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Protein

Alpha-1-acid glycoprotein 1

Gene

ORM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.2 Publications

GO - Biological processi

  • acute-phase response Source: ProtInc
  • inflammatory response Source: ProtInc
  • negative regulation of interleukin-6 production Source: CACAO
  • negative regulation of tumor necrosis factor production Source: CACAO
  • platelet degranulation Source: Reactome
  • regulation of immune system process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Acute phase, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 1
Short name:
AGP 1
Alternative name(s):
Orosomucoid-1
Short name:
OMD 1
Gene namesi
Name:ORM1
Synonyms:AGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8498. ORM1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA260.

Chemistry

ChEMBLiCHEMBL4285.
DrugBankiDB05812. Abiraterone.
DB01418. Acenocoumarol.
DB01426. Ajmaline.
DB00802. Alfentanil.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB01429. Aprindine.
DB01156. Bupropion.
DB08907. Canagliflozin.
DB00482. Celecoxib.
DB00477. Chlorpromazine.
DB01151. Desipramine.
DB00280. Disopyramide.
DB00590. Doxazosin.
DB01142. Doxepin.
DB00530. Erlotinib.
DB00472. Fluoxetine.
DB00317. Gefitinib.
DB00619. Imatinib.
DB00458. Imipramine.
DB08820. Ivacaftor.
DB00934. Maprotiline.
DB08893. Mirabegron.
DB00731. Nateglinide.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00497. Oxycodone.
DB01359. Penbutolol.
DB00454. Pethidine.
DB00946. Phenprocoumon.
DB08860. Pitavastatin.
DB00457. Prazosin.
DB00571. Propranolol.
DB00908. Quinidine.
DB08931. Riociguat.
DB01232. Saquinavir.
DB00864. Tacrolimus.
DB00706. Tamsulosin.
DB05521. Telaprevir.
DB01041. Thalidomide.
DB00656. Trazodone.
DB08867. Ulipristal.
DB05294. Vandetanib.
DB08881. Vemurafenib.
DB08828. Vismodegib.
DB00682. Warfarin.

Polymorphism and mutation databases

BioMutaiORM1.
DMDMi112877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 201183Alpha-1-acid glycoprotein 1PRO_0000017860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid1 Publication
Disulfide bondi23 ↔ 1651 Publication
Glycosylationi33 – 331N-linked (GlcNAc...) (complex)8 Publications
Glycosylationi56 – 561N-linked (GlcNAc...)4 Publications
Glycosylationi72 – 721N-linked (GlcNAc...) (complex)5 Publications
Disulfide bondi90 ↔ 1831 Publication
Glycosylationi93 – 931N-linked (GlcNAc...)8 Publications
Glycosylationi103 – 1031N-linked (GlcNAc...)4 PublicationsCAR_000170

Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).10 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02763.
PeptideAtlasiP02763.
PRIDEiP02763.

2D gel databases

SWISS-2DPAGEP02763.

PTM databases

iPTMnetiP02763.
PhosphoSiteiP02763.
UniCarbKBiP02763.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

BgeeiENSG00000229314.
CleanExiHS_ORM1.
GenevisibleiP02763. HS.

Organism-specific databases

HPAiCAB006265.
HPA046438.
HPA057726.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SERPINE1P051214EBI-976767,EBI-953978

Protein-protein interaction databases

BioGridi111046. 15 interactions.
IntActiP02763. 7 interactions.
MINTiMINT-202382.
STRINGi9606.ENSP00000259396.

Chemistry

BindingDBiP02763.

Structurei

Secondary structure

1
201
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 263Combined sources
Helixi33 – 397Combined sources
Beta strandi41 – 5212Combined sources
Helixi53 – 597Combined sources
Beta strandi62 – 7211Combined sources
Turni73 – 764Combined sources
Beta strandi77 – 8610Combined sources
Beta strandi89 – 10012Combined sources
Turni101 – 1044Combined sources
Beta strandi105 – 1106Combined sources
Beta strandi113 – 1219Combined sources
Beta strandi127 – 1326Combined sources
Helixi137 – 1393Combined sources
Beta strandi141 – 1499Combined sources
Turni153 – 1564Combined sources
Helixi157 – 16610Combined sources
Helixi170 – 1723Combined sources
Helixi178 – 1803Combined sources
Helixi184 – 1929Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KQ0X-ray1.80A19-201[»]
ProteinModelPortaliP02763.
SMRiP02763. Positions 19-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02763.

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.1 Publication

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP02763.
KOiK17308.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP02763.
TreeFamiTF343791.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDQIT GKWFYIASAF
60 70 80 90 100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ
110 120 130 140 150
RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE
160 170 180 190 200
TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE

S
Length:201
Mass (Da):23,512
Last modified:January 1, 1988 - v1
Checksum:i63292233AD6EAD8B
GO

Sequence cautioni

The sequence CAA29229 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti170 – 1701K → R in AAI43315 (PubMed:15489334).Curated
Sequence conflicti182 – 1821Missing AA sequence (PubMed:4561179).Curated
Sequence conflicti193 – 1931Missing AA sequence (PubMed:4561179).Curated

