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Protein

Transthyretin

Gene

TTR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35Thyroid hormones1
Binding sitei74Thyroid hormones1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • thyroid hormone binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Thyroid hormone

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118271-MONOMER.
ReactomeiR-HSA-2453864. Retinoid cycle disease events.
R-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).
R-HSA-3000171. Non-integrin membrane-ECM interactions.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-975634. Retinoid metabolism and transport.
R-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
ATTR
Prealbumin
TBPA
Gene namesi
Name:TTR
Synonyms:PALB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:12405. TTR.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Cytoplasm, Secreted

Pathology & Biotechi

Involvement in diseasei

Amyloidosis, transthyretin-related (AMYL-TTR)64 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.
See also OMIM:105210
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00754730C → R in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918083dbSNPEnsembl.1
Natural variantiVAR_03895932L → P in AMYL-TTR. 2 PublicationsCorresponds to variant rs121918094dbSNPEnsembl.1
Natural variantiVAR_00754838D → E in AMYL-TTR; amyloid polyneuropathy. 1
Natural variantiVAR_00754938D → G in AMYL-TTR; leptomeningeal amyloidosis; leads to unfolding and exposure of N-118 to glycosylation by STT3B and subsequent degradation by the ERAD pathway. 2 PublicationsCorresponds to variant rs121918098dbSNPEnsembl.1
Natural variantiVAR_00755040V → I in AMYL-TTR; late-onset amyloid polyneuropathy with carpal tunnel syndrome. 2 PublicationsCorresponds to variant rs121918093dbSNPEnsembl.1
Natural variantiVAR_03896143S → N in AMYL-TTR. 1 Publication1
Natural variantiVAR_00755144P → S in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs11541790dbSNPEnsembl.1
Natural variantiVAR_01065848V → M in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00755250V → A in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs79977247dbSNPEnsembl.1
Natural variantiVAR_03896250V → G in AMYL-TTR. 1 PublicationCorresponds to variant rs79977247dbSNPEnsembl.1
Natural variantiVAR_00755350V → L in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs28933979dbSNPEnsembl.1
Natural variantiVAR_00755450V → M in AMYL-TTR; amyloid polyneuropathy; by far the most frequent mutation. 10 PublicationsCorresponds to variant rs28933979dbSNPEnsembl.1
Natural variantiVAR_00755553F → I in AMYL-TTR; Jewish 'SKO' amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs121918068dbSNPEnsembl.1
Natural variantiVAR_00755653F → L in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs121918068dbSNPEnsembl.1
Natural variantiVAR_03896453F → V in AMYL-TTR; amyloid polyneuropathy. 4 Publications1
Natural variantiVAR_03896554R → T in AMYL-TTR. 1 Publication1
Natural variantiVAR_03896655K → N in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00755756A → P in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918077dbSNPEnsembl.1
Natural variantiVAR_03896758D → A in AMYL-TTR. 2 Publications1
Natural variantiVAR_03896858D → V in AMYL-TTR. 2 Publications1
Natural variantiVAR_03896961W → L in AMYL-TTR. 1 Publication1
Natural variantiVAR_03897062E → D in AMYL-TTR. 1 PublicationCorresponds to variant rs11541796dbSNPEnsembl.1
Natural variantiVAR_00755862E → G in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs11541796dbSNPEnsembl.1
Natural variantiVAR_03897164F → S in AMYL-TTR. 2 PublicationsCorresponds to variant rs104894665dbSNPEnsembl.1
Natural variantiVAR_00755965A → D in AMYL-TTR; amyloid cardiomyopathy. Corresponds to variant rs730881169dbSNPEnsembl.1
Natural variantiVAR_03897265A → S in AMYL-TTR. 1 Publication1
Natural variantiVAR_00756065A → T in AMYL-TTR; amyloid cardiomyopathy. 2 PublicationsCorresponds to variant rs121918078dbSNPEnsembl.1
Natural variantiVAR_00756167G → A in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs121918090dbSNPEnsembl.1
Natural variantiVAR_03897367G → E in AMYL-TTR. 2 Publications1
Natural variantiVAR_00756267G → R in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs387906523dbSNPEnsembl.1
Natural variantiVAR_00756367G → V in AMYL-TTR; amyloid polyneuropathy with carpal tunnel syndrome. 1
Natural variantiVAR_00756469T → A in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918081dbSNPEnsembl.1
Natural variantiVAR_03897469T → I in AMYL-TTR. 2 Publications1
Natural variantiVAR_00756570S → I in AMYL-TTR; amyloid cardiomyopathy. 1 PublicationCorresponds to variant rs121918080dbSNPEnsembl.1
