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P02772 (FETA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-fetoprotein
Alternative name(s):
Alpha-1-fetoprotein
Alpha-fetoglobulin
Gene names
Name:Afp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds estrogens, fatty acids and metals.

Subcellular location

Secreted.

Tissue specificity

Plasma.

Post-translational modification

Glycosylated; contains two glycans.

Sulfated By similarity.

Sequence similarities

Belongs to the ALB/AFP/VDB family.

Contains 3 albumin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 605587Alpha-fetoprotein
PRO_0000001098

Regions

Domain19 – 207189Albumin 1
Domain208 – 398191Albumin 2
Domain399 – 597199Albumin 3

Amino acid modifications

Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 110 By similarity
Disulfide bond109 ↔ 120 By similarity
Disulfide bond144 ↔ 189 By similarity
Disulfide bond188 ↔ 197 By similarity
Disulfide bond220 ↔ 266 By similarity
Disulfide bond265 ↔ 273 By similarity
Disulfide bond285 ↔ 299 By similarity
Disulfide bond298 ↔ 309 By similarity
Disulfide bond380 ↔ 389 By similarity
Disulfide bond412 ↔ 458 By similarity
Disulfide bond457 ↔ 468 By similarity
Disulfide bond481 ↔ 497 By similarity
Disulfide bond496 ↔ 507 By similarity
Disulfide bond534 ↔ 579 By similarity
Disulfide bond578 ↔ 587 By similarity

Experimental info

Sequence conflict533 – 5364LCQA → RAKL no nucleotide entry Ref.6

Sequences

Sequence LengthMass (Da)Tools
P02772 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: CE09E9F50D74619A

FASTA60567,337
        10         20         30         40         50         60 
MKWITPASLI LLLHFAASKA LHENEFGIAS TLDSSQCVTE KNVLSIATIT FTQFVPEATE 

        70         80         90        100        110        120 
EEVNKMTSDV LAAMKKNSGD GCLESQLSVF LDEICHETEL SNKYGLSGCC SQSGVERHQC 

       130        140        150        160        170        180 
LLARKKTAPA SVPPFQFPEP AESCKAHEEN RAVFMNRFIY EVSRRNPFMY APAILSLAAQ 

       190        200        210        220        230        240 
YDKVVLACCK ADNKEECFQT KRASIAKELR EGSMLNEHVC SVIRKFGSRN LQATTIIKLS 

       250        260        270        280        290        300 
QKLTEANFTE IQKLALDVAH IHEECCQGNS LECLQDGEKV MTYICSQQNI LSSKIAECCK 

       310        320        330        340        350        360 
LPMIQLGFCI IHAENGVKPE GLSLNPSQFL GDRNFAQFSS EEKIMFMASF LHEYSRTHPN 

       370        380        390        400        410        420 
LPVSVILRIA KTYQEILEKC SQSGNLPGCQ DNLEEELQKH IEESQALSKQ SCALYQTLGD 

       430        440        450        460        470        480 
YKLQNLFLIG YTRKAPQLTS AELIDLTGKM VSIASTCCQL SEEKWSGCGE GMADIFIGHL 

       490        500        510        520        530        540 
CIRNEASPVN SGISHCCNSS YSNRRLCITS FLRDETYAPP PFSEDKFIFH KDLCQAQGKA 

       550        560        570        580        590        600 
LQTMKQELLI NLVKQKPELT EEQLAAVTAD FSGLLEKCCK AQDQEVCFTE EGPKLISKTR 


DALGV 

« Hide

References

« Hide 'large scale' references
[1]"Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin."
Law S.W., Dugaiczyk A.
Nature 291:201-205(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes."
Minghetti P.P., Law S.W., Dugaiczyk A.
Mol. Biol. Evol. 2:347-358(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 598.
[3]"Intragenic amplification and divergence in the mouse alpha-fetoprotein gene."
Eiferman F.A., Young P.R., Scott R.W., Tilghman S.M.
Nature 294:713-718(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Amnion, Liver and Placenta.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[6]"The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin."
Gorin M.B., Cooper D.L., Eiferman F.A., van de Rijn P., Tilghman S.M.
J. Biol. Chem. 256:1954-1959(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-605.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00743 mRNA. Translation: CAA24118.1.
M16394 expand/collapse EMBL AC list , M16381, M16382, M16383, M16384, M16385, M16386, M16387, M16388, M16389, M16390, M16391, M16392, M16393 Genomic DNA. Translation: AAA37189.1.
AK010934 mRNA. Translation: BAB27278.1.
AK145975 mRNA. Translation: BAE26798.1.
AK146513 mRNA. Translation: BAE27225.1.
AK146524 mRNA. Translation: BAE27233.1.
AK167549 mRNA. Translation: BAE39615.1.
AK168574 mRNA. Translation: BAE40444.1.
AK168576 mRNA. Translation: BAE40446.1.
AK168751 mRNA. Translation: BAE40591.1.
AK168883 mRNA. Translation: BAE40701.1.
AK169046 mRNA. Translation: BAE40834.1.
AK169054 mRNA. Translation: BAE40842.1.
AK169147 mRNA. Translation: BAE40926.1.
BC066206 mRNA. Translation: AAH66206.1.
CCDSCCDS19413.1.
PIRFPMS. A93254.
RefSeqNP_031449.3. NM_007423.4.
UniGeneMm.358570.

3D structure databases

ProteinModelPortalP02772.
SMRP02772. Positions 40-604.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP02772.

2D gel databases

REPRODUCTION-2DPAGEIPI00113163.

Proteomic databases

MaxQBP02772.
PaxDbP02772.
PRIDEP02772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042755; ENSMUSP00000041006; ENSMUSG00000054932.
GeneID11576.
KEGGmmu:11576.
UCSCuc008yba.2. mouse.

Organism-specific databases

CTD174.
MGIMGI:87951. Afp.

Phylogenomic databases

eggNOGNOG45992.
GeneTreeENSGT00390000000113.
HOGENOMHOG000293137.
HOVERGENHBG004207.
InParanoidP02772.
KOK16144.
OMAFHKDLCQ.
OrthoDBEOG7S4X5C.
PhylomeDBP02772.
TreeFamTF335561.

Gene expression databases

ArrayExpressP02772.
BgeeP02772.
CleanExMM_AFP.
GenevestigatorP02772.

Family and domain databases

InterProIPR000264. ALB/AFP/VDB.
IPR001703. Alpha-fetoprotein.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMSSF48552. SSF48552. 3 hits.
PROSITEPS00212. ALBUMIN_1. 2 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279098.
PROP02772.
SOURCESearch...

Entry information

Entry nameFETA_MOUSE
AccessionPrimary (citable) accession number: P02772
Secondary accession number(s): Q3UJD0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot