Source: ProtInc

GO - Biological processi

  1. blood circulation Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. cell surface receptor signaling pathway Source: ProtInc
  4. cellular response to heat Source: Ensembl
  5. cellular response to lipopolysaccharide Source: MGI
  6. chemokine-mediated signaling pathway Source: UniProt
  7. chemotaxis Source: UniProtKB
  8. defense response to virus Source: Ensembl
  9. G-protein coupled receptor signaling pathway Source: UniProtKB
  10. immune response Source: Ensembl
  11. inflammatory response Source: ProtInc
  12. muscle organ development Source: ProtInc
  13. negative regulation of angiogenesis Source: Ensembl
  14. positive regulation of cAMP-mediated signaling Source: UniProtKB
  15. positive regulation of cAMP metabolic process Source: UniProtKB
  16. positive regulation of cell proliferation Source: ProtInc
  17. positive regulation of leukocyte chemotaxis Source: Ensembl
  18. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  19. positive regulation of T cell migration Source: MGI
  20. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  21. protein secretion Source: Ensembl
  22. regulation of cell proliferation Source: UniProtKB
  23. regulation of protein kinase activity Source: GOC
  24. response to auditory stimulus Source: Ensembl
  25. response to cold Source: Ensembl
  26. response to gamma radiation Source: Ensembl
  27. response to vitamin D Source: Ensembl
  28. signal transduction Source: ProtInc
  29. T cell chemotaxis Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name:
Gamma-IP10
Short name:
IP-10
Small-inducible cytokine B10
Cleaved into the following chain:
Gene namesi
Name:CXCL10
Synonyms:INP10, SCYB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:10637. CXCL10.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular region Source: BHF-UCL
  3. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21213 PublicationsAdd
BLAST
Chaini22 – 9877C-X-C motif chemokine 10PRO_0000005101Add
BLAST
Chaini22 – 9473CXCL10(1-73)PRO_0000005102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Citrulline; by PAD21 Publication
Disulfide bondi30 ↔ 57
Disulfide bondi32 ↔ 74

Post-translational modificationi

CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

MaxQBiP02778.
PaxDbiP02778.
PRIDEiP02778.

PTM databases

PhosphoSiteiP02778.

Expressioni

Inductioni

By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Gene expression databases

BgeeiP02778.
CleanExiHS_CXCL10.
GenevestigatoriP02778.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-7815386,EBI-2871277

Protein-protein interaction databases

BioGridi109839. 2 interactions.
DIPiDIP-5893N.
IntActiP02778. 2 interactions.
MINTiMINT-91448.
STRINGi9606.ENSP00000305651.

Structurei

Secondary structure

1
98
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni42 – 443Combined sources
Beta strandi45 – 517Combined sources
Beta strandi57 – 593Combined sources
Beta strandi61 – 666Combined sources
Turni67 – 693Combined sources
Beta strandi72 – 754Combined sources
Beta strandi77 – 793Combined sources
Helixi80 – 889Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LV9NMR-A22-98[»]
1O7YX-ray3.00A/B/C/D22-98[»]
1O7ZX-ray1.92A/B22-98[»]
1O80X-ray2.00A/B22-98[»]
ProteinModelPortaliP02778.
SMRiP02778. Positions 30-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02778.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47968.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP02778.
KOiK12671.
OMAiSQSCPRV.
OrthoDBiEOG7HHWVH.
PhylomeDBiP02778.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02778-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQTAILICC LIFLTLSGIQ GVPLSRTVRC TCISISNQPV NPRSLEKLEI
60 70 80 90
IPASQFCPRV EIIATMKKKG EKRCLNPESK AIKNLLKAVS KERSKRSP
Length:98
Mass (Da):10,881
Last modified:June 20, 2002 - v2
Checksum:i44AE51967C58DDFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931R → M in CAA26370. (PubMed:3925348)Curated

Mass spectrometryi

Molecular mass is 8641.8 Da from positions 22 - 98. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02530 mRNA. Translation: CAA26370.1.
BC010954 mRNA. Translation: AAH10954.1.
CCDSiCCDS43240.1.
PIRiA03243. TGHUGI.
RefSeqiNP_001556.2. NM_001565.3.
UniGeneiHs.632586.