Natural variantiVAR_00756670S → R in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs386134269dbSNPEnsembl.1
Natural variantiVAR_00756772S → P in AMYL-TTR; amyloid polyneuropathy. 1
Natural variantiVAR_03897573G → E in AMYL-TTR. 1 PublicationCorresponds to variant rs121918097dbSNPEnsembl.1
Natural variantiVAR_00756874E → G in AMYL-TTR; amyloid polyneuropathy. 1
Natural variantiVAR_03897674E → K in AMYL-TTR; early-onset amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00756975L → P in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs121918079dbSNPEnsembl.1
Natural variantiVAR_03897775L → Q in AMYL-TTR. 1 Publication1
Natural variantiVAR_00757078L → H in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918069dbSNPEnsembl.1
Natural variantiVAR_00757178L → R in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918069dbSNPEnsembl.1
Natural variantiVAR_00757279T → K in AMYL-TTR; amyloid cardiomyopathy. 1 PublicationCorresponds to variant rs730881163dbSNPEnsembl.1
Natural variantiVAR_00757380T → A in AMYL-TTR; amyloid polyneuropathy and cardiomyopathy. 4 PublicationsCorresponds to variant rs121918070dbSNPEnsembl.1
Natural variantiVAR_03897881E → G in AMYL-TTR. 1 Publication1
Natural variantiVAR_00757481E → K in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918086dbSNPEnsembl.1
Natural variantiVAR_00757584F → L in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918091dbSNPEnsembl.1
Natural variantiVAR_00757688I → L in AMYL-TTR; amyloid cardiomyopathy. 2 PublicationsCorresponds to variant rs121918085dbSNPEnsembl.1
Natural variantiVAR_00757789Y → H in AMYL-TTR; leptomeningeal amyloidosis; vitreous amyloid in some patients. 1 PublicationCorresponds to variant rs121918100dbSNPEnsembl.1
Natural variantiVAR_00757890K → N in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs267607160dbSNPEnsembl.1
Natural variantiVAR_00757991V → A in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918084dbSNPEnsembl.1
Natural variantiVAR_00758093I → V in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00758297S → Y in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs121918071dbSNPEnsembl.1
Natural variantiVAR_03897998Y → F in AMYL-TTR. 2 Publications1
Natural variantiVAR_007583104I → N in AMYL-TTR; vitrous amyloid. 1 Publication1
Natural variantiVAR_007584104I → S in AMYL-TTR; amyloid polyneuropathy; almost no RBP binding. 3 PublicationsCorresponds to variant rs121918072dbSNPEnsembl.1
Natural variantiVAR_038980104I → T in AMYL-TTR. 1 Publication1
Natural variantiVAR_010659109E → K in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_007585109E → Q in AMYL-TTR; amyloid polyneuropathy and cardiomyopathy. 2 PublicationsCorresponds to variant rs121918082dbSNPEnsembl.1
Natural variantiVAR_007587111A → S in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_007588117A → G in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918087dbSNPEnsembl.1
Natural variantiVAR_038982117A → S in AMYL-TTR. 1 PublicationCorresponds to variant rs267607161dbSNPEnsembl.1
Natural variantiVAR_038984126T → N in AMYL-TTR. 1 Publication1
Natural variantiVAR_038985127I → M in AMYL-TTR. 1 Publication1
Natural variantiVAR_007592127I → V in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918089dbSNPEnsembl.1
Natural variantiVAR_007594131L → M in AMYL-TTR. 1 PublicationCorresponds to variant rs121918073dbSNPEnsembl.1
Natural variantiVAR_007595134Y → C in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918075dbSNPEnsembl.1
Natural variantiVAR_007596136Y → S in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs730881167dbSNPEnsembl.1
Natural variantiVAR_038986140A → S in AMYL-TTR. 1 Publication1
Natural variantiVAR_038987142V → A in AMYL-TTR. 1 Publication1
Natural variantiVAR_007600142V → I in AMYL-TTR. 3 PublicationsCorresponds to variant rs28933980dbSNPEnsembl.1
Natural variantiVAR_038988144N → S in AMYL-TTR. 1 PublicationCorresponds to variant rs144965179dbSNPEnsembl.1
Hyperthyroxinemia, dystransthyretinemic (DTTRH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.
See also OMIM:145680
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007593129A → T in DTTRH; increased affinity for thyroxine. 2 PublicationsCorresponds to variant rs267607159dbSNPEnsembl.1
Carpal tunnel syndrome 1 (CTS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.
See also OMIM:115430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007598134Y → H in CTS1; amyloid deposit on carpal tunnel; patients show no other abnormalities. 1 PublicationCorresponds to variant rs121918088dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi107F → M: Loss of tetramerization; when associated with M-130. 1 Publication1
Mutagenesisi130L → M: Loss of tetramerization; when associated with M-107. 1 Publication1

