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Protein

Major urinary protein

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Behavior, Transport

Keywords - Ligandi

Pheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major urinary protein
Short name:
MUP
Alternative name(s):
Allergen Rat n I
Alpha(2)-euglobulin
Alpha-2u-globulin
alpha-2u globulin PGCL1
Allergen: Rat n 1
Cleaved into the following chain:
15.5 kDa fatty acid-binding protein
Short name:
15.5 kDa FABP
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708506. LOC259246.

Subcellular locationi

15.5 kDa fatty acid-binding protein :
  • Cytoplasmcytosol

  • Note: It is probably taken up from the urinary lumen by endocytosis.

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3464. Rat n 1.0101.
611. Rat n 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000001792520 – 181Major urinary proteinAdd BLAST162
ChainiPRO_000001792629 – 17915.5 kDa fatty acid-binding proteinAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Curated1
Disulfide bondi83 ↔ 1761 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02761.
PRIDEiP02761.

Expressioni

Tissue specificityi

Abundant in the urine of adult male rats but absent from that of females.

Inductioni

Synthesis of this protein in the hepatic parenchymal cells is induced in vivo by androgens, glucocorticoids, growth hormone, and insulin, and inhibited by estrogens.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047327.

Structurei

Secondary structure

1181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 27Combined sources4
Helixi31 – 34Combined sources4
Beta strandi39 – 44Combined sources6
Helixi48 – 50Combined sources3
Beta strandi60 – 67Combined sources8
Beta strandi70 – 81Combined sources12
Beta strandi83 – 92Combined sources10
Beta strandi99 – 114Combined sources16
Beta strandi116 – 128Combined sources13
Beta strandi131 – 144Combined sources14
Helixi147 – 158Combined sources12
Turni159 – 161Combined sources3
Helixi164 – 166Combined sources3
Beta strandi167 – 169Combined sources3
Helixi170 – 172Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A2GX-ray2.90A/B/C/D1-181[»]
2A2UX-ray2.50A/B/C/D1-181[»]
ProteinModelPortaliP02761.
SMRiP02761.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02761.

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP02761.
PhylomeDBiP02761.
TreeFamiTF338197.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLLLLLCL GLTLVCGHAE EASSTRGNLD VAKLNGDWFS IVVASNKREK
60 70 80 90 100
IEENGSMRVF MQHIDVLENS LGFKFRIKEN GECRELYLVA YKTPEDGEYF
110 120 130 140 150
VEYDGGNTFT ILKTDYDRYV MFHLINFKNG ETFQLMVLYG RTKDLSSDIK
160 170 180
EKFAKLCEAH GITRDNIIDL TKTDRCLQAR G
Length:181
Mass (Da):20,737
Last modified:July 21, 1986 - v1
Checksum:i6A01309DC55032DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26R → S in AAA41198 (PubMed:6167987).Curated1
Sequence conflicti55G → D in CAA24531 (PubMed:6163771).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26835 mRNA. Translation: AAA40643.1.
M26837 mRNA. Translation: AAA40641.1.
AB039822 mRNA. Translation: BAA96479.1.
BC088109 mRNA. Translation: AAH88109.1.
BC098654 mRNA. Translation: AAH98654.1.
BC105816 mRNA. Translation: AAI05817.1.
U31287 mRNA. Translation: AAA75511.1.
V01220 mRNA. Translation: CAA24531.1.
J00737 mRNA. Translation: AAA41198.1.
PIRiA92317. UART.
RefSeqiNP_671747.1. NM_147214.2.
UniGeneiRn.224459.

Genome annotation databases

GeneIDi259246.
KEGGirno:259246.
UCSCiRGD:708506. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26835 mRNA. Translation: AAA40643.1.
M26837 mRNA. Translation: AAA40641.1.
AB039822 mRNA. Translation: BAA96479.1.
BC088109 mRNA. Translation: AAH88109.1.
BC098654 mRNA. Translation: AAH98654.1.
BC105816 mRNA. Translation: AAI05817.1.
U31287 mRNA. Translation: AAA75511.1.
V01220 mRNA. Translation: CAA24531.1.
J00737 mRNA. Translation: AAA41198.1.
PIRiA92317. UART.
RefSeqiNP_671747.1. NM_147214.2.
UniGeneiRn.224459.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A2GX-ray2.90A/B/C/D1-181[»]
2A2UX-ray2.50A/B/C/D1-181[»]
ProteinModelPortaliP02761.
SMRiP02761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047327.

Protein family/group databases

Allergomei3464. Rat n 1.0101.
611. Rat n 1.

Proteomic databases

PaxDbiP02761.
PRIDEiP02761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi259246.
KEGGirno:259246.
UCSCiRGD:708506. rat.

Organism-specific databases

RGDi708506. LOC259246.

Phylogenomic databases

eggNOGiENOG410J5XW. Eukaryota.
ENOG411154J. LUCA.
HOGENOMiHOG000231458.
HOVERGENiHBG000215.
InParanoidiP02761.
PhylomeDBiP02761.
TreeFamiTF338197.

Miscellaneous databases

EvolutionaryTraceiP02761.
PROiP02761.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002971. Maj_urinary.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01221. MAJORURINARY.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUP_RAT
AccessioniPrimary (citable) accession number: P02761
Secondary accession number(s): Q54AE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.