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Protein

Platelet factor 4

Gene

PF4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet factor 4
Short name:
PF-4
Alternative name(s):
C-X-C motif chemokine 4
Gene namesi
Name:PF4
Synonyms:CXCL4, SCYB4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442981 – 88Platelet factor 4Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi25 ↔ 51
Disulfide bondi27 ↔ 67
Modified residuei41PhosphoserineBy similarity1

Post-translational modificationi

O-linked glycan consists of Gal-GalNAc disaccharide which is modified with sialic acid residues (microheterogeneity).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PRIDEiP02777

PTM databases

iPTMnetiP02777

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 38Combined sources3
Beta strandi39 – 45Combined sources7
Beta strandi55 – 60Combined sources6
Beta strandi65 – 68Combined sources4
Beta strandi70 – 72Combined sources3
Helixi74 – 83Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PLFX-ray2.20A/B/C/D14-83[»]
ProteinModelPortaliP02777
SMRiP02777
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02777

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 82Heparin-bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG107789
InParanoidiP02777

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
IPR027222 PF4
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF43 PTHR10179:SF43, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

P02777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH
60 70 80
CPSPQLLATK KTGRKICLDQ QRPLYKKILK KLLDGDES
Length:88
Mass (Da):9,523
Last modified:July 21, 1986 - v1
Checksum:i9288E16455250FFB
GO

Sequence databases

PIRiA03242 PFBO4
UniGeneiBt.11581

Similar proteinsi

Entry informationi

Entry nameiPLF4_BOVIN
AccessioniPrimary (citable) accession number: P02777
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health