Keywords - Diseasei

Amyloidosis, Disease mutation, Neuropathy

Organism-specific databases

DisGeNETi7276.
MalaCardsiTTR.
MIMi105210. phenotype.
115430. phenotype.
145680. phenotype.
OpenTargetsiENSG00000118271.
Orphaneti85447. Familial amyloid polyneuropathy.
85451. Transthyretin-related familial amyloid cardiomyopathy.
PharmGKBiPA37069.

Chemistry databases

ChEMBLiCHEMBL3194.
DrugBankiDB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00861. Diflunisal.
DB01093. Dimethyl sulfoxide.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
GuidetoPHARMACOLOGYi2851.

Polymorphism and mutation databases

BioMutaiTTR.
DMDMi136464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 206 PublicationsAdd BLAST20
ChainiPRO_000003575521 – 147TransthyretinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei624-carboxyglutamate; in a patient with Moyamoya disease1 Publication1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi118N-linked (GlcNAc...)2 Publications1

Post-translational modificationi

Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.3 Publications

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP02766.
PaxDbiP02766.
PeptideAtlasiP02766.
PRIDEiP02766.
TopDownProteomicsiP02766.

2D gel databases

DOSAC-COBS-2DPAGEP02766.
REPRODUCTION-2DPAGEP02766.
SWISS-2DPAGEP02766.
UCD-2DPAGEP02766.

PTM databases

iPTMnetiP02766.
PhosphoSitePlusiP02766.

Miscellaneous databases

PMAP-CutDBP02766.

Expressioni

Tissue specificityi

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.2 Publications

Gene expression databases

BgeeiENSG00000118271.
CleanExiHS_TTR.
ExpressionAtlasiP02766. baseline and differential.
GenevisibleiP02766. HS.

Organism-specific databases

HPAiCAB002517.
CAB062567.
CAB073406.
HPA002550.

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-711909,EBI-711909
AGERQ151092EBI-711909,EBI-1646426
CDR2Q018503EBI-711909,EBI-1181367
MT3P257133EBI-711909,EBI-8084264
NECAB2H3BTW23EBI-711909,EBI-10172876

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi113127. 48 interactors.
DIPiDIP-1083N.
IntActiP02766. 48 interactors.
MINTiMINT-1374623.
STRINGi9606.ENSP00000237014.

