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P02770

- ALBU_RAT

UniProt

P02770 - ALBU_RAT

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Protein

Serum albumin

Gene

Alb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Copper
Metal bindingi91 – 911ZincBy similarity
Metal bindingi123 – 1231ZincBy similarity
Metal bindingi271 – 2711ZincBy similarity
Metal bindingi273 – 2731ZincBy similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. drug binding Source: UniProtKB
  3. enzyme binding Source: RGD
  4. fatty acid binding Source: UniProtKB
  5. oxygen binding Source: Ensembl
  6. pyridoxal phosphate binding Source: UniProtKB
  7. toxic substance binding Source: UniProtKB
  8. zinc ion binding Source: RGD

GO - Biological processi

  1. cellular response to starvation Source: UniProtKB
  2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
  3. maintenance of mitochondrion location Source: UniProtKB
  4. negative regulation of apoptotic process Source: UniProtKB
  5. positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
  6. response to mercury ion Source: RGD
  7. response to nutrient Source: RGD
  8. response to organic substance Source: RGD
  9. response to platinum ion Source: RGD
  10. retina homeostasis Source: Ensembl
  11. transport Source: InterPro
  12. vasodilation Source: RGD
Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198732. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:Alb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi2085. Alb.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: RGD
  2. blood microparticle Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. extracellular space Source: RGD
  5. extracellular vesicular exosome Source: Ensembl
  6. nucleus Source: Ensembl
  7. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei756. Rat n 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Propeptidei19 – 224PRO_0000001079
Chaini25 – 608584Serum albuminPRO_0000001080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei443 – 4431PhosphoserineBy similarity
Modified residuei444 – 4441PhosphothreonineBy similarity
Modified residuei446 – 4461PhosphothreonineBy similarity
Modified residuei460 – 4601N6-succinyllysineBy similarity
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Modified residuei543 – 5431N6-succinyllysineBy similarity
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
Modified residuei588 – 5881N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP02770.
PRIDEiP02770.

2D gel databases

UCD-2DPAGEP02770.
World-2DPAGE0004:P02770.

PTM databases

PhosphoSiteiP02770.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

GenevestigatoriP02770.

Interactioni

Protein-protein interaction databases

IntActiP02770. 2 interactions.
MINTiMINT-4542462.

Structurei

3D structure databases

ProteinModelPortaliP02770.
SMRiP02770. Positions 26-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 211193Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini212 – 403192Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 601198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG45992.
GeneTreeiENSGT00390000000113.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP02770.
KOiK16141.
OrthoDBiEOG7S4X5C.
PhylomeDBiP02770.
TreeFamiTF335561.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02770-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKWVTFLLLL FISGSAFSRG VFRREAHKSE IAHRFKDLGE QHFKGLVLIA
60 70 80 90 100
FSQYLQKCPY EEHIKLVQEV TDFAKTCVAD ENAENCDKSI HTLFGDKLCA
110 120 130 140 150
IPKLRDNYGE LADCCAKQEP ERNECFLQHK DDNPNLPPFQ RPEAEAMCTS
160 170 180 190 200
FQENPTSFLG HYLHEVARRH PYFYAPELLY YAEKYNEVLT QCCTESDKAA
210 220 230 240 250
CLTPKLDAVK EKALVAAVRQ RMKCSSMQRF GERAFKAWAV ARMSQRFPNA
260 270 280 290 300
EFAEITKLAT DVTKINKECC HGDLLECADD RAELAKYMCE NQATISSKLQ
310 320 330 340 350
ACCDKPVLQK SQCLAEIEHD NIPADLPSIA ADFVEDKEVC KNYAEAKDVF
360 370 380 390 400
LGTFLYEYSR RHPDYSVSLL LRLAKKYEAT LEKCCAEGDP PACYGTVLAE
410 420 430 440 450
FQPLVEEPKN LVKTNCELYE KLGEYGFQNA VLVRYTQKAP QVSTPTLVEA
460 470 480 490 500
ARNLGRVGTK CCTLPEAQRL PCVEDYLSAI LNRLCVLHEK TPVSEKVTKC
510 520 530 540 550
CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL PDKEKQIKKQ
560 570 580 590 600
TALAELVKHK PKATEDQLKT VMGDFAQFVD KCCKAADKDN CFATEGPNLV

ARSKEALA
Length:608
Mass (Da):68,731
Last modified:January 23, 2007 - v2
Checksum:i07475796EA94938C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741Y → L AA sequence (PubMed:2437111)Curated
Sequence conflicti317 – 3171I → T in CAA24532. (PubMed:7017712)Curated
Sequence conflicti431 – 4311V → I in AAH85359. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti262 – 2621V → L.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01222 mRNA. Translation: CAA24532.1.
BC085359 mRNA. Translation: AAH85359.1.
PIRiA93872. ABRTS.
RefSeqiNP_599153.2. NM_134326.2.
UniGeneiRn.202968.

