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Protein

Serum albumin

Gene

Alb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Copper1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi271ZincBy similarity1
Metal bindingi273ZincBy similarity1

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • drug binding Source: UniProtKB
  • enzyme binding Source: RGD
  • fatty acid binding Source: UniProtKB
  • pyridoxal phosphate binding Source: UniProtKB
  • toxic substance binding Source: UniProtKB
  • zinc ion binding Source: RGD

GO - Biological processi

  • cellular response to starvation Source: UniProtKB
  • hemolysis by symbiont of host erythrocytes Source: UniProtKB
  • maintenance of mitochondrion location Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  • response to mercury ion Source: RGD
  • response to nutrient Source: RGD
  • response to organic substance Source: RGD
  • response to platinum ion Source: RGD
  • transport Source: InterPro
  • vasodilation Source: RGD
Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:Alb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2085. Alb.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: RGD
  • extracellular space Source: RGD
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei756. Rat n 4.

Chemistry databases

ChEMBLiCHEMBL4817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
PropeptideiPRO_000000107919 – 241 Publication6
ChainiPRO_000000108025 – 608Serum albuminAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Modified residuei297PhosphoserineBy similarity1
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei443PhosphoserineCombined sources1
Modified residuei444PhosphothreonineBy similarity1
Modified residuei446PhosphothreonineBy similarity1
Modified residuei460N6-succinyllysineBy similarity1
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Modified residuei513PhosphoserineBy similarity1
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Modified residuei543N6-succinyllysineBy similarity1
Modified residuei558N6-methyllysineBy similarity1
Modified residuei570PhosphothreonineCombined sources1
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
Modified residuei588N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP02770.
PRIDEiP02770.

2D gel databases

UCD-2DPAGEP02770.
World-2DPAGE0004:P02770.

PTM databases

iPTMnetiP02770.
PhosphoSitePlusiP02770.
SwissPalmiP02770.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSRNOG00000002911.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

IntActiP02770. 2 interactors.
MINTiMINT-4542462.
STRINGi10116.ENSRNOP00000003921.

Chemistry databases

BindingDBiP02770.

Structurei

3D structure databases

ProteinModelPortaliP02770.
SMRiP02770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 211Albumin 1PROSITE-ProRule annotationAdd BLAST193
Domaini212 – 403Albumin 2PROSITE-ProRule annotationAdd BLAST192
Domaini404 – 601Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP02770.
KOiK16141.
PhylomeDBiP02770.
TreeFamiTF335561.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFLLLL FISGSAFSRG VFRREAHKSE IAHRFKDLGE QHFKGLVLIA
60 70 80 90 100
FSQYLQKCPY EEHIKLVQEV TDFAKTCVAD ENAENCDKSI HTLFGDKLCA
110 120 130 140 150
IPKLRDNYGE LADCCAKQEP ERNECFLQHK DDNPNLPPFQ RPEAEAMCTS
160 170 180 190 200
FQENPTSFLG HYLHEVARRH PYFYAPELLY YAEKYNEVLT QCCTESDKAA
210 220 230 240 250
CLTPKLDAVK EKALVAAVRQ RMKCSSMQRF GERAFKAWAV ARMSQRFPNA
260 270 280 290 300
EFAEITKLAT DVTKINKECC HGDLLECADD RAELAKYMCE NQATISSKLQ
310 320 330 340 350
ACCDKPVLQK SQCLAEIEHD NIPADLPSIA ADFVEDKEVC KNYAEAKDVF
360 370 380 390 400
LGTFLYEYSR RHPDYSVSLL LRLAKKYEAT LEKCCAEGDP PACYGTVLAE
410 420 430 440 450
FQPLVEEPKN LVKTNCELYE KLGEYGFQNA VLVRYTQKAP QVSTPTLVEA
460 470 480 490 500
ARNLGRVGTK CCTLPEAQRL PCVEDYLSAI LNRLCVLHEK TPVSEKVTKC
510 520 530 540 550
CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL PDKEKQIKKQ
560 570 580 590 600
TALAELVKHK PKATEDQLKT VMGDFAQFVD KCCKAADKDN CFATEGPNLV

ARSKEALA
Length:608
Mass (Da):68,731
Last modified:January 23, 2007 - v2
Checksum:i07475796EA94938C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174Y → L AA sequence (PubMed:2437111).Curated1
Sequence conflicti317I → T in CAA24532 (PubMed:7017712).Curated1
Sequence conflicti431V → I in AAH85359 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti262V → L.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01222 mRNA. Translation: CAA24532.1.
BC085359 mRNA. Translation: AAH85359.1.
PIRiA93872. ABRTS.
RefSeqiNP_599153.2. NM_134326.2.
UniGeneiRn.202968.
Rn.49051.

Genome annotation databases

GeneIDi24186.
KEGGirno:24186.
UCSCiRGD:2085. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01222 mRNA. Translation: CAA24532.1.
BC085359 mRNA. Translation: AAH85359.1.
PIRiA93872. ABRTS.
RefSeqiNP_599153.2. NM_134326.2.
UniGeneiRn.202968.
Rn.49051.

3D structure databases

ProteinModelPortaliP02770.
SMRiP02770.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02770. 2 interactors.
MINTiMINT-4542462.
STRINGi10116.ENSRNOP00000003921.

Chemistry databases

BindingDBiP02770.
ChEMBLiCHEMBL4817.

Protein family/group databases

Allergomei756. Rat n 4.

PTM databases

iPTMnetiP02770.
PhosphoSitePlusiP02770.
SwissPalmiP02770.

2D gel databases

UCD-2DPAGEP02770.
World-2DPAGE0004:P02770.

Proteomic databases

PaxDbiP02770.
PRIDEiP02770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24186.
KEGGirno:24186.
UCSCiRGD:2085. rat.

Organism-specific databases

CTDi213.
RGDi2085. Alb.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP02770.
KOiK16141.
PhylomeDBiP02770.
TreeFamiTF335561.

Miscellaneous databases

PROiP02770.

Gene expression databases

BgeeiENSRNOG00000002911.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_RAT
AccessioniPrimary (citable) accession number: P02770
Secondary accession number(s): P11382, Q5U3X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

A peptide arising from positions 166 to 174 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.