Chemistry databases

BindingDBiP02766.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni23 – 26Combined sources4
Beta strandi32 – 38Combined sources7
Turni39 – 42Combined sources4
Beta strandi49 – 55Combined sources7
Beta strandi57 – 59Combined sources3
Beta strandi61 – 68Combined sources8
Beta strandi73 – 75Combined sources3
Beta strandi77 – 80Combined sources4
Turni81 – 83Combined sources3
Beta strandi86 – 93Combined sources8
Helixi95 – 101Combined sources7
Beta strandi107 – 118Combined sources12
Beta strandi120 – 122Combined sources3
Beta strandi124 – 132Combined sources9
Beta strandi135 – 143Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BM7X-ray2.00A/B21-147[»]
1BMZX-ray2.00A/B21-143[»]
1BZ8X-ray2.00A/B21-147[»]
1BZDX-ray1.90A/B21-147[»]
1BZEX-ray1.80A/B21-147[»]
1DVQX-ray2.00A/B21-144[»]
1DVSX-ray2.00A/B21-144[»]
1DVTX-ray1.90A/B21-144[»]
1DVUX-ray1.90A/B21-144[»]
1DVXX-ray2.00A/B21-144[»]
1DVYX-ray1.90A/B21-144[»]
1DVZX-ray1.90A/B21-144[»]
1E3FX-ray1.90A/B21-145[»]
1E4HX-ray1.80A/B21-147[»]
1E5AX-ray1.80A/B21-147[»]
1ETAX-ray1.701/221-147[»]
1ETBX-ray1.701/221-147[»]
1F41X-ray1.30A/B21-147[»]
1F64model-A21-147[»]
1F86X-ray1.10A/B30-144[»]
1FH2X-ray1.80A/B21-147[»]
1FHNX-ray1.75A/B21-147[»]
1G1OX-ray2.30A/B/C/D21-147[»]
1GKOX-ray2.10A/B/C/D21-147[»]
1ICTX-ray3.00A/B/C/D/E/F/G/H21-147[»]
1IIIX-ray2.00A/B21-147[»]
1IIKX-ray2.00A/B21-147[»]
1IJNX-ray1.70A/B21-147[»]
1QABX-ray3.20A/B/C/D21-147[»]
1QWHX-ray1.36A/B31-147[»]
1RLBX-ray3.10A/B/C/D21-147[»]
1SOKX-ray1.60A/B21-147[»]
1SOQX-ray2.10A/B/C/D21-147[»]
1THAX-ray2.00A/B21-147[»]
1THCX-ray2.30A/B21-147[»]
1TLMX-ray1.90A/B21-147[»]
1TSHX-ray1.70A/B21-147[»]
1TT6X-ray1.80A/B21-147[»]
1TTAX-ray1.70A/B21-147[»]
1TTBX-ray1.70A/B21-147[»]
1TTCX-ray1.70A/B21-147[»]
1TTRX-ray1.90A/B21-147[»]
1TYRX-ray1.80A/B21-147[»]
1TZ8X-ray1.85A/B/C/D21-147[»]
1U21X-ray1.69A/B21-147[»]
1X7SX-ray1.55A/B21-147[»]
1X7TX-ray1.60A/B21-147[»]
1Y1DX-ray1.70A/B21-147[»]
1Z7JX-ray2.20A/B21-147[»]
1ZCRX-ray1.80A/B21-147[»]
1ZD6X-ray1.90A/B21-147[»]
2B14X-ray2.00A/B21-147[»]
2B15X-ray1.70A/B21-147[»]
2B16X-ray1.75A/B21-147[»]
2B77X-ray1.70A/B21-147[»]
2B9AX-ray1.54A/B21-147[»]
2F7IX-ray1.60A/B21-147[»]
2F8IX-ray1.54A/B21-147[»]
2FBRX-ray1.46A/B21-147[»]
2FLMX-ray1.65A/B21-147[»]
2G3XX-ray1.58A/B21-147[»]
2G3ZX-ray1.90A/B21-147[»]
2G4EX-ray2.17A/B21-147[»]
2G4GX-ray1.85A/B21-147[»]
2G5UX-ray1.80A/B21-147[»]
2G9KX-ray1.85A/B21-147[»]
2GABX-ray1.85A/B21-147[»]
2H4EX-ray1.45A/B21-147[»]
2M5NNMR-A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P125-135[»]
2NOYX-ray1.80A/B21-147[»]
2PABX-ray1.80A/B21-147[»]
2QELX-ray2.29A/B/C/D21-147[»]
2QGBX-ray1.40A/B21-147[»]
2QGCX-ray1.30A/B21-147[»]
