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Protein

Major urinary protein 6

Gene

Mup6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

Miscellaneous

There are about 15 group 1 MUP genes and their transcripts make up about 5% of male mouse liver RNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandPheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein 6
Short name:
MUP 6
Alternative name(s):
Alpha-2U-globulin
Group 1, BS6
Allergen: Mus m 1
Gene namesi
Name:Mup6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3378 Mus m 1.0101
478 Mus m 1
8430 Mus m 1.0102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001793219 – 180Major urinary protein 6Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 175

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP02762
PaxDbiP02762
PRIDEiP02762

2D gel databases

SWISS-2DPAGEiP02762

PTM databases

iPTMnetiP02762
PhosphoSitePlusiP02762
SwissPalmiP02762

Expressioni

Tissue specificityi

Abundant in the urine of adult male mice but absent from that of females.

Gene expression databases

BgeeiENSMUSG00000078673
ExpressionAtlasiP02762 baseline and differential
GenevisibleiP02762 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092661

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 27Combined sources5
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 50Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 75Combined sources9
Beta strandi84 – 91Combined sources8
Beta strandi98 – 113Combined sources16
Beta strandi115 – 127Combined sources13
Beta strandi130 – 142Combined sources13
Helixi146 – 158Combined sources13
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I04X-ray2.00A1-180[»]
1I05X-ray2.00A1-180[»]
1I06X-ray1.90A1-180[»]
1MUPX-ray2.40A15-180[»]
2LB6NMR-A19-180[»]
2NNDX-ray1.60A19-75[»]
A82-180[»]
2NNEX-ray1.60A19-75[»]
A82-180[»]
ProteinModelPortaliP02762
SMRiP02762
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02762

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW Eukaryota
ENOG411154J LUCA
GeneTreeiENSGT00530000063356
HOGENOMiHOG000231458
HOVERGENiHBG000215
InParanoidiP02762
OMAiFPKNDEC
TreeFamiTF338197

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002971 Maj_urinary
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01221 MAJORURINARY
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI
60 70 80 90 100
EDNGNFRLFL EQIHVLENSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV
110 120 130 140 150
TYDGFNTFTI PKTDYDNFLM AHLINEKDGE TFQLMGLYGR EPDLSSDIKE
160 170 180
RFAQLCEEHG ILRENIIDLS NANRCLQARE
Length:180
Mass (Da):20,649
Last modified:April 16, 2002 - v2
Checksum:iB4A429BDA0700947
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145S → M in CAA26953 (PubMed:3004935).Curated1
Sequence conflicti158E → K in AAA99109 (PubMed:8065364).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03208 Genomic DNA Translation: CAA26953.1
AK013259 mRNA Translation: BAB28753.1
BC013649 mRNA Translation: AAH13649.1
M17759 Genomic DNA Translation: AAA39763.1
Z32546 Genomic DNA No translation available.
M17818 Genomic DNA Translation: AAA40543.1
M17814 Genomic DNA Translation: AAA40540.1
M17817 Genomic DNA Translation: AAA40544.1
U12201 Genomic DNA Translation: AAA99109.1
CCDSiCCDS51187.2
CCDS57278.1
PIRiA03216 UAMS
RefSeqiNP_001128599.1, NM_001135127.2
NP_001186865.1, NM_001199936.1
NP_001268908.1, NM_001281979.1
XP_006537551.1, XM_006537488.2
UniGeneiMm.335875
Mm.422695
Mm.457980
Mm.457982
Mm.482072
Mm.482231

Genome annotation databases

EnsembliENSMUST00000080606; ENSMUSP00000079442; ENSMUSG00000078673
ENSMUST00000095051; ENSMUSP00000092661; ENSMUSG00000078675
ENSMUST00000107483; ENSMUSP00000103107; ENSMUSG00000078675
ENSMUST00000107506; ENSMUSP00000103130; ENSMUSG00000078686
ENSMUST00000122381; ENSMUSP00000113741; ENSMUSG00000078686
ENSMUST00000201756; ENSMUSP00000143924; ENSMUSG00000106882
ENSMUST00000201846; ENSMUSP00000144228; ENSMUSG00000106882
ENSMUST00000202367; ENSMUSP00000144443; ENSMUSG00000107188
ENSMUST00000202863; ENSMUSP00000143903; ENSMUSG00000107188
GeneIDi100038948
100039177
100189605
KEGGimmu:100038948
mmu:100039177
mmu:100189605
UCSCiuc008tak.3 mouse

Similar proteinsi

Entry informationi

Entry nameiMUP6_MOUSE
AccessioniPrimary (citable) accession number: P02762
Secondary accession number(s): P70119, Q78EF5, Q91V46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 16, 2002
Last modified: April 25, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health