Polymorphismi

Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381Q → R in allele ORM1*S. 4 Publications
VAR_013840
Natural varianti167 – 1671R → C.1 Publication
Corresponds to variant rs3182034 [ dbSNP | Ensembl ].
VAR_056166
Natural varianti174 – 1741V → M in allele ORM1*F2. 2 Publications
Corresponds to variant rs1126801 [ dbSNP | Ensembl ].
VAR_013841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02544 mRNA. Translation: CAA26397.1.
M13692 mRNA. Translation: AAA35515.1.
X05779
, X05780, X05781, X05782, X05783, X05784 Genomic DNA. Translation: CAA29229.1. Sequence problems.
X06676 Genomic DNA. No translation available.
X06680 Genomic DNA. No translation available.
BT019790 mRNA. Translation: AAV38593.1.
AK312035 mRNA. Translation: BAG34972.1.
AL356796 Genomic DNA. Translation: CAI16859.1.
CH471090 Genomic DNA. Translation: EAW87416.1.
BC104818 mRNA. Translation: AAI04819.1.
BC104820 mRNA. Translation: AAI04821.1.
BC143313 mRNA. Translation: AAI43314.1.
BC143314 mRNA. Translation: AAI43315.1.
BC026238 mRNA. Translation: AAH26238.1.
CCDSiCCDS6803.1.
PIRiA28346. OMHU1.
RefSeqiNP_000598.2. NM_000607.2.
UniGeneiHs.522356.

Genome annotation databases

EnsembliENST00000259396; ENSP00000259396; ENSG00000229314.
GeneIDi5004.
KEGGihsa:5004.
UCSCiuc004bik.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02544 mRNA. Translation: CAA26397.1.
M13692 mRNA. Translation: AAA35515.1.
X05779
, X05780, X05781, X05782, X05783, X05784 Genomic DNA. Translation: CAA29229.1. Sequence problems.
X06676 Genomic DNA. No translation available.
X06680 Genomic DNA. No translation available.
BT019790 mRNA. Translation: AAV38593.1.
AK312035 mRNA. Translation: BAG34972.1.
AL356796 Genomic DNA. Translation: CAI16859.1.
CH471090 Genomic DNA. Translation: EAW87416.1.
BC104818 mRNA. Translation: AAI04819.1.
BC104820 mRNA. Translation: AAI04821.1.
BC143313 mRNA. Translation: AAI43314.1.
BC143314 mRNA. Translation: AAI43315.1.
BC026238 mRNA. Translation: AAH26238.1.
CCDSiCCDS6803.1.
PIRiA28346. OMHU1.
RefSeqiNP_000598.2. NM_000607.2.
UniGeneiHs.522356.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KQ0X-ray1.80A19-201[»]
ProteinModelPortaliP02763.
SMRiP02763. Positions 19-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111046. 15 interactions.
IntActiP02763. 7 interactions.
MINTiMINT-202382.
STRINGi9606.ENSP00000259396.

Chemistry

BindingDBiP02763.
ChEMBLiCHEMBL4285.
DrugBankiDB05812. Abiraterone.
DB01418. Acenocoumarol.
DB01426. Ajmaline.
DB00802. Alfentanil.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB01429. Aprindine.
DB01156. Bupropion.
DB08907. Canagliflozin.
DB00482. Celecoxib.
DB00477. Chlorpromazine.
DB01151. Desipramine.
DB00280. Disopyramide.
DB00590. Doxazosin.
DB01142. Doxepin.
DB00530. Erlotinib.
DB00472. Fluoxetine.
DB00317. Gefitinib.
DB00619. Imatinib.
DB00458. Imipramine.
DB08820. Ivacaftor.
DB00934. Maprotiline.
DB08893. Mirabegron.
DB00731. Nateglinide.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00497. Oxycodone.
DB01359. Penbutolol.
DB00454. Pethidine.
DB00946. Phenprocoumon.
DB08860. Pitavastatin.
DB00457. Prazosin.
DB00571. Propranolol.
DB00908. Quinidine.
DB08931. Riociguat.
DB01232. Saquinavir.
DB00864. Tacrolimus.
DB00706. Tamsulosin.
DB05521. Telaprevir.
DB01041. Thalidomide.
DB00656. Trazodone.
DB08867. Ulipristal.
DB05294. Vandetanib.
DB08881. Vemurafenib.
DB08828. Vismodegib.
DB00682. Warfarin.

PTM databases

iPTMnetiP02763.
PhosphoSiteiP02763.
UniCarbKBiP02763.

Polymorphism and mutation databases

BioMutaiORM1.
DMDMi112877.

2D gel databases

SWISS-2DPAGEP02763.

Proteomic databases

PaxDbiP02763.
PeptideAtlasiP02763.
PRIDEiP02763.

Protocols and materials databases

DNASUi5004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259396; ENSP00000259396; ENSG00000229314.
GeneIDi5004.
KEGGihsa:5004.
UCSCiuc004bik.5. human.

Organism-specific databases

CTDi5004.
GeneCardsiORM1.
HGNCiHGNC:8498. ORM1.
HPAiCAB006265.
HPA046438.
HPA057726.
MIMi138600. gene.
neXtProtiNX_P02763.
PharmGKBiPA260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZI. Eukaryota.
ENOG4111C49. LUCA.
HOGENOMiHOG000125170.
HOVERGENiHBG000035.
InParanoidiP02763.
KOiK17308.
OrthoDBiEOG091G0NAQ.
PhylomeDBiP02763.
TreeFamiTF343791.

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiORM1. human.
EvolutionaryTraceiP02763.
GeneWikiiORM1.
GenomeRNAii5004.
PROiP02763.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000229314.
CleanExiHS_ORM1.
GenevisibleiP02763. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR001500. A1A_glycop.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11967. PTHR11967. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036899. AGP. 1 hit.
PRINTSiPR00708. A1AGLPROTEIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1AG1_HUMAN
AccessioniPrimary (citable) accession number: P02763
Secondary accession number(s): B7ZKQ5
, Q5T539, Q5U067, Q8TC16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.