2QGDX-ray1.50A/B21-147[»]
2QGEX-ray1.45A/B21-147[»]
2ROXX-ray2.00A/B21-147[»]
2ROYX-ray2.20A/B21-147[»]
2TRHX-ray1.90A/B21-147[»]
2TRYX-ray2.00A/B21-147[»]
2WQAX-ray2.85A/B/C/D21-147[»]
3A4DX-ray2.00A/B21-147[»]
3A4EX-ray1.70A/B21-147[»]
3A4FX-ray1.99A/B21-147[»]
3B56X-ray1.55A/B21-147[»]
3BSZX-ray3.38A/B/C/D21-147[»]
3BT0X-ray1.59A/B21-147[»]
3CBRX-ray1.70A/B21-147[»]
3CFMX-ray1.60A/B30-147[»]
3CFNX-ray1.87A/B30-147[»]
3CFQX-ray2.09A/B30-147[»]
3CFTX-ray1.87A/B30-147[»]
3CN0X-ray1.52A/B21-147[»]
3CN1X-ray1.52A/B21-147[»]
3CN2X-ray1.52A/B21-147[»]
3CN3X-ray1.80A/B21-147[»]
3CN4X-ray1.40A/B21-147[»]
3CXFX-ray2.30A/B21-147[»]
3D2TX-ray1.85A/B21-147[»]
3D7PX-ray1.72A/B21-147[»]
3DGDX-ray1.38A/B/C/D21-147[»]
3DIDX-ray1.78A/B/C/D21-147[»]
3DJRX-ray2.02A/B21-147[»]
3DJSX-ray1.80A/B21-147[»]
3DJTX-ray2.30A/B21-147[»]
3DJZX-ray1.82A/B21-147[»]
3DK0X-ray1.87A/B21-147[»]
3DK2X-ray2.35A/B21-147[»]
3DO4X-ray2.40A/B/C/D/E/F/G/H21-147[»]
3ESNX-ray1.35A/B21-147[»]
3ESOX-ray1.31A/B21-147[»]
3ESPX-ray1.31A/B21-147[»]
3FC8X-ray1.85A/B21-144[»]
3FCBX-ray1.80A/B21-144[»]
3GLZX-ray1.78A/B21-147[»]
3GPSX-ray1.78A/B/C/D21-147[»]
3GRBX-ray1.75A/B/C/D21-147[»]
3GRGX-ray1.90A/B/C/D21-147[»]
3GS0X-ray1.85A/B21-147[»]
3GS4X-ray1.78A/B21-147[»]
3GS7X-ray1.80A/B21-147[»]
3HJ0X-ray1.34A/B21-147[»]
3I9AX-ray1.65A/B21-147[»]
3I9IX-ray1.80A/B30-145[»]
3I9PX-ray1.90A/B30-145[»]
3IMRX-ray1.70A/B21-147[»]
3IMSX-ray1.40A/B21-147[»]
3IMTX-ray1.40A/B21-147[»]
3IMUX-ray1.40A/B21-147[»]
3IMVX-ray1.47A/B21-147[»]
3IMWX-ray1.31A/B21-147[»]
3IPBX-ray1.90A/B21-147[»]
3IPEX-ray1.40A/B21-147[»]
3KGSX-ray1.80A/B21-147[»]
3KGTX-ray1.95A/B21-147[»]
3KGUX-ray1.85A/B21-147[»]
3M1OX-ray1.20A/B21-147[»]
3NEEX-ray1.55A/B30-145[»]
3NEOX-ray2.00A/B30-145[»]
3NESX-ray1.75A/B30-145[»]
3NEXX-ray1.70A/B30-145[»]
3NG5X-ray1.70A/B21-147[»]
3OZKX-ray1.90A/B21-147[»]
3OZLX-ray1.90A/B21-147[»]
3P3RX-ray1.25A/B21-147[»]
3P3SX-ray1.60A/B21-147[»]
3P3TX-ray1.45A/B21-147[»]
3P3UX-ray1.50A/B21-147[»]
3SSGX-ray2.00A21-147[»]
3TCTX-ray1.30A/B21-147[»]
3TFBX-ray2.03A/B30-145[»]
3U2IX-ray1.70A/B32-147[»]
3U2Jneutron diffraction2.00A/B32-147[»]
3W3BX-ray1.90A/B21-147[»]
4ABQX-ray1.70A/B21-144[»]
4ABUX-ray1.86A/B21-144[»]
4ABVX-ray1.80A/B21-144[»]
4ABWX-ray1.70A/B21-144[»]
4AC2X-ray1.81A/B21-144[»]
4AC4X-ray1.80A/B21-147[»]
4ACTX-ray1.80A/B21-147[»]
4ANKX-ray1.70A/B1-147[»]
4D7BX-ray1.15A/B21-147[»]
4DERX-ray1.90A/B30-145[»]
4DESX-ray1.75A/B30-145[»]
4DETX-ray2.05A/B30-145[»]
4DEUX-ray1.60A/B30-145[»]
4DEWX-ray1.90A/B1-147[»]
4FI6X-ray1.46A/B21-147[»]
4FI7X-ray1.40A/B21-147[»]
4FI8X-ray1.22A/B21-147[»]
4HIQX-ray1.18A/B21-147[»]
4HISX-ray1.20A/B21-147[»]
4HJSX-ray1.22A/B30-145[»]
4HJTX-ray1.45A/B21-147[»]
