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Protein

Serum albumin

Gene

ALB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27CopperBy similarity1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi270ZincBy similarity1
Metal bindingi272ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
BSA
Allergen: Bos d 6
Gene namesi
Name:ALB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei165. Bos d 6.
3166. Bos d 6.0101.

Chemistry databases

ChEMBLiCHEMBL3728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
PropeptideiPRO_000000105719 – 246
ChainiPRO_000000105825 – 607Serum albuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation1 Publication
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation1 Publication
Modified residuei107PhosphothreonineBy similarity1
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation1 Publication
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation1 Publication
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation1 Publication
Modified residuei228N6-succinyllysineBy similarity1
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation1 Publication
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation1 Publication
Modified residuei296PhosphoserineBy similarity1
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation1 Publication
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation1 Publication
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation1 Publication
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation1 Publication
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation1 Publication
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation1 Publication
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation1 Publication
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation1 Publication
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation1 Publication
Modified residuei587N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP02769.
PeptideAtlasiP02769.
PRIDEiP02769.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSBTAG00000017121.

Interactioni

Protein-protein interaction databases

BioGridi158123. 5 interactors.
STRINGi9913.ENSBTAP00000022763.

Chemistry databases

BindingDBiP02769.

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 38Combined sources9
Helixi40 – 54Combined sources15
Beta strandi56 – 58Combined sources3
Helixi60 – 79Combined sources20
Turni84 – 87Combined sources4
Helixi90 – 99Combined sources10
Helixi104 – 108Combined sources5
Helixi109 – 116Combined sources8
Helixi121 – 127Combined sources7
Helixi143 – 152Combined sources10
Helixi154 – 168Combined sources15
Helixi174 – 191Combined sources18
Beta strandi194 – 196Combined sources3
Helixi197 – 229Combined sources33
Helixi231 – 245Combined sources15
Helixi251 – 269Combined sources19
Helixi273 – 288Combined sources16
Helixi291 – 294Combined sources4
Helixi296 – 298Combined sources3
Helixi301 – 303Combined sources3
Helixi306 – 315Combined sources10
Helixi329 – 332Combined sources4
Helixi338 – 344Combined sources7
Helixi346 – 360Combined sources15
Helixi366 – 385Combined sources20
Beta strandi386 – 388Combined sources3
Helixi389 – 393Combined sources5
Helixi396 – 403Combined sources8
Turni404 – 407Combined sources4
Helixi408 – 437Combined sources30
Helixi443 – 460Combined sources18
Beta strandi461 – 463Combined sources3
Helixi465 – 489Combined sources25
Helixi494 – 502Combined sources9
Helixi507 – 512Combined sources6
Beta strandi518 – 520Combined sources3
Helixi527 – 530Combined sources4
Helixi534 – 537Combined sources4
Helixi541 – 558Combined sources18
Helixi564 – 583Combined sources20
Beta strandi584 – 586Combined sources3
Helixi587 – 606Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7UNMR-B148-154[»]
3V03X-ray2.70A/B25-607[»]
4F5SX-ray2.47A/B25-607[»]
4JK4X-ray2.65A/B25-607[»]
4OR0X-ray2.58A/B25-607[»]
ProteinModelPortaliP02769.
SMRiP02769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP02769.
KOiK16141.
TreeFamiTF335561.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFKDLGE EHFKGLVLIA
60 70 80 90 100
FSQYLQQCPF DEHVKLVNEL TEFAKTCVAD ESHAGCEKSL HTLFGDELCK
110 120 130 140 150
VASLRETYGD MADCCEKQEP ERNECFLSHK DDSPDLPKLK PDPNTLCDEF
160 170 180 190 200
KADEKKFWGK YLYEIARRHP YFYAPELLYY ANKYNGVFQE CCQAEDKGAC
210 220 230 240 250
LLPKIETMRE KVLASSARQR LRCASIQKFG ERALKAWSVA RLSQKFPKAE
260 270 280 290 300
FVEVTKLVTD LTKVHKECCH GDLLECADDR ADLAKYICDN QDTISSKLKE
310 320 330 340 350
CCDKPLLEKS HCIAEVEKDA IPENLPPLTA DFAEDKDVCK NYQEAKDAFL
360 370 380 390 400
GSFLYEYSRR HPEYAVSVLL RLAKEYEATL EECCAKDDPH ACYSTVFDKL
410 420 430 440 450
KHLVDEPQNL IKQNCDQFEK LGEYGFQNAL IVRYTRKVPQ VSTPTLVEVS
460 470 480 490 500
RSLGKVGTRC CTKPESERMP CTEDYLSLIL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSALTPDETY VPKAFDEKLF TFHADICTLP DTEKQIKKQT
560 570 580 590 600
ALVELLKHKP KATEEQLKTV MENFVAFVDK CCAADDKEAC FAVEGPKLVV