Genome annotation databases

EnsembliENST00000306602; ENSP00000305651; ENSG00000169245.
GeneIDi3627.
KEGGihsa:3627.
UCSCiuc003hjl.4. human.

Polymorphism databases

DMDMi21542456.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL10 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02530 mRNA. Translation: CAA26370.1 .
BC010954 mRNA. Translation: AAH10954.1 .
CCDSi CCDS43240.1.
PIRi A03243. TGHUGI.
RefSeqi NP_001556.2. NM_001565.3.
UniGenei Hs.632586.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LV9 NMR - A 22-98 [» ]
1O7Y X-ray 3.00 A/B/C/D 22-98 [» ]
1O7Z X-ray 1.92 A/B 22-98 [» ]
1O80 X-ray 2.00 A/B 22-98 [» ]
ProteinModelPortali P02778.
SMRi P02778. Positions 30-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109839. 2 interactions.
DIPi DIP-5893N.
IntActi P02778. 2 interactions.
MINTi MINT-91448.
STRINGi 9606.ENSP00000305651.

PTM databases

PhosphoSitei P02778.

Polymorphism databases

DMDMi 21542456.

Proteomic databases

MaxQBi P02778.
PaxDbi P02778.
PRIDEi P02778.

Protocols and materials databases

DNASUi 3627.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306602 ; ENSP00000305651 ; ENSG00000169245 .
GeneIDi 3627.
KEGGi hsa:3627.
UCSCi uc003hjl.4. human.

Organism-specific databases

CTDi 3627.
GeneCardsi GC04M076942.
HGNCi HGNC:10637. CXCL10.
MIMi 147310. gene.
neXtProti NX_P02778.
PharmGKBi PA35568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47968.
GeneTreei ENSGT00530000063958.
HOGENOMi HOG000220915.
HOVERGENi HBG107789.
InParanoidi P02778.
KOi K12671.
OMAi SQSCPRV.
OrthoDBi EOG7HHWVH.
PhylomeDBi P02778.
TreeFami TF333433.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P02778.
GeneWikii CXCL10.
GenomeRNAii 3627.
NextBioi 14193.
PROi P02778.
SOURCEi Search...

Gene expression databases

Bgeei P02778.
CleanExi HS_CXCL10.
Genevestigatori P02778.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins."
    Luster A.D., Unkeless J.C., Ravetch J.V.
    Nature 315:672-676(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."
    Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J.
    J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-51.
  4. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
    Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
    J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-29.
    Tissue: Keratinocyte.
  5. "Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity."
    Hensbergen P.J., van der Raaij-Helmer E.M.H., Dijkman R., van der Schors R.C., Werner-Felmayer G., Boorsma D.M., Scheper R.J., Willemze R., Tensen C.P.
    Eur. J. Biochem. 268:4992-4999(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-27; 60-67 AND 79-98, MASS SPECTROMETRY, IDENTIFICATION OF CXCL10(1-73).
    Tissue: Foreskin keratinocyte.
  6. "Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation."
    Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P., Van Damme J., Proost P.
    Blood 112:2648-2656(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CITRULLINATION AT ARG-26.
  7. "The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions."
    Booth V., Keizer D.W., Kamphuis M.B., Clark-Lewis I., Sykes B.D.
    Biochemistry 41:10418-10425(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 22-98.

Entry informationi

Entry nameiCXL10_HUMAN
AccessioniPrimary (citable) accession number: P02778
Secondary accession number(s): Q96QJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 20, 2002
Last modified: November 26, 2014
This is version 164 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3