Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Major urinary protein 6

Gene

Mup6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Pheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein 6
Short name:
MUP 6
Alternative name(s):
Alpha-2U-globulin
Group 1, BS6
Allergen: Mus m 1
Gene namesi
Name:Mup6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3378. Mus m 1.0101.
478. Mus m 1.
8430. Mus m 1.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001793219 – 180Major urinary protein 6Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 175

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP02762.
PaxDbiP02762.
PRIDEiP02762.

2D gel databases

SWISS-2DPAGEP02762.

PTM databases

iPTMnetiP02762.
PhosphoSitePlusiP02762.
SwissPalmiP02762.

Expressioni

Tissue specificityi

Abundant in the urine of adult male mice but absent from that of females.

Gene expression databases

BgeeiENSMUSG00000078673.
ExpressionAtlasiP02762. baseline and differential.
GenevisibleiP02762. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092661.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 27Combined sources5
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 50Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 75Combined sources9
Beta strandi84 – 91Combined sources8
Beta strandi98 – 113Combined sources16
Beta strandi115 – 127Combined sources13
Beta strandi130 – 142Combined sources13
Helixi146 – 158Combined sources13
Helixi163 – 165Combined sources3
Beta strandi166 – 168Combined sources3
Turni170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I04X-ray2.00A1-180[»]
1I05X-ray2.00A1-180[»]
1I06X-ray1.90A1-180[»]
1MUPX-ray2.40A15-180[»]
2LB6NMR-A19-180[»]
2NNDX-ray1.60A19-75[»]
A82-180[»]
2NNEX-ray1.60A19-75[»]
A82-180[»]
ProteinModelPortaliP02762.
SMRiP02762.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02762.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP02762.
OMAiFPKNDEC.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI
60 70 80 90 100
EDNGNFRLFL EQIHVLENSL VLKFHTVRDE ECSELSMVAD KTEKAGEYSV
110 120 130 140 150
TYDGFNTFTI PKTDYDNFLM AHLINEKDGE TFQLMGLYGR EPDLSSDIKE
160 170 180
RFAQLCEEHG ILRENIIDLS NANRCLQARE
Length:180
Mass (Da):20,649
Last modified:April 16, 2002 - v2
Checksum:iB4A429BDA0700947
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145S → M in CAA26953 (PubMed:3004935).Curated1
Sequence conflicti158E → K in AAA99109 (PubMed:8065364).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03208 Genomic DNA. Translation: CAA26953.1.
AK013259 mRNA. Translation: BAB28753.1.
BC013649 mRNA. Translation: AAH13649.1.
M17759 Genomic DNA. Translation: AAA39763.1.
Z32546 Genomic DNA. No translation available.
M17818 Genomic DNA. Translation: AAA40543.1.
M17814 Genomic DNA. Translation: AAA40540.1.
M17817 Genomic DNA. Translation: AAA40544.1.
U12201 Genomic DNA. Translation: AAA99109.1.
CCDSiCCDS51187.2.
PIRiA03216. UAMS.
RefSeqiNP_001128599.1. NM_001135127.2.
NP_001186865.1. NM_001199936.1.
NP_001268908.1. NM_001281979.1.
XP_006537551.1. XM_006537488.2.
UniGeneiMm.335875.
Mm.422695.
Mm.457980.
Mm.457982.
Mm.482072.
Mm.482231.