STQTALA
Length:607
Mass (Da):69,293
Last modified:February 1, 1996 - v4
Checksum:i39167DFE768585D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58Missing AA sequence (PubMed:2379503).Curated1
Sequence conflicti116E → A in AAI02743 (Ref. 5) Curated1
Sequence conflicti173Y → L AA sequence (PubMed:2437111).Curated1
Sequence conflicti302C → K AA sequence (Ref. 9) Curated1
Sequence conflicti304 – 305KP → PC AA sequence (Ref. 9) Curated2
Sequence conflicti324N → D AA sequence (Ref. 9) Curated1
Sequence conflicti394 – 395ST → TS AA sequence (Ref. 9) Curated2
Sequence conflicti429A → E in AAI02743 (Ref. 5) Curated1
Sequence conflicti437K → R AA sequence (Ref. 16) Curated1
Sequence conflicti472T → A in AAI02743 (Ref. 5) Curated1
Sequence conflicti493 – 494SE → ES AA sequence (Ref. 9) Curated2
Sequence conflicti579D → G in AAI02743 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti214A → T.4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73993 mRNA. Translation: AAA51411.1.
X58989 mRNA. Translation: CAA41735.1.
Y17769 mRNA. Translation: CAA76847.1.
AF542068 mRNA. Translation: AAN17824.1.
BC102742 mRNA. Translation: AAI02743.1.
BC142272 mRNA. Translation: AAI42273.1.
PIRiA38885. ABBOS.
RefSeqiNP_851335.1. NM_180992.2.
UniGeneiBt.106669.

Genome annotation databases

GeneIDi280717.
KEGGibta:280717.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73993 mRNA. Translation: AAA51411.1.
X58989 mRNA. Translation: CAA41735.1.
Y17769 mRNA. Translation: CAA76847.1.
AF542068 mRNA. Translation: AAN17824.1.
BC102742 mRNA. Translation: AAI02743.1.
BC142272 mRNA. Translation: AAI42273.1.
PIRiA38885. ABBOS.
RefSeqiNP_851335.1. NM_180992.2.
UniGeneiBt.106669.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7UNMR-B148-154[»]
3V03X-ray2.70A/B25-607[»]
4F5SX-ray2.47A/B25-607[»]
4JK4X-ray2.65A/B25-607[»]
4OR0X-ray2.58A/B25-607[»]
ProteinModelPortaliP02769.
SMRiP02769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi158123. 5 interactors.
STRINGi9913.ENSBTAP00000022763.

Chemistry databases

BindingDBiP02769.
ChEMBLiCHEMBL3728.

Protein family/group databases

Allergomei165. Bos d 6.
3166. Bos d 6.0101.

Proteomic databases

PaxDbiP02769.
PeptideAtlasiP02769.
PRIDEiP02769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280717.
KEGGibta:280717.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP02769.
KOiK16141.
TreeFamiTF335561.

Miscellaneous databases

PROiP02769.

Gene expression databases

BgeeiENSBTAG00000017121.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_BOVIN
AccessioniPrimary (citable) accession number: P02769
Secondary accession number(s): A5PJX3
, O02787, P04277, Q3SZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 158 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

A peptide arising from positions 165 to 173 was originally termed neurotensin-related peptide (NRP) and was thought to regulate fat digestion, lipid absorption, and blood flow.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.