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Protein

Alpha-1-acid glycoprotein

Gene

Orm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction.By similarity

GO - Molecular functioni

  • drug binding Source: RGD

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: RGD
  • acute-phase response Source: GO_Central
  • cellular response to glucocorticoid stimulus Source: RGD
  • cellular response to growth hormone stimulus Source: RGD
  • cellular response to retinoic acid Source: RGD
  • chronic inflammatory response to antigenic stimulus Source: RGD
  • organ regeneration Source: RGD
  • regulation of immune system process Source: InterPro
  • response to drug Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to vitamin E Source: RGD
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein
Alternative name(s):
Orosomucoid
Short name:
OMD
Gene namesi
Name:Orm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi67390. Orm1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 205187Alpha-1-acid glycoproteinPRO_0000017868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 183By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02764.
PRIDEiP02764.

PTM databases

iPTMnetiP02764.
PhosphoSiteiP02764.
UniCarbKBiP02764.

Expressioni

Inductioni

Alpha-1-AGP is synthesized in the liver, the synthesis being controlled by glucocorticoids, interleukin-1 and interleukin-6, it increases 5- to 50-fold upon inflammation.

Gene expression databases

BgeeiENSRNOG00000007886.
GenevisibleiP02764. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010454.

Structurei

3D structure databases

ProteinModelPortaliP02764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP02764.
KOiK17308.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP02764.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHMVLVVL SLLPLLEAQN PEPANITLGI PITNETLKWL SDKWFYMGAA
60 70 80 90 100
FRDPVFKQAV QTIQTEYFYL TPNLINDTIE LREFQTTDDQ CVYNFTHLGV
110 120 130 140 150
QRENGTLSKC AGAVKIFAHL IVLKKHGTFM LAFNLTDENR GLSFYAKKPD
160 170 180 190 200
LSPELRKIFQ QAVKDVGMDE SEIVFVDWTK DKCSEQQKQQ LELEKETKKE

TKKDP
Length:205
Mass (Da):23,575
Last modified:July 21, 1986 - v1
Checksum:iE363A742C2B2DE06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00696 mRNA. Translation: AAA40699.1.
V01216 mRNA. Translation: CAA24527.1.
M11329 Genomic DNA. Translation: AAA40700.1.
M10614 Genomic DNA. Translation: AAA40701.1.
PIRiA93069. OMRT1.
RefSeqiNP_445740.1. NM_053288.2.
UniGeneiRn.10295.

Genome annotation databases

GeneIDi24614.
KEGGirno:24614.
UCSCiRGD:67390. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00696 mRNA. Translation: AAA40699.1.
V01216 mRNA. Translation: CAA24527.1.
M11329 Genomic DNA. Translation: AAA40700.1.
M10614 Genomic DNA. Translation: AAA40701.1.
PIRiA93069. OMRT1.
RefSeqiNP_445740.1. NM_053288.2.
UniGeneiRn.10295.

3D structure databases

ProteinModelPortaliP02764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010454.

PTM databases

iPTMnetiP02764.
PhosphoSiteiP02764.
UniCarbKBiP02764.

Proteomic databases

PaxDbiP02764.
PRIDEiP02764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24614.
KEGGirno:24614.
UCSCiRGD:67390. rat.

Organism-specific databases

CTDi5004.
RGDi67390. Orm1.

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP02764.
KOiK17308.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP02764.
TreeFamiTF343791.

Miscellaneous databases

PROiP02764.

Gene expression databases

BgeeiENSRNOG00000007886.
GenevisibleiP02764. RN.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1AG_RAT
AccessioniPrimary (citable) accession number: P02764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.