4HJUX-ray1.35A/B21-147[»]
4I85X-ray1.67A/B21-147[»]
4I87X-ray1.69A/B21-147[»]
4I89X-ray1.69A/B21-147[»]
4IIZX-ray2.10A/B21-147[»]
4IK6X-ray2.00A/B21-147[»]
4IK7X-ray2.10A/B21-147[»]
4IKIX-ray2.00A/B21-147[»]
4IKJX-ray2.10A/B21-147[»]
4IKKX-ray1.90A/B21-147[»]
4IKLX-ray1.90A/B21-147[»]
4KY2X-ray1.13A/B21-147[»]
4L1SX-ray1.50A/B21-147[»]
4L1TX-ray1.16A/B21-147[»]
4MASX-ray1.22A/B21-147[»]
4MRBX-ray1.27A/B21-147[»]
4MRCX-ray1.54A/B22-147[»]
4N85X-ray1.60A/B1-147[»]
4N86X-ray2.00A/B1-147[»]
4N87X-ray1.79A/B1-147[»]
4PM1X-ray1.23A/B21-147[»]
4PMEX-ray1.26A/B29-146[»]
4PMFX-ray1.35A/B29-145[»]
4PVLX-ray1.85A/B21-147[»]
4PVMOther2.00A/B21-147[»]
4PVNOther2.30A/B21-147[»]
4PWEX-ray1.40A/B1-147[»]
4PWFX-ray1.60A/B1-147[»]
4PWGX-ray1.80A/B1-147[»]
4PWHX-ray1.80A/B1-147[»]
4PWIX-ray1.49A/B1-147[»]
4PWJX-ray1.55A/B1-147[»]
4PWKX-ray1.59A/B1-147[»]
4QRFX-ray1.80A/B1-147[»]
4QXVX-ray1.12A/B21-147[»]
4QYAX-ray1.70A/B21-147[»]
4TKWX-ray1.80A/B29-147[»]
4TL4X-ray1.75A/B29-147[»]
4TL5X-ray1.44A/B29-147[»]
4TLKX-ray1.44A/B29-147[»]
4TLSX-ray1.35A/B29-147[»]
4TLTX-ray1.70A/B29-147[»]
4TLUX-ray1.75A/B29-147[»]
4TM9X-ray1.70A/B29-147[»]
4TNEX-ray1.55A/B29-147[»]
4TNFX-ray1.60A/B29-147[»]
4TNGX-ray1.60A/B29-147[»]
4TQ8X-ray1.52A/B21-147[»]
4TQHX-ray1.51A/B21-147[»]
4TQIX-ray1.25A/B21-147[»]
4TQPX-ray1.58A/B21-147[»]
4WNJX-ray1.40A/B21-147[»]
4WNSX-ray1.40A/B21-147[»]
4WO0X-ray1.34A/B21-147[»]
4Y9BX-ray1.40A/B1-147[»]
4Y9CX-ray1.49A/B1-147[»]
4Y9EX-ray1.49A/B1-147[»]
4Y9FX-ray1.50A/B1-147[»]
4Y9GX-ray1.89A/B1-147[»]
4YDMX-ray1.25A/B21-147[»]
4YDNX-ray1.35A/B21-147[»]
5A6IX-ray1.86A21-147[»]
5AKSX-ray1.25A/B21-147[»]
5AKTX-ray1.35A/B21-147[»]
5AKVX-ray1.52A/B21-147[»]
5AL0X-ray1.39A/B21-147[»]
5AL8X-ray1.50A/B21-147[»]
5AYTX-ray1.40A/B1-147[»]
5BOJX-ray1.75A/B21-147[»]
5CLXX-ray1.28A/B21-147[»]
5CLYX-ray1.23A/B21-147[»]
5CLZX-ray1.22A/B21-147[»]
5CM1X-ray1.22A/B21-147[»]
5CN3X-ray1.30A/B21-147[»]
5CNHX-ray1.42A/B21-147[»]
5CR1X-ray1.54A/B30-145[»]
5DEJX-ray1.37A/B30-145[»]
5DWPX-ray1.20A/B30-145[»]
5E23X-ray1.41A/B21-147[»]
5E4AX-ray1.33A/B10-146[»]
5E4OX-ray1.50A/B30-146[»]
5EN3X-ray1.25A/B21-147[»]
5EZPX-ray2.50A/B/C/D/E/F/G/H26-147[»]
5HJGX-ray1.40A/B21-147[»]
5IHHX-ray1.35A/B21-147[»]
5JIDX-ray1.20A/B21-147[»]
5JIMX-ray1.26A/B21-147[»]
5JIQX-ray1.45A/B21-147[»]
5K1JX-ray1.69A/B30-145[»]
5K1NX-ray1.81A/B30-147[»]
5L4FX-ray1.48A/B21-147[»]
5L4IX-ray1.45A/B21-147[»]
5L4JX-ray1.62A/B21-147[»]
5L4MX-ray1.58A/B21-147[»]
5TTRX-ray2.70A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP02766.
SMRiP02766.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02766.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Thyroid hormone binding5

