P02764 (A1AG_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-1-acid glycoprotein

Alternative name(s):
Orosomucoid
Short name=OMD

Gene names

Name:

Orm1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain By similarity. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Subcellular location	Secreted By similarity.
Induction	Alpha-1-AGP is synthesized in the liver, the synthesis being controlled by glucocorticoids, interleukin-1 and interleukin-6, it increases 5- to 50-fold upon inflammation.
Domain	Contains a beta-barrel that binds various ligands in its interior By similarity.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Acute phase Transport
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute inflammatory response to antigenic stimulus Inferred from expression pattern PubMed 15771231. Source: RGD acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW cellular response to glucocorticoid stimulus Inferred from expression pattern PubMed 10453035. Source: RGD cellular response to growth hormone stimulus Inferred from expression pattern PubMed 9862866. Source: RGD cellular response to retinoic acid Inferred from expression pattern PubMed 15157739. Source: RGD chronic inflammatory response to antigenic stimulus Inferred from expression pattern PubMed 16166348. Source: RGD organ regeneration Inferred from expression pattern PubMed 11350548. Source: RGD regulation of immune system process Inferred from electronic annotation. Source: InterPro response to drug Inferred from expression pattern PubMed 11408029PubMed 9920738. Source: RGD response to lipopolysaccharide Inferred from expression pattern PubMed 11350548. Source: RGD response to vitamin E Inferred from expression pattern PubMed 11444866. Source: RGD transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from direct assay PubMed 11408029. Source: RGD
Molecular_function	drug binding Inferred from direct assay PubMed 3252025. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18
	Chain	19 – 205	187	Alpha-1-acid glycoprotein		PRO_0000017868
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Glycosylation	76	1	N-linked (GlcNAc...) Potential
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Disulfide bond	91 ↔ 183		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P02764 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: E363A742C2B2DE06	FASTA	205	23,575
	10 20 30 40 50 60 MALHMVLVVL SLLPLLEAQN PEPANITLGI PITNETLKWL SDKWFYMGAA FRDPVFKQAV 70 80 90 100 110 120 QTIQTEYFYL TPNLINDTIE LREFQTTDDQ CVYNFTHLGV QRENGTLSKC AGAVKIFAHL 130 140 150 160 170 180 IVLKKHGTFM LAFNLTDENR GLSFYAKKPD LSPELRKIFQ QAVKDVGMDE SEIVFVDWTK 190 200 DKCSEQQKQQ LELEKETKKE TKKDP

References

[1]	"Nucleotide sequence of rat alpha 1-acid glycoprotein messenger RNA." Ricca G.A., Taylor J.M. J. Biol. Chem. 256:11199-11202(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of the rat alpha 1-acid glycoprotein gene." Liao Y.C.J., Taylor J.M., Vannice J.L., Clawson G.A., Smuckler E.A. Mol. Cell. Biol. 5:3634-3639(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Rat alpha 1-acid glycoprotein. Gene sequence and regulation by glucocorticoids in transfected L-cells." Reinke R., Feigelson P. J. Biol. Chem. 260:4397-4403(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J00696 mRNA. Translation: AAA40699.1. V01216 mRNA. Translation: CAA24527.1. M11329 Genomic DNA. Translation: AAA40700.1. M10614 Genomic DNA. Translation: AAA40701.1.
IPI	IPI00191715.
PIR	OMRT1. A93069.
RefSeq	NP_445740.1. NM_053288.2.
UniGene	Rn.10295.
3D structure databases
ProteinModelPortal	P02764.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000010454.
PTM databases
GlycoSuiteDB	P02764.
Proteomic databases
PaxDb	P02764.
PRIDE	P02764.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000010454; ENSRNOP00000010454; ENSRNOG00000007886.
GeneID	24614.
KEGG	rno:24614.
UCSC	RGD:67390. rat.
Organism-specific databases
CTD	5004.
RGD	67390. Orm1.
Phylogenomic databases
eggNOG	NOG41523.
GeneTree	ENSGT00390000012130.
HOGENOM	HOG000125170.
HOVERGEN	HBG000035.
InParanoid	P02764.
OMA	HFAHLLI.
OrthoDB	EOG4V9TS3.
Gene expression databases
Genevestigator	P02764.
GermOnline	ENSRNOG00000007886. Rattus norvegicus.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR001500. A1A_glycop. IPR012674. Calycin. IPR011038. Calycin-like. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
PANTHER	PTHR11967. PTHR11967. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PIRSF	PIRSF036899. AGP. 1 hit.
PRINTS	PR00708. A1AGLPROTEIN.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	603858.

Entry information

Entry name

A1AG_RAT

Accession

Primary (citable) accession number: P02764

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program