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P02772

- FETA_MOUSE

UniProt

P02772 - FETA_MOUSE

Protein

Alpha-fetoprotein

Gene

Afp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Binds estrogens, fatty acids and metals.

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. ovulation from ovarian follicle Source: MGI
    2. progesterone metabolic process Source: MGI
    3. sexual reproduction Source: MGI
    4. SMAD protein signal transduction Source: MGI
    5. transport Source: InterPro

    Keywords - Ligandi

    Copper, Metal-binding, Nickel

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-fetoprotein
    Alternative name(s):
    Alpha-1-fetoprotein
    Alpha-fetoglobulin
    Gene namesi
    Name:Afp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:87951. Afp.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 605587Alpha-fetoproteinPRO_0000001098Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi95 ↔ 110PROSITE-ProRule annotation
    Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
    Disulfide bondi144 ↔ 189PROSITE-ProRule annotation
    Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi220 ↔ 266PROSITE-ProRule annotation
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi265 ↔ 273PROSITE-ProRule annotation
    Disulfide bondi285 ↔ 299PROSITE-ProRule annotation
    Disulfide bondi298 ↔ 309PROSITE-ProRule annotation
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
    Disulfide bondi412 ↔ 458PROSITE-ProRule annotation
    Disulfide bondi457 ↔ 468PROSITE-ProRule annotation
    Disulfide bondi481 ↔ 497PROSITE-ProRule annotation
    Disulfide bondi496 ↔ 507PROSITE-ProRule annotation
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi534 ↔ 579PROSITE-ProRule annotation
    Disulfide bondi578 ↔ 587PROSITE-ProRule annotation

    Post-translational modificationi

    Glycosylated; contains two glycans.
    Sulfated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Proteomic databases

    MaxQBiP02772.
    PaxDbiP02772.
    PRIDEiP02772.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00113163.

    PTM databases

    PhosphoSiteiP02772.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    ArrayExpressiP02772.
    BgeeiP02772.
    CleanExiMM_AFP.
    GenevestigatoriP02772.

    Structurei

    3D structure databases

    ProteinModelPortaliP02772.
    SMRiP02772. Positions 40-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 207189Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini208 – 398191Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 597199Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45992.
    GeneTreeiENSGT00390000000113.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    InParanoidiP02772.
    KOiK16144.
    OMAiFHKDLCQ.
    OrthoDBiEOG7S4X5C.
    PhylomeDBiP02772.
    TreeFamiTF335561.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR001703. Alpha-fetoprotein.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00803. AFETOPROTEIN.
    PR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 2 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02772-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWITPASLI LLLHFAASKA LHENEFGIAS TLDSSQCVTE KNVLSIATIT    50
    FTQFVPEATE EEVNKMTSDV LAAMKKNSGD GCLESQLSVF LDEICHETEL 100
    SNKYGLSGCC SQSGVERHQC LLARKKTAPA SVPPFQFPEP AESCKAHEEN 150
    RAVFMNRFIY EVSRRNPFMY APAILSLAAQ YDKVVLACCK ADNKEECFQT 200
    KRASIAKELR EGSMLNEHVC SVIRKFGSRN LQATTIIKLS QKLTEANFTE 250
    IQKLALDVAH IHEECCQGNS LECLQDGEKV MTYICSQQNI LSSKIAECCK 300
    LPMIQLGFCI IHAENGVKPE GLSLNPSQFL GDRNFAQFSS EEKIMFMASF 350
    LHEYSRTHPN LPVSVILRIA KTYQEILEKC SQSGNLPGCQ DNLEEELQKH 400
    IEESQALSKQ SCALYQTLGD YKLQNLFLIG YTRKAPQLTS AELIDLTGKM 450
    VSIASTCCQL SEEKWSGCGE GMADIFIGHL CIRNEASPVN SGISHCCNSS 500
    YSNRRLCITS FLRDETYAPP PFSEDKFIFH KDLCQAQGKA LQTMKQELLI 550
    NLVKQKPELT EEQLAAVTAD FSGLLEKCCK AQDQEVCFTE EGPKLISKTR 600
    DALGV 605
    Length:605
    Mass (Da):67,337
    Last modified:July 21, 1986 - v1
    Checksum:iCE09E9F50D74619A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti533 – 5364LCQA → RAKL no nucleotide entry (PubMed:6161929)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00743 mRNA. Translation: CAA24118.1.
    M16394
    , M16381, M16382, M16383, M16384, M16385, M16386, M16387, M16388, M16389, M16390, M16391, M16392, M16393 Genomic DNA. Translation: AAA37189.1.
    AK010934 mRNA. Translation: BAB27278.1.
    AK145975 mRNA. Translation: BAE26798.1.
    AK146513 mRNA. Translation: BAE27225.1.
    AK146524 mRNA. Translation: BAE27233.1.
    AK167549 mRNA. Translation: BAE39615.1.
    AK168574 mRNA. Translation: BAE40444.1.
    AK168576 mRNA. Translation: BAE40446.1.
    AK168751 mRNA. Translation: BAE40591.1.
    AK168883 mRNA. Translation: BAE40701.1.
    AK169046 mRNA. Translation: BAE40834.1.
    AK169054 mRNA. Translation: BAE40842.1.
    AK169147 mRNA. Translation: BAE40926.1.
    BC066206 mRNA. Translation: AAH66206.1.
    CCDSiCCDS19413.1.
    PIRiA93254. FPMS.
    RefSeqiNP_031449.3. NM_007423.4.
    UniGeneiMm.358570.

