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Protein

Platelet basic protein

Gene

PPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.4 Publications

GO - Molecular functioni

  • chemokine activity Source: GO_Central
  • CXCR chemokine receptor binding Source: GO_Central
  • glucose transmembrane transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Cytokine, Growth factor, Mitogen

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163736-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet basic protein
Short name:
PBP
Alternative name(s):
C-X-C motif chemokine 7
Leukocyte-derived growth factor
Short name:
LDGF
Macrophage-derived growth factor
Short name:
MDGF
Small-inducible cytokine B7
Cleaved into the following 10 chains:
Alternative name(s):
LA-PF4
Low-affinity platelet factor IV
Beta-thromboglobulin
Short name:
Beta-TG
Gene namesi
Name:PPBP
Synonyms:CTAP3, CXCL7, SCYB7, TGB1, THBGB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9240. PPBP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5473.
OpenTargetsiENSG00000163736.
PharmGKBiPA33561.

Polymorphism and mutation databases

BioMutaiPPBP.
DMDMi129874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 342 PublicationsAdd BLAST34
ChainiPRO_000000508835 – 128Platelet basic proteinAdd BLAST94
ChainiPRO_000000508944 – 128Connective tissue-activating peptide IIIAdd BLAST85
ChainiPRO_000000509044 – 126TC-2Add BLAST83
ChainiPRO_000004194944 – 124Connective tissue-activating peptide III(1-81)Add BLAST81
ChainiPRO_000000509148 – 128Beta-thromboglobulinAdd BLAST81
ChainiPRO_000000509255 – 128Neutrophil-activating peptide 2(74)Add BLAST74
ChainiPRO_000000509356 – 128Neutrophil-activating peptide 2(73)Add BLAST73
ChainiPRO_000000509459 – 128Neutrophil-activating peptide 2Add BLAST70
ChainiPRO_000000509559 – 126TC-1Add BLAST68
ChainiPRO_000000509659 – 124Neutrophil-activating peptide 2(1-66)Add BLAST66
ChainiPRO_000004195059 – 121Neutrophil-activating peptide 2(1-63)Add BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 89
Disulfide bondi65 ↔ 105

Post-translational modificationi

Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).
Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.
NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.1 Publication
NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP02775.
PeptideAtlasiP02775.
PRIDEiP02775.
TopDownProteomicsiP02775.

2D gel databases

SWISS-2DPAGEP02775.

PTM databases

iPTMnetiP02775.
PhosphoSitePlusiP02775.

Miscellaneous databases

PMAP-CutDBP02775.

Expressioni

Gene expression databases

BgeeiENSG00000163736.
CleanExiHS_PPBP.
GenevisibleiP02775. HS.

Organism-specific databases

HPAiCAB017624.
HPA008354.

Interactioni

Subunit structurei

Beta-thromboglobulin is a homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111469. 15 interactors.
DIPiDIP-5913N.
IntActiP02775. 20 interactors.
MINTiMINT-1393871.
STRINGi9606.ENSP00000296028.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi50 – 54Combined sources5
Helixi58 – 60Combined sources3
Helixi74 – 76Combined sources3
Beta strandi77 – 83Combined sources7
Beta strandi89 – 91Combined sources3
Beta strandi93 – 98Combined sources6
Beta strandi103 – 106Combined sources4
Helixi111 – 122Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F9PX-ray1.93A44-128[»]
1NAPX-ray1.90A/B/C/D59-128[»]
1TVXX-ray1.75A/B/C/D54-128[»]
ProteinModelPortaliP02775.
SMRiP02775.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02775.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG75. Eukaryota.
ENOG4111BTH. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP02775.
KOiK10029.
OMAiLYAELRC.
OrthoDBiEOG091G10E9.
PhylomeDBiP02775.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027223. PPBP.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF52. PTHR10179:SF52. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRLDTTPS CNSARPLHAL QVLLLLSLLL TALASSTKGQ TKRNLAKGKE
60 70 80 90 100
ESLDSDLYAE LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD
110 120
GRKICLDPDA PRIKKIVQKK LAGDESAD
Length:128
Mass (Da):13,894
Last modified:November 1, 1991 - v3
Checksum:iBEAB7B75916723D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54995 mRNA. Translation: AAA62836.1.
AF349466 Genomic DNA. Translation: AAK29642.1.
CR456805 mRNA. Translation: CAG33086.1.
AC097709 Genomic DNA. Translation: AAY41004.1.
AK312166 mRNA. Translation: BAG35100.1.
CH471057 Genomic DNA. Translation: EAX05695.1.
BC028217 mRNA. Translation: AAH28217.1.
CCDSiCCDS3563.1.
PIRiA39546. TGHU.
RefSeqiNP_002695.1. NM_002704.3.
UniGeneiHs.2164.

Genome annotation databases

EnsembliENST00000296028; ENSP00000296028; ENSG00000163736.
GeneIDi5473.
KEGGihsa:5473.
UCSCiuc003hhj.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M54995 mRNA. Translation: AAA62836.1.
AF349466 Genomic DNA. Translation: AAK29642.1.
CR456805 mRNA. Translation: CAG33086.1.
AC097709 Genomic DNA. Translation: AAY41004.1.
AK312166 mRNA. Translation: BAG35100.1.
CH471057 Genomic DNA. Translation: EAX05695.1.
BC028217 mRNA. Translation: AAH28217.1.
CCDSiCCDS3563.1.
PIRiA39546. TGHU.
RefSeqiNP_002695.1. NM_002704.3.
UniGeneiHs.2164.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F9PX-ray1.93A44-128[»]
1NAPX-ray1.90A/B/C/D59-128[»]
1TVXX-ray1.75A/B/C/D54-128[»]
ProteinModelPortaliP02775.
SMRiP02775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111469. 15 interactors.
DIPiDIP-5913N.
IntActiP02775. 20 interactors.
MINTiMINT-1393871.
STRINGi9606.ENSP00000296028.

PTM databases

iPTMnetiP02775.
PhosphoSitePlusiP02775.

Polymorphism and mutation databases

BioMutaiPPBP.
DMDMi129874.

2D gel databases

SWISS-2DPAGEP02775.

Proteomic databases

PaxDbiP02775.
PeptideAtlasiP02775.
PRIDEiP02775.
TopDownProteomicsiP02775.

Protocols and materials databases

DNASUi5473.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296028; ENSP00000296028; ENSG00000163736.
GeneIDi5473.
KEGGihsa:5473.
UCSCiuc003hhj.4. human.

Organism-specific databases

CTDi5473.
DisGeNETi5473.
GeneCardsiPPBP.
H-InvDBHIX0031528.
HGNCiHGNC:9240. PPBP.
HPAiCAB017624.
HPA008354.
MIMi121010. gene.
neXtProtiNX_P02775.
OpenTargetsiENSG00000163736.
PharmGKBiPA33561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG75. Eukaryota.
ENOG4111BTH. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP02775.
KOiK10029.
OMAiLYAELRC.
OrthoDBiEOG091G10E9.
PhylomeDBiP02775.
TreeFamiTF333433.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163736-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP02775.
GeneWikiiCXCL7.
GenomeRNAii5473.
PMAP-CutDBP02775.
PROiP02775.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163736.
CleanExiHS_PPBP.
GenevisibleiP02775. HS.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027223. PPBP.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF52. PTHR10179:SF52. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL7_HUMAN
AccessioniPrimary (citable) accession number: P02775
Secondary accession number(s): B2R5F3, Q6IBJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 182 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.