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Protein

Alpha-1-acid glycoprotein 1

Gene

ORM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.2 Publications

GO - Biological processi

  • acute-phase response Source: ProtInc
  • inflammatory response Source: ProtInc
  • negative regulation of interleukin-6 production Source: CACAO
  • negative regulation of tumor necrosis factor production Source: CACAO
  • neutrophil degranulation Source: Reactome
  • platelet degranulation Source: Reactome
  • positive regulation of interleukin-1 beta secretion Source: UniProtKB
  • positive regulation of interleukin-1 secretion Source: UniProtKB
  • positive regulation of tumor necrosis factor secretion Source: UniProtKB
  • regulation of immune system process Source: InterPro

Keywordsi

Biological processAcute phase, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 1
Short name:
AGP 1
Alternative name(s):
Orosomucoid-1
Short name:
OMD 1
Gene namesi
Name:ORM1
Synonyms:AGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000229314.5
HGNCiHGNC:8498 ORM1
MIMi138600 gene
neXtProtiNX_P02763

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5004
PharmGKBiPA260

Chemistry databases

ChEMBLiCHEMBL4285
DrugBankiDB05812 Abiraterone
DB01418 Acenocoumarol
DB01426 Ajmaline
DB00802 Alfentanil
DB00321 Amitriptyline
DB00543 Amoxapine
DB01429 Aprindine
DB01156 Bupropion
DB08907 Canagliflozin
DB00482 Celecoxib
DB00477 Chlorpromazine
DB01151 Desipramine
DB00280 Disopyramide
DB00590 Doxazosin
DB01142 Doxepin
DB00530 Erlotinib
DB00472 Fluoxetine
DB00317 Gefitinib
DB00619 Imatinib
DB00458 Imipramine
DB08820 Ivacaftor
DB00934 Maprotiline
DB08893 Mirabegron
DB00731 Nateglinide
DB04821 Nomifensine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00497 Oxycodone
DB01359 Penbutolol
DB00454 Pethidine
DB00946 Phenprocoumon
DB08860 Pitavastatin
DB00457 Prazosin
DB00571 Propranolol
DB00908 Quinidine
DB08931 Riociguat
DB01232 Saquinavir
DB00864 Tacrolimus
DB00706 Tamsulosin
DB05521 Telaprevir
DB01041 Thalidomide
DB00656 Trazodone
DB08867 Ulipristal
DB05294 Vandetanib
DB08881 Vemurafenib
DB08828 Vismodegib
DB00682 Warfarin

Polymorphism and mutation databases

BioMutaiORM1
DMDMi112877

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001786019 – 201Alpha-1-acid glycoprotein 1Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi23 ↔ 1651 Publication
Glycosylationi33N-linked (GlcNAc...) (complex) asparagine8 Publications1
Glycosylationi56N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi72N-linked (GlcNAc...) (complex) asparagine5 Publications1
Disulfide bondi90 ↔ 1831 Publication
Glycosylationi93N-linked (GlcNAc...) asparagine8 Publications1
GlycosylationiCAR_000170103N-linked (GlcNAc...) asparagine4 Publications1

Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).10 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02763
PeptideAtlasiP02763
PRIDEiP02763

2D gel databases

SWISS-2DPAGEiP02763

PTM databases

CarbonylDBiP02763
GlyConnecti14
718
iPTMnetiP02763
PhosphoSitePlusiP02763
UniCarbKBiP02763

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

BgeeiENSG00000229314
CleanExiHS_ORM1
GenevisibleiP02763 HS

Organism-specific databases

HPAiCAB006265
HPA046438
HPA047725
HPA057726

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SERPINE1P051214EBI-976767,EBI-953978

Protein-protein interaction databases

BioGridi111046, 16 interactors
IntActiP02763, 7 interactors
STRINGi9606.ENSP00000259396

Chemistry databases

BindingDBiP02763

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 26Combined sources3
Helixi33 – 39Combined sources7
Beta strandi41 – 52Combined sources12
Helixi53 – 59Combined sources7
Beta strandi62 – 72Combined sources11
Turni73 – 76Combined sources4
Beta strandi77 – 86Combined sources10
Beta strandi89 – 100Combined sources12
Turni101 – 104Combined sources4
Beta strandi105 – 110Combined sources6
Beta strandi113 – 121Combined sources9
Beta strandi127 – 132Combined sources6
Helixi137 – 139Combined sources3
Beta strandi141 – 149Combined sources9
Turni153 – 156Combined sources4
Helixi157 – 166Combined sources10
Helixi170 – 172Combined sources3
Helixi178 – 180Combined sources3
Helixi184 – 192Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KQ0X-ray1.80A19-201[»]
ProteinModelPortaliP02763
SMRiP02763
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02763

Family & Domainsi

Domaini

Contains a beta-barrel that binds various ligands in its interior.1 Publication

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZI Eukaryota
ENOG4111C49 LUCA
HOGENOMiHOG000125170
HOVERGENiHBG000035
InParanoidiP02763
KOiK17308
OrthoDBiEOG091G0NAQ
PhylomeDBiP02763
TreeFamiTF343791

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11967 PTHR11967, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036899 AGP, 1 hit
PRINTSiPR00708 A1AGLPROTEIN
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDQIT GKWFYIASAF
60 70 80 90 100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQDQC IYNTTYLNVQ
110 120 130 140 150
RENGTISRYV GGQEHFAHLL ILRDTKTYML AFDVNDEKNW GLSVYADKPE
160 170 180 190 200
TTKEQLGEFY EALDCLRIPK SDVVYTDWKK DKCEPLEKQH EKERKQEEGE

S
Length:201
Mass (Da):23,512
Last modified:January 1, 1988 - v1
Checksum:i63292233AD6EAD8B
GO

Sequence cautioni

The sequence CAA29229 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170K → R in AAI43315 (PubMed:15489334).Curated1
Sequence conflicti182Missing AA sequence (PubMed:4561179).Curated1
Sequence conflicti193Missing AA sequence (PubMed:4561179).Curated1

Polymorphismi

Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01384038Q → R in allele ORM1*S. 4 Publications1
Natural variantiVAR_056166167R → C1 PublicationCorresponds to variant dbSNP:rs3182034Ensembl.1
Natural variantiVAR_013841174V → M in allele ORM1*F2. 2 PublicationsCorresponds to variant dbSNP:rs1126801Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02544 mRNA Translation: CAA26397.1
M13692 mRNA Translation: AAA35515.1
X05779
, X05780, X05781, X05782, X05783, X05784 Genomic DNA Translation: CAA29229.1 Sequence problems.
X06676 Genomic DNA No translation available.
X06680 Genomic DNA No translation available.
BT019790 mRNA Translation: AAV38593.1
AK312035 mRNA Translation: BAG34972.1
AL356796 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87416.1
BC104818 mRNA Translation: AAI04819.1
BC104820 mRNA Translation: AAI04821.1
BC143313 mRNA Translation: AAI43314.1
BC143314 mRNA Translation: AAI43315.1
BC026238 mRNA Translation: AAH26238.1
CCDSiCCDS6803.1
PIRiA28346 OMHU1
RefSeqiNP_000598.2, NM_000607.2
UniGeneiHs.522356

Genome annotation databases

EnsembliENST00000259396; ENSP00000259396; ENSG00000229314
GeneIDi5004
KEGGihsa:5004
UCSCiuc004bik.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiA1AG1_HUMAN
AccessioniPrimary (citable) accession number: P02763
Secondary accession number(s): B7ZKQ5
, Q5T539, Q5U067, Q8TC16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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