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P02770

- ALBU_RAT

UniProt

P02770 - ALBU_RAT

Protein

Serum albumin

Gene

Alb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Copper
    Metal bindingi91 – 911ZincBy similarity
    Metal bindingi123 – 1231ZincBy similarity
    Metal bindingi271 – 2711ZincBy similarity
    Metal bindingi273 – 2731ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. drug binding Source: UniProtKB
    3. enzyme binding Source: RGD
    4. fatty acid binding Source: UniProtKB
    5. oxygen binding Source: Ensembl
    6. pyridoxal phosphate binding Source: UniProtKB
    7. toxic substance binding Source: UniProtKB
    8. zinc ion binding Source: RGD

    GO - Biological processi

    1. cellular response to starvation Source: UniProtKB
    2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
    3. maintenance of mitochondrion location Source: UniProtKB
    4. negative regulation of apoptotic process Source: UniProtKB
    5. positive regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
    6. response to mercury ion Source: RGD
    7. response to nutrient Source: RGD
    8. response to organic substance Source: RGD
    9. response to platinum ion Source: RGD
    10. transport Source: InterPro
    11. vasodilation Source: RGD

    Keywords - Ligandi

    Copper, Lipid-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198732. Scavenging of heme from plasma.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum albumin
    Gene namesi
    Name:Alb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi2085. Alb.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: RGD
    2. cytoplasm Source: Ensembl
    3. extracellular space Source: RGD
    4. extracellular vesicular exosome Source: Ensembl
    5. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei756. Rat n 4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Propeptidei19 – 224PRO_0000001079
    Chaini25 – 608584Serum albuminPRO_0000001080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
    Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
    Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
    Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
    Modified residuei443 – 4431PhosphoserineBy similarity
    Modified residuei444 – 4441PhosphothreonineBy similarity
    Modified residuei446 – 4461PhosphothreonineBy similarity
    Modified residuei460 – 4601N6-succinyllysineBy similarity
    Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
    Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
    Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
    Modified residuei543 – 5431N6-succinyllysineBy similarity
    Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
    Modified residuei588 – 5881N6-succinyllysineBy similarity

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiP02770.
    PRIDEiP02770.

    2D gel databases

    UCD-2DPAGEP02770.
    World-2DPAGE0004:P02770.

    PTM databases

    PhosphoSiteiP02770.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    GenevestigatoriP02770.

    Interactioni

    Protein-protein interaction databases

    IntActiP02770. 2 interactions.
    MINTiMINT-4542462.

    Structurei

    3D structure databases

    ProteinModelPortaliP02770.
    SMRiP02770. Positions 26-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 211193Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini212 – 403192Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 601198Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45992.
    GeneTreeiENSGT00390000000113.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    InParanoidiP02770.
    KOiK16141.
    OrthoDBiEOG7S4X5C.
    PhylomeDBiP02770.
    TreeFamiTF335561.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02770-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWVTFLLLL FISGSAFSRG VFRREAHKSE IAHRFKDLGE QHFKGLVLIA    50
    FSQYLQKCPY EEHIKLVQEV TDFAKTCVAD ENAENCDKSI HTLFGDKLCA 100
    IPKLRDNYGE LADCCAKQEP ERNECFLQHK DDNPNLPPFQ RPEAEAMCTS 150
    FQENPTSFLG HYLHEVARRH PYFYAPELLY YAEKYNEVLT QCCTESDKAA 200
    CLTPKLDAVK EKALVAAVRQ RMKCSSMQRF GERAFKAWAV ARMSQRFPNA 250
    EFAEITKLAT DVTKINKECC HGDLLECADD RAELAKYMCE NQATISSKLQ 300
    ACCDKPVLQK SQCLAEIEHD NIPADLPSIA ADFVEDKEVC KNYAEAKDVF 350
    LGTFLYEYSR RHPDYSVSLL LRLAKKYEAT LEKCCAEGDP PACYGTVLAE 400
    FQPLVEEPKN LVKTNCELYE KLGEYGFQNA VLVRYTQKAP QVSTPTLVEA 450
    ARNLGRVGTK CCTLPEAQRL PCVEDYLSAI LNRLCVLHEK TPVSEKVTKC 500
    CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL PDKEKQIKKQ 550
    TALAELVKHK PKATEDQLKT VMGDFAQFVD KCCKAADKDN CFATEGPNLV 600
    ARSKEALA 608
    Length:608
    Mass (Da):68,731
    Last modified:January 23, 2007 - v2
    Checksum:i07475796EA94938C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741Y → L AA sequence (PubMed:2437111)Curated
    Sequence conflicti317 – 3171I → T in CAA24532. (PubMed:7017712)Curated
    Sequence conflicti431 – 4311V → I in AAH85359. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621V → L.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01222 mRNA. Translation: CAA24532.1.
    BC085359 mRNA. Translation: AAH85359.1.
    PIRiA93872. ABRTS.
    RefSeqiNP_599153.2. NM_134326.2.
    UniGeneiRn.202968.