Domaini

Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3006. Eukaryota.
COG2351. LUCA.
GeneTreeiENSGT00390000005321.
HOGENOMiHOG000251776.
HOVERGENiHBG000285.
InParanoidiP02766.
KOiK20731.
PhylomeDBiP02766.
TreeFamiTF300210.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHRLLLLC LAGLVFVSEA GPTGTGESKC PLMVKVLDAV RGSPAINVAV
60 70 80 90 100
HVFRKAADDT WEPFASGKTS ESGELHGLTT EEEFVEGIYK VEIDTKSYWK
110 120 130 140
ALGISPFHEH AEVVFTANDS GPRRYTIAAL LSPYSYSTTA VVTNPKE
Length:147
Mass (Da):15,887
Last modified:March 20, 1987 - v1
Checksum:i3A6AEBCBBA56BC44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41R → P in AAA98771 (PubMed:4054629).Curated1
Sequence conflicti147E → D in CAG33189 (Ref. 12) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00754626G → S Common polymorphism. 5 PublicationsCorresponds to variant rs1800458dbSNPEnsembl.1
Natural variantiVAR_00754730C → R in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918083dbSNPEnsembl.1
Natural variantiVAR_03895932L → P in AMYL-TTR. 2 PublicationsCorresponds to variant rs121918094dbSNPEnsembl.1
Natural variantiVAR_03896033M → I.1 Publication1
Natural variantiVAR_00754838D → E in AMYL-TTR; amyloid polyneuropathy. 1
Natural variantiVAR_00754938D → G in AMYL-TTR; leptomeningeal amyloidosis; leads to unfolding and exposure of N-118 to glycosylation by STT3B and subsequent degradation by the ERAD pathway. 2 PublicationsCorresponds to variant rs121918098dbSNPEnsembl.1
Natural variantiVAR_00755040V → I in AMYL-TTR; late-onset amyloid polyneuropathy with carpal tunnel syndrome. 2 PublicationsCorresponds to variant rs121918093dbSNPEnsembl.1
Natural variantiVAR_03896143S → N in AMYL-TTR. 1 Publication1
Natural variantiVAR_00755144P → S in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs11541790dbSNPEnsembl.1
Natural variantiVAR_01065848V → M in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00755250V → A in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs79977247dbSNPEnsembl.1
Natural variantiVAR_03896250V → G in AMYL-TTR. 1 PublicationCorresponds to variant rs79977247dbSNPEnsembl.1
Natural variantiVAR_00755350V → L in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs28933979dbSNPEnsembl.1
Natural variantiVAR_00755450V → M in AMYL-TTR; amyloid polyneuropathy; by far the most frequent mutation. 10 PublicationsCorresponds to variant rs28933979dbSNPEnsembl.1
Natural variantiVAR_03896353F → C in a patient with amyloidosis. 2 Publications1
Natural variantiVAR_00755553F → I in AMYL-TTR; Jewish 'SKO' amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs121918068dbSNPEnsembl.1
Natural variantiVAR_00755653F → L in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs121918068dbSNPEnsembl.1
Natural variantiVAR_03896453F → V in AMYL-TTR; amyloid polyneuropathy. 4 Publications1
Natural variantiVAR_03896554R → T in AMYL-TTR. 1 Publication1
Natural variantiVAR_03896655K → N in AMYL-TTR; amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00755756A → P in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918077dbSNPEnsembl.1
Natural variantiVAR_03896758D → A in AMYL-TTR. 2 Publications1
Natural variantiVAR_03896858D → V in AMYL-TTR. 2 Publications1