Genome annotation databases

EnsembliENSMUST00000080606; ENSMUSP00000079442; ENSMUSG00000078673.
ENSMUST00000095051; ENSMUSP00000092661; ENSMUSG00000078675.
ENSMUST00000107483; ENSMUSP00000103107; ENSMUSG00000078675.
ENSMUST00000107506; ENSMUSP00000103130; ENSMUSG00000078686.
ENSMUST00000122381; ENSMUSP00000113741; ENSMUSG00000078686.
ENSMUST00000201756; ENSMUSP00000143924; ENSMUSG00000106882.
ENSMUST00000201846; ENSMUSP00000144228; ENSMUSG00000106882.
ENSMUST00000202367; ENSMUSP00000144443; ENSMUSG00000107188.
ENSMUST00000202863; ENSMUSP00000143903; ENSMUSG00000107188.
GeneIDi100038948.
100039177.
100189605.
KEGGimmu:100038948.
mmu:100039177.
mmu:100189605.
UCSCiuc008tak.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03208 Genomic DNA. Translation: CAA26953.1.
AK013259 mRNA. Translation: BAB28753.1.
BC013649 mRNA. Translation: AAH13649.1.
M17759 Genomic DNA. Translation: AAA39763.1.
Z32546 Genomic DNA. No translation available.
M17818 Genomic DNA. Translation: AAA40543.1.
M17814 Genomic DNA. Translation: AAA40540.1.
M17817 Genomic DNA. Translation: AAA40544.1.
U12201 Genomic DNA. Translation: AAA99109.1.
CCDSiCCDS51187.2.
PIRiA03216. UAMS.
RefSeqiNP_001128599.1. NM_001135127.2.
NP_001186865.1. NM_001199936.1.
NP_001268908.1. NM_001281979.1.
XP_006537551.1. XM_006537488.2.
UniGeneiMm.335875.
Mm.422695.
Mm.457980.
Mm.457982.
Mm.482072.
Mm.482231.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I04X-ray2.00A1-180[»]
1I05X-ray2.00A1-180[»]
1I06X-ray1.90A1-180[»]
1MUPX-ray2.40A15-180[»]
2LB6NMR-A19-180[»]
2NNDX-ray1.60A19-75[»]
A82-180[»]
2NNEX-ray1.60A19-75[»]
A82-180[»]
ProteinModelPortaliP02762.
SMRiP02762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092661.

Protein family/group databases

Allergomei3378. Mus m 1.0101.
478. Mus m 1.
8430. Mus m 1.0102.

PTM databases

iPTMnetiP02762.
PhosphoSitePlusiP02762.
SwissPalmiP02762.

2D gel databases

SWISS-2DPAGEP02762.

Proteomic databases

MaxQBiP02762.
PaxDbiP02762.
PRIDEiP02762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080606; ENSMUSP00000079442; ENSMUSG00000078673.
ENSMUST00000095051; ENSMUSP00000092661; ENSMUSG00000078675.
ENSMUST00000107483; ENSMUSP00000103107; ENSMUSG00000078675.
ENSMUST00000107506; ENSMUSP00000103130; ENSMUSG00000078686.
ENSMUST00000122381; ENSMUSP00000113741; ENSMUSG00000078686.
ENSMUST00000201756; ENSMUSP00000143924; ENSMUSG00000106882.
ENSMUST00000201846; ENSMUSP00000144228; ENSMUSG00000106882.
ENSMUST00000202367; ENSMUSP00000144443; ENSMUSG00000107188.
ENSMUST00000202863; ENSMUSP00000143903; ENSMUSG00000107188.
GeneIDi100038948.
100039177.
100189605.
KEGGimmu:100038948.
mmu:100039177.
mmu:100189605.
UCSCiuc008tak.3. mouse.

Organism-specific databases

CTDi100038948.
100039177.
100189605.

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
GeneTreeiENSGT00530000063356.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP02762.
OMAiFPKNDEC.
TreeFamiTF338197.

Miscellaneous databases

EvolutionaryTraceiP02762.
PROiP02762.

Gene expression databases

BgeeiENSMUSG00000078673.
ExpressionAtlasiP02762. baseline and differential.
GenevisibleiP02762. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUP6_MOUSE
AccessioniPrimary (citable) accession number: P02762
Secondary accession number(s): P70119, Q78EF5, Q91V46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 16, 2002
Last modified: November 2, 2016
This is version 174 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are about 15 group 1 MUP genes and their transcripts make up about 5% of male mouse liver RNA.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.