    Genome annotation databases

    EnsembliENSRNOT00000003921; ENSRNOP00000003921; ENSRNOG00000002911.
    GeneIDi24186.
    KEGGirno:24186.
    UCSCiRGD:2085. rat.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01222 mRNA. Translation: CAA24532.1 .
    BC085359 mRNA. Translation: AAH85359.1 .
    PIRi A93872. ABRTS.
    RefSeqi NP_599153.2. NM_134326.2.
    UniGenei Rn.202968.

    3D structure databases

    ProteinModelPortali P02770.
    SMRi P02770. Positions 26-608.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P02770. 2 interactions.
    MINTi MINT-4542462.

    Chemistry

    BindingDBi P02770.
    ChEMBLi CHEMBL4817.

    Protein family/group databases

    Allergomei 756. Rat n 4.

    PTM databases

    PhosphoSitei P02770.

    2D gel databases

    UCD-2DPAGE P02770.
    World-2DPAGE 0004:P02770.

    Proteomic databases

    PaxDbi P02770.
    PRIDEi P02770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003921 ; ENSRNOP00000003921 ; ENSRNOG00000002911 .
    GeneIDi 24186.
    KEGGi rno:24186.
    UCSCi RGD:2085. rat.

    Organism-specific databases

    CTDi 213.
    RGDi 2085. Alb.

    Phylogenomic databases

    eggNOGi NOG45992.
    GeneTreei ENSGT00390000000113.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    InParanoidi P02770.
    KOi K16141.
    OrthoDBi EOG7S4X5C.
    PhylomeDBi P02770.
    TreeFami TF335561.

    Enzyme and pathway databases

    Reactomei REACT_198732. Scavenging of heme from plasma.

    Miscellaneous databases

    NextBioi 602549.
    PROi P02770.

    Gene expression databases

    Genevestigatori P02770.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cloned rat serum albumin messenger RNA."
      Sargent T.D., Yang M., Bonner J.
      Proc. Natl. Acad. Sci. U.S.A. 78:243-246(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-262.
      Tissue: Ovary.
    3. "Rat liver pre-proalbumin: complete amino acid sequence of the pre-piece. Analysis of the direct translation product of albumin messenger RNA."
      Strauss A.W., Bennett C.D., Donohue A.M., Rodkey J.A., Alberts A.W.
      J. Biol. Chem. 252:6846-6855(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-38, PROTEOLYTIC PROCESSING.
    4. "Amino acid sequences of fragments I and II obtained by cyanogen bromide cleavage of rat serum albumin."
      Isemura S., Ikenaka T.
      J. Biochem. 83:35-48(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-222.
    5. "Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s)."
      Carraway R.E., Mitra S.P., Cochrane D.E.
      J. Biol. Chem. 262:5968-5973(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 166-174.
      Tissue: Plasma.
    6. Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 35-57; 66-75; 89-97; 168-181; 247-264; 287-298; 361-372; 376-383; 414-434; 439-452; 470-483; 509-524; 528-545; 570-581 AND 585-602, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain, Hippocampus and Spinal cord.
    7. "Fragmentation of rat serum albumin by cyanogen bromide cleavage and the amino acid sequences of four fragments."
      Isemura S., Ikenaka T.
      J. Biochem. 79:1183-1196(1976) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 223-288 AND 572-608.
    8. "Copper(II)-binding ability of human alpha-fetoprotein."
      Aoyagi Y., Ikenaka T., Ichida F.
      Cancer Res. 38:3483-3486(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: COPPER-BINDING.

    Entry informationi

    Entry nameiALBU_RAT
    AccessioniPrimary (citable) accession number: P02770
    Secondary accession number(s): P11382, Q5U3X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    A peptide arising from positions 166 to 174 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3