Natural variantiVAR_03896961W → L in AMYL-TTR. 1 Publication1
Natural variantiVAR_03897062E → D in AMYL-TTR. 1 PublicationCorresponds to variant rs11541796dbSNPEnsembl.1
Natural variantiVAR_00755862E → G in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs11541796dbSNPEnsembl.1
Natural variantiVAR_03897164F → S in AMYL-TTR. 2 PublicationsCorresponds to variant rs104894665dbSNPEnsembl.1
Natural variantiVAR_00755965A → D in AMYL-TTR; amyloid cardiomyopathy. Corresponds to variant rs730881169dbSNPEnsembl.1
Natural variantiVAR_03897265A → S in AMYL-TTR. 1 Publication1
Natural variantiVAR_00756065A → T in AMYL-TTR; amyloid cardiomyopathy. 2 PublicationsCorresponds to variant rs121918078dbSNPEnsembl.1
Natural variantiVAR_00756167G → A in AMYL-TTR; amyloid polyneuropathy. 2 PublicationsCorresponds to variant rs121918090dbSNPEnsembl.1
Natural variantiVAR_03897367G → E in AMYL-TTR. 2 Publications1
Natural variantiVAR_00756267G → R in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs387906523dbSNPEnsembl.1
Natural variantiVAR_00756367G → V in AMYL-TTR; amyloid polyneuropathy with carpal tunnel syndrome. 1
Natural variantiVAR_00756469T → A in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918081dbSNPEnsembl.1
Natural variantiVAR_03897469T → I in AMYL-TTR. 2 Publications1
Natural variantiVAR_00756570S → I in AMYL-TTR; amyloid cardiomyopathy. 1 PublicationCorresponds to variant rs121918080dbSNPEnsembl.1
Natural variantiVAR_00756670S → R in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs386134269dbSNPEnsembl.1
Natural variantiVAR_00756772S → P in AMYL-TTR; amyloid polyneuropathy. 1
Natural variantiVAR_03897573G → E in AMYL-TTR. 1 PublicationCorresponds to variant rs121918097dbSNPEnsembl.1
Natural variantiVAR_00756874E → G in AMYL-TTR; amyloid polyneuropathy. 1
Natural variantiVAR_03897674E → K in AMYL-TTR; early-onset amyloid polyneuropathy. 1 Publication1
Natural variantiVAR_00756975L → P in AMYL-TTR; amyloid polyneuropathy. 4 PublicationsCorresponds to variant rs121918079dbSNPEnsembl.1
Natural variantiVAR_03897775L → Q in AMYL-TTR. 1 Publication1
Natural variantiVAR_00757078L → H in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918069dbSNPEnsembl.1
Natural variantiVAR_00757178L → R in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918069dbSNPEnsembl.1
Natural variantiVAR_00757279T → K in AMYL-TTR; amyloid cardiomyopathy. 1 PublicationCorresponds to variant rs730881163dbSNPEnsembl.1
Natural variantiVAR_00757380T → A in AMYL-TTR; amyloid polyneuropathy and cardiomyopathy. 4 PublicationsCorresponds to variant rs121918070dbSNPEnsembl.1
Natural variantiVAR_03897881E → G in AMYL-TTR. 1 Publication1
Natural variantiVAR_00757481E → K in AMYL-TTR; amyloid polyneuropathy. 1 PublicationCorresponds to variant rs121918086dbSNPEnsembl.1
Natural variantiVAR_00757584F → L in AMYL-TTR; amyloid polyneuropathy. 3 PublicationsCorresponds to variant rs121918091dbSNPEnsembl.1
Natural variantiVAR_00757688I → L in AMYL-TTR; amyloid cardiomyopathy. 2 PublicationsCorresponds to variant rs121918085dbSNPEnsembl.1
Natural variantiVAR_00757789Y → H in AMYL-TTR; leptomeningeal amyloidosis; vitreous amyloid in some patients. 1 Publication