Genome annotation databases

EnsembliENSRNOT00000003921; ENSRNOP00000003921; ENSRNOG00000002911.
GeneIDi24186.
KEGGirno:24186.
UCSCiRGD:2085. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V01222 mRNA. Translation: CAA24532.1 .
BC085359 mRNA. Translation: AAH85359.1 .
PIRi A93872. ABRTS.
RefSeqi NP_599153.2. NM_134326.2.
UniGenei Rn.202968.

3D structure databases

ProteinModelPortali P02770.
SMRi P02770. Positions 26-608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P02770. 2 interactions.
MINTi MINT-4542462.

Chemistry

BindingDBi P02770.
ChEMBLi CHEMBL4817.

Protein family/group databases

Allergomei 756. Rat n 4.

PTM databases

PhosphoSitei P02770.

2D gel databases

UCD-2DPAGE P02770.
World-2DPAGE 0004:P02770.

Proteomic databases

PaxDbi P02770.
PRIDEi P02770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003921 ; ENSRNOP00000003921 ; ENSRNOG00000002911 .
GeneIDi 24186.
KEGGi rno:24186.
UCSCi RGD:2085. rat.

Organism-specific databases

CTDi 213.
RGDi 2085. Alb.

Phylogenomic databases

eggNOGi NOG45992.
GeneTreei ENSGT00390000000113.
HOGENOMi HOG000293137.
HOVERGENi HBG004207.
InParanoidi P02770.
KOi K16141.
OrthoDBi EOG7S4X5C.
PhylomeDBi P02770.
TreeFami TF335561.

Enzyme and pathway databases

Reactomei REACT_198732. Scavenging of heme from plasma.

Miscellaneous databases

NextBioi 602549.
PROi P02770.

Gene expression databases

Genevestigatori P02770.

Family and domain databases

InterProi IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view ]
Pfami PF00273. Serum_albumin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSi PR00802. SERUMALBUMIN.
SMARTi SM00103. ALBUMIN. 3 hits.
[Graphical view ]
SUPFAMi SSF48552. SSF48552. 3 hits.
PROSITEi PS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cloned rat serum albumin messenger RNA."
    Sargent T.D., Yang M., Bonner J.
    Proc. Natl. Acad. Sci. U.S.A. 78:243-246(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-262.
    Tissue: Ovary.
  3. "Rat liver pre-proalbumin: complete amino acid sequence of the pre-piece. Analysis of the direct translation product of albumin messenger RNA."
    Strauss A.W., Bennett C.D., Donohue A.M., Rodkey J.A., Alberts A.W.
    J. Biol. Chem. 252:6846-6855(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-38, PROTEOLYTIC PROCESSING.
  4. "Amino acid sequences of fragments I and II obtained by cyanogen bromide cleavage of rat serum albumin."
    Isemura S., Ikenaka T.
    J. Biochem. 83:35-48(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-222.
  5. "Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s)."
    Carraway R.E., Mitra S.P., Cochrane D.E.
    J. Biol. Chem. 262:5968-5973(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 166-174.
    Tissue: Plasma.
  6. Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 35-57; 66-75; 89-97; 168-181; 247-264; 287-298; 361-372; 376-383; 414-434; 439-452; 470-483; 509-524; 528-545; 570-581 AND 585-602, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain, Hippocampus and Spinal cord.
  7. "Fragmentation of rat serum albumin by cyanogen bromide cleavage and the amino acid sequences of four fragments."
    Isemura S., Ikenaka T.
    J. Biochem. 79:1183-1196(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 223-288 AND 572-608.
  8. "Copper(II)-binding ability of human alpha-fetoprotein."
    Aoyagi Y., Ikenaka T., Ichida F.
    Cancer Res. 38:3483-3486(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: COPPER-BINDING.

Entry informationi

Entry nameiALBU_RAT
AccessioniPrimary (citable) accession number: P02770
Secondary accession number(s): P11382, Q5U3X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

A peptide arising from positions 166 to 174 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3