    Genome annotation databases

    EnsembliENSMUST00000042755; ENSMUSP00000041006; ENSMUSG00000054932.
    GeneIDi11576.
    KEGGimmu:11576.
    UCSCiuc008yba.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00743 mRNA. Translation: CAA24118.1 .
    M16394
    , M16381 , M16382 , M16383 , M16384 , M16385 , M16386 , M16387 , M16388 , M16389 , M16390 , M16391 , M16392 , M16393 Genomic DNA. Translation: AAA37189.1 .
    AK010934 mRNA. Translation: BAB27278.1 .
    AK145975 mRNA. Translation: BAE26798.1 .
    AK146513 mRNA. Translation: BAE27225.1 .
    AK146524 mRNA. Translation: BAE27233.1 .
    AK167549 mRNA. Translation: BAE39615.1 .
    AK168574 mRNA. Translation: BAE40444.1 .
    AK168576 mRNA. Translation: BAE40446.1 .
    AK168751 mRNA. Translation: BAE40591.1 .
    AK168883 mRNA. Translation: BAE40701.1 .
    AK169046 mRNA. Translation: BAE40834.1 .
    AK169054 mRNA. Translation: BAE40842.1 .
    AK169147 mRNA. Translation: BAE40926.1 .
    BC066206 mRNA. Translation: AAH66206.1 .
    CCDSi CCDS19413.1.
    PIRi A93254. FPMS.
    RefSeqi NP_031449.3. NM_007423.4.
    UniGenei Mm.358570.

    3D structure databases

    ProteinModelPortali P02772.
    SMRi P02772. Positions 40-604.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P02772.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00113163.

    Proteomic databases

    MaxQBi P02772.
    PaxDbi P02772.
    PRIDEi P02772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042755 ; ENSMUSP00000041006 ; ENSMUSG00000054932 .
    GeneIDi 11576.
    KEGGi mmu:11576.
    UCSCi uc008yba.2. mouse.

    Organism-specific databases

    CTDi 174.
    MGIi MGI:87951. Afp.

    Phylogenomic databases

    eggNOGi NOG45992.
    GeneTreei ENSGT00390000000113.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    InParanoidi P02772.
    KOi K16144.
    OMAi FHKDLCQ.
    OrthoDBi EOG7S4X5C.
    PhylomeDBi P02772.
    TreeFami TF335561.

    Miscellaneous databases

    NextBioi 279098.
    PROi P02772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02772.
    Bgeei P02772.
    CleanExi MM_AFP.
    Genevestigatori P02772.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR001703. Alpha-fetoprotein.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00803. AFETOPROTEIN.
    PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 2 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin."
      Law S.W., Dugaiczyk A.
      Nature 291:201-205(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes."
      Minghetti P.P., Law S.W., Dugaiczyk A.
      Mol. Biol. Evol. 2:347-358(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 598.
    3. "Intragenic amplification and divergence in the mouse alpha-fetoprotein gene."
      Eiferman F.A., Young P.R., Scott R.W., Tilghman S.M.
      Nature 294:713-718(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Liver and Placenta.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    6. "The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin."
      Gorin M.B., Cooper D.L., Eiferman F.A., van de Rijn P., Tilghman S.M.
      J. Biol. Chem. 256:1954-1959(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-605.

    Entry informationi

    Entry nameiFETA_MOUSE
    AccessioniPrimary (citable) accession number: P02772
    Secondary accession number(s): Q3UJD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3